Buy Generic Inspra Online

Generic Inspra Information

Introduction

Inspra (generic name eplerenone) is a selective mineralocorticoid receptor antagonist approved for the management of hypertension and heart failure with reduced ejection fraction. In Hong Kong, the drug is listed on the Hospital Authority formulary and is prescribed when clinicians seek a potassium‑sparing alternative to traditional diuretics. Its primary therapeutic aim is to block the effects of aldosterone, thereby lowering blood pressure and reducing cardiac remodeling. Secondary uses include treatment of secondary hyperaldosteronism in certain endocrine disorders.

What is Inspra?

Inspra is a tablet formulation containing the active compound eplerenone. It belongs to the class of selective mineralocorticoid receptor antagonists (MRAs). The molecule was developed by the pharmaceutical company Bristol‑Myers Squibb and received regulatory approval in the United States in 2002; it later gained approval in the European Union, Japan, and Hong Kong. Inspra is marketed as a branded product, while eplerenone is also available as a generic medication produced by several licensed manufacturers.

How Inspra Works

Eplerenone binds selectively to mineralocorticoid receptors in the distal nephron of the kidney. By antagonizing aldosterone, it reduces sodium reabsorption and potassium excretion. The net effect is:

• Decreased extracellular fluid volume, leading to lower systolic and diastolic blood pressure.
• Attenuation of myocardial fibrosis, which improves left‑ventricular function in heart‑failure patients.

Onset of antihypertensive action typically occurs within 2–4 hours after oral dosing, with a half‑life of approximately 4–6 hours. Steady‑state concentrations are achieved after 3–4 days of once‑daily administration. Eplerenone is eliminated primarily via renal excretion; dose adjustments are required in patients with moderate to severe renal impairment.

Conditions Treated with Inspra

• Hypertension – Recommended as add‑on therapy when blood pressure remains uncontrolled on first‑line agents.
• Heart Failure with Reduced Ejection Fraction (HFrEF) – Proven to reduce cardiovascular mortality and hospitalization when combined with ACE inhibitors or ARBs.

In Hong Kong, cardiovascular disease accounts for roughly 30 % of all deaths, and hypertension prevalence exceeds 25 % among adults aged 45 years and older. The availability of an MRA such as eplerenone provides clinicians with a tool to address aldosterone‑mediated cardiac remodeling, which is a common pathophysiological component in the local population.

Who is Inspra For?

• Adults with stage 1 or stage 2 hypertension who require an additional agent after lifestyle modification and a first‑line antihypertensive.
• Patients with HFrEF (LVEF ≤ 40 %) who are already receiving an ACE inhibitor or ARB and a β‑blocker, and who have a serum potassium < 5. mmol/L.
• Individuals with secondary hyperaldosteronism (e.g., primary aldosteronism) when surgical options are not feasible.

Contraindications include:

• Serum potassium ≥ 5. mmol/L or severe hyperkalaemia.
• End‑stage renal disease (eGFR < 15 mL/min/1.73 m²).
• Known hypersensitivity to eplerenone or any tablet excipients.

Pregnant or lactating women should avoid Inspra because safety data are limited.

Risks, Side Effects, and Interactions

Common

• Hyperkalaemia (elevated serum potassium)
• Dizziness or light‑headedness, especially after the first dose
• Diarrhoea or mild gastrointestinal upset

Rare

• Gynecomastia (breast tissue enlargement) – markedly less frequent than with non‑selective MRAs such as spironolactone
• Hepatic enzyme elevations (ALT, AST)

Serious

• Severe hyperkalaemia leading to cardiac arrhythmia
• Acute renal failure in patients with pre‑existing kidney disease
• Anaphylactic reactions (rare)

Drug–Drug Interactions

• Potassium‑rich supplements or salt substitutes – may precipitate hyperkalaemia.
• ACE inhibitors, ARBs, or renin inhibitors – additive effect on potassium; close monitoring required.
• Non‑steroidal anti‑inflammatory drugs (NSAIDs) – can impair renal clearance of eplerenone, increasing the risk of renal dysfunction and hyperkalaemia.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) – raise eplerenone plasma concentrations; dose reduction may be necessary.

Patients should inform their healthcare provider of all concomitant medicines, including over‑the‑counter products and herbal supplements.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing for hypertension: 25 mg once daily; may be increased to 50 mg once daily based on blood pressure response and serum potassium.
• Standard dosing for HFrEF: Start with 25 mg once daily; titrate to 50 mg once daily as tolerated.
• Renal adjustment: For eGFR 30–60 mL/min/1.73 m², limit to 25 mg daily; avoid use when eGFR < 30 mL/min/1.73 m².

