Buy Generic Hydrochlorothiazide Online

Generic Hydrochlorothiazide Information

Introduction

Hydrochlorothiazide is a thiazide‑type diuretic that is widely prescribed for the management of elevated blood pressure and fluid retention. In Hong Kong, it is listed on the Hospital Authority formulary and is commonly used in primary‑care clinics to reduce cardiovascular risk. The active compound, Hydrochlorothiazide, belongs to the blood‑pressure medication group and is also effective in treating edema associated with heart failure, liver cirrhosis, or renal disease.

What is Hydrochlorothiazide?

Hydrochlorothiazide is a synthetic sulfonamide diuretic that was first introduced by Merck & Co. in the late 195s. It is classified as a thiazide‑type diuretic (sometimes listed as a thiazide‑like diuretic) and works primarily on the distal convoluted tubule of the nephron to increase urinary sodium and water excretion.

Hydrochlorothiazide is the generic version of Microzide, Esidrix, and Hydrodiuril, containing the same active compound Hydrochlorothiazide. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

The medication is supplied as oral tablets of various strengths (usually 12.5 mg, 25 mg, and 50 mg) and contains inactive ingredients such as lactose, magnesium stearate, and microcrystalline cellulose, which may vary among manufacturers.

How Hydrochlorothiazide Works

Hydrochlorothiazide inhibits the sodium‑chloride symporter (NCC) located on the luminal membrane of the distal convoluted tubule. By blocking NCC, the drug reduces reabsorption of sodium and chloride, leading to increased excretion of these ions together with water. The resulting decrease in extracellular fluid volume lowers preload and cardiac output, which contributes to a reduction in systemic blood pressure.

Additionally thiazide diuretics cause a modest relaxation of arteriolar smooth muscle, an effect that is independent of volume depletion and further supports blood‑pressure control. Onset of diuretic action usually occurs within 2 hours after oral administration, with peak natriuretic effect at about 4–6 hours. The elimination half‑life ranges from 6 to 15 hours, allowing once‑daily dosing for most patients.

Conditions Treated with Hydrochlorothiazide

• Essential (primary) hypertension – Thiazide diuretics are recommended as first‑line agents by the Hong Kong Clinical Practice Guidelines for hypertension because they reduce stroke, myocardial infarction, and heart‑failure risk.
• Edema – Fluid overload secondary to congestive heart failure, hepatic cirrhosis, or chronic kidney disease can be mitigated by the natriuretic effect of Hydrochlorothiazide.
• Nephrolithiasis prophylaxis – By increasing urinary calcium excretion and reducing supersaturation, the drug can help prevent calcium‑oxalate stone formation in selected patients.
• Hypercalciuria – Thiazides reduce calcium loss in urine, which is useful in patients with bone‑loss disorders who need higher bone mineral density.

In Hong Kong, hypertension prevalence exceeds 25 % of adults over 45 years, making Hydrochlorothiazide a cornerstone of public‑health pharmacotherapy.

Who is Hydrochlorothiazide For?

Hydrochlorothiazide is appropriate for adult patients who require blood‑pressure reduction or diuresis and who have no contraindications to thiazide therapy. Typical candidates include:

• Newly diagnosed hypertensive adults – especially those without severe renal impairment or electrolyte abnormalities.
• Patients with mild to moderate edema – when fluid overload is not severe enough to warrant loop diuretics.
• Individuals at risk of calcium‑based kidney stones – where the calcium‑conserving effect is advantageous.

Contraindications or cautionary scenarios include:

• Severe renal impairment (eGFR < 30 mL/min/1.73 m²) – reduced clearance may precipitate toxicity.
• Known hypersensitivity to sulfonamides – cross‑reactivity can cause severe rash.
• Pregnancy (first trimester) and lactation – limited safety data; alternative agents are preferred.
• Gout or hyperuricemia – thiazides may raise serum uric acid levels, potentially triggering attacks.

Risks, Side Effects, and Interactions

Common

• Electrolyte disturbances – hyponatremia, hypokalemia, hypomagnesemia, and hypercalcemia are reported in up to 10 % of users.
• Post‑ural diuresis – transient dizziness or light‑headedness when standing up quickly.
• Increased uric acid – may exacerbate gout in predisposed individuals.

Rare

• Photosensitivity reactions – rash or sunburn‑like lesions after ultraviolet exposure.
• Pancreatitis – isolated case reports suggest a possible association.
• Severe allergic reactions – including Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Serious

• Severe electrolyte imbalance – particularly profound hypokalemia that can precipitate cardiac arrhythmias.
• Acute renal failure – may occur if volume depletion is excessive, especially in the elderly or those on concurrent nephrotoxic drugs.
• Hyponatremic encephalopathy – rare but life‑threatening consequence of severe sodium loss.

Clinically Relevant Drug–Drug Interactions

• Non‑steroidal anti‑inflammatory drugs (NSAIDs) – may blunt diuretic efficacy and increase risk of kidney injury.
• Potassium‑sparing diuretics or ACE inhibitors/ARBs – can offset potassium loss, but combined therapy requires close monitoring of serum potassium.
• Lithium – thiazides reduce lithium clearance, raising the risk of lithium toxicity.
• Antidiabetic agents (e.g., insulin, sulfonylureas) – may enhance hypoglycemic effect; glucose monitoring is advised.

