Buy Generic Lozol Online

Generic Lozol Information

Introduction

Lozol is an oral antihypertensive and diuretic medication marketed in Hong Kong. Its single active ingredient is indapamide, a thiazide‑like diuretic that lowers blood pressure by promoting sodium and water excretion while also causing modest vasodilation. The product is classified within the Blood Pressure and Diuretics therapeutic groups and is indicated for the treatment of primary hypertension and for adjunctive fluid‑retaining states such as edema associated with congestive heart failure or renal disease. In Hong Kong’s ageing population, hypertension prevalence exceeds 30 %, making effective, affordable agents like Lozol essential for cardiovascular risk reduction.

What is Lozol?

Lozol is a brand‑name formulation that delivers indapamide in tablet form. The medication is manufactured by a licensed pharmaceutical company (the specific manufacturer varies by import batch, but all products sold in Hong Kong meet the standards of the Department of Health). Indapamide belongs to the class of thiazide‑like diuretics and has been available worldwide since the 198s. While several brand names such as Natrilix, Moduretic, and Indapril contain the same active compound, Lozol provides a locally registered alternative that complies with Hong Kong’s pharmacovigilance requirements.

How Lozol Works

Indapamide exerts its antihypertensive effect through two complementary mechanisms:

• Renal Sodium‑Chloride Transport Inhibition – Indapamide blocks the Na⁺/Cl⁻ cotransporter located in the distal convoluted tubule of the nephron. This inhibition reduces reabsorption of sodium and chloride, leading to an increased urinary excretion of sodium, chloride, and water. The resulting decrease in extracellular fluid volume lowers cardiac preload and modestly reduces cardiac output.

• Direct Arteriolar Vasodilation – Unlike classic thiazides, indapamide also stimulates the production of prostaglandins and nitric oxide in vascular smooth muscle. This action dilates peripheral arterioles, decreasing systemic vascular resistance (afterload). The combined preload and afterload reductions produce a sustained fall in systolic and diastolic blood pressure.

Pharmacokinetically, indapamide is well‑absorbed after oral administration, reaching peak plasma concentrations within 2–4 hours. The drug’s half‑life ranges from 12 to 24 hours, permitting once‑daily dosing for most patients. Approximately 80 % of an oral dose is excreted unchanged in the urine, and renal clearance is the primary elimination pathway.

Conditions Treated with Lozol

• Primary (essential) hypertension – Clinical trials have demonstrated that indapamide reduces both systolic and diastolic blood pressure by an average of 10–15 mm Hg, translating into lower rates of stroke, myocardial infarction, and heart failure when used as part of a comprehensive risk‑reduction strategy.
• Edema associated with congestive heart failure (CHF) – By promoting diuresis, Lozol helps relieve pulmonary and peripheral congestion, improving functional class and exercise tolerance in CHF patients.
• Renal or hepatic‑related fluid overload – Indapamide is frequently employed when cirrhosis‑related ascites or nephrotic syndrome produces persistent peripheral edema.
• Adjunct therapy for resistant hypertension – In patients whose blood pressure remains uncontrolled on two or more agents, adding indapamide often achieves target pressures without substantial adverse effects.

In Hong Kong, hypertension is a leading cause of cardiovascular disease and a major contributor to premature mortality. The prevalence of chronic kidney disease (CKD) is also rising, making a diuretic that is effective at low doses and has a favorable electrolyte profile especially relevant.

Who is Lozol For?

Lozol is most appropriate for adult patients who meet any of the following criteria:

• Diagnosed primary hypertension (stage 1 or 2) where lifestyle modification alone has not achieved target blood pressure (<140/90 mm Hg).
• Mild to moderate fluid retention secondary to CHF, CKD, or hepatic cirrhosis, when a low‑dose diuretic is clinically indicated.
• Patients requiring a thiazide‑like diuretic but who are intolerant to classic thiazides (e.g., hydrochlorothiazide) because indapamide has a lower propensity for causing hypokalemia and hyperuricemia.

