Buy Generic Ticlopidine Online

Generic Ticlopidine Information

Introduction

Ticlopidine (active compound: ticlopidine) is an antiplatelet agent belonging to the thienopyridine class. It is prescribed primarily for the secondary prevention of non‑cardioembolic ischemic stroke and transient ischaemic attack (TIA). In Hong Kong, ticlopidine is listed under the “General health” medication group and is used when clinicians consider clopidogrel or aspirin unsuitable or when additional antiplatelet potency is required. Its relevance derives from the increasing prevalence of cerebrovascular disease in the ageing Hong Kong population and the need for reliable platelet inhibition to reduce recurrent events.

What is Ticlopidine?

Ticlopidine is a synthetic analogue of ADP‑blocking antiplatelet drugs. It was originally marketed under the brand name Ticlid (also known as Stalys in some regions). The formulation contains the same active compound, ticlopidine, as the branded product.

Ticlopidine is the generic version of Ticlid, containing the same active compound Ticlopidine. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

The drug is produced by licensed pharmaceutical manufacturers that comply with International Council for Harmonisation (ICH) guidelines and is distributed in capsule or tablet form for adult oral administration.

How Ticlopidine Works

Ticlopidine exerts its therapeutic effect through irreversible inhibition of the platelet P2Y12 ADP receptor. By covalently binding to the receptor’s intracellular domain, the drug blocks ADP‑mediated signaling that normally leads to platelet activation and aggregation. Because platelets are anucleate, the inhibition persists for the lifespan of the affected platelet (approximately 7–10 days).

Key pharmacokinetic points:

• Onset of action: 2–8 days after the first dose, reflecting the time required for incorporation of the drug into newly formed platelets.
• Elimination half‑life: 7–11 hours; metabolism occurs primarily via the cytochrome P450 2C19 (CYP2C19) pathway, with minor renal excretion of unchanged drug.
• Duration of effect: Continues for the remaining life of the inhibited platelets; steady‑state platelet inhibition is reached after ~10 days of twice‑daily dosing.

Conditions Treated with Ticlopidine

Patient Populations Most Likely to Benefit

• Adults who have experienced a recent non‑cardioembolic ischemic stroke or TIA and require robust platelet inhibition.
• Individuals with documented aspirin intolerance (e.g., gastrointestinal ulceration or hypersensitivity) where ticlopidine can serve as a primary antiplatelet.
• Patients in whom clopidogrel therapy has failed due to poor platelet response or adverse effects; ticlopidine’s irreversible binding may overcome suboptimal clopidogrel activity.
• Patients undergoing lower‑limb revascularisation who need adjunct antiplatelet protection to maintain graft patency.

Ticlopidine is not appropriate for patients with active bleeding, severe hepatic impairment, or a history of life‑threatening neutropenia. Caution is also advised for those on concurrent strong CYP2C19 inhibitors (e.g., fluconazole, voriconazole) or drugs that markedly increase bleeding risk (e.g., warfarin, non‑steroidal anti‑inflammatory drugs).

Risks, Side Effects, and Interactions

Common

• Diarrhoea – mild to moderate, usually self‑limiting.
• Nausea / abdominal discomfort – may improve with food intake.
• Transient rash or pruritus – skin manifestations are generally mild.

Rare

• Hepatotoxicity – abnormal liver function tests; requires periodic monitoring.
• Agranulocytosis – bone‑marrow suppression presenting with fever and infection; reported in <1 % of users.

Serious

• Severe neutropenia – absolute neutrophil count <.5 × 10⁹ /L, potentially leading to opportunistic infections.
• Aplastic anaemia – pancytopenia with life‑ threatening consequences.
• Life‑threatening haemorrhage – especially when combined with other antithrombotics.

Clinically Relevant Drug–Drug Interactions

• Warfarin – additive anticoagulant effect; INR should be monitored closely.
• Aspirin, NSAIDs, or other antiplatelet agents – heightened bleeding risk; combination generally reserved for short‑term bridging.
• Selective serotonin re‑uptake inhibitors (e.g., fluoxetine, sertraline) – increased risk of gastrointestinal bleeding.
• CYP2C19 inhibitors (e.g., fluconazole, voriconazole, omeprazole) – may raise ticlopidine plasma concentrations, enhancing toxicity risk.
• Antibiotics such as sulfamethoxazole/trimethoprim – can exacerbate neutropenia; complete blood counts are advisable during co‑administration.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dosing: 250 mg orally twice daily (approximately 12 hours apart). The dose may be reduced to 250 mg once daily in patients with severe hepatic impairment.
• Missed dose: If a dose is forgotten, take it as soon as remembered unless the next scheduled dose is due within 2 hours; in that case, skip the missed dose and continue the regular schedule. Do not double the dose.
• Overdose: Immediate medical evaluation is essential. Supportive care includes monitoring of complete blood count, liver function, and coagulation parameters. No specific antidote exists; treatment is symptomatic and may involve activated charcoal if presentation is early.
• Precautions:
  • Food: Take with meals to minimise gastrointestinal upset.
  • Alcohol: Limit intake; excessive alcohol can exacerbate bone‑marrow suppression.
  • Comorbidities: Adjust dose in severe hepatic disease; avoid use in uncontrolled hypertension or active peptic ulcer disease.

