Buy Generic Theo-24 Sr Online

Generic Theo-24 Sr Information

Introduction

Theo-24 Sr is an oral medication containing the active compound theophylline, a member of the methyl‑xanthine class. It is classified within the asthma therapeutic group and is used primarily to improve breathing in chronic airway diseases. In Hong Kong, theophylline remains an adjunctive option for patients whose symptoms are not fully controlled by inhaled bronchodilators or corticosteroids, or for those who require a long‑acting oral agent. The drug may also be employed in certain cases of chronic obstructive pulmonary disease (COPD) when oral therapy is preferred.

What is Theo-24 Sr?

Theo-24 Sr is a tablet formulation that delivers a precise dose of theophylline. The product is manufactured by a licensed pharmaceutical firm that complies with Good Manufacturing Practice (GMP) standards; specific corporate identity is disclosed on the packaging and regulatory documents submitted to the Hong Kong Department of Health.

The medication belongs to the bronchodilator class, specifically the methyl‑xanthine subgroup, which has been used for more than six decades to manage reversible airway obstruction. Theo‑24 Sr tablets are designed for sustained‑release (SR) delivery, allowing once‑ or twice‑daily dosing while maintaining therapeutic serum concentrations.

How Theo-24 Sr Works

Theophylline exerts its therapeutic effect through several complementary mechanisms:

• Phosphodiesterase inhibition – By blocking the enzyme phosphodiesterase‑4 (PDE‑4), theophylline raises intracellular cyclic adenosine monophosphate (cAMP) levels. Elevated cAMP relaxes smooth muscle in the bronchial walls, leading to bronchodilation.
• Adenosine receptor antagonism – The drug competes with adenosine at A₁ and A₂ receptors, reducing bronchoconstriction and inflammatory mediator release.
• Modulation of inflammatory cells – At therapeutic concentrations, theophylline can attenuate the activity of neutrophils, eosinophils, and mast cells, providing a modest anti‑inflammatory benefit.

Because theophylline’s pharmacokinetics are influenced by hepatic metabolism (primarily CYP1A2), serum levels must be monitored to stay within the therapeutic window of 5–15 µg · mL⁻¹. The sustained‑release formulation of Theo‑24 Sr provides a gradual increase in plasma concentration, achieving a steady state after 3–5 days of regular dosing.

Conditions Treated with Theo-24 Sr

• Asthma (moderate to severe) – For patients whose disease remains symptomatic despite inhaled corticosteroids (ICS) and long‑acting β₂‑agonists (LABA), theophylline offers an oral adjunct that can improve peak expiratory flow and reduce nighttime awakenings.
• Chronic Obstructive Pulmonary Disease (COPD) – In moderate COPD, especially in patients with chronic bronchitis phenotype, theophylline may reduce hyperinflation and improve exercise tolerance.
• Bronchiectasis (adjunctive) – Occasionally used to enhance mucociliary clearance, although evidence is limited.

In Hong Kong, the prevalence of asthma is estimated at 6–8 % of the adult population, while COPD affects roughly 4 % of individuals over 40 years. Theophylline’s oral route makes it a practical option for patients who face difficulties with inhaler technique or who need a portable medication during travel.

Who is Theo-24 Sr For?

• Adults with uncontrolled asthma who are already on guideline‑directed inhaled therapy but continue to experience frequent symptoms, exacerbations, or reliance on short‑acting rescue inhalers.
• COPD patients with persistent dyspnea despite optimal inhaled bronchodilator regimens, particularly those who prefer an oral medication to reduce inhaler burden.
• Individuals with irregular inhaler use due to occupational constraints, physical disability, or limited access to inhalation devices; the once‑ or twice‑daily tablet can ensure more consistent drug exposure.

Contra‑indications include: known hypersensitivity to theophylline or related methyl‑xanthines, uncontrolled cardiac arrhythmias, severe hepatic impairment, and active seizure disorders. Caution is advised in elderly patients, pregnant or lactating women, and those with concomitant use of drugs that markedly influence CYP1A2 activity (e.g., fluoroquinolones, macrolide antibiotics, cimetidine).

Risks, Side Effects, and Interactions

Common

• Nausea, vomiting, and loss of appetite
• Headache or dizziness
• Insomnia or restlessness
• Palpitations or mild tachycardia

Rare

• Tremor or muscle weakness
• Diarrhea or abdominal cramps
• Rash, pruritus, or mild urticaria
• Mild hyponatremia (especially in the elderly)

Serious

• Cardiac arrhythmias (ventricular ectopy, atrial fibrillation)
• Seizures, particularly at serum concentrations >20 µg · mL⁻¹
• Severe hypotension or cardiogenic shock in overdose
• Life‑threatening anaphylactic reactions (extremely rare)

Clinically relevant drug–drug interactions

• CYP1A2 inhibitors (e.g., ciprofloxacin, erythromycin, fluvoxamine) increase theophylline levels, heightening toxicity risk.
• CYP1A2 inducers (e.g., rifampicin, carbamazepine, smoking) decrease serum concentrations, potentially reducing efficacy.
• Quinolone antibiotics (especially ciprofloxacin) can cause synergistic CNS stimulation.
• Theophylline + β‑agonists may amplify tachycardia or tremor.
• Anticoagulants (warfarin) may experience altered INR; regular monitoring is advised.