Contra‑indications and cautious use include:

• Severe renal impairment (eGFR < 30 mL/min/1.73 m²) – reduced clearance may precipitate toxicity.
• Known hypersensitivity to indapamide or any excipients in the Lozol tablet.
• Acute electrolyte disturbances (e.g., severe hyponatremia, hypokalemia) that are not corrected before initiation.
• Pregnancy (category C) – use only if the potential benefit justifies the potential risk to the fetus.

Elderly patients, who constitute a large proportion of Hong Kong’s hypertensive cohort, may require dose adjustments because renal function commonly declines with age.

Risks, Side Effects, and Interactions

Common

• Electrolyte shifts – mild hyponatremia, hypokalemia, or hypomagnesemia. Routine monitoring of serum electrolytes is advised after the first few weeks of therapy.
• Gastro‑intestinal discomfort – nausea, abdominal cramping, or dyspepsia. Taking the tablet with food often mitigates these symptoms.
• Headache or dizziness – usually transient as blood pressure falls; advise patients to rise slowly from seated or supine positions.

Rare

• Hyperuricemia – may precipitate gout attacks in predisposed individuals. Periodic uric acid testing is reasonable for patients with a history of gout.
• Photosensitivity rash – sun‑exposed skin may develop a mild erythematous reaction; sunscreen and protective clothing are recommended.
• Elevated liver enzymes – transient hepatic enzyme elevations have been reported; repeat testing if clinically indicated.

Serious

• Severe electrolyte depletion – profound hypokalemia can cause cardiac arrhythmias; immediate medical evaluation is required if muscle weakness, palpitations, or syncope occur.
• Acute kidney injury (AKI) – especially in patients with volume depletion, NSAID use, or concurrent nephrotoxic drugs. Discontinue Lozol and seek urgent care if renal function deteriorates.
• Hypersensitivity anaphylaxis – rare but life‑threatening; characterized by bronchospasm, angioedema, or hypotensive shock. Emergency treatment with epinephrine is mandatory.

Drug‑Drug Interactions

• Lithium – indapamide reduces renal lithium clearance, increasing the risk of lithium toxicity. Dose reduction and close serum level monitoring are required.
• Digitalis glycosides (e.g., digoxin) – electrolyte disturbances, particularly hypokalemia, can heighten digoxin toxicity.
• Non‑steroidal anti‑inflammatory drugs (NSAIDs) – may blunt the diuretic effect and increase the risk of renal impairment.
• Other antihypertensives – additive blood‑pressure‑lowering effects may lead to symptomatic hypotension; dose titration of one or both agents may be necessary.

Patients should provide a complete medication list, including over‑the‑counter supplements, to their prescriber before initiating Lozol.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dosing – 1.5 mg tablet taken orally once daily in the morning. Some clinicians start with 1. mg for frail or elderly patients and titrate upward based on blood‑pressure response.
• Missed dose – If a dose is forgotten within 12 hours of the scheduled time, take it as soon as remembered. If it is later than 12 hours, skip the missed dose and resume the regular schedule; do not double‑dose.
• Overdose – Symptoms may include excessive diuresis, profound dehydration, electrolyte abnormalities, and hypotension. Seek emergency medical care; treatment is supportive with intravenous fluids, electrolyte repletion, and monitoring of renal function.
• Food and alcohol – Lozol can be taken with or without food. Alcohol may amplify hypotensive effects; patients are advised to limit intake, especially when initiating therapy.
• Comorbidities – In diabetes, careful monitoring of glucose is needed because diuresis can affect insulin sensitivity. In patients with gout, prophylactic urate‑lowering therapy may be considered.

Buying Lozol from Our Online Pharmacy

Patients in Hong Kong can obtain Lozol safely through our online pharmacy. Key advantages include:

• Affordability – Prices are set close to manufacturer cost, delivering a genuine cost‑saving compared with many retail outlets.
• Verified quality – All stock is sourced from licensed overseas suppliers that meet Hong Kong’s stringent pharmaceutical standards; each batch is accompanied by a certificate of analysis.
• Reliable delivery – Discreet, insulated packaging ensures privacy and product integrity. Standard shipping reaches most districts within 7 days (express) or approximately 3 weeks via regular airmail.
• Online‑only access – For patients who face limited local pharmacy stock or insurance coverage gaps, our pharmacy broker service connects directly with accredited overseas pharmacies, enabling access to international formulations that may not be listed locally.

