Buy Generic Naltrexone Online

Generic Naltrexone Information

Introduction

Naltrexone Hydrochloride is an opioid‑receptor antagonist approved primarily for the management of alcohol‑dependence. In Hong Kong the drug is listed under the “Alcoholism” medication group and is available through licensed pharmacies and, increasingly, through reputable online sources. The medication is also prescribed off‑label for opioid‑use disorder, certain pain syndromes, and emerging low‑dose protocols for inflammatory conditions. Its role is to block the rewarding effects of alcohol and opioids, thereby supporting abstinence and relapse prevention.

What is Naltrexone?

Naltrexone is the generic version of the original brand Revia™ (and the injectable brand Vivitrol™), containing the same active compound Naltrexone Hydrochloride. It belongs to the class of opioid‑receptor antagonists and was first synthesized in the 196s by the pharmaceutical company Alza (now part of Johnson & Johnson). Our online pharmacy provides this generic alternative as a cost‑effective treatment option for adults seeking to reduce harmful alcohol consumption or support opioid‑use recovery.

How Nrexone Works

Naltrexone binds competitively to µ‑opioid receptors in the central nervous system with high affinity but little intrinsic activity. By occupying these receptors, it prevents endogenous opioids (such as β‑endorphin) and exogenous substances (alcohol‑derived opioid peptides) from activating the reward pathway. The blockade reduces the pleasurable sensations associated with drinking, making relapse less likely.

Key pharmacokinetic points:

• Onset of action: Oral tablets begin to block µ‑receptors within 30–60 minutes after ingestion.
• Duration: A single 50 mg dose maintains receptor occupancy for approximately 24 hours; steady‑state is reached after 3–4 days of daily dosing.
• Clearance: Naltrexone is metabolised in the liver to an active 6‑β‑hydroxynaltrexone metabolite, which is eliminated renally. The average plasma half‑life is 4 hours for the parent drug and 13 hours for the metabolite.

Conditions Treated with Naltrexone

• Alcohol‑dependence (Alcohol Use Disorder) – The sole FDA‑approved oral indication; supported by multiple Hong Kong‑based clinical trials showing reduced relapse rates.
• Opioid‑use disorder (off‑label) – Oral Naltrexone is used after detoxification to prevent opioid‑induced euphoria; the longer‑acting injectable Vivitrol™ is also available worldwide.
• Chronic pain syndromes (off‑label) – Low‑dose Naltrexone (LDN, 1.5–4.5 mg) has been explored for fibromyalgia, complex regional pain syndrome, and neuropathic pain, capitalising on its modulatory effect on glial cell activation.
• Inflammatory and autoimmune conditions (off‑label) – Emerging evidence suggests LDN may attenuate inflammatory cytokine production in conditions such as Crohn’s disease and multiple sclerosis.

In Hong Kong, alcohol‑related morbidity accounts for a significant proportion of liver disease and accidents; thus, Naltrexone’s role in relapse prevention aligns with public‑health priorities.

Who is Naltrexone For?- Adults with moderate to severe alcohol‑use disorder who have achieved initial abstinence and are motivated to maintain sobriety.

• Individuals who have completed medically supervised opioid detoxification and need a non‑opioid pharmacologic barrier against relapse.
• Patients with chronic pain unresponsive to conventional analgesics, where low‑dose Naltrexone may provide adjunctive benefit.
• Patients with comorbid liver disease where alternative treatments (e.g., disulfiram) pose higher hepatic risk.

Contra‑indications include: active opioid use (including opioid‑containing cough medicines), acute hepatitis, severe hepatic impairment, and pregnancy. Caution is advised in patients with renal insufficiency or a history of hypersensitivity to Naltrexone or its excipients.

Risks, Side Effects, and Interactions

Common

• Nausea or vomiting
• Headache
• Dizziness or light‑headedness, especially upon standing (orthostatic hypotension)
• Fatigue or mild insomnia

Rare

• Elevated liver enzymes (ALT/AST) – monitoring recommended in patients with pre‑existing hepatic disease.
• Mood changes, including dysphoria or depressive symptoms.
• Skin rash or pruritus

Serious

• Severe hepatotoxicity (rare, but reported at doses >300 mg/day).
• Anaphylactic reaction or angioedema.
• Acute opioid withdrawal precipitated by inadvertent opioid exposure while on Naltrexone.

Drug–drug interactions

• Opioid analgesics (e.g., morphine, oxycodone, codeine): Naltrexone blocks their effect and may precipitate withdrawal.
• Benzodiazepines: Co‑administration can increase sedation risk; dose adjustment may be required.
• Hepatotoxic agents (e.g., isoniazid, methotrexate): Additive liver stress; regular liver function testing is prudent.
• Disulfiram or acamprosate: No direct pharmacologic interaction, but combined use should be coordinated by a clinician to avoid overlapping adverse‑effect profiles.

Practical Use: Dosing, Missed Dose, Overdose

• Standard oral dose for alcohol‑dependence: 50 mg once daily, taken with or without food.
• Low‑dose protocols for pain/inflammation: 1.5–4.5 mg once daily, typically taken at bedtime.
• Initial titration: Some clinicians start with 25 mg on day 1 to assess tolerance, then increase to the target dose on day 2.

