Buy Generic Bupropion + Naltrexone Online

Generic Bupropion + Naltrexone Information

Introduction

Bupropion + Naltrexone is a fixed‑dose combination medication approved for chronic weight management in adults with obesity or overweight (BMI ≥ 30 kg/m², or BMI ≥ 27 kg/m² with at least one weight‑related comorbidity). The product belongs to the weight‑loss medication group and is marketed for its ability to reduce appetite and increase energy expenditure. In Hong Kong, the combination is available through qualified prescribers and can be sourced from international suppliers via our online pharmacy, which offers a regulated, cost‑effective pathway for patients who have limited local access.

What is Bupropion + Naltrexone?

Bupropion + Naltrexone is a tablet that contains two active pharmaceutical ingredients: bupropion hydrochloride (an atypical antidepressant and norepinephrine‑dopamine reuptake inhibitor) and naltrexone hydrochloride (an opioid‑receptor antagonist). The combination was developed by Orexigen Therapeutics and is marketed under the brand name Contrave in the United States and several other regions.

Bupropion + Naltrexone is the generic version of Contrave, containing the same active compounds bupropion and naltrexone. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

The fixed‑dose tablet is approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for chronic weight management and is classified as a prescription‑only medication in Hong Kong.

How Bupropion + Naltrexone Works

The therapeutic effect arises from complementary actions on central pathways that regulate food intake and reward:

• Bupropion stimulates hypothalamic pro‑opiomelanocortin (POMC) neurons, which increase the release of α‑melanocyte‑stimulating hormone (α‑MSH). α‑MSH activates melanocortin‑4 receptors (MC4R) to suppress appetite.
• Naltrexone blocks μ‑opioid receptors that normally provide negative feedback on POMC neurons. By antagonising these receptors, naltrexone prolongs the activity of the POMC pathway initiated by bupropion, enhancing satiety signals.

The effect reduces cravings, diminishes the pleasure derived from eating, and modestly raises resting energy expenditure. Onset of appetite suppression typically occurs within 1–2 weeks, while maximal weight‑loss effect is observed after 12–16 weeks of continuous therapy. The drug’s half‑life is approximately 20 hours for bupropion’s active metabolite (hydroxy‑bupropion) and 4 hours for naltrexone, supporting once‑daily dosing.

Conditions Treated with Bupropion + Naltrexone

• Chronic obesity and overweight (BMI ≥ 30 kg/m², or BMI ≥ 27 kg/m² with comorbidities such as hypertension, type 2 diabetes, dyslipidaemia, or obstructive sleep apnoea).
• Weight‑related metabolic disorders (e.g., improving glycaemic control in type 2 diabetes as an adjunct to diet and exercise).

In Hong Kong, prevalence studies estimate that approximately 15 % of adults have obesity (BMI ≥ 30 kg/m²), creating a sizable patient population that may benefit from pharmacologic weight‑management options when lifestyle modification alone is insufficient.

Patient Groups Most Likely to Benefit

• Adults with BMI ≥ 30 kg/m² who have not achieved adequate weight loss through diet, physical activity, or behavioural counselling.
• Individuals with BMI ≥ 27 kg/m² and at least one obesity‑related comorbidity (e.g., hypertension, dyslipidaemia, pre‑diabetes).
• Patients who respond to the appetite‑suppressing effects of bupropion but require additional reinforcement of satiety; the naltrexone component can address reward‑driven eating.

Contra‑indications (situations where the medication is not appropriate) include uncontrolled hypertension, seizure disorders, current use of monoamine‑oxidase inhibitors (MAOIs), chronic opioid use, or a history of severe hepatic impairment. Pregnant or breastfeeding women should avoid the medication because safety data are limited.

Risks, Side Effects, and Interactions

Common

• Nausea
• Dry mouth- Constipation
• Headache
• Insomnia or vivid dreams (more frequent with bupropion)
• Elevated blood pressure (monitoring required)

Rare

• Dizziness or light‑headedness
• Decreased appetite leading to hypoglycaemia in diabetic patients
• Mood changes (e.g., irritability, anxiety)

Serious

• Seizures (risk increased with high bupropion doses, electrolyte imbalance, or concomitant drugs that lower seizure threshold)
• Severe hypertension or hypertensive crisis
• Hepatotoxicity (elevated transaminases)
• Allergic reactions such as rash, angio‑edema, or anaphylaxis

Drug–Drug Interactions

• Medications that lower seizure threshold (e.g., other antidepressants, antipsychotics, tramadol, antimalarials).
• CYP2B6 inhibitors (e.g., ticlopidine, clopidogrel) may increase bupropion plasma concentrations.
• CYP3A4 inducers (e.g., carbamazepine, rifampicin) can reduce naltrexone levels.
• Opioid analgesics (e.g., morphine, oxycodone) may be less effective due to naltrexone’s antagonism; abrupt opioid discontinuation can precipitate withdrawal.
• MAOIs must be discontinued at least 14 days before starting bupropion + naltrexone because of the risk of hypertensive reactions.

Patients should provide a full medication list, including over‑the‑counter products and herbal supplements, to their prescriber.

