Buy Generic Imipramine Online

Generic Imipramine Information

Introduction

Imipramine is a tricyclic antidepressant (TCA) that has been used for several decades to treat major depressive disorder and other psychiatric and neurologic conditions. In Hong Kong, the drug is listed under the Pharmacy and Poisons Ordinance and can be prescribed by qualified physicians for approved indications. The active compound, imipramine, belongs to the antidepressant medication group and exerts its therapeutic effects by modulating monoamine neurotransmitters in the brain. In addition to depression, clinicians in Hong Kong also employ imipramine for certain anxiety disorders, nocturnal enuresis in children, and chronic pain syndromes where serotonergic and noradrenergic pathways are implicated.

What is Imipramine?

Imipramine is a synthetic, aromatic amine classified as a secondary‑amine tricyclic antidepressant. It was first synthesized in the early 195s by Janssen Pharmaceutica and introduced to the market under the brand name Tofranil. The molecule is chemically identical across brand‑name and generic formulations.

• Generic version statement – Imipramine is the generic version of Tofranil, containing the same active compound imipramine. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

In most jurisdictions, imipramine is supplied as immediate‑release tablets containing 10 mg, 25 mg, 50 mg, or 75 mg of the active ingredient, together with inert excipients such as lactose, starch, and magnesium stearate. The medication is regulated by the Hong Kong Department of Health and must be dispensed with a valid prescription.

How Imipramine Works

Imipramine’s primary mechanism of action is the inhibition of the presynaptic re‑uptake of two key neurotransmitters: serotonin (5‑hydroxy‑tryptamine) and norepinephrine. By blocking the serotonin transporter (SERT) and the norepinephrine transporter (NET), the drug increases the extracellular concentration of these catecholamines in the synaptic cleft, enhancing neuronal signaling in mood‑regulating pathways.

The pharmacodynamic profile explains several clinical observations:

• Onset of therapeutic effect – Although plasma concentrations rise within hours, most patients notice mood improvement after 2–4 weeks of consistent dosing, reflecting the time needed for downstream neuroadaptive changes (e.g., receptor desensitization and neurotrophic factor modulation).
• Duration of action – Imipramine has a half‑life of approximately 10–20 hours, permitting once‑daily or divided dosing depending on tolerability.
• Metabolism and clearance – The drug is metabolized hepatically via the cytochrome P450 iso‑enzymes CYP2D6 and CYP1A2 to active metabolites (desipramine, imipramine‑N‑oxide). Renal excretion accounts for roughly 15 % of the dose, making hepatic function a more critical determinant of clearance.

Through these actions, imipramine restores the balance of monoaminergic neurotransmission, which is often disrupted in depressive and anxiety states.

Conditions Treated with Imipramine

• Major Depressive Disorder (MDD) – Clinical trials in the 196s and 197s demonstrated that imipramine significantly reduced Hamilton Depression Rating Scale scores compared with placebo. In Hong Kong, prevalence studies suggest a lifetime depression prevalence of 7–9 %, underscoring the need for effective antidepressants.
• Panic Disorder – Imipramine reduces the frequency and intensity of panic attacks by stabilising serotonergic pathways.
• Nocturnal Enuresis (Bedwetting) in Children – Low‑dose imipramine (25 mg at bedtime) decreases nighttime urine production and improves bladder capacity, a use supported by pediatric urology guidelines.
• Chronic Neuropathic Pain – By enhancing descending inhibitory pathways, imipramine can alleviate pain associated with diabetic neuropathy or post‑herpetic neuralgia when first‑line agents are insufficient.
• Migraine Prophylaxis – The drug’s anticholinergic and antihistaminic properties help reduce migraine frequency in select patients, though this is an off‑label indication.

Is Imipramine the Right Medication for You?

Imipramine is most appropriate for patients who meet the following criteria:

• Diagnosed depressive or anxiety disorder that has not responded adequately to selective serotonin reuptake inhibitors (SSRIs) or other first‑line agents.
• No contraindications such as recent myocardial infarction, uncontrolled narrow‑angle glaucoma, or a history of severe cardiac conduction abnormalities.
• Ability to tolerate anticholinergic side effects (dry mouth, constipation, blurred vision) which are dose‑dependent.

Patients with the following conditions should discuss alternatives with their clinician:

• Severe liver impairment (Child‑Pugh class C), as reduced metabolic clearance may raise plasma levels.
• Concurrent use of monoamine oxidase inhibitors (MAOIs) – a washout period of at least 14 days is required to avoid serotonin syndrome.
• Pregnancy and lactation – limited safety data exist; benefits must outweigh potential fetal or neonatal risks.

A thorough psychiatric evaluation, cardiac assessment (ECG), and review of comorbidities are essential before initiating therapy.

Risks, Side Effects, and Interactions

Common

• Dry mouth
• Constipation
• Drowsiness or sedation
• Weight gain
• Orthostatic hypotension (postural dizziness)

Rare

• Sexual dysfunction (decreased libido, erectile difficulty)
• Tinnitus or ringing in the ears
• Skin rash or photosensitivity
• Elevated serum cholesterol or triglycerides

Serious

• Cardiac arrhythmias (e.g., QT prolongation, ventricular tachycardia) – risk increases with higher doses and in patients with pre‑existing cardiac disease.
• Seizures – particularly in individuals with a seizure disorder or electrolyte disturbances.
• Serotonin syndrome – can occur if combined with other serotonergic agents (SSRIs, SNRIs, triptans, certain herbal supplements).
• Acute angle‑closure glaucoma – anticholinergic properties can precipitate an ocular emergency.

