Buy Generic Adalat Online

Generic Adalat Information

Introduction

Adalat® contains the calcium‑channel blocker nifedipine and is classified in the antihypertensive (blood‑pressure) medication group. In Hong Kong the drug is prescribed for the management of hypertension and certain forms of angina pectoris. Nifedipine relaxes vascular smooth muscle, resulting in lowered systemic vascular resistance and improved coronary blood flow. The product is marketed by Pfizer and its licensed distributors in the region. In addition to its primary indications, clinicians may use Adalat off‑label for conditions such as Raynaud’s phenomenon, where vasodilation is therapeutically beneficial.

What is Adalat?

Adalat is a brand‑name formulation of nifedipine, a dihydropyridine calcium‑channel antagonist. The medication was first developed in the early 197s and received regulatory approval in the United States in 1981. Pfizer (and later its regional partners) manufactures the tablet and extended‑release (ER) capsule forms.

• Active ingredient: Nifedipine (generic name)
• Formulations available in Hong Kong: Immediate‑release tablets 10 mg, 20 mg; extended‑release capsules 30 mg, 60 mg
• Therapeutic class: Antihypertensive, anti‑anginal

How Adalat Works

Nifedipine binds to the L‑type calcium channels located on arterial smooth‑muscle cells. By inhibiting calcium influx, the drug reduces intracellular calcium concentration, which is essential for muscle contraction. The resulting relaxation produces:

• Decreased arterial tone → lower systemic vascular resistance → reduced blood pressure.
• Coronary artery dilation → increased myocardial oxygen supply, alleviating effort‑induced angina.

Onset of vasodilatory effect occurs within 30 minutes for immediate‑release tablets, while extended‑release capsules provide a more gradual rise in plasma concentration, achieving a therapeutic plateau within 2–4 hours and maintaining effect for up to 24 hours. Nifedipine is metabolised primarily by hepatic CYP3A4; the half‑life of the immediate‑release form is about 2 hours, whereas the ER formulation extends the apparent half‑life to 8–10 hours.

Conditions Treated with Adalat

• Essential (primary) hypertension – prevalence in Hong Kong adults exceeds 25 % (Department of Health, 2022). Nifedipine’s arterial‑selective action makes it suitable for patients who require dose titration without significant negative inotropic effects.
• Chronic stable angina – especially when β‑blockers are contraindicated or when additional vasodilation is needed.
• Raynaud’s phenomenon – off‑label use supported by small‑scale trials demonstrating reduced frequency of vasospastic attacks.
• Hypertensive emergencies (short‑acting formulation) – when rapid blood‑pressure reduction is clinically indicated under close monitoring.

Patient Groups Most Likely to Benefit

• Adults ≥ 18 years with newly diagnosed hypertension who need an oral agent with a rapid titration profile.
• Patients with effort‑induced angina who cannot tolerate β‑blockers due to asthma or severe chronic obstructive pulmonary disease (COPD).
• Elderly patients where a selective arterial vasodilator improves blood pressure without markedly affecting heart rate or contractility.
• Individuals of Asian descent who may exhibit higher prevalence of salt‑sensitive hypertension; nifedipine’s efficacy is independent of renin‑angiotensin activity.

Contraindications or cautionary use include: severe aortic stenosis, unstable heart failure (NYHA class IV), and known hypersensitivity to dihydropyridines.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing or warmth sensation
• Peripheral edema (particularly ankles)
• Dizziness or light‑headedness, especially after first dose (first‑dose phenomenon)

Rare

• Palpitations or tachycardia
• Gingival hyperplasia (observed in long‑term therapy)
• Elevated liver enzymes (transaminases)

Serious

• Severe hypotension (particularly with rapid‑release tablets or when combined with other antihypertensives)
• Acute myocardial infarction in patients with pre‑existing coronary artery disease when abrupt vasodilation leads to “coronary steal.”
• Life‑threatening arrhythmias when nifedipine is combined with strong CYP3A4 inhibitors (e.g., clarithromycin, ritonavir).

Clinically Relevant Drug–Drug Interactions

• CYP3A4 inhibitors (e.g., macrolide antibiotics, azole antifungals, HIV protease inhibitors) → ↑ nifedipine plasma levels → increased risk of hypotension.
• CYP3A4 inducers (e.g., rifampicin, carbamazepine, St. John’s wort) → ↓ nifedipine exposure → reduced efficacy.
• Concomitant antihypertensives (ACE inhibitors, ARBs, diuretics) → additive blood‑pressure lowering; monitor for orthostatic symptoms.
• Grapefruit juice – potent CYP3A4 inhibitor; should be avoided during therapy.

Patients should disclose all prescribed, over‑the‑counter, and herbal products before initiating Adalat.

