Buy Intagra Online

Intagra Information

Introduction

Intagra is a sildenafil‑based oral medication indicated for the treatment of erectile dysfunction (ED) in adult men. In Hong Kong, ED affects an estimated 10‑15 % of men aged 40 years and older, making effective therapy a significant public‑health concern. Intagra belongs to the phosphodiesterase‑5 (PDE‑5) inhibitor class, a cornerstone of men’s sexual health management. The product is marketed for men who experience difficulty achieving or maintaining an erection sufficient for satisfactory sexual activity. Although primarily used for ED, sildenafil is also approved in other formulations for pulmonary arterial hypertension (PAH) under the brand name Revatio; however, Intagra is supplied only for the ED indication.

What is Intagra?

Intagra is a tablet containing 25 mg, 50 mg, or 100 mg of the active pharmaceutical ingredient (API) sildenafil citrate. It is manufactured by a licensed pharmaceutical company that complies with Good Manufacturing Practice (GMP) standards and is distributed through regulated channels. The medication is classified as a prescription‑only drug (POM) in Hong Kong, reflecting the need for medical assessment before use.

Sildenafil, the API, was first approved by the United States Food and Drug Administration (FDA) in 1998 under the brand name Viagra. Subsequent generic versions have been introduced worldwide, offering comparable efficacy and safety at reduced cost. Intagra is one such generic product, providing the same therapeutic molecule as the original brand while meeting the same quality criteria required by the Hong Kong Department of Health.

How Intagra Works

Sildenafil exerts its effect by selectively inhibiting the enzyme phosphodiesterase‑5 (PDE‑5) that degrades cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. Sexual stimulation releases nitric oxide (NO), which activates guanylate cyclase and raises intracellular cGMP levels. Elevated cGMP relaxes smooth muscle and dilates penile arteries, allowing increased blood flow and erection. By blocking PDE‑5, sildenafil prolongs the action of cGMP, facilitating a physiologically normal erectile response when sexual arousal occurs.

Pharmacokinetic characteristics relevant to patients include:

• Onset of action: Typically 30–60 minutes after oral ingestion.
• Peak plasma concentration: Occurs 1–2 hours post‑dose.
• Duration of effect: Effective for up to 4–6 hours, varying with dose and individual metabolism.
• Elimination: Primarily hepatic metabolism via CYP3A4, with a terminal half‑life of approximately 4 hours.

These parameters guide timing of dosing relative to anticipated sexual activity and help anticipate interactions with other drugs metabolised by the same hepatic pathway.

Conditions Treated with Intagra

Erectile Dysfunction in Hong Kong
Epidemiological surveys by the Hong Kong Hospital Authority report that about 1 million men in the territory experience ED at some point in life. Risk factors prevalent in the local population include diabetes mellitus, hypertension, dyslipidaemia, and lifestyle factors such as smoking and reduced physical activity. Sildenafil’s rapid onset and oral route make it a practical option for men seeking timely symptom relief without invasive procedures.

Who is Intagra For?

Intagra is appropriate for adult men (≥ 18 years) who have been clinically diagnosed with erectile dysfunction and for whom sexual stimulation is present. Typical candidates include:

• Men with vasculogenic ED resulting from atherosclerosis, hypertension, or diabetes.
• Individuals with neurogenic ED secondary to spinal cord injury, prostate surgery, or neuropathy.
• Patients preferring on‑demand therapy rather than continuous hormonal or device‑based treatments.

Contraindications exclude men with:

• Known hypersensitivity to sildenafil or any tablet excipient.
• Concurrent use of nitrates (e.g., nitroglycerin) or nitric‑oxide donors, due to risk of severe hypotension.
• Unstable cardiovascular disease (recent myocardial infarction, uncontrolled angina).
• Severe hepatic impairment, which may prolong drug exposure.

Clinicians should assess cardiovascular risk, concomitant medications, and renal/hepatic function before initiating therapy.

