Buy Generic Parlodel Online

Generic Parlodel Information

Introduction

Parlodel is a prescription medication that contains the ergot‑derived dopamine‑agonist bromocriptine. It is classified within the Women’s Health therapeutic area because of its primary use in treating disorders of prolactin excess, such as hyperprolactinemia and prolactin‑producing pituitary adenomas. In Hong Kong, bromocriptine is listed under the Pharmacy and Poisons Ordinance and is supplied by licensed pharmacies on a prescription basis. In addition to its endocrine applications, bromocriptine has documented efficacy for certain metabolic and neurological conditions, including type 2 diabetes adjunct therapy and Parkinson’s disease, although those indications are not the main focus of this article.

What is Parlogram?

Parlodel is a brand‑name formulation that delivers the active compound bromocriptine. The drug belongs to the class of dopamine‑2 (D₂) receptor agonists. Bromocriptine was first synthesized in the 196s and subsequently marketed under several brand names worldwide, including Dostinex (Novartis) and Cycloset (Cytokinetics/Novartis). Parlodel represents a parallel generic‑style product that contains the identical molecule and is manufactured according to Good Manufacturing Practice (GMP) standards. Our online pharmacy provides this generic alternative as a cost‑effective treatment option for patients in Hong Kong who need reliable access to bromocriptine.

How Parlodel Works

Bromocriptine binds selectively to dopamine‑2 receptors located on the lactotroph cells of the anterior pituitary gland. Activation of these receptors inhibits the secretion of prolactin, the hormone responsible for milk production and many reproductive functions. By reducing circulating prolactin levels, the drug restores normal gonadal hormone balance, relieves galactorrhoea, and can shrink prolactin‑secreting pituitary tumours.

The pharmacokinetic profile of bromocriptine shows rapid oral absorption, with peak plasma concentrations reached within 1–2 hours. The drug undergoes extensive hepatic metabolism via CYP3A4 and is eliminated primarily in the feces. The biologic half‑life is approximately 6 hours, which supports once‑daily or divided‑dose regimens depending on the indication and patient tolerance.

Conditions Treated with Parlodel

• Hyperprolactinemia – Excess prolactin production leads to menstrual irregularities, infertility, and inappropriate lactation. Bromocriptine normalises prolactin levels in >80 % of patients, facilitating restoration of ovulation.
• Prolactin‑secreting pituitary adenomas (macro‑ or micro‑adenomas) – The dopamine agonist effect can reduce tumour size by 30–50 % in many cases, decreasing the need for surgical intervention.
• Adjunct therapy for type 2 diabetes – Low‑dose bromocriptine (2.5 mg) has been approved in some jurisdictions to improve glycaemic control by modulating circadian rhythms of glucose metabolism. While not a first‑line diabetes drug in Hong Kong, it may be considered when other agents are insufficient.
• Parkinson’s disease (early‑stage) – By stimulating central D₂ receptors, bromocriptine can ameliorate motor symptoms such as rigidity and bradykinesia. Use in Hong Kong is limited to specialist neurology practice.

Epidemiologically, hyperprolactinemia affects an estimated .4 % of women of reproductive age in Hong Kong, mirroring global prevalence. Early diagnosis and treatment with bromocriptine reduce long‑term complications, including osteoporosis and persistent infertility.

Who is Parlodel For?

• Women with persistent menstrual disturbances (oligo‑ or amenorrhoea) attributable to elevated prolactin.
• Patients diagnosed with prolactin‑producing pituitary micro‑adenomas (<10 mm) who prefer medical management over surgery.
• Individuals experiencing galactorrhoea unrelated to pregnancy or lactation and confirmed to have hyperprolactinemia.
• Adults with type 2 diabetes whose glycaemic profile remains suboptimal despite maximised standard therapy, provided they have no contraindications to dopamine agonists.
• Early‑stage Parkinson’s disease patients who respond to dopaminergic stimulation and can tolerate oral therapy.