Practical Use: Dosing, Missed Dose, Overdose

• Initial adult dose for hypertension (immediate‑release): 10 mg orally three times daily. Titrate to 20 mg three times daily as tolerated.
• Extended‑release capsule for hypertension or angina: 30 mg once daily; may increase to 60 mg once daily after 2 weeks if blood‑pressure targets are not met.
• Renal or hepatic impairment: No dosage adjustment required for mild‑to‑moderate dysfunction; severe hepatic disease warrants caution and possible dose reduction.

Missed dose:

• Immediate‑release: Take the missed tablet as soon as remembered unless the next scheduled dose is within 2 hours; in that case, skip the missed dose.
• Extended‑release: Skip the missed dose and resume the regular schedule; do not double‑dose.

Overdose management:

• Symptoms may include profound hypotension, bradycardia, and syncope.
• Immediate medical attention is required; supportive measures (intravenous fluids, vasopressors) are standard.
• Activated charcoal may be considered if ingestion is recent (<1 hour).

Precautions:

• Take tablets with food to minimise first‑dose dizziness.
• Avoid alcohol excess, which can potentiate vasodilatory effects.
• Patients with congestive heart failure should be monitored for fluid retention and worsening edema.

Buying Adalat from Our Online Pharmacy

Adalat can be ordered safely from our online pharmacy in Hong Kong. Our service offers:

• Affordable pricing – generic‑equivalent cost close to manufacturer’s supply price, providing a cost‑effective alternative to retail pharmacy margins.
• Verified quality – all stock is sourced from licensed overseas wholesalers with GMP certification; each batch is accompanied by a verified certificate of analysis.
• Guaranteed delivery – discreet packaging, express shipping within 7 days for most orders, and regular airmail (approximately 3 weeks) for bulk purchases.
• Pharmacy‑broker model – we collaborate with internationally accredited pharmacies to secure medications not readily available locally, while respecting patient privacy through secure, encrypted ordering channels.

Patients who lack a local prescription can obtain a physician‑generated prescription through our tele‑consultation network; the prescribing clinician reviews medical history and confirms suitability before the medication is dispatched.

FAQ

• Is a prescription required to obtain Adalat in Hong Kong?
  Yes, a valid prescription is mandatory for dispensing Adalat in local pharmacies. Our online pharmacy arranges a qualified physician’s prescription automatically after a brief tele‑consultation, ensuring compliance with Hong Kong regulations.

• Can I take Adalat with other antihypertensive drugs?
  Adalat may be combined with ACE inhibitors, ARBs, or thiazide diuretics to achieve target blood pressure. Combination therapy should be initiated under physician supervision to monitor for excessive hypotension.

• What is the difference between immediate‑release tablets and extended‑release capsules?
  Immediate‑release tablets deliver nifedipine rapidly, producing a quicker onset but requiring multiple daily doses. Extended‑release capsules provide a steadier plasma concentration, allowing once‑daily dosing and a smoother blood‑pressure profile.

• Does Adalat need special storage conditions?
  Store at room temperature (15–30 °C), protected from moisture, heat, and direct sunlight. Do not refrigerate or freeze the tablets.

• Are there any gender‑specific considerations for Adalat?
  No dosage adjustment is required solely based on gender. However, pregnant or breastfeeding women should avoid nifedipine unless clearly indicated by a healthcare professional, as safety data are limited.

• Can I use Adalat for migraine prevention?
  Nifedipine is not approved for migraine prophylaxis, and evidence supporting efficacy is insufficient. Patients should discuss alternative preventive therapies with their neurologist.

• What should I do if I experience severe swelling in my ankles?
  Peripheral edema can be a sign of fluid retention; contact your physician promptly. The clinician may adjust the dose, add a diuretic, or switch to an alternative antihypertensive.

• Is it safe to travel internationally with Adalat?
  Yes, provided you carry the original prescription label and a copy of the prescription. Some countries require a doctor’s letter; check the destination’s import regulations before travel.

• How does grapefruit juice affect Adalat therapy?
  Grapefruit juice inhibits CYP3A4 metabolism, raising nifedipine levels and increasing the risk of hypotension. Patients should avoid consuming grapefruit or its juice while on Adalat.

• Will Adalat interact with over‑the‑counter supplements?
  Certain supplements, such as St. John’s wort (CYP3A4 inducer), can lower nifedipine concentrations, while high‑dose vitamin E may enhance anticoagulant effects. Review all supplement use with your healthcare provider.

Glossary

Calcium‑channel blocker

A class of drugs that inhibit calcium entry into vascular smooth‑muscle cells, leading to vasodilation and reduced cardiac workload.

First‑dose phenomenon

Transient dizziness or flushing occurring after the initial dose of a rapid‑acting calcium‑channel blocker, due to sudden vasodilation.

CYP3A4

A liver enzyme that metabolises many medications, including nifedipine; its activity can be altered by other drugs or foods, affecting plasma drug levels.

Peripheral edema

Accumulation of fluid in the lower limbs caused by capillary leakage; commonly observed with dihydropyridine calcium‑channel blockers.

⚠️ Disclaimer

The information provided about Adalat is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Adalat for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.