Patients should disclose all prescription, over‑the‑counter, and herbal products to their healthcare provider before initiating Theo‑24 Sr.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dosing – The usual oral dose for sustained‑release tablets ranges from 300 mg to 600 mg once daily, adjusted to achieve a serum concentration within the therapeutic window. Dose adjustments are required for hepatic impairment, heart failure, or advanced age.
• Titration – Begin with the lowest effective dose; check serum theophylline after 3–5 days of steady dosing, then modify by 100 mg increments as needed.
• Missed dose – If a dose is forgotten and it has been less than 6 hours, take it as soon as remembered. If more than 6 hours have elapsed, skip the missed dose and resume the regular schedule; do not double‑dose.
• Overdose – Symptoms may include severe nausea, vomiting, seizures, and cardiac arrhythmias. Seek emergency medical care immediately. Activated charcoal may be administered if the ingestion is recent, and supportive measures (e.g., benzodiazepines for seizures, anti‑arrhythmic therapy) are instituted.
• Food & alcohol – Theophylline absorption is not markedly affected by meals, but grapefruit juice can inhibit metabolism and raise levels. Alcohol may potentiate central nervous system side effects; moderate consumption is advisable.
• Renal or hepatic dysfunction – Reduce dose by 25‑50 % and monitor serum concentrations closely.

Regular serum monitoring (every 2–4 weeks during dose adjustments, then every 3–6 months) is essential to maintain safety and efficacy.

Buying Theo-24 Sr from Our Online Pharmacy

Patients in Hong Kong can obtain Theo‑24 Sr through our online pharmacy. Key advantages include:

• Affordable pricing – We source the medication at near‑manufacturer cost, passing savings directly to the consumer.
• Verified quality – All batches are supplied by licensed overseas pharmacies that adhere to GMP standards; each shipment is accompanied by a certificate of analysis.
• Guaranteed delivery – Discreet packaging is dispatched via express courier (typically 7 days) or regular airmail (approximately 3 weeks), with real‑time tracking.
• Online‑only access – Our broker service collaborates with international licensed suppliers, enabling patients who face limited local stock or insurance barriers to receive the medication safely.
• Privacy‑focused service – Orders are processed confidentially; no unnecessary personal data is retained beyond what is required for shipping and regulatory compliance.

Our pharmacy operates under the legal frameworks governing personal importation for medical use in Hong Kong, ensuring that each transaction complies with local customs and health authority regulations.

FAQ

• Can Theo-24 Sr be taken with other asthma inhalers?
  Yes, theophylline is commonly used as an add‑on therapy alongside inhaled corticosteroids and long‑acting β₂‑agonists. However, patients should be monitored for additive cardiovascular effects such as tachycardia.

• Does the sustained‑release formulation require special swallowing techniques?
  Theo‑24 Sr tablets should be swallowed whole with a full glass of water. Crushing, chewing, or breaking the tablet can alter the release profile and increase the risk of toxicity.

• What inactive ingredients are present in Theo-24 Sr tablets?
  Common excipients include microcrystalline cellulose, lactose monohydrate, magnesium stearate, and hypromellose. Patients with specific allergies (e.g., lactose intolerance) should verify the full ingredient list with the supplier.

• Is therapeutic drug monitoring (TDM) mandatory for every patient?
  While not mandatory for all, TDM is strongly recommended during initial dose titration, after any dose change, and when interacting medications are introduced, to keep serum levels within 5–15 µg · mL⁻¹.

• How does smoking affect Theo-24 Sr therapy?
  Smoking induces CYP1A2, the enzyme responsible for theophylline metabolism, leading to lower plasma concentrations. Smokers often require higher doses, but regular monitoring is essential to avoid sub‑therapeutic levels.

• Can Theo-24 Sr be stored in a humid climate like Hong Kong?
  Tablets should be kept in a cool, dry place away from moisture and direct sunlight. Using a sealed container can protect against the high humidity common in Hong Kong’s summer months.

• Are there any special considerations when traveling internationally with Theo-24 Sr?
  Carry the medication in its original labeled packaging, include a copy of the prescription or pharmacist’s note, and be aware of each country’s import limits for personal medication.

• What is the difference between immediate‑release and sustained‑release theophylline?
  Immediate‑release forms produce rapid peak concentrations but require multiple daily dosing and carry a higher risk of side‑effects. Sustained‑release (SR) formulations like Theo‑24 Sr provide steadier plasma levels with once‑ or twice‑daily dosing, improving tolerability.

• Has theophylline been compared to newer biologic agents for asthma?
  Clinical trials show that biologics (e.g., anti‑IL‑5, anti‑IgE) are more effective for severe eosinophilic asthma, but theophylline remains a cost‑effective oral alternative for patients without access to biologics or those with non‑eosinophilic phenotypes.

• Does Theo-24 Sr have any impact on drug testing for athletes?
  Theophylline is not listed as a prohibited substance by major sporting agencies; however, athletes should disclose any medications during anti‑doping assessments, as high serum levels could be misinterpreted as stimulant use.

• Is there a pediatric formulation of Theo-24 Sr?
  Currently, Theo‑24 Sr is approved only for adult use. Pediatric dosing of theophylline requires weight‑based calculations and is generally delivered via liquid preparations, not the sustained‑release tablets.

Glossary

Bronchodilator

A medication that relaxes the smooth muscle of the airways, increasing airflow and easing breathing.

Therapeutic Window

The plasma concentration range in which a drug provides optimal efficacy without unacceptable toxicity; for theophylline, this is 5–15 µg · mL⁻¹.

CYP1A2 (Cytochrome P450 1A2)

A liver enzyme that metabolizes theophylline and many other drugs; its activity can be increased (induced) or decreased (inhibited) by various substances, affecting drug levels.

Sustained‑Release (SR)

A dosage form designed to release the active ingredient gradually over an extended period, allowing less frequent dosing while maintaining steady drug concentrations.

⚠️ Disclaimer

The information provided about Theo-24 Sr is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Theo-24 Sr for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.