Buy Generic Prometrium Online

Generic Prometrium Information

Introduction

Prometrium is a prescription medication that delivers the natural hormone progesterone in oral micronized form. It belongs to the Women’s Health therapeutic group and is used primarily to treat progesterone deficiency and to support various reproductive‑related conditions. In Hong Kong, the drug is prescribed for hormone replacement therapy, luteal‑phase support in assisted reproduction, and the prevention of preterm birth in high‑risk pregnancies. The formulation is marketed by a number of reputable pharmaceutical companies worldwide, and the active ingredient is identical to that found in endogenous progesterone.

What is Prometrium?

Prometrium is a brand‑name oral capsule that contains micronized progesterone, a bioidentical hormone identical to the progesterone produced by the human ovary. The micronization process reduces particle size to improve gastrointestinal absorption, allowing the capsule to achieve systemic hormone levels comparable with natural luteal‑phase concentrations. The product is manufactured under Good Manufacturing Practice (GMP) standards in facilities approved by health authorities such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA). In Hong Kong, Prometrium is regulated by the Department of Health and may be dispensed by licensed pharmacies with a valid prescription.

How Prometrium Works

Progesterone plays a central role in the menstrual cycle, pregnancy maintenance, and the modulation of estrogen‑driven tissue growth. After oral ingestion, micronized progesterone is absorbed through the small intestine, entering the hepatic portal circulation. The liver metabolises a portion of the dose, but sufficient unchanged hormone reaches the systemic circulation to bind intracellular progesterone receptors (PR‑A and PR‑B). Receptor activation regulates gene transcription that stabilises the endometrium, inhibits uterine contractility, and suppresses the hypothalamic‑pituitary‑gonadal (HPG) axis to prevent ovulation. In menopause, progesterone counteracts unopposed estrogen, reducing the risk of endometrial hyperplasia. During pregnancy, supplemental progesterone supports the uterine environment and reduces inflammatory pathways implicated in preterm labor.

Conditions Treated with Prometrium

• Hormone‑Replacement Therapy (HRT) for Menopausal Women – Combined estrogen‑progesterone regimens protect the endometrium from estrogen‑induced hyperplasia while relieving vasomotor symptoms.
• Luteal‑Phase Support in Assisted Reproductive Technology (ART) – After in‑vitro fertilisation (IVF) or intra‑uterine insemination (IUI), progesterone sustains the endometrial lining to improve implantation rates.
• Prevention of Preterm Birth – In women with a history of spontaneous preterm delivery or a short cervical length, daily progesterone reduces the incidence of delivery before 37 weeks.
• Management of Menstrual Disorders – For individuals with luteal‑phase defect, irregular menses, or secondary amenorrhoea, progesterone supplementation restores normal cyclicity.

In Hong Kong, an estimated 10 % of women aged 45–60 experience menopause‑related symptoms, and the prevalence of infertility requiring ART has risen steadily, creating a clear clinical demand for reliable progesterone therapy.

Who is Prometrium For?

• Perimenopausal and Postmenopausal Women who require a combined estrogen‑progesterone regimen to manage hot flashes, night sweats, and prevent endometrial pathology.
• Women Undergoing IVF, IUI, or other ART procedures who need luteal‑phase support to maximise implantation success.
• Pregnant Women at High Risk of Preterm Delivery (e.g., prior preterm birth, cervical shortening, uterine anomalies) in whom daily progesterone is recommended by obstetric guidelines.
• Patients with Confirmed Progesterone Deficiency due to ovarian insufficiency, hypothalamic‑pituitary disorders, or after surgical removal of the corpus luteum.

Prometrium is not suitable for individuals with active deep‑vein thrombosis, known hypersensitivity to progesterone or any capsule excipients, uncontrolled hypertension, or hormone‑sensitive cancers such as breast or endometrial carcinoma. Women who are breastfeeding should consult a clinician before use, as progesterone can be excreted in breast milk.

Risks, Side Effects, and Interactions

Common

• Drowsiness or fatigue
• Breast tenderness or enlargement
• Mood changes, including mild irritability or depression
• Nausea, abdominal bloating, or mild stomach discomfort
• Headache

Rare

• Elevated liver enzymes (monitoring advised in patients with hepatic disease)
• Fluid retention leading to peripheral oedema
• Acne or seborrhoeic dermatitis
• Dysmenorrhoea or intermittent spotting

Serious

• Venous thromboembolism (VTE) – rare but reported, particularly in women with pre‑existing clotting disorders.
• Allergic reactions: urticaria, angio‑edema, or anaphylaxis.
• Hyperglycaemia in patients with poorly controlled diabetes.

Drug–Drug Interactions

• Antifungal azoles (e.g., ketoconazole, itraconazole): May increase plasma progesterone levels, heightening side‑effect risk.
• Rifampin and other potent CYP3A4 inducers: Can reduce progesterone exposure, potentially compromising therapeutic efficacy.
• Anticoagulants (warfarin, direct oral anticoagulants): Progesterone may potentiate anticoagulant effects; coagulation parameters should be monitored.
• Hormonal contraceptives: Concomitant use can alter progesterone metabolism and affect bleeding patterns.

Patients should disclose all prescription, over‑the‑counter, and herbal products to their healthcare provider before initiating therapy.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dosing for HRT: 200 mg micronized progesterone nightly (typically taken at bedtime to minimise drowsiness).
• Luteal‑phase support: 200 mg orally once daily beginning after embryo transfer and continuing for 10–14 days, or as advised by the fertility specialist.
• Preterm‑birth prevention: 200 mg daily, administered at the same time each day from 16–20 weeks gestation until 36 weeks, or per obstetric recommendation.

