Buy Generic Imdur Online

Generic Imdur Information

Introduction

Imdur is a prescription medication containing the active compound isosorbide. It belongs to the pain relief medication group and is manufactured by Merck & Co., Inc. In Hong Kong, Imdur is prescribed primarily for the prevention of angina pectoris, a condition that causes chest pain due to insufficient blood flow to the heart. The drug’s nitrate properties help to relax and dilate coronary vessels, reducing the frequency and severity of anginal attacks. Availability of a generic form of isosorbide in Hong Kong expands treatment options for patients seeking cost‑effective therapy while maintaining clinical efficacy.

What is Imdur?

Imdur is a long‑acting oral nitrate formulated as an extended‑release tablet. The product was developed by Merck & Co., Inc. and received regulatory approval in numerous jurisdictions, including Hong Kong, where it is listed on the Hong Kong Department of Health’s Product Register. The tablet contains isosorbide, a nitrate derivative that acts as a vasodilator. Imdur is marketed under the trade name Imdur worldwide; in some markets, the same active compound is sold under brand names such as Isordil (isosorbide dinitrate) and Monoket (isosorbide mononitrate). While the therapeutic indication remains angina, the drug’s classification within the pain‑relief group reflects its role in alleviating the painful symptoms of myocardial ischemia.

How Imdur Works

Isosorbide, the single active ingredient in Imdur, is a nitrate that releases nitric oxide (NO) after metabolic conversion in the vascular smooth‑muscle cells. NO activates guanylate cyclase, increasing cyclic guanosine monophosphate (cGMP) levels. Elevated cGMP leads to relaxation of smooth muscle and dilation of both coronary arteries and systemic veins. Venodilation reduces preload (the volume of blood returning to the heart), while arterial dilation lowers afterload (the resistance against which the heart pumps). Together, these effects decrease myocardial oxygen demand and improve oxygen supply, thereby preventing the onset of angina.

Imdur’s extended‑release matrix provides a gradual rise in plasma isosorbide concentrations, achieving therapeutic levels within 30–60 minutes after ingestion. The drug’s half‑life is approximately 5 hours, allowing once‑daily dosing for most patients. Renal excretion accounts for the majority of clearance; dose adjustments are rarely needed in mild to moderate renal impairment, but severe renal dysfunction warrants careful monitoring.

Conditions Treated with Imdur

• Chronic stable angina pectoris – The primary approved indication in Hong Kong. Angina prevalence in Hong Kong is estimated at 5–7 % among adults over 55 years, reflecting the region’s evolving cardiovascular risk profile.
• Prophylaxis of angina episodes during exertion or emotional stress – By reducing myocardial oxygen consumption, Imdur helps maintain functional capacity in patients who experience predictable chest pain.

Although isosorbide has been investigated for other vascular conditions (e.g., heart failure, peripheral arterial disease), regulatory bodies in Hong Kong have not approved Imdur for these uses. Prescribers therefore limit its application to the indications listed above.

Who is Imdur For?

• Adults with documented chronic stable angina who require a once‑daily nitrate to prevent chest pain episodes.
• Patients who have responded poorly to short‑acting nitrates (e.g., sublingual glyceryl trinitrate) or who experience frequent “breakthrough” attacks despite standard therapy.
• Individuals who prefer simplified dosing – the extended‑release formulation enables a single daily dose, enhancing adherence compared with multiple short‑acting administrations.
• Patients with preserved renal function (eGFR ≥ 30 mL/min/1.73 m²) because the drug is primarily eliminated unchanged by the kidneys.

Imdur is not appropriate for:

• Patients with a known hypersensitivity to isosorbide, other nitrates, or any tablet excipients.
• Individuals with severe hypotension (systolic blood pressure < 90 mmHg) or recent myocardial infarction where rapid preload reduction could be hazardous.
• Patients taking phosphodiesterase‑5 (PDE‑5) inhibitors (e.g., sildenafil) because combined vasodilation may cause dangerous drops in blood pressure.
• Pregnant or breastfeeding women unless the benefit clearly outweighs potential risk, as safety data in these populations are limited.

Risks, Side Effects, and Interactions

Common

• Headache (often described as throbbing)
• Flushing or warmth in the face and neck
• Dizziness, especially upon standing (orthostatic hypotension)
• Nausea or mild gastrointestinal discomfort

Rare

• Palpitations or tachycardia
• Mild anxiety or restlessness
• Skin rash or mild pruritus

Serious

• Severe hypotension leading to syncope or falls
• Reflex tachycardia causing ischemic chest pain
• Life‑threatening allergic reaction (anaphylaxis) – characterized by swelling of the throat, bronchospasm, or widespread rash
• Methemoglobinemia (extremely rare) – presenting with cyanosis and dyspnea

Drug–Drug Interactions

• Phosphodiesterase‑5 inhibitors (sildenafil, tadalafil, vardenafil): additive vasodilatory effect → contraindicated.
• Other nitrates or nitrites (e.g., nitroglycerin patches, isosorbide dinitrate): may cause cumulative hypotension; co‑administration should be avoided or spaced at least 24 hours apart.
• Antihypertensive agents (e.g., ACE inhibitors, beta‑blockers): may amplify blood pressure‑lowering effect; monitor for symptomatic hypotension.
• Azole antifungals (ketoconazole, fluconazole) and macrolide antibiotics (erythromycin): can inhibit hepatic metabolism, modestly increasing isosorbide plasma concentrations.
• Alcohol: potentiates vasodilatory action, increasing dizziness and fall risk.

