Buy Generic Benemid Online

Generic Benemid Information

Introduction

Benemid is a prescription medication that contains the active compound probenecid. It belongs to the therapeutic group traditionally associated with pain relief, but its primary clinical role is as a uricosuric agent that enhances the renal excretion of uric acid. In Hong Kong, Benemid is prescribed mainly for the long‑term management of gout and for specific pharmacokinetic interactions that increase the plasma concentrations of certain antibiotics and antiviral agents. The drug is marketed in several regions by manufacturers such as Pfizer and various generic producers that meet the standards of the Hong Kong Pharmacy and Poisons Board.

What is Benemid?

• Drug classification: Urate‑lowering agent; classified as a uricosuric diuretic.
• Active ingredient: Probenecid, a sulfonamide derivative that inhibits renal tubular reabsorption of uric acid.
• Development history: First introduced in the United States in the 195s, Benemid quickly became a standard therapy for gout after clinical trials demonstrated its ability to lower serum urate levels.
• Manufacturer: The original brand name Benemid was produced by Pfizer. Today, the formulation is also available from multiple reputable generic manufacturers that supply the Hong Kong market under strict quality‑control regulations.

How Benemid Works

Probenecid acts on the proximal tubule of the kidney where it blocks the organic anion transporter‑1 (OAT1) and, to a lesser extent, OAT3. These transporters are responsible for the reabsorption of uric acid from the glomerular filtrate back into the bloodstream. By inhibiting this pathway, probenecid:

1. Increases urinary uric acid excretion – up to 50 % more uric acid can be cleared in the urine, leading to a sustained reduction in serum urate concentration.
2. Provides a therapeutic window – the drug reaches peak plasma concentrations within 1–2 hours after oral intake, and its uricosuric effect persists for 8–12 hours, allowing once‑daily or twice‑daily dosing.
3. Modulates drug clearance – the same OAT inhibition reduces renal elimination of certain β‑lactam antibiotics (e.g., ceftriaxone) and antivirals (e.g., acyclovir), prolonging their effective plasma levels. This property is intentionally used in specific infectious‑disease regimens.

Renal clearance of probenecid itself is relatively low; the drug is metabolized minimally and excreted unchanged, which contributes to its predictable dosing requirements.

Conditions Treated with Benemid

• Chronic gout (hyperuricemia) – Benemid is indicated for patients with recurrent gout attacks or tophi who cannot achieve target serum urate levels with xanthine oxidase inhibitors alone. In Hong Kong, gout prevalence is estimated at 2–3 % of adults, with higher rates in males over 50.
• Adjunctive therapy for certain infections – By inhibiting renal clearance, probenecid is used to boost plasma concentrations of penicillins (e.g., ampicillin, amoxicillin) and cephalosporins, enabling higher efficacy against resistant organisms.
• Prevention of uric acid kidney stones – In selected patients with recurrent uric acid calculi, Benemid reduces stone formation by lowering supersaturation of uric acid in urine.

These indications are grounded in guidelines from the Hong Kong Hospital Authority and international bodies such as the American College of Rheumatology, which endorse uricosuric therapy when serum urate remains > 6 mg/dL despite other measures.

Patient Groups Most Likely to Benefit

• Adults with documented hyperuricemia who have experienced two or more gout flares in the past year.
• Patients on high‑dose β‑lactam antibiotics where therapeutic drug monitoring suggests sub‑optimal serum levels; probenecid can be co‑prescribed to achieve desired concentrations.
• Individuals with uric acid nephrolithiasis in whom dietary and hydration measures have not prevented stone recurrence.

Benemid is not recommended for:

• Patients with severe renal impairment (creatinine clearance < 30 mL/min) because the uricosuric effect is markedly reduced and the risk of accumulation rises.
• Those with a known hypersensitivity to sulfonamides, as probenecid shares a sulfonamide moiety.
• Pregnant or breastfeeding women, where safety data are insufficient.

Risks, Side Effects, and Interactions

Common

• Gastro‑intestinal discomfort – nausea, abdominal cramping, and occasional diarrhea.
• Headache – mild to moderate intensity, often transient after initiation.
• Dizziness – usually resolves within a few days of continued therapy.

