Buy Generic Reglan Online

Generic Reglan Information

Introduction

Reglan (generic name Metoclopramide) is a prescription medicine classified under the Gastro Health group. Its primary therapeutic purpose is to enhance gastrointestinal motility and to alleviate nausea and vomiting of various origins. In Hong Kong, Metoclopramide is listed on the Hospital Authority formulary for acute and chronic gastrointestinal disorders, and it is also supplied by international manufacturers such as Roche. Secondary uses include facilitation of radiological examinations that require rapid gastric emptying and adjunctive therapy for certain migraine‑related nausea.

What is Reglan?

Reglan is a brand‑name formulation of the synthetic dopamine‑receptor antagonist Metoclopramide. The drug was first synthesized in the 195s and later commercialised by Roche Laboratories. Metoclopramide is available in several dosage forms, most commonly as oral tablets (10 mg) and injectable solutions (5 mg mL⁻¹). While Reglan is the original proprietary name, other well‑known brand names that contain the same active compound include Maxolon, Primperan, and Micro‑M. All of these products share identical pharmacological activity; the differences lie mainly in packaging, excipients, and regional marketing.

How Reglan Works

Metoclopramide exerts its therapeutic effect through two principal mechanisms:

• Dopamine D₂‑receptor antagonism in the chemoreceptor trigger zone (CTZ) of the medulla. By blocking dopamine signaling, the drug suppresses the central vomiting reflex, reducing nausea and emesis from chemotherapy, postoperative states, and vestibular disturbances.
• Serotonin 5‑HT₄ receptor agonism in the gastrointestinal tract. Stimulation of these receptors enhances the release of acetylcholine from enteric neurons, which promotes coordinated, forceful contractions of the upper gastrointestinal smooth muscle. The result is accelerated gastric emptying and increased antral tone, which alleviates symptoms of gastroparesis and functional dyspepsia.

Onset of action after oral administration occurs within 30 minutes, with peak plasma concentrations reached at approximately 1–2 hours. The elimination half‑life in healthy adults is 5–6 hours, primarily via renal excretion; dose adjustment is recommended in patients with creatinine clearance < 30 mL min⁻¹.

Conditions Treated with Reglan

• Gastroparesis (delayed gastric emptying) – a common complication of long‑standing diabetes and post‑vagotomy states. In Hong Kong, epidemiological surveys estimate that 1–2 % of the adult diabetic population experiences symptomatic gastroparesis, for which Metoclopramide remains a first‑line pro‑kinetic agent.
• Nausea and vomiting associated with chemotherapy, radiotherapy, and postoperative recovery. Metoclopramide’s anti‑emetic properties complement 5‑HT₃ antagonists and corticosteroids in multimodal regimens.
• Reflux‑related dyspepsia – by speeding gastric emptying, the drug reduces the volume of gastric contents available for retrograde flow into the esophagus.
• Facilitation of diagnostic radiology – pre‑procedure administration of Metoclopramide yields more rapid clearance of oral contrast agents, improving image quality for upper‑GI series.
• Migraine‑associated nausea – although not a migraine‑specific treatment, Metoclopramide is frequently employed as an adjunct to abortive agents to control accompanying vomiting.

Who is Reglan For?

Reglan is appropriate for adult patients who meet any of the following criteria:

• Documented delayed gastric emptying confirmed by scintigraphic or breath‑test evaluation.
• Acute or chronic nausea/vomiting where dopamine‑mediated pathways are suspected (e.g., chemotherapy‑induced emesis).
• Need for rapid gastric emptying prior to gastrointestinal imaging or endoscopy.
• Absence of contraindications such as known hypersensitivity to Metoclopramide, uncontrolled epilepsy, or severe extrapyramidal disorders.

Patients who should avoid Metoclopramide include those with a history of tardive dyskinesia, neuroleptic malignant syndrome, or significant renal impairment without dose adjustment. Caution is also advised in pregnant or lactating women; the drug is classified as Category B in Hong Kong, indicating limited human data but no demonstrated teratogenicity in animal studies.

Risks, Side Effects, and Interactions

Common

• Drowsiness or fatigue – occurs in up to 10 % of users, usually transient.
• Diarrhoea or abdominal cramping – reflects the pro‑kinetic action on the intestine.
• Restlessness (akathisia) – mild motor restlessness reported in 5–8 % of patients.

Rare

• Extrapyramidal symptoms (EPS) – including acute dystonia, Parkinsonism‑like rigidity, and tremor; incidence is approximately .5–1 % with short‑term use.
• Hyperprolactinemia – elevated prolactin levels may cause galactorrhoea or menstrual irregularities, observed in < .5 % of cases.

Serious

• Tardive dyskinesia – a potentially irreversible movement disorder that can develop after prolonged therapy (> 12 weeks) or high cumulative doses. The risk rises sharply with daily doses exceeding 30 mg.
• Neuroleptic malignant syndrome – a life‑threatening condition characterized by hyperthermia, rigid muscles, autonomic instability, and altered mental status; extremely rare but requires immediate cessation of the drug and emergency care.

Drug‑Drug Interactions

• CYP2D6 substrates (e.g., tramadol, codeine) – Metoclopramide can inhibit CYP2D6, raising plasma concentrations of co‑administered drugs.
• Anticholinergic agents (e.g., atropine, scopolamine) – may counteract the pro‑kinetic effect, reducing therapeutic benefit.
• Central nervous system depressants (benzodiazepines, alcohol) – additive sedation is possible; dose titration is advisable.
• Other dopamine antagonists (e.g., haloperidol, risperidone) – increase the likelihood of EPS and should be avoided if possible.