Clinically relevant drug–drug interactions

• Monoamine oxidase inhibitors (MAOIs) – co‑administration can precipitate hypertensive crisis or serotonin syndrome.
• CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine) – may increase imipramine plasma concentrations, heightening toxicity risk.
• CNS depressants (e.g., benzodiazepines, alcohol) – additive sedation and impaired psychomotor performance.
• Anticholinergic drugs (e.g., antihistamines, antispasmodics) – may exacerbate dryness, urinary retention, and constipation.

Patients should disclose all prescribed, over‑the‑counter, and herbal products before starting imipramine.

Practical Use: Dosing, Missed Dose, Overdose

• Initial dosing for depression – 25 mg taken orally at bedtime. The dose may be increased by 25 mg increments every 3–7 days, targeting a typical therapeutic range of 150–300 mg per day, divided or administered once nightly based on tolerability.
• Nocturnal enuresis – 25 mg taken once nightly, usually at 10 p.m., with dose escalation only under pediatric specialist supervision.
• Chronic pain – start at 25 mg daily; titrate up to 100 mg as needed, monitoring for analgesic benefit versus side effects.

Missed dose – If a dose is missed and the scheduled time is more than 6 hours away, skip the forgotten tablet and resume the regular dosing schedule. Do not double‑dose to compensate.

Overdose management – Symptoms may include severe CNS depression, cardiac arrhythmias, seizures, and anticholinergic toxicity. Immediate medical attention is required; activated charcoal may be administered within one hour of ingestion. Cardiac monitoring and supportive care are standard.

Precautions

• Take imipramine with food or a light snack if gastrointestinal upset occurs.
• Avoid alcohol, as it can potentiate sedation and impair coordination.
• Patients with hypertension should monitor blood pressure regularly, especially during dose escalation.
• Renal impairment does not significantly affect clearance, but hepatic dysfunction necessitates dose reduction (usually 25–50 % of the usual dose).

Buying Imipramine from Our Online Pharmacy

Imipramine can be purchased safely from our online pharmacy in Hong Kong. We specialize in providing verified generic medications at prices close to manufacturer cost, thereby reducing the financial burden on patients who lack comprehensive insurance coverage.

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By choosing our service, Hong Kong residents obtain a reliable supply of imipramine without compromising on safety or confidentiality.

FAQ

• Is Imipramine available in both brand‑name and generic forms in Hong Kong?
  Yes. The original brand name is Tofranil, while generic versions containing the same active ingredient imipramine are widely marketed. Generic imipramine offers the same therapeutic effect at a lower cost.

• Does Imipramine require special storage conditions?
  The tablets should be stored at room temperature (15–30 °C), protected from excess moisture, direct sunlight, and heat sources. A bathroom cabinet is unsuitable due to humidity.

• What does the imprint on an imipramine tablet look like?
  Imipramine tablets commonly bear imprints such as “IMI 10” or “TOF 25”, indicating the manufacturer and dose strength. The exact legend varies by the licensed supplier.

• Can I travel internationally with imipramine in my carry‑on luggage?
  Yes, provided you retain the original pharmacy label and keep the medication in its original packaging. Some jurisdictions may require a physician’s declaration, so verify local customs regulations before travel.

• Are there any dietary restrictions while taking Imipramine?
  No specific foods are contraindicated, but grapefruit juice can inhibit CYP2D6 and raise plasma levels. It is advisable to limit grapefruit products during therapy.

• How does the Asian population respond to Imipramine compared with Western cohorts?
  Pharmacogenomic studies indicate a higher prevalence of CYP2D6 poor‑metabolizer alleles in certain Asian groups, which can increase drug exposure. Clinicians often start at lower doses and monitor plasma levels or side effects more closely.

• Is there a difference between immediate‑release and extended‑release formulations?
  Immediate‑release imipramine is the standard form used for depression and nocturnal enuresis. Extended‑release versions have been developed in some markets to reduce dosing frequency and mitigate peak‑related side effects, but they are not universally available in Hong Kong.

• What should I do if I experience severe dry mouth while on Imipramine?
  Sipping water regularly, chewing sugar‑free gum, and using saliva substitutes can alleviate dryness. If the symptom interferes with daily activities, contact your healthcare provider for possible dose adjustment.

• Can Imipramine cause false‑positive results on drug tests?
  Routine workplace drug screens typically do not target TCAs. However, specialized toxicology panels may detect imipramine metabolites, which could be misinterpreted without clinical context.

• Is it legal to import a personal supply of Imipramine into Hong Kong?
  Personal import of a three‑month supply for personal use is permitted under Hong Kong customs regulations, provided the medication is accompanied by a valid prescription and the importer declares it at the point of entry.

Glossary

Monoamine transporter

Proteins (e.g., SERT, NET) that remove neurotransmitters such as serotonin and norepinephrine from the synaptic cleft, thereby terminating their signaling.

Anticholinergic effect

Pharmacologic action that blocks acetylcholine receptors, leading to side effects like dry mouth, blurred vision, constipation, and urinary retention.

CYP2D6 poor metabolizer

An individual whose genetic makeup results in reduced activity of the CYP2D6 enzyme, causing slower metabolism of drugs like imipramine and potentially higher plasma concentrations.

Serotonin syndrome

A potentially life‑threatening condition characterized by agitation, hyperthermia, tremor, and autonomic instability, arising from excessive serotonergic activity in the nervous system.

⚠️ Disclaimer

The information provided about Imipramine is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Imipramine for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.