Buy Generic Dasatinib Online

Generic Dasatinib Information

Introduction

Dasatinib is an oral tyrosine‑kinase inhibitor (TKI) primarily prescribed for chronic myeloid leukemia (CML) and Philadelphia chromosome‑positive acute lymphoblastic leukemia (Ph‑positive ALL). It is marketed worldwide under the brand name Sprycel (Novartis) and is also available as a generic tablet containing the active compound Dasatinib. In Hong Kong, Dasatinib is listed on the Hospital Authority’s formulary for eligible patients and can be accessed through specialist oncology clinics. The medication belongs to the cancer drug group and works by blocking abnormal signaling pathways that drive malignant cell growth.

What is Dasatinib?

Dasatinib is a small‑molecule inhibitor of multiple tyrosine kinases, including BCR‑ABL, SRC family kinases, c‑KIT, and PDGFR. It was developed by Novartis and received its first regulatory approval in the United States in 2006 for CML.

Generic statement
Dasatinib is the generic version of Sprycel, containing the same active compound Dasatinib. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

The drug is supplied as film‑coated tablets, most commonly in 20 mg and 100 mg strengths, and is taken orally with water.

How Dasatinib Works

Dasatinib binds to the ATP‑binding site of the BCR‑ABL fusion protein, a constitutively active tyrosine kinase produced by the Philadelphia chromosome translocation (t(9;22)). By occupying this pocket, Dasatinib prevents phosphorylation of downstream substrates, halting the proliferative signal that drives leukemic cells.

In addition to BCR‑ABL inhibition, Dasatinib blocks SRC family kinases, which are implicated in disease progression and resistance to first‑generation TKIs such as imatinib. The broad kinase inhibition accounts for its activity against both chronic‑phase CML and more aggressive disease phases, as well as Ph‑positive ALL.

Pharmacokinetically, Dasatinib reaches peak plasma concentrations within 2–3 hours after oral dosing. It is metabolised primarily by CYP3A4 and eliminated mainly via feces, with a terminal half‑life of approximately 5 hours, allowing once‑daily dosing in most clinical regimens.

Conditions Treated with Dasatinib

• Chronic Myeloid Leukemia (CML), chronic phase – FDA‑ and EMA‑approved; first‑line or second‑line therapy in Hong Kong when resistance/intolerance to imatinib occurs.
• CML, accelerated or blast phase – approved for patients who have progressed despite prior TKI therapy.
• Philadelphia chromosome‑positive Acute Lymphoblastic Leukemia (Ph‑positive ALL) – indicated in combination with chemotherapy for adult patients.

Epidemiological relevance in Hong Kong
CML incidence in Hong Kong is estimated at 1–2 per 100,000 adults per year, representing several hundred new cases annually. Ph‑positive ALL accounts for roughly 20–30 % of adult ALL cases, translating to a modest but clinically important patient population that benefits from targeted TKIs such as Dasatinib.

Patient Groups Most Likely to Benefit

• Adults with newly diagnosed chronic‑phase CML who are unsuitable for imatinib (e.g., due to drug–drug interactions or intolerance).
• Patients with CML resistant or intolerant to first‑generation TKIs; Dasatinib’s potency against many BCR‑ABL mutations makes it a preferred second‑line option.
• Adults with Ph‑positive ALL receiving multi‑agent chemotherapy, where Dasatinib improves remission rates.

Contra‑indicated or cautionary groups

• Individuals with severe hepatic impairment (Child‑Pugh C) due to altered metabolism.
• Patients on strong CYP3A4 inducers (e.g., rifampicin) or inhibitors (e.g., ketoconazole) without dose adjustment.
• Pregnant or breastfeeding women; Dasatinib is classified as pregnancy category D (risk to fetus).

Risks, Side Effects, and Interactions

Common

• Myelosuppression (neutropenia, thrombocytopenia, anemia)
• Fluid retention (edema, pleural effusion)
• Gastrointestinal upset (diarrhoea, nausea, abdominal pain)
• Fatigue and headache

Rare

• Hepatotoxicity (elevated transaminases)
• Cutaneous rash or photosensitivity
• Hypertension

Serious

• Severe myelosuppression leading to infection or bleeding
• Pulmonary arterial hypertension (PAH) – may be irreversible if not recognised early
• Cardiac dysfunction (congestive heart failure, left ventricular ejection fraction decline)
• Severe bleeding, especially in patients with concomitant anticoagulants

Drug‑Drug Interactions

• CYP3A4 inhibitors (ketoconazole, clarithromycin, grapefruit juice) → increase Dasatinib plasma levels; dose reduction recommended.
• CYP3A4 inducers (rifampicin, carbamazepine, St. John’s wort) → decrease exposure; may require dose escalation.
• Anticoagulants/antiplatelet agents (warfarin, aspirin, clopidogrel) → heightened bleeding risk; monitor haemostasis.
• Proton‑pump inhibitors (omeprazole, esomeprazole) → reduce absorption; separate dosing by at least 2 hours.

Patients should disclose all medications, herbal supplements, and over‑the‑counter products to their prescriber.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dosing for chronic‑phase CML: 100 mg once daily (full dose).
• Accelerated or blast phase CML: 140 mg once daily may be considered, based on tolerability.
• Ph‑positive ALL: 140 mg once daily in combination with chemotherapy, adjusted per protocol.