Patients should disclose all concurrent medications, herbal products, and over‑the‑counter supplements to their healthcare provider before initiating Metoclopramide.

Practical Use: Dosing, Missed Dose, Overdose

• Standard oral dosing for gastroparesis: 10 mg taken 30 minutes before meals, up to three times daily (maximum 30 mg/day).
• Nausea/vomiting protocols often employ a single 10 mg dose every 6–8 hours, not exceeding 30 mg per day.
• Injectable formulation (IV/IM): 10‑mg bolus over 1–2 minutes, repeatable after 30 minutes if needed; maximum daily dose remains 30 mg.

Missed dose: If a scheduled dose is forgotten and the next dose is more than 4 hours away, take the missed dose. If the next dose is due within 4 hours, skip the missed dose to avoid exceeding the recommended daily maximum.

Overdose: Acute ingestion of > 200 mg may precipitate severe EPS, seizures, or cardiac arrhythmia. Immediate medical attention is required. Activated charcoal can be considered if presentation is within 1 hour of ingestion; supportive care includes benzodiazepines for seizures and anticholinergics for dystonia.

Precautions: Avoid alcohol while on Metoclopramide, as it may potentiate central sedation. Patients with hepatic dysfunction should be monitored closely, although the drug is primarily renally cleared. Use with caution in the elderly due to increased susceptibility to EPS.

Buying Reglan from Our Online Pharmacy

Reglan can be obtained safely from our online pharmacy in Hong Kong. Our service offers several advantages for patients who require timely, affordable access to this essential gastrointestinal medication:

• Cost‑effective pricing – we source Metoclopramide directly from licensed overseas manufacturers, enabling us to sell near‑manufacturer cost without compromising quality.
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• Discreet, reliable delivery – standard shipping arrives within 7 days via express courier; regular airmail typically reaches the customer within 3 weeks. All packages are unmarked and privacy‑protected.
• Online‑only access – our pharmacy broker model partners with accredited international pharmacies, allowing us to provide medications that may have limited local stock or are not covered by insurance schemes.

Patients seeking an affordable generic alternative to brand‑name Metoclopramide can place an order through our secure website. Our dedicated support team assists with customs documentation and ensures compliance with Hong Kong import regulations for personal use quantities.

FAQ

• Can Metoclopramide be taken with food?
  Metoclopramide is most effective when administered on an empty stomach, preferably 30 minutes before meals. Taking the drug with food can delay its absorption and diminish its pro‑kinetic effect, especially for gastroparesis treatment.

• What is the appearance of the Reglan tablet?
  The commercial Reglan tablet is a white, round, film‑coated tablet scored on one side, containing 10 mg of Metoclopramide. The coating may vary slightly between manufacturers, but the imprint typically includes “ROCHE” and the dosage strength.

• Is refrigeration required for Metoclopramide tablets?
  No. Oral tablets should be stored at room temperature, protected from moisture, heat, and direct sunlight. The injectable solution, however, may require refrigeration (2‑8 °C) after reconstitution, depending on the supplier’s specifications.

• Can I travel internationally with Reglan?
  Yes, provided you carry the medication in its original packaging with a copy of the prescription or a doctor’s letter, as required by customs authorities. For trips longer than three months, arrange a supply from a licensed local pharmacy to avoid import complications.

• Are there differences between Metoclopramide produced in the EU versus the US?
  The active ingredient and its potency are identical across regions, but excipients such as fillers, dyes, or tablet coatings may differ. These variations rarely affect clinical efficacy but can influence tolerability in patients with specific allergies.

• How does Metoclopramide influence drug testing?
  Metoclopramide is not a controlled substance and does not typically appear on standard occupational drug screens. However, its metabolites may be detectable with specialized assays, though this is uncommon outside of forensic investigations.

• What regulatory status does Metoclopramide hold in Hong Kong?
  Metoclopramide is classified as a Prescription‑Only Medicine (POM) by the Hong Kong Department of Health. It is listed in the Hong Kong Pharmaceutical Directory and requires a valid prescription for dispensing in local pharmacies.

• Has Metoclopramide been linked to long‑term neurological effects?
  Extensive clinical data indicate that prolonged use (> 12 weeks) at high doses increases the risk of tardive dyskinesia, a potentially irreversible movement disorder. Current guidelines advise limiting therapy duration and monitoring patients for early signs of extrapyramidal symptoms.

• What historical milestone led to Metoclopramide’s development?
  In the early 196s, researchers at the Swiss pharmaceutical firm Roche discovered that the compound could both block dopamine receptors and stimulate gastrointestinal motility. Its dual action led to rapid adoption for postoperative nausea and later for diabetic gastroparesis.

• Is Metoclopramide suitable for patients with Parkinson’s disease?
  No. Because Metoclopramide antagonizes dopamine receptors, it can exacerbate parkinsonian symptoms and is contraindicated in patients with Parkinson’s disease or other dopamine‑deficient disorders.

Glossary

Dopamine D₂‑receptor antagonist

A drug that blocks dopamine binding at the D₂ subtype of receptors, reducing dopamine‑mediated signaling in the brain and gut.

Extrapyramidal symptoms (EPS)

Movement disorders such as dystonia, tremor, or rigidity that result from interference with dopaminergic pathways in the central nervous system.

Tardive dyskinesia

A potentially irreversible, involuntary, repetitive movement disorder that can develop after long‑term exposure to dopamine antagonists.

⚠️ Disclaimer

The information provided about Reglan is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Reglan for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.