Missed dose: If a dose is forgotten and less than 12 hours have elapsed, take it as soon as remembered. If more than 12 hours have passed, skip the missed dose and resume the regular schedule. Do not double‑dose.

Overdose: Symptoms may include profound nausea, vomiting, dizziness, or loss of consciousness. Immediate medical evaluation is required; supportive care (gastric lavage, activated charcoal) may be administered in a hospital setting.

Precautions:

• Avoid alcohol consumption while on therapy; even small amounts can trigger unpleasant reactions.
• Take the tablet with a full glass of water; food does not significantly affect absorption but may reduce gastrointestinal upset.
• Patients with chronic liver disease should have baseline and periodic liver function tests.
• Renal impairment does not require dose adjustment, but monitoring is advisable.

Buying Naltrexone from Our Online Pharmacy

Naltrexone can be purchased safely from our online pharmacy in Hong Kong. Our service offers:

• Affordable pricing – generic Naltrexone Hydrochloride is sourced near manufacturer cost, providing a lower price point than many brand‑name alternatives.
• Verified quality – all stock is procured from licensed overseas manufacturers that meet WHO‑GMP standards; each batch undergoes third‑party authentication.
• Guaranteed delivery – discreet packaging, express delivery within 7 days for local shipments, and regular airmail (≈ 3 weeks) for remote locations.
• Online‑only access – we act as a pharmacy‑broker service, partnering with overseas licensed pharmacies to bring international medications to Hong Kong residents who may face limited local supply or high out‑of‑pocket costs.
• Privacy‑focused service – transactions are encrypted, and packaging contains no identifying labels, ensuring confidentiality for patients who value discretion.

Our platform enables patients to obtain Naltrexone reliably without compromising safety or affordability.

FAQ

• Is Naltrexone available in both brand‑name and generic forms in Hong Kong?
  Yes. The original brand Revia™ (oral) and Vivitrol™ (injectable) are marketed alongside generic Naltrexone Hydrochloride tablets, which contain the identical active ingredient at a lower cost.

• Does Naltrexone require any special storage conditions?
  The tablets should be stored at room temperature (15‑30 °C), protected from excess moisture, direct sunlight, and heat. No refrigeration is needed.

• What do Naltrexone tablets look like?
  Generic tablets are typically white, round or oval, and may be scored for ease of splitting. Imprint codes vary by manufacturer but are listed on the packaging label.

• Can I travel internationally with Naltrexone in my luggage?
  Yes, provided the medication is kept in its original container with a copy of the prescription (if required) and declared according to the destination country’s customs regulations. In Hong Kong, a personal import permit is not necessary for a supply intended for personal use.

• Are there any dietary restrictions while taking Naltrexone?
  There are no specific food interactions, but patients are advised to avoid alcohol entirely, as the drug blocks its rewarding effects and may cause unpleasant sensations if alcohol is consumed.

• How does low‑dose Naltrexone differ from the standard dose?
  Low‑dose regimens (1.5–4.5 mg) are intended for anti‑inflammatory or analgesic purposes and are sub‑therapeutic for alcohol‑dependence. The low dose is thought to transiently block opioid receptors, leading to a rebound increase in endogenous opioid production and immune modulation.

• What is the legal status of importing Naltrexone for personal use into Hong Kong?
  Naltrexone is a prescription‑only medication in Hong Kong. Personal import of a three‑month supply for a genuine treatment purpose is permitted under the Health Products Regulation, provided the importer holds a valid prescription (or a medical certificate when buying from a licensed overseas pharmacy).

• Do Asian populations experience different side‑effects from Naltrexone?
  Pharmacogenomic studies suggest similar efficacy across ethnicities, but a slightly higher incidence of mild gastrointestinal upset has been reported in some East‑Asian cohorts. Routine monitoring remains advisable.

• How long does it take for liver enzymes to normalise after stopping Naltrexone?
  In most cases, ALT and AST levels return to baseline within 2–4 weeks after discontinuation, assuming no ongoing hepatic insult. Persistent elevation warrants further hepatic evaluation.

• Can Naltrexone be used concurrently with nicotine‑replacement therapy?
  Yes. There is no known pharmacologic interaction between Naltrexone and nicotine patches, gum, or lozenges. Combining the two may enhance overall substance‑use cessation outcomes when coordinated by a healthcare professional.

Glossary

µ‑Opioid Receptor

A protein on nerve cells that mediates the effects of endogenous and exogenous opioids; blocking this receptor reduces reward signalling associated with alcohol and opioid use.

Hepatotoxicity

Chemical‑induced liver injury, reflected by elevated liver enzymes (ALT/AST) or clinical signs of liver dysfunction.

Pharmacokinetics

The study of how a drug is absorbed, distributed, metabolised, and eliminated by the body.

Off‑Label Use

Prescribing a medication for an indication, dosage, or patient group that has not received formal regulatory approval.

⚠️ Disclaimer

The information provided about Naltrexone is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Naltrexone for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.