Parlodel is not appropriate for:

• Pregnant or breastfeeding women (dopamine agonism may affect fetal development and milk production).
• Patients with uncontrolled hypertension, cardiac valvular disease, or recent myocardial infarction.
• Individuals with severe hepatic impairment, as metabolism is compromised.
• Those taking potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) without dose adjustment.

A thorough clinical assessment, including serum prolactin measurement and imaging when indicated, is essential before initiating therapy.

Risks, Side Effects, and Interactions

Common

• Nausea, vomiting, and abdominal discomfort.
• Headache, dizziness, or light‑headedness, especially when standing (orthostatic hypotension).
• Fatigue or somnolence, often transient during dose titration.
• Nasal congestion or rhinitis.

Rare

• Nasal septal perforation (with chronic intranasal use, not typical for oral formulation).
• Hyponatremia secondary to syndrome of inappropriate antidiuretic hormone secretion (SIADH).
• Hallucinations or psychotic symptoms in susceptible individuals.

Serious

• Cardiac valvulopathy – Ergot derivatives have been linked to fibrotic valvular disease; baseline echocardiography is recommended for long‑term use.
• Severe hypotension leading to syncope or falls.
• Pulmonary fibrosis – Very rare but reported in case studies; persistent cough or dyspnoea warrants investigation.

Clinically Relevant Drug–Drug Interactions

• CYP3A4 inhibitors (e.g., antifungals, macrolide antibiotics) can increase bromocriptine plasma concentrations, heightening the risk of hypotension and nausea. Dose reduction or alternative therapy is advised.
• Antihypertensive agents (especially α‑blockers) may potentiate orthostatic hypotension; monitor blood pressure closely.
• Antipsychotics (particularly dopamine antagonists such as haloperidol) can antagonise bromocriptine’s effect, diminishing prolactin suppression.
• Macrolide antibiotics (e.g., erythromycin) may delay gastric emptying, potentially enhancing gastrointestinal irritation.

Patients should disclose all prescribed, over‑the‑counter, and herbal products to their healthcare provider before starting Parlodel.

Practical Use: Dosing, Missed Dose, Overdose

• Initial dosing for hyperprolactinemia: 2.5 mg orally once daily, usually taken with the evening meal to minimise nausea. The dose may be increased by 2.5 mg increments every 1–2 weeks, targeting a maintenance range of 5–15 mg per day based on prolactin response and tolerability.
• Low‑dose diabetes indication: 2.5 mg taken once daily within 30 minutes of the first meal of the day.
• Parkinson’s disease: Starting dose of 2.5 mg three times daily, titrated up to 10 mg three times daily as required.

Missed dose: If a dose is forgotten and the scheduled time is still >4 hours away, take the missed tablet at the next scheduled dosing interval. Do not double the dose to compensate.

Overdose: Symptoms may include severe nausea, vomiting, profound hypotension, and cardiac arrhythmias. Immediate medical attention is required. Activated charcoal may be considered if presentation is within one hour of ingestion. Supportive care, including intravenous fluids and vasopressors, is the mainstay of treatment.

Precautions:

• Take Parlodel with food to reduce gastrointestinal upset.
• Avoid alcoholic beverages, which can amplify hypotensive effects.
• Patients with renal insufficiency should have dose adjustments based on clinical response.
• Regular monitoring of serum prolactin, liver function tests, and blood pressure is recommended during the first 12 weeks of therapy.

Buying Parlodel from Our Online Pharmacy

Patients residing in Hong Kong can obtain Parlodel through our online pharmacy. The service offers several advantages:

• Affordable pricing – We source the medication at near‑manufacturer cost, passing savings directly to the consumer.
• Verified quality – All products are supplied by licensed, GMP‑certified manufacturers and undergo independent quality testing before dispatch.
• Guaranteed delivery – Discreet, reliable shipping options include 7‑day express service for urgent needs and a regular airmail route (approximately 3 weeks) for routine orders.
• Online‑only access – As a pharmacy broker service, we collaborate with overseas licensed pharmacies to provide international medicines that may not be stocked locally. This model ensures a discreet service that respects patient privacy while complying with Hong Kong import regulations for personal use.