Rare

• Skin reactions – maculopapular rash or pruritus; occasional mild photosensitivity.
• Elevated liver enzymes – isolated transaminase increases without clinical hepatitis.
• Hypersensitivity – rare sulfonamide‑type allergic responses such as urticaria or angioedema.

Serious

• Nephrolithiasis – paradoxical increase in uric acid stone formation if fluid intake is inadequate.
• Severe allergic reactions – anaphylaxis or Stevens‑Johnson syndrome, requiring immediate medical attention.
• Blood dyscrasias – agranulocytosis or hemolytic anemia have been reported infrequently, particularly in patients with glucose‑6‑phosphate dehydrogenase (G6PD) deficiency.

Clinically Relevant Drug Interactions

• β‑lactam antibiotics (e.g., ampicillin, ceftriaxone) – probenecid reduces renal clearance, increasing plasma levels; dose adjustments may be required.
• Antiviral agents (e.g., acyclovir, valacyclovir) – co‑administration prolongs antiviral exposure, useful in certain viral infections.
• Warfarin – probenecid may enhance anticoagulant effect; INR should be monitored closely.
• Methotrexate – increased plasma concentration may occur, raising risk of toxicity; dosage modification is advised.
• Diuretics – concurrent use can augment uric acid excretion, potentially leading to electrolyte imbalances; monitor serum electrolytes.

Patients should disclose all prescribed, over‑the‑counter, and herbal products before starting Benemid.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dose for gout – 500 mg orally twice daily, taken after meals to reduce gastrointestinal irritation. Dose may be titrated up to 1 g twice daily based on serum urate response tolerability.
• Adjunctive infection dosing – a single 500 mg dose given one hour before the antibiotic, followed by 500 mg at 6‑hour intervals for the duration of the antimicrobial course (usually 2–3 days).
• Kidney stone prophylaxis – 500 mg twice daily, combined with high fluid intake (≥ 2 L/day).

Missed dose: If a dose is forgotten within 6 hours, take it as soon as remembered. If more than 6 hours have passed, skip the missed dose and resume the regular schedule; do not double‑dose.

Overdose: Symptoms may include severe nausea, vomiting, dizziness, and possible renal dysfunction. Immediate medical evaluation is required. Activated charcoal may be administered if presentation is within one hour of ingestion; supportive care and monitoring of renal function are the mainstays of treatment.

Precautions:

• Take with a full glass of water and avoid taking on an empty stomach.
• Alcohol may increase the risk of kidney stone formation; limit intake.
• Patients with hypertension or cardiovascular disease should maintain regular blood pressure monitoring, as fluid shifts can occur.

Buying Benemid from Our Online Pharmacy

Benemid is available for purchase through our online pharmacy in Hong Kong, which specializes in sourcing high‑quality, internationally‑approved generics at prices close to the manufacturer’s cost. Key advantages include:

• Affordable pricing – competitive rates that reflect bulk procurement and low overhead.
• Verified quality – every batch is sourced from licensed pharmaceutical manufacturers that comply with WHO Good Manufacturing Practice (GMP) standards and is inspected by our quality‑assurance team.
• Guaranteed delivery – discreet packaging with express shipping (typically 7 days) or regular airmail (approximately 3 weeks), tracked from dispatch to doorstep.
• Online‑only access – we serve patients who encounter limited local stock, lack insurance coverage for specialty gout medications, or prefer the convenience of home delivery.

Our service operates as a pharmacy broker, partnering with overseas licensed pharmacies to bring Benemid to Hong Kong while respecting patient privacy. All orders are processed in compliance with local import regulations, and we provide clear documentation for personal‑use customs clearance.

FAQ

• Is Benemid covered by Hong Kong’s public healthcare scheme?
  Public reimbursement for Benemid is limited and generally reserved for patients who meet strict clinical criteria for gout unresponsive to first‑line therapy. Private insurers may cover the drug on a case‑by‑case basis.

• Can Benemid be taken together with allopurinol?
  Yes, combination therapy is common when monotherapy does not achieve target urate levels. However, monitoring for hypersensitivity and renal function is