Buy Avanafil Online

Avanafil Information

Introduction

Avanafil is a phosphodiesterase‑5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED) in adult men. In Hong Kong, where an estimated 15 % of men over 40 experience some degree of ED, timely and effective therapy is an essential component of men’s health care. The active compound, avanafil, was developed by Vivus Inc. and approved by the U.S. Food and Drug Administration (FDA) under the brand name Stendra. The medication belongs to the broader class of men’s‑health agents that improve penile blood flow during sexual stimulation. While its primary indication is ED, avanafil’s rapid onset and favorable safety profile make it a valuable option for patients who desire spontaneity and a short waiting period before sexual activity.

What is Avanafil?

• Classification: Selective phosphodiesterase‑5 (PDE5) inhibitor.
• Development: Discovered and chemically synthesised by Vivus Inc.; first approved in the United States in 2012.
• Manufacturer (brand): The original branded product is Stendra, marketed by Vivus (later acquired by Allergan).
• Generic version: Avanafil is the generic version of Stendra, containing the same active compound avanafil. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

Avanafil tablets are available in strengths of 50 mg, 100 mg, and 200 mg and are taken orally. The drug is formulated for rapid absorption, allowing men to achieve an erection within minutes after dosing.

How Avanafil Works

Avanafil inhibits the enzymatic activity of PDE5, the enzyme responsible for degrading cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. During sexual arousal, nitric oxide released from nerve endings stimulates the production of cGMP, which relaxes smooth muscle and permits inflow of blood into the penile tissue. By blocking PDE5, avanafil prolongs the action of cGMP, maintaining smooth‑muscle relaxation and facilitating engorgement.

Key pharmacological characteristics:

• Onset of action: Clinical trials report effective erections as early as 15 minutes after ingestion, the fastest among approved PDE5 inhibitors.
• Duration: Therapeutic effect can persist for up to 6 hours, providing a flexible window for sexual activity.
• Clearance: Avanafil is metabolised primarily by hepatic CYP3A4 enzymes; the mean plasma half‑life is approximately 5 hours, supporting once‑daily or as‑needed dosing.

Conditions Treated with Avanafil

• Erectile Dysfunction (ED): The only FDA‑approved indication. In Hong Kong, ED prevalence rises with age, diabetes, and cardiovascular disease, making avanafil a clinically relevant option for a sizable male population.
• Off‑label considerations: Some clinicians explore PDE5 inhibition for pulmonary arterial hypertension, but avanafil has not received regulatory approval for this use and is therefore not recommended for such indications.

The drug’s rapid onset and short dosing window are particularly valuable for men who value spontaneity and wish to minimise the planning required for sexual activity.

Patient Groups Most Likely to Benefit

• Men with mild‑to‑moderate ED who desire a quick onset of action.
• Patients with diabetes‑related vascular dysfunction, where rapid pharmacodynamic response can compensate for reduced endogenous nitric‑oxide availability.
• Post‑prostate‑cancer surgery patients who have regained sufficient nerve function and need an on‑demand solution.
• Individuals who use alcohol socially, as avanafil’s efficacy is less affected by moderate alcohol intake compared with some other PDE5 inhibitors.

Contra‑indications or cautionary groups:

• Men taking organic nitrates (e.g., nitroglycerin) or nitric‑oxide donors, due to risk of profound hypotension.
• Patients with severe uncontrolled hypertension or recent myocardial infarction where sexual activity itself may pose cardiovascular risk.
• Individuals with a known hypersensitivity to avanafil or any tablet excipients.

Risks, Side Effects, and Interactions

Common

• Headache
• Facial flushing
• Nasal congestion or rhinitis
• Back pain or myalgia
• Dizziness (usually mild and transient)

These events typically appear within the first hour after dosing and resolve without medical intervention.

Rare

• Visual disturbances (e.g., blue‑tinted vision, blurred vision)
• Priapism (erection lasting > 4 hours)
• Severe hypotension when combined with potent vasodilators

Patients experiencing rare events should seek prompt medical evaluation.

Serious

• Acute myocardial infarction or unstable angina
• Ischemic stroke
• Life‑threatening hypotension leading to syncope

These serious outcomes are uncommon and usually occur in patients with pre‑existing cardiovascular disease who use contraindicated medications (e.g., nitrates).

Clinically Relevant Drug–Drug Interactions

• Nitrates (nitroglycerin, isosorbide dinitrate) – contraindicated.
• Alpha‑blockers (e.g., tamsulosin) – may cause additive blood‑pressure lowering; initiate avanafil at the lowest dose and monitor.
• Strong CYP3A4 inhibitors (ketoconazole, itraconazole, erythromycin, clarithromycin) – increase avanafil plasma concentration; dose reduction to 50 mg advised.
• CYP3A4 inducers (rifampin, carbamazepine, phenytoin) – may reduce efficacy.
• Other PDE5 inhibitors – concurrent use is prohibited due to cumulative risk of hypotension and priapism.
• Herbal supplements (e.g., ginkgo biloba, yohimbine) – limited data, but caution is advised as they may affect vascular tone.

Practical Use: Dosing, Missed Dose, Overdose

• Starting dose: 100 mg taken with or without food, at least 15 minutes before anticipated sexual activity.
• Dose titration: If the 100 mg dose is well tolerated but insufficient, increase to 200 mg. If side effects are problematic, reduce to 50 mg.
• Maximum frequency: Do not exceed one dose per 24 hours. Daily dosing is permissible for men who anticipate sexual activity on successive days, but the same daily dose should not be taken more than once in a 24‑hour period.

