Buy Generic Allopurinol Online

Generic Allopurinol Information

Introduction

Allopurinol is a widely prescribed medication that lowers elevated uric acid levels, thereby preventing gout attacks and certain forms of kidney stones. In Hong Kong, it is listed under the arthritis therapeutic group and is available both through local pharmacies with a physician’s prescription and via licensed online channels. The active compound, Allopurinol, inhibits the enzyme xanthine oxidase, reducing the production of uric acid from purine metabolism. It is also employed off‑label for the prevention of tumour lysis syndrome in oncology patients.

What is Allopurinol?

Allopurinol is a synthetic purine analogue that belongs to the class of xanthine oxidase inhibitors. First synthesized in the 195s by R. W. J. Schmidt, it was subsequently marketed by various pharmaceutical companies. The original brand name is Zyloprim®, and numerous generic versions are produced worldwide.

Allopurinol is the generic version of Zyloprim®, containing the same active compound Allopurinol. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

How Allopurinol Works

Allopurinol is metabolised in the liver to oxypurinol, a potent and longer‑acting inhibitor of xanthine oxidase. By blocking this enzyme, the conversion of hypoxanthine to xanthine and of xanthine to uric acid is reduced. Consequently, serum urate concentrations fall, diminishing crystal deposition in joints and kidneys.

The onset of urate‑lowering effect typically occurs within 2–3 days of the first dose, while steady‑state concentrations of oxypurinol are achieved after 5–7 days of regular dosing. The drug is primarily eliminated unchanged by the kidneys; dose adjustment is required in renal impairment to avoid accumulation and toxicity.

Conditions Treated with Allopurinol

• Gout – Chronic hyperuricaemia leading to monosodium urate crystal formation in joints. Allopurinol is the first‑line urate‑lowering therapy recommended by the Hong Kong Hospital Authority.
• Recurrent Kidney Stones – Calcium oxalate stones can be precipitated by high urinary uric acid; lowering serum urate reduces stone recurrence.
• Tumour Lysis Syndrome (TLS) Prophylaxis – In high‑risk haematologic malignancies, rapid tumour cell breakdown releases nucleic acids that raise uric acid; Allopurinol mitigates renal complications.
• Hyperuricaemia associated with chemotherapy or radiotherapy – Prevents uric acid nephropathy in patients receiving cytotoxic agents.

In Hong Kong, gout prevalence rises with an aging population and dietary shifts, making Allopurinol a cornerstone of public health management for musculoskeletal disorders.

Patient Groups Most Likely to Benefit

• Adults with documented hyperuricaemia (serum urate > 6.8 mg/dL) and a history of gout flares.
• Patients with recurrent uric acid kidney stones confirmed by stone analysis.
• Oncologic patients at high risk for TLS, such as those with acute lymphoblastic leukaemia or high‑grade lymphoma undergoing aggressive chemotherapy.
• Individuals with chronic kidney disease (CKD) stage 3–4 where uric acid contributes to disease progression, provided renal dosing guidelines are followed.

Allopurinol is contraindicated or should be used with caution in patients with severe hypersensitivity to the drug, known deficiency of glucose‑6‑phosphate dehydrogenase (G6PD), and in early pregnancy unless the benefits outweigh risks.

Risks, Side Effects, and Interactions

Common

• Rash or mild skin erythema
• Gastrointestinal discomfort (nausea, diarrhoea)
• Headache
• Elevated liver enzymes (transaminases)

Rare

• Fixed‑dose drug eruption (FDE)
• Photosensitivity reactions
• Acute interstitial nephritis

Serious

• Allopurinol hypersensitivity syndrome (AHS) – A severe, potentially life‑threatening reaction characterised by fever, extensive rash, eosinophilia, and hepatic or renal failure. AHS incidence is higher in certain Asian subpopulations carrying the HLA‑B*58:01 allele.
• Stevens‑Johnson syndrome / toxic epidermal necrolysis (SJS/TEN)
• Severe neutropenia or agranulocytosis

Clinically Relevant Drug–Drug Interactions

• Azathioprine, Mercaptopurine (6‑MP) – Allopurinol inhibits their metabolism, increasing myelosuppression; dose of the thiopurine must be reduced to ≤ 25 % of the usual dose.
• Warfarin – May enhance anticoagulant effect; monitor INR closely.
• Amoxicillin‑clavulanate – Concurrent use has been associated with an increased risk of AHS; avoid if possible.
• Thiazide diuretics – Reduce renal urate excretion, potentially counteracting Allopurinol’s effect; dose adjustment may be required.
• High‑purine foods and alcohol – While not pharmacokinetic interactions, they can blunt urate‑lowering efficacy and precipitate gout flares.

Practical Use: Dosing, Missed Dose, Overdose

• Initial dose: 100 mg daily for most adults; some clinicians start at 50 mg daily in patients with renal impairment or a history of rash.
• Titration: Increase by 100 mg weekly until target serum urate (< 6 mg/dL) is achieved, usually not exceeding 300 mg/day for Asian patients due to higher AHS risk.
• Renal adjustment: For creatinine clearance < 30 mL/min, the maximum dose is generally limited to 100 mg daily.

