Buy Generic Capnat Online

Generic Capnat Information

Introduction

Capnat is a chemotherapeutic agent marketed in Hong Kong for the treatment of several solid tumours. It contains the active compound Capecitabine, an oral pro‑drug that is converted to 5‑fluorouracil (5‑FU) in tumour tissue. Capnat belongs to the cancer medication group and is prescribed by oncologists for cancers where 5‑FU‑based regimens have proven benefit. In addition to its primary oncologic indications, capecitabine is sometimes used off‑label in combination protocols for other malignancies after specialist evaluation.

What is Capnat?

Capnat is the generic version of the brand‑name drug Xeloda, containing the same active ingredient, capecitabine, in identical pharmaceutical strength. It is manufactured by a licensed supplier that follows Good Manufacturing Practice standards. Our online pharmacy provides this generic alternative as a cost‑effective treatment option for patients who have a valid prescription and require reliable access to capecitabine in Hong Kong.

How Capnat Works

Capecitabine is a fluoropyrimidine pro‑drug. After oral ingestion, it undergoes three enzymatic steps:

• First, hepatic carboxylesterase converts capecitabine to 5′‑deoxy‑5‑fluorocytidine (5′‑DFCR).
• Second, cytidine deaminase transforms 5′‑DFCR into 5′‑deoxy‑5‑fluorouridine (5′‑DFUR).
• Finally, tumour‑localized thymidine phosphorylase converts 5′‑DFUR to 5‑fluorouracil (5‑FU).

The preferential activation of capecitabine within tumour tissue raises local 5‑FU concentrations while limiting systemic exposure. 5‑FU interferes with DNA synthesis by inhibiting thymidylate synthase, leading to cell‑cycle arrest and apoptosis of rapidly dividing cancer cells. Oral administration provides convenient dosing, and the drug’s half‑life allows a twice‑daily schedule that maintains therapeutic plasma levels.

Conditions Treated with Capnat

• Metastatic colorectal cancer (mCRC) – Capecitabine is approved as monotherapy or in combination with oxaliplatin or irinotecan for patients who have progressed after standard therapies.
• Early‑stage and metastatic breast cancer – Used as adjuvant therapy or in combination with trastuzumab for HER2‑positive disease, and as part of combination regimens for hormone‑receptor negative tumours.
• Gastric and gastro‑esophageal adenocarcinoma – Recommended in combination with cisplatin or oxaliplatin for advanced disease.

In Hong Kong, colorectal cancer remains the third most common cancer among adults, with an estimated 6,500 new cases reported annually by the Hong Kong Cancer Registry. Breast cancer is the leading malignancy in women, accounting for roughly 9,000 new diagnoses each year. Gastric cancer, although less prevalent, still represents a significant health burden, particularly in older adults. Capnat’s oral formulation helps reduce hospital visits for infusion, aligning with local healthcare priorities of minimizing patient burden while maintaining efficacy.

Patient Groups Most Likely to Benefit

• Adult patients with confirmed metastatic colorectal cancer who have failed first‑line fluorouracil‑based regimens.
• Women with early‑stage HER2‑negative breast cancer receiving adjuvant capecitabine after surgery and radiation.
• Patients with advanced gastric adenocarcinoma unsuitable for continuous intravenous chemotherapy due to vascular access issues.
• Individuals preferring oral chemotherapy for convenience, provided they have adequate renal and hepatic function to tolerate capecitabine.

Capnat may be inappropriate for patients with severe dihydropyrimidine dehydrogenase (DPD) deficiency, uncontrolled cardiac disease, or those who are pregnant or breastfeeding. Dose adjustments are required for moderate renal impairment (creatinine clearance 30–50 mL/min) and for elderly patients with frailty.

Risks, Side Effects, and Interactions

Common

• Nausea and vomiting
• Diarrhoea or loose stool
• Hand‑foot syndrome (palmar‑plantar erythrodysesthesia)
• Fatigue and weakness
• Mild alopecia

Rare

• Elevated liver enzymes (AST, ALT)
• Mild neutropenia (white‑blood‑cell count reduction)
• Dermatologic reactions such as rash or photosensitivity

Serious

• Severe hand‑foot syndrome leading to ulceration or infection
• Grade 3–4 neutropenia or thrombocytopenia, increasing infection and bleeding risk
• Cardiac ischemia or arrhythmia, especially in patients with pre‑existing coronary disease
• Life‑threatening diarrhoea (potentially leading to dehydration)

Drug–drug interactions

• Anticoagulants (e.g., warfarin) – capecitabine can enhance anticoagulant effect; monitor INR closely.
• Other fluoropyrimidines – concurrent use markedly increases toxicity; avoid unless under specialist guidance.
• CYP2C9 or CYP2C19 inhibitors/inducers – may alter capecitabine metabolism indirectly; dose adjustments may be required.
• Immunosuppressants (e.g., corticosteroids, azathioprine) – heightened risk of myelosuppression; monitor blood counts.