Missed dose: Avanafil is taken only when sexual activity is planned. If a dose is forgotten and sexual activity is still anticipated within a reasonable time frame, take the dose immediately. If the scheduled time for the next dose is approaching (within 24 hours), skip the missed dose—do not double‑dose.

Overdose: Symptoms may include severe headache, dizziness, profound hypotension, or prolonged erection. In case of suspected overdose, seek emergency medical care. No specific antidote exists; treatment is supportive and symptomatic.

Practical precautions:

• Avoid heavy or high‑fat meals immediately before dosing, as they may delay absorption.
• Limit alcohol intake to moderate levels (≤ 2 standard drinks) because excessive alcohol can diminish the drug’s efficacy and increase the risk of dizziness.
• Discuss all current medications, including over‑the‑counter products, with a healthcare provider before initiating avanafil.

Buying Avanafil from Our Online Pharmacy

Patients in Hong Kong who encounter limited availability of brand‑name PDE5 inhibitors or who seek a more affordable option can purchase avanafil from our online pharmacy.

• Cost‑effectiveness: Prices are set near the manufacturer’s wholesale cost, substantially lower than many local retail pharmacies.
• Verified quality: We source avanafil exclusively from licensed overseas manufacturers that meet international Good Manufacturing Practice (GMP) standards. Each batch undergoes third‑party quality testing before shipment.
• Delivery options:
  • Express service: Delivered within 7 days to most Hong Kong districts.
  • Standard airmail: Arrives in approximately 2–3 weeks, with tracking available for all parcels.
• Discreet packaging: Medications are packaged in unbranded, tamper‑evident containers to protect privacy.
• Pharmacy broker model: Our service operates as a broker connecting patients with accredited overseas pharmacies. This arrangement enables us to provide medications that may not be stocked in local retail outlets while maintaining compliance with Hong Kong’s import regulations for personal use.

For men who have a prescription from a licensed healthcare professional, our platform can streamline the fulfillment process, often arranging the prescription electronically without requiring a physical copy. This eliminates the need for in‑person pharmacy visits, which can be advantageous for those seeking privacy or who reside in remote areas.

FAQ

• Is Avanafil covered by Hong Kong’s public health insurance scheme?
  Currently, the Hospital Authority’s public drug formulary does not include PDE5 inhibitors such as avanafil. Patients typically obtain the medication through private prescriptions or by purchasing it from private pharmacies, including our online pharmacy.

• Can I order Avanafil without a local prescription in Hong Kong?
  Our online pharmacy collaborates with licensed overseas prescribers who can issue a valid prescription after a telemedicine consultation. While a traditional Hong Kong prescription is not required, the medication is still dispensed based on a legitimate medical order in compliance with local regulations.

• How long does shipping take when I order avanafil from abroad?
  Express delivery usually arrives within 7 days, whereas standard airmail takes about 2–3 weeks. Shipping times may vary due to customs clearance or public holidays.

• Are there any formulation differences between Stendra and generic avanafil tablets?
  Both contain the same active ingredient, avanafil, at equivalent strengths. Generic tablets may use different inert excipients, but these variations do not affect the drug’s efficacy or safety when manufactured according to GMP standards.

• What is the recommended storage condition for avanafil tablets?
  Store at room temperature (15 °C–30 °C), protected from excessive moisture, direct sunlight, and heat sources. Do not refrigerate the tablets.

• Can men with hypertension take avanafil safely?
  Yes, avanafil can be used in patients with well‑controlled hypertension. However, those receiving antihypertensive agents that cause vasodilation (e.g., alpha‑blockers) should start with the lowest dose and be monitored for blood‑pressure changes.

• Does avanafil interact with herbal supplements such as ginkgo biloba?
  Limited clinical data exist, but ginkgo biloba may have mild antiplatelet effects. Combining it with avanafil does not appear to cause significant interactions, yet patients should inform their physician of any supplement use.

• Is it safe to buy avanafil from unverified websites?
  Purchasing from unverified sources raises the risk of counterfeit or sub‑standard products, which can lead to treatment failure or harmful side effects. Our online pharmacy guarantees authenticity through verified suppliers.

• What should I do with unused avanafil tablets?
  Unused tablets should be disposed of in accordance with local pharmaceutical waste guidelines—typically by returning them to a pharmacy or using a designated medication‑take‑back program. Do not flush them down the toilet.

• Can avanafil be taken daily, or is it strictly an “as‑needed” medication?
  Avanafil may be taken daily if the patient anticipates frequent sexual activity, provided the total daily dose does not exceed 200 mg. Daily use follows the same safety profile as intermittent dosing, but patients should discuss their dosing schedule with a healthcare professional.

Glossary

Phosphodiesterase‑5 (PDE5) inhibitor

A class of drugs that block the PDE5 enzyme, preventing the breakdown of cyclic guanosine monophosphate (cGMP) and thereby enhancing smooth‑muscle relaxation in the penis.

Cyclic guanosine monophosphate (cGMP)

A messenger molecule that mediates smooth‑muscle relaxation in the corpus cavernosum, allowing increased blood flow during sexual arousal.

Priapism

A prolonged, often painful erection lasting more than four hours that persists without sexual stimulation; it is a medical emergency.

Pharmacokinetics

The study of how a drug is absorbed, distributed, metabolized, and excreted by the body. For avanafil, key parameters include rapid absorption, a half‑life of ~5 hours, and hepatic metabolism via CYP3A4.

⚠️ Disclaimer

The information provided about Avanafil is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Avanafil for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.