Buy Generic Seroquel Online

Generic Seroquel Information

Introduction

Seroquel, marketed under the name Quetiapine, is an atypical antipsychotic that belongs to the antidepressant‑related therapeutic group. It is prescribed to manage mood‑stabilising and psychotic conditions, including bipolar disorder, schizophrenia, and major depressive disorder (as an adjunct). In Hong Kong, the drug is available through licensed hospitals, private clinics, and increasingly through specialised online pharmacy services that import international formulations for patients with limited local supply.

What is Seroquel?

Seroquel is the commercial brand of the active compound quetiapine. The product was originally developed by Astra Zeneca and is approved by the Hong Kong Department of Health for several psychiatric indications. Quetiapine is a synthetic dibenzothiazepine that acts on multiple neurotransmitter receptors, giving it both antipsychotic and antidepressant properties. The tablet formulation contains quetiapine fumarate together with standard excipients such as lactose, magnesium stearate, and coating agents.

How Seroquel Works

Quetiapine exhibits a dose‑dependent receptor profile. At low doses it primarily blocks serotonin 5‑HT₂A receptors, which accounts for its mood‑stabilising and anxiolytic effects. As the dose increases, antagonism of dopamine D₂ receptors in the mesolimbic pathway becomes clinically relevant, providing antipsychotic activity. Additional antagonism of α₁‑adrenergic, H₁ histamine, and muscarinic receptors contributes to the sedating and orthostatic side‑effect profile.

Pharmacokinetic studies show an average terminal half‑life of 5–6 hours after a single dose, with steady‑state concentrations reached in 2–3 days of regular dosing. Quetiapine is metabolised mainly by cytochrome P450 3A4 (CYP3A4), and its clearance is influenced by hepatic function, age, and concomitant CYP3A4 modulators. These properties underlie the delayed onset of therapeutic benefit in depressive states (often 2–3 weeks) and the relatively rapid resolution of acute psychotic symptoms at higher doses.

Conditions Treated with Seroquel

*Dose ranges are presented for adult patients (≥18 years) and are not individualized. Exact titration must follow clinical assessment and monitoring.

In Hong Kong’s 2022 mental‑health census, an estimated 12 % of the adult population required treatment for schizophrenia or bipolar disorder, underscoring the public‑health relevance of quetiapine‑based regimens.

Suitable Candidates for Seroquel Treatment

• Adults with diagnosed schizophrenia who have experienced inadequate response to first‑generation antipsychotics or who are prone to extrapyramidal side effects.
• Patients presenting with acute bipolar mania whose symptoms include heightened agitation, decreased need for sleep, or psychotic features.
• Individuals with major depressive disorder who have failed to achieve remission with selective serotonin re‑uptake inhibitors (SSRIs) or serotonin‑noradrenaline re‑uptake inhibitors (SNRIs) and whose clinicians consider augmentation beneficial.
• Those requiring a medication with both antipsychotic and mood‑stabilising effects—for example, patients with rapid cycling bipolar disorder or schizoaffective disorder.

Contra‑indications include known hypersensitivity to quetiapine, concurrent use of other strong dopamine antagonists, and severe hepatic impairment. Caution is advised in patients with pre‑existing cardiac conduction abnormalities, uncontrolled diabetes, or a personal history of suicide attempts.

Risks, Side Effects, and Interactions

Common

• Sedation / Somnolence – especially after the first weeks of therapy or at higher doses.
• Dizziness / Orthostatic hypotension – related to α₁‑adrenergic antagonism; usually transient.
• Weight gain & Increased appetite – may exacerbate metabolic syndrome in predisposed patients.
• Dry mouth – anticholinergic effect; manageable with adequate fluid intake.

Rare

• Extrapyramidal symptoms (EPS) – tremor, rigidity, or akathisia, more likely at rapid dose escalations.
• Hypoglycaemia – particularly in patients on insulin or sulfonylureas; monitor glucose levels.
• Elevated fasting lipids – occasional dyslipidaemia reported in long‑term use.

Serious

• QTc prolongation & Torsades de Pointes – risk increases with electrolytic imbalance, concurrent QT‑prolonging drugs, or congenital long‑QT syndrome.
• Suicidal ideation or worsening depression – psychiatric monitoring is essential during the first few weeks.
• Severe allergic reactions – angioedema, rash, or anaphylactoid responses requiring immediate medical attention.
• Neuroleptic malignant syndrome (NMS) – rare but life‑ threatening; characterised by rigidity, fever, autonomic instability, and elevated creatine kinase.

Clinically Relevant Interactions

• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir) → ↑ quetiapine plasma concentrations; may intensify sedation and cardiac effects.
• CYP3A4 inducers (e.g., carbamazepine, rifampicin, St. John’s wort) → ↓ quetiapine levels; may reduce therapeutic efficacy.
• Other CNS depressants (alcohol, benzodiazepines, opioids) → additive sedation, respiratory depression risk.
• Drugs that prolong QT interval (e.g., haloperidol, certain macrolide antibiotics) → cumulative risk of torsades.
• Antidiabetic agents – monitor for hypoglycaemic episodes.

Patients are urged to disclose all current medications, over‑the‑counter products, and herbal supplements to their prescriber before initiating Seroquel.