Patients should disclose all prescribed medicines, over‑the‑counter products, and herbal supplements to their oncologist before initiating Capnat.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing – 125 mg/m² taken orally twice daily (approximately 12 hours apart) for 14 consecutive days, followed by a 7‑day rest period. The cycle is repeated every 21 days. Dose may be reduced to 100 mg/m² in patients with moderate renal impairment.
• Administration – swallow tablets whole with water; food may be taken but high‑fat meals can increase absorption and risk of gastrointestinal upset.
• Missed dose – if a dose is remembered within 4 hours, take it immediately; otherwise skip the missed dose and continue the regular schedule. Do not double the dose.
• Overdose – seek emergency medical attention or contact the Poisons Information Centre in Hong Kong. Symptoms may include severe nausea, vomiting, and myelosuppression; supportive care is required.

Precautions: avoid excessive alcohol, maintain adequate hydration, and report any new cardiac symptoms promptly. Adjustments are needed for hepatic dysfunction (bilirubin >1.5 × ULN) and in patients receiving other myelosuppressive agents.

Buying Capnat from Our Online Pharmacy

Capnat can be purchased safely from our online pharmacy in Hong Kong. Our service offers:

• Affordable pricing – near‑manufacturer cost, substantially lower than many local retail pharmacies.
• Verified quality – sourced exclusively from licensed overseas manufacturers that meet international quality standards.
• Guaranteed delivery – discreet packaging with express shipping (typically 7 days) or regular airmail (approximately 3 weeks).
• Online‑only access – we specialise in international medications not readily stocked in local pharmacies, providing a reliable channel for patients who need timely treatment.

Our pharmacy operates as a broker service, partnering with accredited overseas pharmacies and suppliers. This model ensures a discreet, privacy‑respecting service while complying with Hong Kong’s regulatory framework for prescription medicines.

FAQ

• Is Capnat covered by the Hong Kong Hospital Authority’s drug formulary?
  Capnat, as a generic capecitabine, may be listed for specific oncology indications within the Hospital Authority’s formulary, but coverage depends on individual patient eligibility and clinical assessment. Private patients should verify coverage with their insurer or the Hospital Authority directly.

• Can Capnat be stored at home, or does it require refrigeration?
  Capnat tablets are stable at room temperature (15 °C–30 °C). Store them in a dry place away from direct sunlight, heat, and moisture. Do not refrigerate unless instructed by the pharmacist.

• What packaging does Capnat come in when ordered online?
  The medication is supplied in sealed, child‑resistant blister packs containing the prescribed number of tablets. Each pack includes a label with dosage instructions, batch number, and expiry date for traceability.

• Is it legal to import Capnat for personal use in Hong Kong?
  Importation of prescription medicines for personal use is permitted when the purchaser holds a valid prescription from a Hong Kong‑licensed practitioner and the quantity does not exceed a 30‑day supply. Our online pharmacy ensures compliance by requiring a professional evaluation before dispatch.

• Are there any known differences in capecitabine formulation between regions (e.g., US vs EU vs Asia)?
  The active ingredient, capecitabine, is identical across approved formulations. Minor variations may exist in inert excipients, but these do not affect clinical efficacy. Patients with known excipient allergies should consult their physician before use.

• Does Capnat interact with traditional Chinese medicines commonly used in Hong Kong?
  Some herbal products can affect liver enzymes or platelet function, potentially altering capecitabine metabolism or bleeding risk. Patients should disclose all herbal supplements to their oncologist, who can evaluate possible interactions.

• Can Capnat be used in a telemedicine‑based treatment plan?
  Yes, provided the telemedicine consultation includes a comprehensive medical assessment, laboratory evaluation, and the issuance of a valid electronic prescription. Our online pharmacy accepts electronic prescriptions and conducts an independent professional review before dispensing.

• What should I do if I experience severe hand‑foot syndrome while taking Capnat?
  Contact your oncology team immediately. Early intervention may involve dose reduction, temporary discontinuation, or topical treatments to prevent progression. Severe cases may require hospital‑based care.

• How often are blood tests required during Capnat therapy?
  Complete blood counts, liver function, and renal function tests are typically performed before each treatment cycle (every 3 weeks). Additional testing may be needed if adverse effects arise.

  How does our online service handle the prescription requirement for Capnat in Hong Kong?

• How long does delivery of Capnat take after the prescription is approved?
  Once the professional evaluation is completed and the prescription confirmed, standard express shipping delivers the medication within 7 days to most areas of Hong Kong. Regular airmail may take up to 3 weeks, depending on customs processing.

• Can I request a split‑tablet package for dose adjustments?
  Capnat tablets are scored for ease of splitting, but dose adjustments are typically made by prescribing a different number of whole tablets rather than splitting. Your oncologist can provide precise instructions based on body surface area calculations.

Glossary

Capecitabine

An oral pro‑drug that is metabolised into 5‑fluorouracil, a chemotherapy agent that disrupts DNA synthesis in rapidly dividing cancer cells.

Hand‑foot syndrome

A dermatologic toxicity characterised by redness, swelling, and pain on the palms of the hands or soles of the feet; may progress to blistering if not managed.

Therapeutic window

The dosage range in which a drug achieves its intended effect without causing unacceptable side effects.

DPD deficiency

A genetic condition causing reduced activity of dihydropyrimidine dehydrogenase, the enzyme responsible for metabolising fluoropyrimidines; patients with this deficiency are at high risk of severe toxicity from capecitabine.

⚠️ Disclaimer

The information provided about Capnat is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Capnat for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.