Buy Generic Diane 35 Online

Generic Diane 35 Information

Introduction

Diane 35 is a combined hormonal medication containing cyproterone acetate and ethinylestradiol. It belongs to the hormone group and is primarily prescribed for severe acne and for the treatment of moderate to severe hirsutism in women. In Hong Kong the product is available only with a prescription and is regulated by the Department of Health. The formulation also possesses contraceptive properties, which is reflected in its secondary indication for birth control.

What is Diane 35?

Diane 35 is a fixed‑dose oral tablet that combines two synthetic hormones:

• Cyproterone acetate (2 mg) – a progestogen with strong anti‑androgen activity.
• Ethinylestradiol (35 µg) – a synthetic estrogen that suppresses ovarian hormone production.

The medication was developed by Schering (now part of Bayer) and first marketed in Europe in the early 199s. It is registered in Hong Kong under the same brand name and is listed in the Pharmaceutical Service of the Hospital Authority for specialist dermatology and endocrine clinics.

How Diane 35 Works

Cyproterone acetate competitively blocks androgen receptors in the skin and sebaceous glands, reducing the influence of testosterone and dihydrotestosterone on acne‑forming pores. At the same time it inhibits the hypothalamic‑pituitary‑gonadal axis, decreasing luteinising hormone (LH) surge and ovarian androgen production.

Ethinylestradiol provides negative feedback to the pituitary, further suppressing LH and follicle‑stimulating hormone (FSH) release. The estrogen component stabilises the endometrial lining, providing reliable contraceptive protection when taken as directed.

Together, the two hormones lower circulatingens, diminish sebum output, and prevent new comedone formation. Clinical improvement in acne lesions typically becomes noticeable after 4–6 weeks, with maximal benefit by 3–6 months of continuous therapy.

Conditions Treated with Diane 35

• Severe acne vulgaris – especially when resistant to topical therapy or oral antibiotics.
  Hirsutism** – excessive terminal hair growth in a male‑pattern distribution, usually associated with polycystic ovary syndrome (PCOS) or idiopathic hyperandrogenism.
• Contraception – the combined estrogen‑progestogen formulation offers a 99 %‑plus pregnancy‑prevention rate when taken correctly.

In Hong Kong, dermatology clinics report that up to 8 % of women of reproductive age present with moderate to severe acne, and the prevalence of PCOS‑related hirsutism is estimated at 6–10 % among the female population. Diane 35 addresses both dermatologic and endocrine aspects of these conditions, providing a pharmacologic option when lifestyle modifications and first‑line agents are insufficient.

Patient Groups Most Likely to Benefit

• Women aged 18–35 with refractory acne who have not responded to topical retinoids, benzoyl peroxide, or short‑course oral antibiotics.
• Patients with clinical hirsutism secondary to hyperandrogenic disorders, particularly when a reliable contraceptive method is also desired.
• Women seeking a single‑tablet regimen that combines anti‑androgenic and contraceptive effects, thereby simplifying adherence.

Contra‑indications include current or past thrombo‑embolic disease, uncontrolled hypertension, active liver disease, known estrogen‑dependent tumor, and pregnancy. Patients who smoke heavily (>15 cigarettes/day) and are over 35 years should avoid combined hormonal contraceptives because of elevated cardiovascular risk.

Risks, Side Effects, and Interactions

Common

• Nausea, mild abdominal discomfort, or bloating.
• Headache or migraine (often related to estrogen fluctuation).
• Breast tenderness or enlargement.
• Mood changes, including mild depressive symptoms.

These events generally resolve within the first menstrual cycles as the body adapts to hormonal levels.

Rare

• Elevated liver enzymes or cholestatic hepatitis.
• Decrease in visual acuity due to rare optic neuritis.
• Hypertriglyceridaemia, which may be clinically relevant in patients with metabolic syndrome.

Routine monitoring of liver function tests is advisable for patients on long‑term therapy, especially those with pre‑existing hepatic risk factors.

Serious

• Venous thrombo‑embolism (deep vein thrombosis, pulmonary embolism).
• Arterial thrombosis (stroke, myocardial infarction).
• Severe hypertension or hypertensive crisis.
• Allergic reactions such as angio‑edema or anaphylaxis.

If any signs of thrombosis (e.g., unilateral leg swelling, sudden chest pain, shortness of breath) or severe allergic response occur, immediate medical attention is required and the medication must be discontinued.

Clinically Relevant Interactions

• Enzyme inducers (e.g., rifampicin, carbamazepine, phenytoin) may lower serum concentrations of both components, reducing efficacy.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) can increase cyproterone acetate levels, potentially heightening anti‑androgenic side effects.
• Anticoagulants (warfarin) may have an enhanced effect due to estrogen‑induced changes in coagulation factor synthesis; INR monitoring is advised.
• Selective serotonin reuptake inhibitors (SSRIs) may increase the risk of mood disturbances.

Patients should disclose all current medications, over‑the‑counter supplements, and herbal products to the prescribing clinician.

