Buy Generic Flunarizine Online

Generic Flunarizine Information

Introduction

Flunarizine is a calcium‑channel antagonist primarily prescribed for the prevention of migraine attacks and the management of certain vestibular disorders. In Hong Kong, it is classified within the Pain Relief group, although its therapeutic actions extend beyond analgesia to include modulation of neuronal excitability. The medication contains the active compound flunarizine and is available from several manufacturers worldwide. Because the same molecule can be supplied under various brand names, many patients seek a cost‑effective generic alternative.

What is Flunarizine?

Flunarizine is the generic version of the original product that has been marketed under the name Flunarizine (original brand) and, in some regions, as Flunarizine dihydrochloride tablets. Both the brand‑name and generic formulations contain the identical active compound, flunarizine, a lipophilic piperazine‑derived calcium‑channel blocker. Our online pharmacy provides this generic alternative as a lower‑cost option without compromising therapeutic quality. The drug was first synthesized in the 197s by the French pharmaceutical company Servier and later licensed to other manufacturers for global distribution.

How Flunarizine Works

Flunarizine inhibits voltage‑dependent L‑type calcium channels in neuronal membranes. By reducing calcium influx, it dampens the release of excitatory neurotransmitters such as glutamate and substance P, which are implicated in migraine pathophysiology. The drug also possesses antihistaminic activity (H₁‑receptor antagonism) and modest dopaminergic antagonism, contributing to its effectiveness in vestibular migraine and certain balance disorders.

• Onset of therapeutic effect: Clinical trials show a reduction in migraine frequency typically within 2–4 weeks of daily dosing.
• Duration of action: The half‑life ranges from 18 to 30 hours, allowing once‑daily administration.
• Metabolism and clearance: Flunarizine is extensively metabolised by hepatic cytochrome P450 enzymes (primarily CYP2C19 and CYP3A4) and excreted mainly in the feces.

Conditions Treated with Flunarizine

• Migraine prophylaxis – Reduces attack frequency and severity in episodic and chronic migraine sufferers.
• Vestibular migraine – Improves vertigo, disequilibrium, and associated nausea.
• Secondary vestibular disorders – Such as benign paroxysmal positional vertigo (when other agents are unsuitable).
• Cluster headache (off‑label) – Limited evidence supports use in refractory cases.

In Hong Kong, migraine prevalence is estimated at 12–15 % of the adult population, making effective preventive therapy a public‑health priority. Vestibular disorders affect an estimated 3 % of older adults, and flunarizine’s dual action on calcium channels and histamine receptors offers a pharmacologic advantage in these cohorts.

Suitable Candidates for Flunarizine Treatment

• Adults (≥ 18 years) with a documented history of ≥ 4 migraine days per month who have not responded adequately to first‑line abortive therapies.
• Patients with vestibular migraine or chronic vertigo where calcium‑channel blockade is indicated.
• Individuals seeking a once‑daily preventive regimen with a relatively long therapeutic window.

Contraindications / cautionary scenarios

• History of depression or suicidal ideation – flunarizine can exacerbate depressive symptoms.
• Severe hepatic impairment – reduced metabolism may increase plasma concentrations.
• Pregnant or breastfeeding women – safety data are insufficient; use only if benefits clearly outweigh risks.

Risks, Side Effects, and Interactions

Common

• Drowsiness or somnolence
• Weight gain (often modest, linked to increased appetite)
• Dry mouth

These events occur in ≤ 10 % of patients and are usually transient. Adjusting dosing time (e.g., taking the tablet at night) can mitigate somnolence.

Rare

• Extrapyramidal symptoms (e.g., parkinsonism, akathisia) – reported in < 1 % of long‑term users.
• Depression or worsening mood disorders – careful monitoring advised, especially in patients with prior psychiatric history.

Serious

• Severe allergic reactions (anaphylaxis, angioedema) – immediate medical attention required.
• Persistent depression with suicidal thoughts – discontinue promptly and seek psychiatric care.

Drug–Drug Interactions

• CYP2C19 or CYP3A4 inhibitors (e.g., fluconazole, erythromycin) – may raise flunarizine plasma levels, increasing side‑effect risk.
• Antihistamines – additive sedative effect; dose adjustments may be needed.
• Dopaminergic agents (e.g., levodopa) – antagonistic interaction may diminish therapeutic benefit for Parkinsonian symptoms.
• Other calcium‑channel blockers – combined use can potentiate hypotensive effects.

Patients should disclose all prescription, over‑the‑counter, and herbal products to their healthcare provider before initiating flunarizine.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dosing for migraine prophylaxis: 5 mg (one tablet) taken orally once daily, preferably in the evening. Some clinicians may start with 2.5 mg and titrate upward based on tolerance.
• Vestibular migraine: The same 5 mg daily regimen is commonly employed; dose adjustments follow the same principle.

Missed dose – If a dose is forgotten, take it as soon as remembered unless it is within 12 hours of the next scheduled dose. In that case, skip the missed tablet and resume the regular schedule. Do not double‑dose.