Patients should disclose all concurrent medications, including over‑the‑counter products and herbal supplements, to minimize interaction risk.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing: Imdur is typically initiated at 30 mg once daily. Based on therapeutic response and tolerability, the dose may be titrated up to 60 mg once daily after at least one week. Maximum recommended daily dose in Hong Kong is 60 mg.
• Administration: Swallow the extended‑release tablet whole with a full glass of water. Do not crush, chew, or split the tablet, as this destroys the controlled‑release matrix and may precipitate severe hypotension.
• Missed dose: If a dose is forgotten and the scheduled time for the next dose is more than 12 hours away, take the missed tablet as soon as remembered. If the next dose is imminent, skip the missed dose and resume the regular schedule. Do not double‑dose.
• Overdose: In the event of accidental ingestion of > 2 × the prescribed daily dose, seek immediate medical attention. Symptoms may include profound hypotension, severe headache, dizziness, and fainting. Treatment is supportive, focusing on fluid resuscitation and vasopressor therapy if needed.
• Precautions: Avoid consuming large amounts of alcohol or grapefruit juice while on Imdur, as both can exacerbate vasodilatory effects. Patients with liver disease should be monitored closely, although hepatic metabolism plays a minor role in clearance.

Buying Imdur from Our Online Pharmacy

Imdur can be purchased safely from our online pharmacy in Hong Kong. Our service offers several advantages for patients who need reliable access to this essential nitrate therapy:

• Affordable pricing – We source Imdur directly from licensed overseas manufacturers, allowing us to sell the medication at a cost close to the wholesale price, without compromising quality.
• Verified quality – Every batch is verified by third‑party laboratories for potency, purity, and compliance with international Good Manufacturing Practice (GMP) standards.
• Guaranteed delivery – Orders are dispatched through discreet, temperature‑controlled packaging. Express shipping typically arrives within 7 days, while regular airmail delivery is completed in ~3 weeks. Tracking information is provided for each shipment.
• Online‑only access – Our pharmacy broker model partners with licensed overseas pharmacies, enabling us to offer international medicines that may not be stocked in local retail pharmacies. This model also ensures patient privacy; shipments are unmarked and packaged to respect confidentiality.

Patients in Hong Kong who experience limited availability of Imdur through conventional channels, or who seek a cost‑effective generic alternative, can benefit from our streamlined, secure purchasing process.

FAQ

• Is Imdur approved for use in Hong Kong?
  Yes. Imdur is listed on the Hong Kong Department of Health’s Product Register for the treatment of chronic stable angina.

• Can Imdur be taken with other nitrate medications?
  No. Concurrent use of two nitrate agents can cause severe hypotension. If a short‑acting nitrate is needed for breakthrough angina, it should be taken at least 24 hours after the Imdur dose, under medical supervision.

• What should I do if I experience a severe headache after taking Imdur?
  Headache is a common side effect. Over‑the‑counter analgesics such as acetaminophen may be used, but you should inform your physician if the headache is persistent or interferes with daily activities.

• Does Imdur require refrigeration?
  No. Imdur tablets should be stored at room temperature, between 15 °C and 30 °C, away from direct sunlight, moisture, and heat sources.

• How long can I safely store Imdur after purchase?
  The product retains full potency for 24 months when stored as directed. Check the expiration date printed on the packaging before use.

• Is it legal to import Imdur for personal use into Hong Kong?
  Personal import of a prescription medication is permitted if the quantity does not exceed a 30‑day supply and a valid prescription from a Hong Kong‑registered practitioner is retained. Our online pharmacy provides documentation that complies with local import regulations.

• Do the tablets contain any allergens such as lactose or gluten?
  Imdur tablets contain lactose and maize starch as inactive ingredients. Patients with severe lactose intolerance or corn allergy should discuss alternatives with their healthcare provider.

• Can Imdur be taken during a fast, such as for Ramadan?
  Yes, Imdur may be taken with water during non‑fasting hours. Because it can cause dizziness, patients should avoid activities that require full alertness (e.g., driving) shortly after dosing, especially if blood pressure is low.

• What is the difference between Imdur and Isordil?
  Imdur contains isosorbide mononitrate, whereas Isordil contains isosorbide dinitrate. Both are nitrates but differ in pharmacokinetic profiles: mononitrate provides a smoother, longer‑lasting effect, while dinitrate may require more frequent dosing.

• How does smoking affect the efficacy of Imdur?
  Tobacco smoke induces oxidative stress and can diminish nitrate responsiveness, a phenomenon known as nitrate tolerance. Smoking cessation improves the therapeutic benefit of Imdur and reduces cardiovascular risk overall.

• Are there any special considerations for elderly patients?
  Older adults may be more susceptible to orthostatic hypotension and dizziness. Initiating therapy at the lowest dose (30 mg) and monitoring blood pressure after the first dose are recommended to minimize fall risk.

• What packaging does Imdur arrive in when ordered online?
  Each order is packaged in a sealed, tamper‑evident blister strip inside a discreet envelope. The outer packaging bears only the shipping label and does not display the medication name to protect privacy.

Glossary

Nitrate vasodilator

A class of drugs that release nitric oxide to relax smooth muscle in blood vessels, thereby lowering blood pressure and reducing cardiac workload.

Extended‑release (ER) formulation

A tablet design that releases the active ingredient slowly over several hours, allowing once‑daily dosing and more stable plasma concentrations.

Orthostatic hypotension

A drop in blood pressure that occurs when a person stands up quickly, causing dizziness or fainting.

cGMP (cyclic guanosine monophosphate)

A second messenger molecule that mediates smooth‑muscle relaxation in response to nitric oxide signaling.

⚠️ Disclaimer

The information provided about Imdur is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Imdur for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.