Buying Ticlopidine from Our Online Pharmacy

Ticlopidine can be purchased safely from our online pharmacy in Hong Kong. Our service combines several advantages that are particularly valuable for Hong Kong residents:

• Affordable pricing: Generic ticlopidine is offered at a cost close to the manufacturer’s production price, providing a clear saving versus brand‑name imports.
• Verified quality: All shipments originate from overseas licensed pharmacies that hold GMP certification; each batch is cross‑checked against International Pharmacopeia standards.
• Guaranteed delivery: Discreet, reliable shipping options include 7‑day express courier for urgent needs and a regular airmail service (≈ 3 weeks) for non‑urgent orders.
• Pharmacy‑broker model: Acting as a broker, we work with approved overseas suppliers, ensuring privacy‑preserving receipt of medication that respects patient confidentiality.

Our online pharmacy thus offers a safe, cost‑effective route for patients who have limited access to regular pharmacy outlets or whose insurance plans do not cover this antiplatelet agent.

FAQ

• Is Ticlopidine available in both brand‑name and generic forms in Hong Kong?
  The medication is marketed internationally as the brand Ticlid (also known as Stalys) and as a generic ticlopidine product. In Hong Kong, both forms can be sourced, though the generic version is more frequently procured through online channels for cost savings.

• What storage conditions are recommended for Ticlopidine tablets?
  Store tablets at room temperature (15 °C – 30 °C), protected from direct light, moisture, and heat. Do not place them in bathrooms or near kitchen sinks where humidity fluctuates.

• Does Ticlopidine require cold‑chain handling?
  No cold storage is required; the formulation is stable at standard ambient conditions for the duration specified on the label.

• How is Ticlopidine packaged when ordered online?
  Each shipment contains sealed, tamper‑evident blister packs, with a printed medication guide in English and Chinese. Packages are placed in insulated, discreet mailing envelopes to maintain privacy.

• Can I travel internationally with Ticlopidine in my carry‑on bag?
  Yes. Carry the medication in its original packaging, along with the printed prescription or medical documentation if requested by customs. The sealed packaging and the accompanying information typically satisfy airline security protocols.

• Are there any specific warnings for Asian populations taking Ticlopidine?
  Studies have indicated a marginally higher incidence of neutropenia in East Asian patients, possibly related to genetic polymorphisms of CYP2C19. Regular complete blood‑count monitoring is therefore recommended for Asian individuals commencing therapy.

• Is Ticlopidine classified as a Schedule 5 or controlled substance in Hong Kong?
  Ticlopidine is listed as a non‑controlled therapeutic drug; it does not fall under the Hong Kong Dangerous Drugs Ordinance and may be imported for personal use under the Pharmacy Act guidelines.

• What are the inactive ingredients in Ticlopidine tablets?
  Generic formulations commonly contain lactose, microcrystalline cellulose, magnesium stearate, and film‑coating agents. Patients with hypersensitivity to these excipients should verify the specific product label before use.

• How does Ticlopidine differ from clopidogrel on a pharmacological level?
  Both drugs block the P2Y12 receptor, but ticlopidine binds irreversibly and requires incorporation into platelets over several days, leading to a more prolonged effect. Clopidogrel is a pro‑drug activated by CYP2C19, with a quicker onset but also a higher susceptibility to drug‑interaction variability.

• Is a blood‑test required before starting Ticlopidine?
  Baseline complete blood count (CBC) and liver‑function tests (ALT, AST, bilirubin) are strongly recommended to identify pre‑existing neutropenia or hepatic impairment that could increase the risk of severe adverse events.

• Does Ticlopidine have any impact on laboratory coagulation assays?
  Ticlopidine prolongs platelet function assays (e.g., PFA‑100, VerifyNow) but does not significantly affect standard clot‑based tests such as PT/INR or aPTT. Laboratories interpreting platelet function should be aware of the drug’s presence.

• Can Ticlopidine be imported for personal use without a Hong Kong prescription?
  Under the Personal Medication Import Scheme, individuals may import a 3‑month supply of ticlopidine for personal use provided a valid medical justification is supplied. Our online pharmacy assists customers in preparing the necessary documentation.

Glossary

P2Y12 receptor – A purinergic ADP‑activated receptor on platelets that triggers intracellular signaling leading to platelet aggregation.

Irreversible inhibition – A binding that permanently deactivates the target enzyme or receptor until new cells are generated; in the case of platelets, the effect lasts the lifespan of the inhibited platelet.

CYP2C19 – An enzyme of the cytochrome P450 family responsible for metabolizing many drugs, including ticlopidine; genetic variants can alter drug clearance.

Neutropenia – A condition defined by an abnormally low absolute neutrophil count, increasing susceptibility to bacterial infection.

⚠️ Disclaimer

The information provided about Ticlopidine is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Ticlopidine for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.