Practical Use: Dosing, Missed Dose, Overdose

• Initiation: Start with one tablet (containing 75 mg bupropion + 25 mg naltrexone) taken in the morning for the first week.
• Titration: Increase to one tablet twice daily (150 mg bupropion + 50 mg naltrexone per dose) after one week, provided tolerability is acceptable.
• Maintenance: Continue the twice‑daily regimen for the duration of therapy. Dose adjustments are rarely needed, but the maximum recommended dose is two tablets twice daily (300 mg bupropion + 100 mg naltrexone).

Missed dose – If a dose is missed for more than 12 hours, skip it and resume the regular schedule. Do not double‑dose to compensate.

Overdose – Symptoms may include severe nausea, vomiting, agitation, seizures, or hypertensive crisis. Immediate medical attention is required; emergency services should be contacted and the patient may need activated charcoal, seizure control, and cardiovascular monitoring.

Precautions – Take tablets with food to reduce nausea. Avoid excessive alcohol, as it can lower seizure threshold. Regular blood pressure monitoring (at least weekly for the first month) is advised. Patients with moderate hepatic impairment may require dose reduction; severe hepatic disease is a contraindication.

Buying Bupropion + Naltrexone from Our Online Pharmacy

Patients in Hong Kong can purchase Bupropion + Naltrexone directly from our online pharmacy.

• Affordable pricing – We source the generic formulation at near‑manufacturer cost, offering a price advantage over many local pharmacies.
• Verified quality – All batches are obtained from licensed overseas manufacturers that comply with Good Manufacturing Practice (GMP) standards. Independent laboratory testing confirms potency and purity.
• Guaranteed delivery – Discreet, reliable shipping is provided with a choice of 7‑day express courier or standard airmail (approximately 3 weeks). Tracking information is supplied for every order.
• Online‑only access – Our pharmacy broker service partners with internationally accredited pharmacies, allowing patients who face limited local availability or high out‑of‑pocket expenses to obtain the medication safely.
• Privacy‑focused – Packages use unmarked, tamper‑evident envelopes to protect patient confidentiality.

Our platform follows Hong Kong’s import regulations for prescription medicines intended for personal use, and we require a valid prescription from a qualified healthcare professional before processing any order.

FAQ

• Is Bupropion + Naltrexone available in both brand‑name and generic forms in Hong Kong?
  Yes, the combination is marketed under the brand name Contrave and also as a generic product containing the same active ingredients. Our online pharmacy offers the generic version at a lower price while maintaining identical efficacy and safety profiles.

• Can Bupropion + Naltrexone be stored at room temperature, or does it require refrigeration?
  The tablets should be stored at controlled room temperature (15 °C – 30 °C), away from direct sunlight, moisture, and heat sources. Refrigeration is not necessary and may cause condensation on the tablets.

• What packaging does Bupropion + Naltrexone come in when ordered online?
  Orders are shipped in sealed, tamper‑evident blister packs or bottles, each labeled with the batch number, expiration date, and dosage strength. The outer shipping box is plain and unmarked for privacy.

• Is it legal to import Bupropion + Naltrexone for personal use into Hong Kong?
  Yes, Hong Kong permits the import of a 30‑day supply of prescription medicines for personal use, provided the purchaser holds a valid prescription and the medication is declared to customs if required. Our online pharmacy assists with documentation to ensure compliance.

• Are there specific safety warnings for Asian populations taking Bupropion + Naltrexone?
  Clinical studies have not identified ethnicity‑specific adverse events. However, individuals of Asian descent may have a lower average body weight, so clinicians often start at the lower dose and monitor blood pressure and liver enzymes closely.

• Do formulation differences exist between the US, EU, and Asian markets?
  The active ingredients, dosage strengths, and excipients are generally consistent across regions. Minor differences may relate to tablet coating or filler composition, but these do not affect clinical efficacy.

• Can Bupropion + Naltrexone be used as part of a telemedicine weight‑loss program?
  Yes, many telehealth providers prescribe Bupropion + Naltrexone after a remote evaluation, provided a qualified clinician verifies the indication, contraindications, and baseline investigations. Follow‑up visits can also be conducted virtually.

• How long does it typically take to see a noticeable weight loss after starting the medication?
  Most patients observe a modest reduction in appetite within the first two weeks. Clinically significant weight loss (≥ 5 % of baseline weight) usually emerges after 12 weeks of consistent therapy combined with lifestyle modification.

• What should a patient do if they experience severe nausea that does not improve?
  Persistent or severe nausea may warrant dose reduction or temporary interruption of therapy. Patients should contact their prescribing clinician to assess the need for anti‑emetic support or alternative treatment options.

• Are there any dietary restrictions while taking Bupropion + Naltrexone?
  No specific food is contraindicated, but taking the medication with a meal can lessen gastrointestinal upset. Patients should avoid excessive alcohol consumption, as it can increase seizure risk and interfere with blood‑pressure control.

Glossary

Pro‑opiomelanocortin (POMC) neurons

A group of hypothalamic cells that release peptide hormones influencing appetite, satiety, and energy expenditure. Activation of POMC neurons reduces food intake.

Melanocortin‑4 receptor (MC4R)

A receptor in the brain’s appetite‑regulation pathway; stimulation of MC4R leads to decreased appetite and increased energy use.

Seizure threshold

The level of neuronal excitability at which a seizure may occur. Certain drugs, metabolic imbalances, or abrupt withdrawal from substances can lower this threshold.

⚠️ Disclaimer

The information provided about Bupropion + Naltrexone is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Bupropion + Naltrexone for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.