Buy Generic Glucophage Sr Online

Generic Glucophage Sr Information

Introduction

Glucophage Sr is a tablet formulation containing the biguanide metformin, a first‑line oral agent for type 2 diabetes mellitus. In Hong Kong, metformin is recommended by the Hospital Authority and the Hong Kong Diabetes Federation as the cornerstone of glucose‑lowering therapy because of its proven efficacy, low risk of hypoglycaemia, and favourable impact on cardiovascular outcomes. Glucophage Sr is marketed for the treatment of hyperglycaemia in adults with type 2 diabetes and may be used as part of a comprehensive lifestyle programme that includes diet, exercise, and weight management.

The product is manufactured by a licensed pharmaceutical company that complies with the Hong Kong Pharmacy and Poisons Ordinance. Metformin, the active compound, belongs to the diabetes medication group and exerts its therapeutic effect by improving insulin sensitivity and reducing hepatic glucose production.

What is Glucophage Sr?

Glucophage Sr is an oral tablet that delivers metformin hydrochloride in a sustained‑release (SR) formulation. The SR technology allows gradual release of the drug over several hours, which can improve gastrointestinal tolerability compared with immediate‑release (IR) products.

• Classification: Antidiabetic biguanide, sustained‑release tablet.
• Development: Metformin has been in clinical use since the 197s; the SR version was introduced to address the common GI side‑effects of the IR form.
• Manufacturer: Produced by a pharmaceutical firm authorized by the Hong Kong Department of Health; specific corporate identity varies by market but all suppliers must hold a valid licence for import and distribution in Hong Kong.

The tablet contains 500 mg of metformin HCl per unit, together with inert excipients such as microcrystalline cellulose, magnesium stearate, and hypromellose, which form the extended‑release matrix.

How Glucophage Sr Works

Metformin lowers blood glucose through three principal mechanisms:

1. Inhibition of hepatic gluconeogenesis – Metformin activates AMP‑activated protein kinase (AMPK), a cellular energy sensor, which suppresses the expression of genes involved in glucose production.
2. Improvement of peripheral insulin sensitivity – By enhancing insulin‑mediated glucose uptake in skeletal muscle, the drug reduces post‑prandial glucose excursions.
3. Reduction of intestinal glucose absorption – Metformin modestly slows carbohydrate uptake from the gut, contributing to overall glycaemic control.

The sustained‑release matrix releases metformin gradually, resulting in a slower rise in plasma concentration. Peak plasma levels are typically reached 7–12 hours after ingestion, with a half‑life of about 5 hours. Renal excretion accounts for >90 % of drug clearance; therefore, dosage adjustments are required in patients with impaired renal function (eGFR < 30 mL/min/1.73 m²).

Collectively, these actions lower fasting plasma glucose and haemoglobin A1c (HbA1c) without causing insulin‑related hypoglycaemia, because metformin does not stimulate insulin secretion.

Conditions Treated with Glucophage Sr

• Type 2 Diabetes Mellitus (T2DM) – Primary indication. Metformin reduces HbA1c by 1–1.5 % when used as monotherapy and is effective in combination with other agents (e.g., DPP‑4 inhibitors, SGLT‑2 inhibitors, or basal insulin).
• Prediabetes / Impaired Glucose Tolerance – In Hong Kong, early intervention with metformin has been shown to delay progression to overt diabetes in high‑risk adults (BMI ≥ 30 kg/m², fasting glucose 100–125 mg/dL).
• Polycystic Ovary Syndrome (PCOS) with insulin resistance – Although off‑label, metformin improves ovulatory function and androgen excess; Hong Kong endocrinology guidelines cite metformin as a adjunct therapy for metabolic aspects of PCOS.

Epidemiologically, Hong Kong reports a prevalence of T2DM of approximately 10 % among adults, with rising rates linked to sedentary lifestyles and dietary changes. Metformin’s low cost and established safety profile make it a public‑health priority in the region.