Practical Use: Dosing, Missed Dose, Overdose

• Standard regimen: One tablet taken orally day, preferably at the same time, for 21 consecutive days followed by a 7‑day pill‑free interval (or tablets) to allow withdrawal bleeding.
• Missed dose: If a dose is forgotten and it is less than 12 hours late, take and continue with the next scheduled tablet. If more than 12 hours have passed, skip the missed tablet, resume the regular schedule, and use a backup non‑hormonal contraceptive method for the next 7 days.
• Overdose: Ingestion of a large number of tablets may cause nausea, vomiting, and severe headache. Immediate medical evaluation is required; activated charcoal may be considered if presentation is within one hour of ingestion. No specific antidote exists.
• Food & alcohol: Tablets can be taken with or without food. Moderate alcohol intake does not affect efficacy but excessive consumption can increase the risk of liver toxicity and hypertension.
• Comorbidities: In patients with controlled hypertension, regular blood pressure monitoring is recommended. Those with a history of migraine with aura should avoid combined hormonal therapy due to increased stroke risk.

Buying Diane 35 from Our Online Pharmacy

Patients in Hong Kong can obtain Diane 35 through our online pharmacy. The service offers:

• Competitive pricing – generic‑equivalent cost close to the manufacturer’s supply price, making long‑term therapy affordable.
• Verified quality – all tablets are sourced from licensed overseas pharmacies that comply with Good Manufacturing Practice (GMP) standards; batch numbers and certificates of analysis are available on request.
• Reliable delivery – discreet packaging with express shipping (typically 7 days) or standard airmail (approximately 3 weeks) to any Hong Kong address.
• Convenient access – the platform operates as a pharmacy broker, partnering with internationally accredited suppliers, which enables patients without local prescription coverage to receive the medication safely.

Our pharmacy respects patient privacy, providing a secure portal for health information and a confidential delivery service that protects personal data.

FAQ

• Can I import Diane 35 for personal use in Hong Kong?
  Yes, personal import of prescription medicines is permitted under Hong Kong law provided the quantity does not exceed a 30‑day supply and a valid prescription is presented. Importation should be done through a licensed pharmacy broker to ensure product authenticity and regulatory compliance.

• Is a prescription required for Diane 35 in Hong Kong?
  Purchasing Diane 35 from a local pharmacy in Hong Kong requires a valid prescription from a licensed medical practitioner. Our online service streamlines this requirement. Every order undergoes a mandatory professional evaluation conducted by an independent, licensed healthcare professional who reviews the health information supplied during checkout. If additional details are needed, our care team will contact the customer to clarify the necessary information, ensuring the prescription issued is safe and appropriate.

• How does the anti‑androgen effect of cyproterone acetate differ from other progestins?
  Cyproterone acetate possesses a unique high‑affinity binding to androgen receptors, directly blocking the action of testosterone and dihydrotestosterone. Most other progestins lack this anti‑androgenic potency, making cyproterone acetate particularly effective for hirsutism and severe acne.

• What monitoring is recommended during long‑term Diane 35 therapy?
  Baseline periodic liver function tests, lipid profile, and blood pressure measurements are advisable. For women over 35 who smoke or have additional cardiovascular risk factors, a more frequent assessment of coagulation status may be warranted.

• Can Diane 35 be used during breastfeeding?
  No. Both cyproterone acetate and ethinylestradiol are excreted in breast milk and may affect the infant’s hormonal development. Lactating women should be offered an alternative contraceptive method that does not contain estrogen.

• Does the dosage of ethinylestradiol in Diane 35 affect clotting risk compared with lower‑dose pills?
  The 35 µg ethinylestradiol dose is higher than many modern low‑dose combined oral contraceptives (20–30 µg). Evidence from epidemiological studies indicates a modestly increased risk of venous thrombo‑embolism with higher estrogen doses, especially in women with additional risk factors such as smoking or a family history of clotting disorders.

• Are there any dietary restrictions while taking Diane 35?
  No specific foods need to be avoided. However, excessive grapefruit juice can inhibit CYP3A4 metabolism, potentially raising cyproterone acetate levels. Patients are advised to consume grapefruit in moderation.

• Is it safe to switch from another combined oral contraceptive to Diane 35?
  Transition is generally safe. Patients should finish the active pills of their current regimen, then start Diane 35 on the first day of the next menstrual cycle or after a 7‑day placebo interval. A brief overlap is unnecessary, but backup contraception should be used for the first 7 days of the new regimen.

• be used to obtain a prescription for Diane 35?**
  Yes. Telemedicine platforms staffed by licensed physicians can assess eligibility, review medical history, and issue a digital prescription that is accepted by our pharmacy broker, provided all regulatory requirements are met.

• What packaging does Diane 35 arrive in when ordered online?
  The medication is supplied in a tamper‑evident blister pack containing 21 active tablets and 7 placebo tablets, enclosed within a discreet cardboard box. Each pack includes a patient information leaflet in English and Traditional Chinese.

• Does the formulation of Diane 35 differ between Europe and Asia?
  The European Union and Asian markets both contain 2 mg cyproterone acetate and 35 µg ethinylestradiol per tablet. Minor differences may exist in excipients such as lactose or magnesium stearate, which are listed on the packaging. Patients with specific excipient allergies should verify the ingredient list before purchase.

Glossary

Anti‑androgen

A substance that blocks the effects of male hormones (androgens) on target tissues, reducing symptoms such as acne and excess hair growth.

Negative feedback

A physiological mechanism where increased hormone levels suppress further secretion of releasing hormones from the hypothalamus or pit, stabilising endocrine balance.

Contraceptive efficacy

The ability of a birth‑control method to prevent pregnancy; expressed as a percentage of pregnancies prevented under typical use.

⚠️ Disclaimer

The information provided about Diane 35 is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Diane 35 for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.