Risks, Side Effects, and Interactions

Common

• Headache
• Facial flushing
• Dyspepsia or indigestion
• Nasal congestion
• Visual disturbances (e.g., blue‑tinted vision)

These events are generally mild, transient, and dose‑related. Over‑the‑counter analgesics or antacids may alleviate discomfort without affecting sildenafil efficacy.

Rare

• Priapism (prolonged erection > 4 hours) – requires immediate medical attention.
• Sudden hearing loss or tinnitus.
• Severe hypotension, especially when combined with alcohol or antihypertensive agents.

Patients experiencing any of these symptoms should discontinue use and seek professional evaluation promptly.

Serious

• Cardiovascular events (myocardial infarction, stroke) in individuals with pre‑existing heart disease.
• Anaphylactic reaction (rare) manifesting as urticaria, bronchospasm, or angioedema.

Although causality is uncommon, clinicians must consider these possibilities when prescribing to high‑risk groups.

Drug–Drug Interactions

• Nitrates (e.g., glyceryl trinitrate, isosorbide dinitrate): Concomitant use can cause profound vasodilation and life‑threatening hypotension.
• Alpha‑blockers (e.g., tamsulosin, doxazosin): May lead to additive blood‑pressure lowering; start with the lowest sildenafil dose and monitor.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir): Increase sildenafil plasma concentrations; dose reduction to 25 mg is advised.
• CYP3A4 inducers (e.g., rifampicin, carbamazepine): Decrease efficacy; consider alternative therapy or higher dosing under supervision.

Patients should disclose all current medications, including over‑the‑counter products and herbal supplements, to avoid adverse interactions.

Practical Use: Dosing, Missed Dose, Overdose

• Starting dose: 50 mg taken as a single tablet, approximately 30 minutes to 1 hour before anticipated sexual activity.
• Dose adjustments: Based on efficacy and tolerability, the dose may be lowered to 25 mg or increased to 100 mg. No more than one tablet per 24‑hour period.
• Food considerations: A high‑fat meal can delay absorption and reduce peak concentration; patients may take Intagra with or without food, but should note that a heavy meal may postpone onset.
• Alcohol: Moderate consumption is permissible, but excessive alcohol may exacerbate hypotensive effects and impair erection.

Missed dose – If the scheduled sexual activity does not occur, the tablet should be discarded; do not double the dose to “catch up.”

Overdose – Symptoms may include severe hypotension, dizziness, prolonged erection, or visual disturbances. Immediate medical evaluation is essential. Supportive care includes fluid resuscitation, vasopressors if needed, and monitoring of cardiovascular status.

Special populations – In men with mild to moderate renal impairment (creatinine clearance 30–60 mL/min), a reduced dose of 25 mg is recommended. Severe renal or hepatic dysfunction warrants specialist consultation before use.

Buying Intagra from Our Online Pharmacy

Intagra can be ordered directly from our online pharmacy in Hong Kong, which offers a streamlined, discreet purchasing experience for adults seeking a reliable generic alternative to brand‑name sildenafil. Key advantages include:

• Affordability: Prices are set near manufacturer cost, delivering savings of up to 70 % compared with branded products.
• Verified quality: All batches are sourced from GMP‑certified manufacturers and undergo third‑party testing for potency and purity.
• Guaranteed delivery: Discreet packaging and secure shipping options, with express delivery typically within 7 days and regular airmail arriving in approximately 3 weeks.
• Online‑only access: Our pharmacy broker service partners with licensed overseas pharmacies, enabling patients to obtain medications not always stocked in local brick‑and‑mortar outlets.

Because Intagra is a prescription‑only medication, the purchase process includes a mandatory verification step to confirm that the buyer is a qualified adult resident of Hong Kong. This safeguard aligns with local regulatory requirements while preserving user privacy.

FAQ

• What is the typical onset time for Intagra after swallowing the tablet?
  Most men notice an effect within 30 to 60 minutes. Food, especially high‑fat meals, can slow absorption and delay the onset by up to an additional 30 minutes.