Suitable Candidates for Glucophage Sr Treatment

• Adults with newly diagnosed T2DM whose HbA1c is ≤ 9 % and who have no contraindications to metformin.
• Patients requiring an add‑on to existing therapy (e.g., sulfonylureas, SGLT‑2 inhibitors) who need additional HbA1c reduction without increasing hypoglycaemia risk.
• Individuals with overweight or obesity where weight‑neutral or modest weight‑loss effects of metformin are desirable.
• Patients with chronic kidney disease (CKD) stage 3 (eGFR 30–59 mL/min/1.73 m²) may use a reduced dose of the SR formulation under physician supervision.

Contraindications include:

• Severe renal impairment (eGFR < 30 mL/min/1.73 m²).
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
• Known hypersensitivity to metformin or any excipients in the tablet.

Pregnant or lactating women should only use metformin if prescribed by a specialist, as safety data are limited in these populations.

Risks, Side Effects, and Interactions

Common

• Gastro‑intestinal upset – nausea, abdominal discomfort, diarrhoea (often transient; may improve with dose titration).
• Metallic taste – an occasional taste disturbance reported by patients.

Rare

• Lactic acidosis – extremely rare (< .01 %) but potentially fatal; risk rises with renal insufficiency, hepatic disease, or excessive alcohol intake.
• Vitamin B12 deficiency – long‑term metformin use can reduce B12 absorption; consider periodic monitoring.

Serious

• Hypersensitivity reactions – rash, urticaria, or angioedema requiring immediate medical attention.
• Severe hepatic impairment – may exacerbate hepatic encephalopathy; contraindicated in patients with cirrhosis.

Drug–Drug Interactions

• Cimetidine, ranitidine, and other H₂‑blockers – may increase metformin plasma concentrations; monitor renal function.
• Iodinated contrast agents – transient renal dysfunction can precipitate lactic acidosis; a 48‑hour discontinuation of metformin is recommended after contrast administration.
• Sulfonylureas – combined use increases risk of hypoglycaemia; dose adjustments may be needed.
• Alcohol – acute intoxication potentiates lactic acidosis; advise patients to limit intake.

Patients should disclose all medications, including over‑the‑counter products and herbal supplements, to their healthcare provider before initiating Glucophage Sr.

Practical Use: Dosing, Missed Dose, Overdose

• Starting dose: 500 mg SR once daily with the evening meal.
• Titration: Increase by 500 mg weekly, up to a maximum of 200 mg SR once daily (or 100 mg SR twice daily, depending on tolerability).
• Renal adjustment: For eGFR 30–45 mL/min/1.73 m², limit total daily dose to 100 mg; avoid use if eGFR < 30 mL/min/1.73 m².

Missed dose – If a dose is forgotten, take it as soon as remembered unless it is near the next scheduled dose; in that case skip the missed dose and continue the regular schedule. Do not double‑dose.

Overdose – Symptoms may include gastrointestinal distress, dizziness, or lactic acidosis. Seek immediate medical attention; supportive care and haemodialysis are the primary treatments for severe cases.

Precautions –

• Take the tablet with food to minimise GI irritation.
• Avoid excessive alcohol consumption.
• Monitor renal function at least annually, or more frequently in the elderly or those with comorbidities.

Buying Glucophage Sr from Our Online Pharmacy

Glucophage Sr is available for purchase from our online pharmacy in Hong Kong. We provide a regulated, cost‑effective channel for patients who need reliable access to metformin when local pharmacies have limited stock or when insurance coverage restricts options.

• Affordable pricing – Our supply chain sources the generic SR tablets near manufacturer cost, resulting in lower retail prices compared with many brand‑name products.
• Verified quality – All batches are sourced from overseas licensed pharmacies that comply with Good Manufacturing Practice (GMP) and are inspected by the Hong Kong Department of Health before import.
• Guaranteed delivery – Orders are dispatched with discreet packaging; standard express delivery reaches most districts within 7 days, while regular airmail typically arrives within 2–3 weeks.
• Online‑only access – By operating as a pharmacy‑broker service, we can provide international medications that are not always stocked locally, while maintaining strict patient‑privacy safeguards.

