Buy Generic Cilostazol Online

Generic Cilostazol Information

Introduction

Cilostazol is an oral phosphodiesterase‑3 (PDE‑3) inhibitor that is principally prescribed to improve walking distance in adults with intermittent claudication, a manifestation of peripheral arterial disease (PAD). In Hong Kong, the drug is classified under the General health medication group and is available both as a branded product (Pletal®) and as a generic formulation. The active compound—cilostazol—exerts vasodilatory and antiplatelet actions that address the hemodynamic and thrombotic components of PAD. Although its primary indication is PAD‑related claudication, clinical trials have also explored secondary‑stroke prevention and chronic limb‑ischemia, contributing to a broader therapeutic profile.

What is Cilostazol?

Cilostazol is the generic version of Pletal®, the original brand introduced by Novartis. Both the branded and generic tablets contain the same active compound, cilostazol, and are pharmacologically equivalent. Our online pharmacy provides this generic alternative as a cost‑effective treatment option, ensuring the same therapeutic benefit at a price closer to the manufacturer’s production cost.

• Active compound: Cilostazol
• Therapeutic class: Phosphodiesterase‑3 inhibitor (antiplatelet and vasodilator)
• Medication group: General health

The drug is marketed worldwide in 5‑mg and 10‑mg tablets, with the 10‑mg dose being the standard for intermittent claudication.

How Cilostazol Works

Cilostazol selectively inhibits the PDE‑3 enzyme in vascular smooth‑muscle cells and platelets. PDE‑3 normally degrades cyclic adenosine monophosphate (cAMP); inhibition results in increased intracellular cAMP. The downstream effects are twofold:

1. Vasodilation: Elevated cAMP in smooth‑muscle cells reduces intracellular calcium, promoting relaxation of peripheral arterioles. Improved microvascular flow reduces ischaemic pain during exertion.
2. Antiplatelet activity: In platelets, higher cAMP suppresses activation and aggregation pathways, decreasing the formation of occlusive thrombi in narrowed arteries.

Pharmacokinetic profile (typical for healthy adults):

• Onset of action: 2–4 hours after ingestion.
• Peak plasma concentration: 4–6 hours.
• Half‑life: Approximately 11 hours (extended in hepatic impairment).
• Elimination: Primarily hepatic metabolism via CYP3A4 and CYP2C19 to inactive metabolites, with renal excretion of ~25 % of the dose.

By simultaneously widening the peripheral vessels and limiting platelet clumping, cilostazol improves oxygen delivery to ischemic muscles, translating into measurable gains in maximal walking distance.

Conditions Treated with Cilostazol

The primary, well‑established indication remains intermittent claudication. Use outside this indication should be under specialist supervision and may be off‑label.

Patient Groups Most Likely to Benefit

• Adults ≥ 50 years with diagnosed PAD exhibiting intermittent claudication (pain score ≥ 3 on a –10 scale).
• Patients able to walk without assistive devices but limited by leg‑pain after ≤ 200 m.
• Individuals with preserved hepatic function (Child‑Pugh A) and adequate renal clearance (eGFR ≥ 30 mL/min).
• Patients not on concurrent dual antiplatelet therapy or potent anticoagulants, where added antiplatelet effect could increase bleeding risk.

Contra‑indications / less‑appropriate scenarios

• Severe hepatic dysfunction (Child‑Pugh B or C).
• End‑stage renal disease (eGFR < 15 mL/min).
• Active or recent (≤ 3 months) myocardial ischaemia, unstable angina, or acute coronary syndrome.
• Concomitant use of strong CYP3A4 inhibitors (e.g., ketoconazole) or other PDE‑3 inhibitors.
• Pregnancy, lactation, or children (use not established).

Risks, Side Effects, and Interactions

Common

• Headache – frequently mild, may respond to simple analgesics.
• Diarrhoea or abdominal pain – usually transient; adequate hydration is advisable.
• Palpitations or tachycardia – related to vasodilatory effect; monitor heart rate during initiation.

Rare

• Peripheral oedema – may occur in patients with borderline cardiac function.
• Hypotension – especially when combined with other vasodilators or antihypertensives.

Serious

• Myocardial ischaemia or acute coronary events – contraindicated in patients with known coronary artery disease; close monitoring required if such history exists.
• Severe bleeding (gastrointestinal or intracranial) – due to additive antiplatelet effect with other agents.
• Allergic reactions (angio‑oedema, anaphylaxis) – immediate medical attention necessary.

Clinically Relevant Interactions

• CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin): ↑ plasma cilostazol → increased risk of cardiovascular adverse events.
• CYP2C19 inhibitors (e.g., fluvoxamine, clopidogrel): similar risk of accumulation.
• Oral anticoagulants (warfarin, direct oral anticoagulants): potentiated bleeding risk; co‑administration generally discouraged.
• Antihypertensive agents (ACE‑inhibitors, β‑blockers, calcium‑channel blockers): additive hypotensive effect; dose adjustments may be needed.
• Other antiplatelet drugs (clopidogrel, aspirin): combined therapy can markedly raise bleeding risk; not recommended unless specifically ordered by a vascular specialist.

Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, to the evaluating health professional before starting cilostazol.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing for intermittent claudication: 100 mg (one 10‑mg tablet) taken twice daily, 30 minutes before breakfast and dinner, with a full glass of water.
• Renal or hepatic impairment: initiate at 50 mg once daily; titrate cautiously while monitoring hepatic enzymes and renal function.
• Missed dose: If ≥ 12 hours have elapsed, take the missed tablet as soon as possible, then resume regular schedule. Avoid double‑dosing to prevent excess cAMP‑related side effects.
• Overdose: Early symptoms include severe headache, palpitations, and hypotension. Contact emergency services (999) and provide details of the ingested amount.
• Food & alcohol: High‑fat meals do not significantly affect absorption, but excessive alcohol may exacerbate vasodilatory effects and should be limited.
• Comorbidities: In patients with diabetes or chronic kidney disease, routine monitoring of blood glucose and renal function is advisable.

Buying Cilostazol from Our Online Pharmacy

Cilostazol can be purchased directly from our online pharmacy in Hong Kong:

• Affordable pricing – generic tablets are sourced at near‑manufacturer cost, passing savings to the consumer.
• Verified quality – each batch originates from internationally licensed manufacturers audited for compliance with Good Manufacturing Practice (GMP) standards.
• Guaranteed delivery – discreet, reliable shipping with express option (‑7 days) or regular airmail (≈ 3 weeks).
• Pharmacy‑broker service – we collaborate with overseas licensed pharmacies and certified suppliers, enabling a discreet pathway that respects patient privacy while fulfilling local regulatory requirements.
• Prescription facilitation – every order is subject to a mandatory professional evaluation by an independent, licensed healthcare practitioner, ensuring the medication is appropriate for the individual’s clinical profile.

Our service is especially valuable for patients who face limited access to regular community pharmacies or whose insurance plans do not cover the branded product.

FAQ

• Is Cilostazol approved for use in Hong Kong?
  Yes, cilostazol is registered with the Hong Kong Department of Health for the indication of intermittent claudication secondary to peripheral arterial disease.

• Can I obtain Cilostazol without a prescription in Hong Kong?
  Purchasing cilostazol from a local pharmacy requires a valid prescription. Our online service streamlines this requirement by providing a professional evaluation of each order.

• How does the professional evaluation work?
  Every order is reviewed by an independent, licensed healthcare professional who assesses the health information supplied during checkout. If additional details are needed, our care team will contact the customer to clarify, ensuring the prescription is safe and medically appropriate.

• What is the typical price for a generic 10‑mg tablet of Cilostazol?
  Prices vary with supplier and order volume, but generic tablets are generally 30 %–45 % lower than the branded product, reflecting near‑manufacturer cost.

• Are there any storage requirements for Cilostazol?
  Cilostazol tablets should be stored at room temperature (15 °C – 30 °C), protected from excess moisture, heat, and direct sunlight. No refrigeration is needed.

• What packaging will I receive when ordering online?
  Orders are dispatched in tamper‑evident, child‑resistant containers with unit of use (UOU) labeling, ensuring safe handling and compliance with local regulations.

• Is Cilostazol suitable for patients with a history of heart failure?
  Cilostazol is contraindicated in individuals with severe heart failure (NYHA class III/IV) because the vasodilatory effect may exacerbate cardiac stress.

• Can I import Cilostazol for personal use into Hong Kong?
  Personal importation is permissible only with a valid prescription and a declaration of therapeutic intent. Our pharmacy broker service ensures customs compliance by providing the required documentation.

• Will the generic formulation have the same efficacy as Pletal®?
  Yes. The generic version contains the identical active ingredient, cilostazol, and undergoes bioequivalence testing to confirm comparable efficacy and safety.

• Does Cilostazol interact with common Asian herbal remedies?
  Some traditional herbs (e.g., ginkgo biloba, St. John’s wort) modulate CYP enzymes and could increase cilostazol levels. Patients using such products should discuss potential interactions with their clinician.

• How long does it take to see improvement in walking distance?
  Clinical trials report significant gains in maximal walking distance after 6 weeks of consistent therapy, with further improvements up to 12 weeks.

• Is there a pediatric use for Cilostazol?
  Pediatric indications have not been established; the drug is approved only for adult use (≥ 18 years) under current regulatory guidance.

• Can Cilostazol be used in telemedicine‑based treatment plans?
  Yes. Telemedicine evaluations that capture a complete medical history can fulfill the professional assessment required for prescription, provided the remote clinician is licensed in Hong Kong.

• What are the consequences of accidental overdose?
  Overdose may present with severe headache, hypotension, and cardiac arrhythmias. Immediate medical attention is essential; treatment focuses on supportive care and monitoring.

• Is there a difference in formulation between regions (e.g., US vs EU)?
  While the active ingredient is identical, excipients may vary by manufacturer. Generic tablets marketed in Hong Kong follow local pharmacopeial standards and are consistent with international GMP‑certified production.

Glossary

Phosphodiesterase‑3 (PDE‑3) inhibitor

A class of drugs that block the PDE‑3 enzyme, leading to higher intracellular cyclic adenosine monophosphate (cAMP) levels, which promote vasodilation and inhibit platelet aggregation.

cAMP (Cyclic Adenosine Monophosphate)

A second messenger molecule that mediates smooth‑muscle relaxation and platelet inhibition; increased cAMP underlies the therapeutic action of cilostazol.

Therapeutic window

The concentration range of a drug in plasma where efficacy is achieved without causing unacceptable toxicity; for cilostazol, this is generally maintained with twice‑daily dosing.

Peripheral arterial disease (PAD)

A chronic atherosclerotic condition causing narrowed arteries in the limbs, most commonly the legs, leading to reduced blood flow and exertional pain (claudication).

⚠️ Disclaimer

The information provided about Cilostazol is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Cilostazol for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.