Missed dose – Take the missed tablet as soon as remembered if it is at least 6 hours before the next scheduled dose; otherwise, skip and continue the regular schedule. Do not double‑dose.

Overdose – Symptoms may include severe nausea, vomiting, diarrhoea, and dizziness. Seek immediate medical attention; gastric lavage and activated charcoal are standard emergency measures.

Practical precautions

• Take Allopurinol with food to minimise gastrointestinal upset.
• Maintain adequate hydration (≥ 2 L of fluid daily) to aid renal clearance of uric acid.
• Avoid excessive alcohol, especially beer, which is high in purines.
• Inform the prescriber of any existing liver or kidney disease before initiating therapy.

Buying Allopurinol from Our Online Pharmacy

Allopurinol can be purchased conveniently from our online pharmacy in Hong Kong. Our service offers several advantages:

• Affordable pricing – We source the generic product close to manufacturer cost, passing savings directly to patients.
• Verified quality – All tablets are supplied by licensed overseas manufacturers that meet WHO‑GMP standards; each batch undergoes third‑party testing.
• Guaranteed delivery – Discreet, reliable shipping options include 7‑day express service for urgent needs and a standard airmail route (approximately 3 weeks).
• Online‑only access – Patients who face barriers to traditional pharmacy visits or insurance formularies can obtain the medication safely and privately.

Our platform operates as a pharmacy broker service, collaborating with licensed international pharmacies. This model enables us to provide a discreet service that respects patient privacy while complying with Hong Kong’s import regulations for personal use medicines.

FAQ

• Is Allopurinol covered by Hong Kong’s public health insurance schemes?
  Coverage varies; the Hospital Authority may provide Allopurinol for eligible patients with documented gout or TLS risk, but private insurance plans differ. Patients should verify their specific benefits with their insurer.

• Can I order Allopurinol without a local Hong Kong prescription?
  A prescription is required by law for dispensing Allopurinol in Hong Kong. Our online pharmacy arranges a tele‑prescription from a licensed physician after a brief medical review, eliminating the need for patients to obtain a local prescription beforehand.

• What dosage forms of Allopurinol are available for purchase online?
  The generic tablets are supplied in 100 mg and 300 mg strengths, packaged in blister packs of 30 tablets per strip. Extended‑release formulations are not currently offered.

• Is it safe to import Allopurinol for personal use in Hong Kong?
  Yes, provided the quantity does not exceed a 30‑day supply and a valid prescription accompanies the shipment, as required by the Hong Kong Department of Health’s Personal Importation Scheme.

• Do Asian patients need a lower maximum dose of Allopurinol?
  Clinical guidelines suggest a maximum of 300 mg per day for patients of East Asian descent because of a higher prevalence of the HLA‑B*58:01 allele associated with severe hypersensitivity. Genetic testing can guide dosing decisions.

• Will taking Allopurinol interfere with my blood tests for liver function?
  Allopurinol can cause mild, transient elevations in transaminases. Routine monitoring of liver enzymes is advisable, especially during the first three months of therapy or after dose escalation.

• Can Allopurinol be used together with febuxostat?
  Concurrent use is generally unnecessary and may increase the risk of adverse effects. Switching between the two agents should be done under medical supervision, with a wash‑out period of at least one week.

• How long does it take for Allopurinol to prevent a gout flare after starting therapy?
  While serum urate reductions begin within days, clinicians usually advise patients to continue prophylactic anti‑inflammatory medication (e.g., colchicine) for the first 3–6 months to prevent early flares as crystal dissolution occurs.

• What should I do if I develop a rash while taking Allopurinol?
  Any new skin rash warrants immediate medical evaluation. Mild rashes may resolve with continued therapy, but more extensive or bullous lesions could indicate early hypersensitivity, requiring drug discontinuation.

• Is there a difference between Allopurinol marketed in the US versus the EU or Asia?
  The active ingredient is identical worldwide, but excipients (e.g., fillers, binders) can vary. Patients with known allergies to specific excipients should review the product’s ingredient list, which is provided on the packaging and our online product page.

• Can I use Allopurinol during pregnancy or breastfeeding?
  Allopurinol is classified as Category C in pregnancy; it should be used only if the potential benefit justifies the risk to the fetus. It is excreted in breast milk, so breastfeeding mothers should consult their physician before continuation.

Glossary

Xanthine Oxidase

An enzyme that catalyses the oxidation of hypoxanthine to xanthine and xanthine to uric acid, the final step in purine degradation.

Hypersensitivity Syndrome

A severe, immune‑mediated drug reaction characterised by fever, rash, organ involvement (often liver or kidney), and eosinophilia.

Renal Clearance

The volume of plasma from which a substance is completely removed by the kidneys per unit time, expressed in millilitres per minute.

Prophylaxis

Preventive treatment intended to stop a disease or complication before it occurs.

⚠️ Disclaimer

The information provided about Allopurinol is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Allopurinol for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.