Overdose – Symptoms may include profound drowsiness, hypotension, and cardiac conduction abnormalities. Seek emergency medical care immediately. Activated charcoal may be administered if presentation is early; supportive care is the mainstay of treatment.

Practical precautions

• Take with food if gastrointestinal upset occurs.
• Avoid alcohol, which can accentuate sedation and dizziness.
• Patients with liver disease should have baseline liver function tests and periodic monitoring.

Buying Flunarizine from Our Online Pharmacy

Flunarizine can be ordered safely from our online pharmacy in Hong Kong. We specialise in providing verified, high‑quality generic medicines at prices close to manufacturer cost. Key benefits include:

• Affordable pricing – We negotiate directly with licensed overseas suppliers to keep costs low.
• Verified quality – Every batch is sourced from approved manufacturers and undergoes independent testing for potency and purity.
• Guaranteed delivery – Discreet packaging with express shipping (typically 7 days) or regular airmail (approximately 3 weeks) to any Hong Kong address.
• Online‑only access – For patients who face limited local stock or insurance barriers, our pharmacy broker service connects you with reputable overseas pharmacies while maintaining strict privacy standards.

Our platform operates as a pharmacy‑broker, collaborating with internationally licensed pharmacies to ensure that each order meets Hong Kong’s import regulations. This model enables us to deliver a reliable, confidential service that respects patient privacy.

FAQ

• Is Flunarizine available in both brand‑name and generic forms in Hong Kong?
  Yes. The medication is marketed under the original brand name Flunarizine as well as under generic formulations that contain the identical active compound. Generic versions are typically less expensive while offering the same therapeutic effect.

• Does Flunarizine require refrigeration or any special storage conditions?
  No. Flunarizine tablets should be stored at controlled room temperature (15–30 °C), away from excess heat, moisture, and direct sunlight. A dry cabinet or pharmacy shelf is sufficient.

• What do the tablets look like, and are there any identifying markings?
  Generic flunarizine tablets are usually round, film‑coated, and scored for easy splitting. They may be white or pale pink and bear a imprint indicating the manufacturer’s logo and the strength “5 mg”.

• Can I travel internationally with Flunarizine, and are there any customs restrictions?
  Travelers may carry a personal supply for up to three months, provided the medication is in its original packaging with a copy of the prescription or a doctor’s letter. Hong Kong customs permits personal import of up to 30 days’ worth without a licence; longer periods may require a formal import permit.

• Are there any known differences in formulation between European and Asian markets?
  The core active ingredient, flunarizine, is identical across regions. In some Asian markets, excipients such as lactose or magnesium stearate may differ, which can be relevant for patients with specific allergies or intolerances.

• What clinical evidence supports the use of Flunarizine for vestibular migraine?
  Randomised controlled trials have shown that daily flunarizine reduces vertigo frequency and improves quality of life scores in vestibular migraine patients, with statistically significant benefits observed after 8 weeks of therapy.

• Does Flunarizine interact with common antihistamines used for allergies?
  Yes. Because flunarizine has antihistaminic properties, concurrent use with other H₁‑antagonists may increase sedation. Adjusting the timing of each medication can minimise this effect.

• How long should a patient remain on Flunarizine before assessing efficacy?
  A therapeutic trial of at least 8–12 weeks is recommended to evaluate reduction in migraine days. Early assessment (< 4 weeks) may not reflect the drug’s full preventive potential.

• Is weight gain a reversible side effect, and how can it be managed?
  Weight gain associated with flunarizine is usually modest and reversible upon dose reduction or discontinuation. Monitoring body weight and incorporating balanced nutrition and regular exercise can mitigate this effect.

• Can Flunarizine be used in patients with a history of epilepsy?
  There is no direct contraindication; however, because calcium‑channel blockers can influence neuronal excitability, patients with uncontrolled epilepsy should be monitored closely, and alternative prophylactics may be considered.

• What is the legal basis for personal import of Flunarizine into Hong Kong?
  The Pharmacy and Poisons Ordinance permits individuals to import a three‑month supply of prescription medicines for personal use, provided the medication is approved by a recognised overseas regulatory authority and appropriate documentation accompanies the shipment.

Glossary

Calcium‑channel blocker

A class of drugs that inhibit the flow of calcium ions into cells, reducing muscle contraction and neurotransmitter release.

Antihistamine (H₁‑receptor antagonist)

A compound that blocks histamine receptors, decreasing allergic symptoms and, in flunarizine’s case, contributing to its sedative effects.

Half‑life

The time required for the plasma concentration of a drug to decrease by 50 %. For flunarizine, this is approximately 18–30 hours, supporting once‑daily dosing.

CYP450 enzymes

A family of liver enzymes (e.g., CYP2C19, CYP3A4) that metabolise many medications, influencing drug interactions and clearance.

⚠️ Disclaimer

The information provided about Flunarizine is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Flunarizine for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.