Patients should inform their healthcare provider of all concurrent medications, including over‑the‑counter products and herbal supplements.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dosing – 12.5 mg to 25 mg once daily for hypertension; up to 50 mg daily may be used when combined with other antihypertensives. For edema, 25 mg to 50 mg once daily is typical, adjusted based on response and renal function.
• Missed dose – Take the missed tablet as soon as remembered unless it is near the time of the next scheduled dose; in that case, skip the missed dose and resume the regular schedule. Do not double‑dose.
• Overdose – Symptoms may include excessive diuresis, dehydration, severe electrolyte abnormalities, and hypotension. Immediate medical attention is required; treatment focuses on fluid and electrolyte replacement and monitoring of cardiac rhythm.
• Food and alcohol – Hydrochlorothiazide can be taken with or without food; however, a high‑salt meal may diminish its diuretic efficacy. Alcohol can exacerbate orthostatic hypotension and should be consumed cautiously.
• Comorbidities – In patients with diabetes, regular monitoring of blood glucose is advisable. Those with gout should have periodic serum uric acid checks.

Buying Hydrochlorothiazide from Our Online Pharmacy

Hydrochlorothiazide can be purchased from our online pharmacy in Hong Kong with a streamlined ordering process designed for privacy and convenience.

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For Hong Kong residents who encounter barriers to regular pharmacy supply or who seek a cost‑effective generic alternative, our platform provides a reliable route to acquire Hydrochlorothiazide safely.

FAQ

• **Can Hydrochlorothiazide be used by people with mild kidney disease?**
  Yes, Hydrochlorothiazide can be prescribed for patients with mild to moderate renal impairment (eGFR ≥ 30 mL/min/1.73 m²). Dose adjustment and close monitoring of electrolytes and renal function are recommended to avoid accumulation and adverse effects.

• **What is the recommended storage condition for Hydrochlorothiazide tablets?**
  The medication should be stored at controlled room temperature (15 °C–30 °C), protected from excess moisture, heat, and direct sunlight. Keep the bottle tightly closed and out of reach of children.

• **Does Hydrochlorothiazide have a known effect on blood glucose levels?**
  Thiazide diuretics may impair glucose tolerance modestly, potentially increasing fasting blood glucose in susceptible individuals. Patients with diabetes should monitor glycemic control regularly when initiating therapy.

• **Are there any special considerations for travelers taking Hydrochlorothiazide?**
  Travelers should carry a sufficient supply in original packaging, keep the drug with them in hand luggage to avoid temperature extremes in cargo holds, and stay hydrated, especially in hot climates, to minimize the risk of dehydration.

• **What distinguishes the Hong Kong formulation from those sold in the United States or Europe?**
  The active ingredient is identical, but inactive excipients such as filler or binder may differ. Some Hong Kong products use lactose‑free formulations, which can be important for individuals with lactose intolerance.

• **Is Hydrochlorothiazide detectable in standard drug‑testing programs?**
  Hydrochlorothiazide is not a controlled substance and is not screened for in typical occupational or sports drug‑testing panels.

• **Can Hydrochlorothiazide cause weight loss?**
  The drug induces fluid loss, which may result in a modest reduction in body weight during the initial treatment phase. This effect reflects loss of water, not fat, and stabilizes after several weeks.

• **How long does it take for blood pressure to reach its maximal reduction after starting Hydrochlorothiazide?**
  Blood‑pressure lowering effects are usually evident within 1–2 weeks, with the greatest reduction occurring after about 4–6 weeks of consistent therapy.

• **Are there any differences in tablet appearance among generic manufacturers?**
  Yes, tablet color, shape, and imprint can vary; common identifiers include a round 12.5 mg tablet marked “12.5 HCTZ” and a pink 25 mg tablet marked “25 CTZ”. Checking the imprint ensures the correct product is taken.

• **What regulatory safeguards exist for importing Hydrochlorothiazide into Hong Kong for personal use?**
  Personal import of a three‑month supply of prescription medicines for self‑use is allowed under Hong Kong customs regulations, provided the product is accompanied by a valid prescription and originates from a licensed overseas pharmacy.

• **Has Hydrochlorothiazide been studied specifically in Asian populations?**
  Several clinical trials conducted in East Asian cohorts have confirmed comparable efficacy and safety profiles to Western populations, though some studies suggest a slightly higher incidence of hyponatremia, warranting careful electrolyte monitoring.

• **What is the impact of Hydrochlorothiazide on serum calcium levels?**
  Thiazide diuretics reduce calcium excretion, often leading to a modest increase in serum calcium. This effect can be therapeutic for patients with osteoporosis but requires monitoring in those prone to hypercalcemia.

Glossary

Thiazide diuretic

A class of medications that act on the distal convoluted tubule of the kidney to increase excretion of sodium and water, thereby lowering blood pressure and reducing fluid overload.

Electrolyte imbalance

A disturbance in the normal concentrations of minerals such as sodium, potassium, magnesium, or calcium in the blood, which can affect nerve, muscle, and cardiac function.

eGFR (estimated Glomerular Filtration Rate)

A calculated value that reflects kidney filtration capacity; used to assess renal function and guide dosing of renally excreted drugs.

Hyperuricemia

Elevated levels of uric acid in the blood, which can precipitate gout attacks if crystals deposit in joints.

⚠️ Disclaimer

The information provided about Hydrochlorothiazide is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Hydrochlorothiazide for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.