Missed dose: If a dose is forgotten, take it as soon as remembered unless it is within 12 hours of the next scheduled dose. In that case, skip the missed dose and resume the regular schedule. Do not double‑dose.

Overdose: Symptoms may include profound drowsiness, nausea, or vomiting. Seek immediate medical attention. Activated charcoal may be considered if presentation occurs within one hour of ingestion.

Precautions:

• Take capsules with food or a light snack to improve absorption and reduce gastrointestinal upset.
• Alcohol can potentiate drowsiness; limit intake while on therapy.
• Patients with hepatic impairment should be monitored closely, as metabolism may be altered.

Buying Prometrium from Our Online Pharmacy

Prometrium is available for purchase through our online pharmacy in Hong Kong, offering a discreet, cost‑effective pathway to obtain this essential hormone therapy. Key advantages include:

• Affordable pricing: Near‑manufacturer cost, significantly lower than many local retail pharmacies.
• Verified quality: All batches are sourced from licensed overseas suppliers that adhere to international GMP standards.
• Guaranteed delivery: Discreet packaging with express shipping (typically 7 days) or standard airmail (approximately 3 weeks).
• Online‑only access: Enables patients who face limited local pharmacy stock or insurance coverage constraints to receive the medication promptly.

Our service operates as a pharmacy‑broker platform, collaborating with accredited overseas pharmacies and wholesale distributors. This model ensures a secure supply chain while maintaining patient privacy throughout the ordering and delivery process.

FAQ

• Is Prometrium available in both brand‑name and generic forms in Hong Kong?
  Yes. The original brand name is marketed as Prometrium, while several generic manufacturers produce identical micronized progesterone capsules. Generic versions contain the same active ingredient and are generally less expensive.

• Does Prometrium require special storage conditions?
  The capsules should be stored at room temperature (15 °C–30 °C), away from direct sunlight, moisture, and heat. No refrigeration is needed, but the product must be kept in its original container to protect it from humidity.

• What does the Prometrium capsule look like?
  Prometrium capsules are typically opaque, soft‑gel or hard‑gel capsules, often white or off‑white in colour, marked with the dosage strength (e.g., “200 mg”) on the body. In some regions the capsule may be clear with a printed label.

• Can Prometrium be taken with food or must it be taken on an empty stomach?
  Taking the capsule with a small amount of food, especially a light snack, improves absorption and reduces the risk of stomach upset. However, it should not be taken with a high‑fat meal, which can delay onset of action.

• Are there any known differences in formulation between the US, EU, and Asian markets?
  The active ingredient, micronized progesterone, is the same worldwide. In some regions, inactive excipients such as gelatin or specific stabilisers may differ to meet local regulatory requirements, but therapeutic efficacy remains equivalent.

• Will taking Prometrium affect drug testing for employment or sports?
  Progesterone is a naturally occurring hormone and is not typically screened for in standard employment drug panels. In sports, endogenous hormone levels are monitored; therapeutic use of progesterone should be declared to anti‑doping authorities to avoid inadvertent violations.

• Is it safe to travel internationally with Prometrium capsules?
  Yes, provided the medication remains in its original packaging with a clear label. Carry a copy of the prescription (if required by customs) and keep the capsules in your carry‑on luggage to maintain temperature control.

• What should a patient do if they experience persistent dizziness while on Prometrium?
  Persistent or severe dizziness may indicate an adverse reaction or interaction with another sedating agent. The patient should discontinue use and seek medical evaluation promptly.

• Can Prometrium be used to treat abnormal uterine bleeding unrelated to menopause?
  Progesterone can stabilize the endometrium and is sometimes employed off‑label for certain bleeding disorders, but its use should be guided by a clinician familiar with the patient’s specific aetiology.

• Are there any known contraindications for Asian populations specifically?
  No ethnicity‑specific contraindications have been identified. However, clinicians may consider higher prevalence of certain clotting disorders in some Asian subpopulations when evaluating VTE risk.

• Does the micronized formulation affect the onset of action compared with oil‑based injections?
  Oral micronized progesterone reaches peak plasma concentrations within 2–4 hours, whereas intramuscular oil‑based injections have a slower, more prolonged release. The oral route is therefore suitable for daily hormonal maintenance, while injections are used for acute therapeutic needs.

• What is the typical shelf‑life of Prometrium once the bottle is opened?
  Unopened packs retain potency for up to 24 months from the manufacture date. After opening, capsules should be used within 12 months, provided they have been stored correctly and show no signs of degradation.

• Can Prometrium be combined with herbal supplements such as black cohosh?
  While no direct interaction has been documented, both agents can influence estrogenic pathways and may exacerbate side effects like breast tenderness. Patients should discuss any complementary therapies with their healthcare provider.

Glossary

Micronized Progesterone

Progesterone particles reduced to a fine powder (≤10 µm) to enhance oral absorption and bioavailability.

Luteal‑Phase Support

Administration of progesterone after ovulation or embryo transfer to prepare the uterine lining for implantation.

Venous Thromboembolism (VTE)

Formation of blood clots in the deep veins (deep‑vein thrombosis) that can travel to the lungs (pulmonary embolism).

Endometrial Hyperplasia

Excessive proliferation of the uterine lining, often caused by unopposed estrogen, which can increase cancer risk if untreated.

⚠️ Disclaimer

The information provided about Prometrium is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Prometrium for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.