Our platform operates as a pharmacy broker service, adhering to Hong Kong’s import regulations for personal use. All transactions are conducted securely, and customer data is handled in compliance with privacy laws.

FAQ

• Is Lozol available in both brand‑name and generic forms in Hong Kong?
  Yes. Lozol is a branded product, but the same active ingredient, indapamide, is also sold as generic tablets by various manufacturers. Generic versions are typically less expensive while delivering identical therapeutic effects.

• Does Lozol require refrigeration or special temperature control?
  No. Lozol tablets should be stored at controlled room temperature (15 °C–30 °C). Keep them away from direct sunlight, excessive heat, and moisture, such as in a bathroom cabinet.

• What do Lozol tablets look like, and how can I identify them?
  Lozol is supplied as a white, round, film‑coated tablet, imprinted with “LZ 1.5 mg” on one side. The appearance may vary slightly depending on the manufacturing batch, but the imprint and dosage strength remain consistent.

• Can I travel internationally with Lozol, and are there any customs restrictions?
  Yes, you may carry Lozol for personal use when traveling abroad. It is advisable to bring a copy of the prescription label or a physician’s note, and to keep the medication in its original packaging to satisfy customs officers.

• Are there any known differences in indapamide formulation between regions (e.g., EU vs. Asia)?
  Minor differences can exist in inactive excipients such as binders or coating agents, which may affect tolerability in sensitive individuals. However, the active ingredient content (1.5 mg) and pharmacological profile are standardized worldwide.

• What is the recommended shelf life of Lozol, and how can I tell if a tablet has degraded?
  The typical expiry date is three years from the date of manufacture. Discoloration, crumbling, or an unusual smell may indicate degradation; discard any tablets that appear compromised.

• How does indapamide compare with classic thiazide diuretics like hydrochlorothiazide?
  Indapamide has a longer half‑life, allowing once‑daily dosing, and is associated with a lower incidence of hypokalemia and hyperuricemia. Both classes lower blood pressure, but indapamide may be preferred in patients at higher risk for electrolyte disturbances.

• Can Lozol affect drug testing for employment or sports?
  Indapamide is not a prohibited substance in standard drug‑screening panels. However, some specialized tests may detect diuretics, so athletes subject to anti‑doping regulations should disclose any use to the relevant authority.

• What lifestyle modifications enhance the effectiveness of Lozol?
  Reducing sodium intake, maintaining a healthy body weight, regular aerobic exercise, limiting alcohol, and adhering to a DASH‑style diet can synergistically improve blood‑pressure control alongside Lozol therapy.

• Is there any evidence that indapamide improves outcomes beyond blood‑pressure reduction?
  Large‐scale outcome trials, such as the HYVET (Hypertension in the Very Elderly Trial), demonstrated that indapamide‑based regimens reduce the incidence of stroke, heart failure, and cardiovascular mortality in elderly hypertensive patients, indicating benefits that extend beyond simple pressure lowering.

Glossary

Thiazide‑like diuretic

A class of diuretics that act on the distal convoluted tubule to inhibit sodium‑chloride reabsorption, leading to increased urine output. Indapamide belongs to this group but has additional vasodilatory properties.

Afterload

The resistance the left ventricle must overcome to eject blood into the systemic circulation. Reducing afterload lowers the workload on the heart.

eGFR (estimated Glomerular Filtration Rate)

A calculation based on serum creatinine, age, sex, and body size that estimates kidney filtration capacity. It guides dosing adjustments for renally cleared drugs like indapamide.

Electrolyte shift

A change in the concentration of ions such as sodium, potassium, or magnesium in the blood, often caused by diuretic therapy and potentially leading to clinical symptoms.

⚠️ Disclaimer

The information provided about Lozol is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Lozol for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.