• Can Intagra be taken daily as a continuous therapy?
  While the approved regimen is on‑demand, some clinicians prescribe a lower daily dose (e.g., 25 mg) for men who desire spontaneous sexual activity. This approach should only be used under medical supervision.

• Is there a difference in tablet appearance between Intagra and other generic sildenafil products?
  Intagra tablets are round, film‑coated, and colour‑coded by strength (e.g., pink for 25 mg, blue for 50 mg, green for 100 mg). Inactive ingredients such as lactose, microcrystalline cellulose, and magnesium stearate are common across many generics, but exact excipient composition may vary by manufacturer.

• How should Intagra be stored in Hong Kong’s humid climate?
  Keep the tablets in the original blister pack, stored at 15 °C–30 °C, away from moisture and direct sunlight. A cool, dry cabinet or drawer is preferable to bathroom cabinets where humidity fluctuates.

• Can I travel internationally with Intagra in my carry‑on luggage?
  Yes, provided the medication is in its original packaging with a clear label. For trips longer than three months, it is advisable to carry a copy of the prescription or a doctor’s note, as some jurisdictions may require proof of legitimate medical use.

• Does Intagra interact with over‑the‑counter antihistamines?
  Most antihistamines (e.g., cetirizine, loratadine) have minimal impact on sildenafil metabolism and are generally safe. However, first‑generation antihistamines that cause sedation may compound dizziness, especially when combined with alcohol.

• Are there any known differences in efficacy of sildenafil among Asian populations?
  Clinical studies have not demonstrated a significant ethnic variation in response to sildenafil when dosing is adjusted for body weight and comorbidities. Nonetheless, clinicians may start at a lower dose (25 mg) for men with lower body mass index or heightened sensitivity to side effects.

• What is the legal limit for personal import of Intagra into Hong Kong?
  The Hong Kong Customs and Excise Department allows individuals to import a maximum of three months’ supply for personal use, provided the medication is for a legitimate medical purpose and is accompanied by a valid prescription.

• Can Intagra be crushed or split to adjust the dose?
  The tablet is not formulated for splitting; crushing may affect the drug’s release characteristics and increase the risk of adverse effects. If a lower dose is required, a 25 mg tablet should be used instead of modifying a higher‑strength tablet.

• How does Intagra compare with older PDE‑5 inhibitors such as vardenafil or tadalafil?
  Sildenafil has a shorter duration (4–6 hours) compared with tadalafil (up to 36 hours) and a similar onset to vardenafil. Choice of agent depends on patient preference for timing, side‑effect profile, and cost considerations; sildenafil remains the most widely studied and cost‑effective option.

• Is there any evidence that Intagra improves fertility or sperm parameters?
  Current research indicates that sildenafil does not significantly affect sperm count, motility, or morphology. Its primary action is vascular, not hormonal, and it should not be used as a fertility treatment.

• What should I do if I experience a sudden, painful erection lasting longer than four hours?
  This condition, known as priapism, is a medical emergency. Apply a cold compress to the genital area and seek immediate care at the nearest emergency department; delayed treatment can lead to permanent tissue damage.

Glossary

Phosphodiesterase‑5 (PDE‑5) Inhibitor

A class of drugs that block the enzyme PDE‑5, preventing the breakdown of cGMP and thereby facilitating smooth‑muscle relaxation and increased blood flow in the penis.

cGMP (Cyclic Guanosine Monophosphate)

A secondary messenger molecule that mediates smooth‑muscle relaxation in response to nitric oxide; elevated levels produce an erection.

Priapism

A prolonged, often painful erection lasting more than four hours without sexual stimulation; requires urgent medical intervention to prevent tissue injury.

Cytochrome P450 3A4 (CYP3A4)

A liver enzyme responsible for metabolising many drugs, including sildenafil; inhibitors or inducers of CYP3A4 can alter sildenafil’s plasma concentration.

⚠️ Disclaimer

The information provided about Intagra is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Intagra for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.