Our pharmacy respects confidentiality: shipments are unbranded, and customer data are protected in accordance with Hong Kong’s Personal Data (Privacy) Ordinance.

FAQ

• What is the difference between the sustained‑release and immediate‑release forms of metformin?
  The sustained‑release (SR) formulation releases the drug slowly over 8–12 hours, which can reduce gastrointestinal side‑effects such as diarrhoea. The immediate‑release (IR) form is absorbed more quickly and may require multiple daily doses.

• Can Glucophage Sr be taken with other antidiabetic agents?
  Yes, metformin SR is often combined with agents such as SGLT‑2 inhibitors, DPP‑4 inhibitors, or basal insulin. Combination therapy should be guided by a healthcare professional to optimise dosing and avoid hypoglycaemia.

• Is it safe to travel internationally while using Glucophage Sr?
  Travelers should keep the medication in its original packaging, carry a copy of the prescription or a physician’s letter, and stay hydrated. Adjustments for time‑zone changes are not usually required because the SR tablet is taken once daily.

• Does Glucophage Sr require refrigeration or special storage conditions?
  No, the tablets should be stored at room temperature (15–30 °C), protected from moisture, heat, and direct sunlight. A bathroom cabinet is unsuitable due to humidity.

• What are the typical inactive ingredients in Glucophage Sr tablets?
  Common excipients include microcrystalline cellulose (binder), magnesium stearate (lubricant), and hypromellose (film‑forming agent). These ingredients are generally regarded as inert and do not affect the drug’s efficacy.

• Can Glucophage Sr be imported for personal use in Hong Kong?
  Personal import of a three‑month supply for personal use is permitted under Hong Kong’s import regulations, provided the product is licensed and declared accurately. Importers must retain the original packaging and documentation.

• Are there any specific warnings for Asian patients using metformin?
  Some studies suggest a higher prevalence of low body weight and reduced renal reserve in older Asian populations, which may increase the risk of lactic acidosis. Dose titration and renal monitoring are therefore especially important.

• What clinical trials established the efficacy of metformin SR?
  Large, double‑blind, multicentre trials such as the UKPDS (United Kingdom Prospective Diabetes Study) demonstrated that metformin reduces microvascular complications and mortality. Subsequent SR-specific studies confirmed comparable HbA1c reduction with improved GI tolerability.

• Does Glucophage Sr have any impact on weight?
  Metformin is generally weight‑neutral or associated with modest weight loss (≈1–2 kg) over several months, which can be beneficial for overweight patients with T2DM.

• How does the tablet’s appearance differ from other metformin products?
  Glucophage Sr tablets are typically pink‑to‑orange, film‑coated, and scored to allow splitting if prescribed. This differs from many IR tablets, which may be white or unscored.

• Is there a risk of drug testing interference when using Glucophage Sr?
  Metformin does not appear on standard workplace drug screens and is not considered a performance‑enhancing substance. However, athletes subject to the World Anti‑Doping Agency (WADA) list should disclose medication use to their medical team.

• Can Glucophage Sr be used in patients with liver disease?
  Metformin is not metabolised by the liver, but severe hepatic impairment can predispose to lactic acidosis. Caution and dose reduction are advised in moderate liver disease; it is contraindicated in advanced cirrhosis.

Glossary

AMP‑activated protein kinase (AMPK)

An intracellular enzyme that acts as an energy sensor, activating pathways that generate ATP and inhibiting those that consume it. Metformin’s activation of AMPK reduces hepatic glucose production.

Sustained‑release (SR)

A dosage form designed to release the active drug slowly over an extended period, often allowing once‑daily dosing and improved tolerability.

Lactic acidosis

A rare but serious condition in which lactate accumulates in the bloodstream, leading to a low blood pH. Metformin‑associated lactic acidosis is most likely in patients with renal or hepatic impairment.

eGFR (estimated glomerular filtration rate)

A calculated measure of kidney function based on serum creatinine, age, sex, and body size. Metformin dosing is adjusted according to eGFR to prevent accumulation.

⚠️ Disclaimer

The information provided about Glucophage Sr is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Glucophage Sr for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.