Our platform enables patients with limited access to traditional pharmacies or those seeking a cost‑effective generic alternative to obtain Parlodel safely and conveniently.

FAQ

• Is Parlodel available in both brand‑name and generic forms in Hong Kong?
  Yes. The original brand name Dostinex (Novartis) and other branded versions contain bromocriptine. Generic formulations, such as Parlodel, contain the same active molecule and are typically offered at a lower price.

• What is the recommended storage condition for bromocriptine tablets?
  Keep the tablets at room temperature (15 °C–30 °C), away from direct sunlight, moisture, and heat sources. Do not store in bathrooms or near kitchen stoves.

• Can I travel internationally with Parlodel in my carry‑on luggage?
  Yes, provided you carry a copy of the prescription and a pharmacist‑validated medication label. It is advisable to keep the medication in its original packaging and to declare it if required by the destination country's customs regulations.

• Does food influence the absorption of bromocriptine?
  Taking Parlodel with a moderate‑fat meal can reduce nausea but may slightly delay absorption. The overall bioavailability remains clinically adequate, so routine dosing with meals is acceptable.

• Are there any differences in inactive ingredients between Asian and European formulations?
  Some regional manufacturers adjust excipients for local manufacturing standards. Common inactive components include lactose, microcrystalline cellulose, and magnesium stearate. Patients with specific allergies should review the full ingredient list provided by the supplier.

• Do Hong Kong regulations permit personal import of bromocriptine for self‑medication?
  The Hong Kong Department of Health allows individuals to import a 30‑day supply of prescription medicines for personal use, provided a valid prescription and import permit are presented. Our online pharmacy assists customers in complying with these requirements.

• Can bromocriptine affect drug testing for employment or sports?
  Bromocriptine is not typically screened for in standard occupational drug panels. However, some anti‑doping agencies may flag dopamine‑modulating agents; athletes should disclose usage to the relevant governing body.

• What is the mechanism behind bromocriptine’s effect on blood glucose in diabetes?
  The drug modulates central serotonergic pathways that regulate circadian rhythm of glucose production, leading to reduced hepatic glucose output and improved insulin sensitivity. Clinical trials have shown modest reductions in HbA1c when added to standard therapy.

• Is there a risk of developing tolerance to the prolactin‑lowering effect?
  Long‑term studies indicate sustained prolactin suppression in the majority of patients. Occasionally, dose escalation is required if prolactin levels rise after several months.

• What should I do if I experience severe dizziness after taking Parlodel?
  Sit or lie down immediately, avoid standing quickly, and hydrate. If dizziness persists for more than 30 minutes or is accompanied by fainting, seek medical attention promptly.

• Do tablets have a distinctive imprint or colour that helps identify them?
  Generic bromocriptine tablets, such as those sold under the Parlodel name, are typically white or off‑white, round, and may carry the imprint “BRC” or the manufacturer's logo. The exact imprint can vary by supplier, so always verify against the packaging label.

• Are there special considerations for elderly patients using bromocriptine?
  Older adults may be more susceptible to orthostatic hypotension and gastrointestinal side effects. Initiating therapy at a lower dose (1.25 mg) and titrating slowly is recommended, along with close blood pressure monitoring.

Glossary

Dopamine‑2 (D₂) receptor

A subtype of dopamine receptor primarily located in the pituitary gland; activation inhibits prolactin secretion.

Hyperprolactinemia

A condition characterized by abnormally high levels of prolactin in the blood, leading to menstrual disturbances, infertility, and inappropriate milk production.

Ergot‑derived agonist

A class of compounds originally derived from the fungus Claviceps purpurea that mimic dopamine activity at specific receptor sites.

Orthostatic hypotension

A drop in blood pressure upon standing, causing dizziness or faintness; a known side effect of dopamine agonists.

⚠️ Disclaimer

The information provided about Parlodel is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Parlodel for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.