Missed dose – Take the missed tablet as soon as remembered if more than 4 hours have not passed. If the next scheduled dose is within 4 hours, skip the missed tablet and resume the regular schedule. Do not double‑dose.

Overdose – Symptoms may include severe hyperkalaemia, hypotension, and nausea. Immediate medical attention is required. Activated charcoal is ineffective; treatment focuses on electrolyte correction (calcium gluconate, insulin‑glucose infusion) and supportive care.

Precautions – Take Inspra with or without food; consistency improves absorption. Alcohol does not directly interfere but excessive intake can exacerbate blood‑pressure fluctuations. Avoid high‑potassium foods (e.g., bananas, oranges, tomatoes) if serum potassium is borderline.

Buying Inspra from Our Online Pharmacy

Patients in Hong Kong can obtain Inspra through our online pharmacy. Our service offers:

• Affordability – Prices are set close to manufacturer cost, providing a substantial saving compared with local retail pharmacies.
• Verified quality – All stock is sourced from licensed overseas suppliers who meet international GMP standards.
• Reliable delivery – Discreet packaging with express shipping (typically 5–7 business days) or regular airmail (approximately 2–3 weeks).
• Privacy‑first model – As a pharmacy broker, we collaborate with accredited overseas pharmacies, ensuring confidentiality while complying with Hong Kong import regulations for personal use.

For residents who encounter limited supply or high out‑of‑pocket expenses at traditional pharmacies, our online pharmacy presents a safe, cost‑effective alternative.

FAQ

• Is Inspra available in both brand‑name and generic forms in Hong Kong?
  Yes. The branded product is marketed as Inspra, while generic eplerenone tablets are produced by several international manufacturers. Both contain the same active ingredient and are therapeutically equivalent.

• What temperature range is recommended for storing Inspra tablets?
  Store the tablets at room temperature, between 15 °C and 30 °C, away from direct sunlight, moisture, and heat sources. Do not refrigerate unless instructed by a pharmacist.

• Can I travel internationally with Inspra in my carry‑on luggage?
  Yes, provided the medication is in its original packaging with a clear label. Carry a copy of the prescription or a physician’s letter if requested by customs authorities, especially when entering countries with strict import controls.

• Do different regions formulate eplerenone tablets differently?
  Minor variations exist in inactive ingredients (e.g., lactose, magnesium stearate) depending on the manufacturer and regulatory jurisdiction. These differences do not affect the pharmacological activity of the active compound.

• Are there specific warnings for Asian populations taking Inspra?
  No ethnicity‑specific contraindications are listed. However, Asian patients may have a higher prevalence of low‑body‑mass index, which can influence drug distribution; clinicians often monitor potassium and renal function closely.

• How does Inspra compare with spironolactone in terms of side‑effects?
  Both drugs block aldosterone receptors, but spironolactone is non‑selective and more likely to cause endocrine‑related adverse events such as gynecomastia. Eplerenone’s selectivity results in a lower incidence of these hormonal side‑effects while maintaining similar cardiovascular benefits.

• What is the typical time frame for seeing blood‑pressure reduction after starting Inspra?
  Most patients experience a measurable reduction in systolic and diastolic pressure within 2–4 weeks of consistent daily dosing, with maximal effect often achieved after 8–12 weeks.

• Can Inspra be crushed or split for dose adjustments?
  The tablets are not formulated for sustained release, so crushing is permissible if a patient cannot swallow whole tablets. However, splitting may lead to dose inaccuracy; use a calibrated splitter if dose reduction is required.

• Is routine blood testing required while on Inspra?
  Yes. Baseline serum potassium and creatinine should be measured before initiation, followed by repeat testing after 1 week, then monthly for the first 3 months, and periodically thereafter, especially after dose changes.

• Does Inspra affect drug testing for employment or sports?
  Eplerenone is not a prohibited substance by major anti‑doping agencies and does not appear on standard occupational drug‑screening panels. However, athletes should disclose all medications to their governing bodies.

Glossary

Mineralocorticoid Receptor Antagonist

A class of drugs that block aldosterone receptors, reducing sodium retention and potassium loss.

Ejection Fraction (EF)

The percentage of blood pumped out of the left ventricle with each heartbeat; reduced EF indicates impaired heart‑pump function.

Hyperkalaemia

An elevated level of potassium in the blood, which can cause cardiac arrhythmias if severe.

eGFR (Estimated Glomerular Filtration Rate)

A calculated measure of kidney function based on serum creatinine, age, sex, and body size.

⚠️ Disclaimer

The information provided about Inspra is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Inspra for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.