Practical Use: Dosing, Missed Dose, Overdose

Standard dosing (adult)

• Schizophrenia: start 25 mg once daily; titrate to 200–300 mg/day as tolerated.
• Bipolar mania: begin 50 mg twice daily; increase by 50 mg increments every 2 days up to 400 mg/day.
• Adjunct depression: initiate 150 mg once daily; adjust between 150–300 mg/day based on response.

Missed dose – If a dose is forgotten, take it as soon as it is remembered unless the next scheduled dose is within 4 hours; in that case, skip the missed dose and continue the regular schedule. Never double the dose to compensate for a missed tablet.

Overdose – Immediate medical attention is imperative. Symptoms may include pronounced CNS depression, hypotension, and cardiac arrhythmias. Supportive care includes monitoring of vital signs, ECG, and respiratory function; activated charcoal may be considered if presentation is early.

Precautions

• Food: quetiapine can be taken with or without meals; however, high‑fat meals may delay absorption slightly.
• Alcohol: avoid concurrent consumption as it may potentiate sedative effects and worsen orthostatic hypotension.
• Comorbidities: regular assessment of liver function, fasting glucose, lipid profile, and ECG is recommended for long‑term users, especially those with diabetes, cardiovascular disease, or a history of arrhythmias.

Buying Seroquel from Our Online Pharmacy

Patients residing in Hong Kong can obtain Seroquel through our online pharmacy, which specialises in safe importation and delivery of internationally sourced generic quetiapine. Key advantages include:

• Competitive pricing – products are sourced near the manufacturer’s list price, reducing the cost‑to‑patient gap.
• Verified quality – all batches are supplied by licensed overseas pharmacies that adhere to GMP standards; we retain certificates of analysis for each shipment.
• Discreet, reliable delivery – express shipping (typically 7 working days) for urgent need, or standard airmail (approximately 3 weeks) for routine refills. Packages are unbranded to protect patient privacy.
• Pharmacy‑broker model – we act as an intermediary, matching Hong Kong patients with reputable international suppliers; this structure enables the import of medicines that may not be stocked locally while complying with local customs regulations and personal import limits.

Our service is intended for individuals who experience limited access to conventional pharmacy channels, face restrictive insurance formularies, or seek a cost‑effective generic option under professional medical supervision.

FAQ

• Is Seroquel available in both brand‑name and generic forms in Hong Kong?
  Yes. The original brand‑name product (Quetiapine) is marketed by Astra Zeneca, while generic tablets containing the same active ingredient are supplied by multiple licensed manufacturers. Generic versions are typically priced lower than the brand.

• What is the recommended storage condition for quetiapine tablets?
  Store at room temperature (15 °C – 30 °C), protected from excess moisture, heat, and direct sunlight. Do not refrigerate or freeze the tablets.

• How can I identify genuine Seroquel tablets when they arrive?
  Authentic tablets are round, film‑coated, and display the imprint “SER 10 MG” (or equivalent strength) with the manufacturer's logo. The packaging includes a patient leaflet with batch number, expiry date, and tamper‑evident seal.

• Can I travel internationally with Seroquel in my carry‑on luggage?
  Yes, provided the medication is in its original packaging, accompanied by a copy of the prescription, and the quantity does not exceed the personal import limit set by the Hong Kong customs authority (generally 90 days’ supply).

• Does Seroquel interact with common Asian herbal remedies?
  Certain herbal products, such as St. John’s wort, act as CYP3A4 inducers and may lower quetiapine concentrations, potentially reducing efficacy. Patients should discuss any herbal supplement use with their clinician.

• Is there a difference in inactive ingredients between Asian‑market and Western formulations?
  While the active ingredient (quetiapine fumarate) is identical, some Asian‑market tablets may contain alternative binders (e.g., microcrystalline cellulose) or coating agents. These differences do not affect therapeutic action but may be relevant for patients with specific excipient allergies.

• What are the Hong Kong customs rules for importing personal amounts of Seroquel?
  Personal import of medicines for personal use is permitted up to a 90‑day supply without a special licence, provided a valid prescription is supplied. Larger quantities require a licensed import permit.

• Are there special warnings for Seroquel use in the elderly Asian population?
  Elderly patients (>65 years) are more susceptible to orthostatic hypotension and sedation. Dose initiation should be lower (e.g., 25 mg nightly) with gradual titration and close monitoring of blood pressure and falls risk.

• How does quetiapine affect laboratory test results?
  Quetiapine may cause mild elevations in liver enzymes and, infrequently, transient increases in serum prolactin. Routine laboratory monitoring should be discussed with the prescribing clinician.

• Can Seroquel be safely taken while fasting for religious observances?
  Quetiapine can be taken with a small amount of water during the fasting window. However, patients should avoid taking it on an empty stomach if they experience pronounced dizziness, and they may prefer dosing at times when food is permitted.

Glossary

Dopamine D₂ receptor

A brain receptor that mediates reward, motivation, and motor control; its blockade reduces psychotic symptoms.

CYP3A4

An enzyme in the liver that metabolises many drugs; inhibition or induction of this enzyme changes quetiapine plasma levels.

Orthostatic hypotension

A drop in blood pressure upon standing, leading to dizziness or fainting; common with agents that block α₁‑adrenergic receptors.

Therapeutic window

The range of drug concentrations where the medication is effective without causing unacceptable toxicity.

Disclaimer

The information provided about Seroquel is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Seroquel for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.