Missed dose
If a dose is missed and the scheduled time is still >12 hours away, take the missed tablet as soon as remembered. Skip the dose if it is near the time of the next scheduled dose; do not double‑dose.

Overdose
Symptoms may include severe nausea, vomiting, diarrhoea, and profound myelosuppression. Seek immediate medical attention. Management is supportive; activated charcoal may be considered if presentation is within one hour of ingestion.

Precautions

• Take Dasatinib with a full glass of water, preferably on an empty stomach (at least 30 minutes before or 2 hours after meals).
• Avoid grapefruit and grapefruit juice.
• Alcohol can exacerbate hepatic toxicity; limit intake.
• Regular laboratory monitoring (complete blood count, liver function tests, chest X‑ray) is mandatory during therapy.

Buying Dasatinib from Our Online Pharmacy

Patients in Hong Kong can purchase Dasatinib through our online pharmacy. The service offers:

• Affordable pricing – generic tablets are sourced near the manufacturer’s cost, providing a lower price point than many local hospital dispensaries.
• Verified quality – every batch is supplied by licensed, GMP‑certified manufacturers and undergoes third‑party testing for purity and potency.
• Guaranteed delivery – discreet, temperature‑controlled packaging with express shipping (typically 5–7 working days) and regular airmail (approximately 3 weeks).
• International medication access – we act as a pharmacy broker, partnering with overseas licensed pharmacies to source medications that may experience stock shortages locally.

Our platform respects patient privacy; orders are shipped in unmarked envelopes, and all personal data is encrypted. This model is especially useful for patients who encounter long waiting times at public hospitals or who lack comprehensive insurance coverage for oncology drugs.

FAQ

All answers are provided in a patient‑centred manner and are not a substitute for professional medical advice.

• Is Dasatinib covered by the Hong Kong Hospital Authority’s subsidy scheme?
  Yes, Dasatinib is listed on the Hospital Authority’s drug formulary for eligible oncology patients. Eligibility is determined by the treating haematologist and may require prior authorization based on disease phase and previous therapy.

• Can I import Dasatinib for personal use without a Hong Kong prescription?
  Importation of prescription‑only medicines into Hong Kong requires a valid local prescription. Our online pharmacy facilitates the professional evaluation step to ensure compliance with local regulations before the medication is dispatched.

• What distinguishes the generic Dasatinib tablets from the brand‑name Sprycel?
  The generic formulation contains the identical active compound, Dasatinib, at the same strength and bioequivalence profile as Sprycel. Differences, any, lie solely in inactive excipients, which have been demonstrated not to affect clinical efficacy.

• Does Dasatinib need to be stored in a refrigerator?
  No, Dasatinib tablets are stable at room temperature (15‑30 °C). They should be kept in a dry place away from direct sunlight, heat, and moisture. Do not store them in bathrooms or near kitchen appliances that generate steam.

• What type of packaging will I receive when ordering Dasatinib online?
  Each shipment is placed in a tamper‑evident, sealed blister pack containing the prescribed quantity of tablets. The outer envelope is unmarked and labelled only with the recipient’s address to protect privacy.

• Are there specific warnings for Asian patients taking Dasatinib?
  Pharmacokinetic studies have not identified ethnicity‑specific dosing adjustments for Asian populations. However, clinicians may monitor liver function closely, as some East‑Asian patients exhibit modestly higher transaminase elevations.

• Can Dasatinib be used together with herbal supplements such as St. John’s wort?
  St. John’s wort is a strong CYP3A4 inducer and can markedly reduce Dasatinib blood levels, potentially compromising efficacy. Patients should avoid this supplement or discuss alternative options with their healthcare provider.

• Is it safe to combine Dasatinib with COVID‑19 vaccines?
  Current guidance suggests that patients receiving TKIs may safely receive inactivated or mRNA COVID‑19 vaccines. Immunogenicity is not expected to be significantly impaired, but timing should be coordinated with the oncology team.

• What is the typical duration of Dasatinib therapy for chronic‑phase CML?
  The goal of treatment is lifelong disease control. Many patients remain on Dasatinib indefinitely, with periodic assessment for potential treatment‑free remission based on sustained deep molecular response.

  Purchasing Dasatinib from a local pharmacy in Hong Kong requires a valid prescription. Our online service streamlines this requirement. Every order undergoes a mandatory professional evaluation conducted by an independent, licensed healthcare professional who reviews the health information supplied at checkout. If additional details are needed to confirm safety and appropriateness, our care team will contact the customer for clarification, ensuring that each prescription meets the highest standards of patient safety.

Glossary

Tyrosine‑Kinase Inhibitor (TKI)

A class of drugs that block enzymes (tyrosine kinases) involved in signaling pathways that promote cancer cell growth.

BCR‑ABL Fusion Protein

An abnormal enzyme produced by a genetic translocation (Philadelphia chromosome) that drives uncontrolled proliferation in CML and Ph‑positive ALL.

Pharmacokinetics

The study of how a drug is absorbed, distributed, metabolized, and excreted by the body.

Myelosuppression

Suppression of bone‑marrow activity leading to reduced blood cell production (white cells, red cells, platelets).

⚠️ Disclaimer

The information provided about Dasatinib is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Dasatinib for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.