Buy Generic Uniphyl Cr Online

Generic Uniphyl Cr Information

Introduction

Uniphyl Cr is a bronchodilator medication indicated primarily for the long‑term management of asthma and chronic obstructive pulmonary disease (COPD). It contains the active compound theophylline, a methylxanthine that relaxes airway smooth muscle and improves respiratory function. In Hong Kong, theophylline‑based products are prescribed when inhaled therapies alone do not achieve adequate symptom control or when clinicians seek an oral adjunct to inhaled corticosteroids and β2‑agonists. The medication is marketed by a pharmaceutical company that follows international Good Manufacturing Practice (GMP) standards, ensuring consistent potency and safety.

What is Uniphyl Cr?

Uniphyl Cr is an oral tablet formulation of theophylline. It belongs to the class of methylxanthine bronchodilators. The product is manufactured by a licensed pharmaceutical firm that supplies medicines to the Asian market, including Hong Kong. The tablet contains a fixed dose of theophylline (typically 200 mg per tablet) together with inert excipients such as lactose, microcrystalline cellulose, and magnesium stearate, which aid tablet integrity and dissolution.

Uniphyl Cr is registered with the Hong Kong Department of Health under the relevant drug classification for asthma‑related therapies. It is not a controlled substance, but it is subject to prescription‑only status because therapeutic dosing requires careful monitoring of blood levels.

How Uniphyl Cr Works

Theophylline exerts its pharmacologic effect through several mechanisms:

• Phosphodiesterase inhibition – By blocking phosphodiesterase‑4 (PDE‑4), theophylline prevents the breakdown of cyclic adenosine monophosphate (cAMP) in airway smooth‑muscle cells. Elevated cAMP leads to relaxation of bronchial smooth muscle and bronchodilation.
• Adenosine receptor antagonism – Theophylline competes with endogenous adenosine at A1 and A2 receptors, reducing bronchoconstriction mediated by adenosine release during inflammation.
• Anti‑inflammatory modulation – At therapeutic concentrations, theophylline modestly suppresses inflammatory cytokine production and may enhance the efficacy of inhaled corticosteroids.

After oral ingestion, theophylline is absorbed rapidly from the gastrointestinal tract, reaching peak plasma concentrations within 1–2 hours. The drug distributes widely, crosses the blood‑brain barrier, and is metabolized primarily by hepatic cytochrome P450 enzymes (CYP1A2, CYP2E1, CYP3A4). The elimination half‑life ranges from 6 to 12 hours in healthy adults, but it can be prolonged in the elderly, smokers, or patients with hepatic impairment. Because the therapeutic window is narrow (plasma concentrations of 10–20 µg/mL are considered effective, while >20 µg/mL increase toxicity risk), clinicians often monitor serum levels, especially when dose adjustments are needed.

Conditions Treated with Uniphyl Cr

• Asthma (moderate to severe) – Theophylline serves as an add‑on therapy for patients whose symptoms are not fully controlled by inhaled corticosteroids and long‑acting β2‑agonists. In Hong Kong, asthma prevalence is estimated at 8–10 % of the adult population, with a substantial proportion experiencing persistent symptoms.
• Chronic Obstructive Pulmonary Disease (COPD) – For stable COPD, theophylline can improve exercise tolerance and reduce exacerbation frequency when combined with bronchodilator inhalers. COPD affects roughly 4 % of Hong Kong adults over 40 years, and oral options are valuable for patients who have difficulty using inhalers correctly.
• Bronchiectasis (off‑label) – Some clinicians prescribe low‑dose theophylline to reduce mucus hypersecretion, although evidence is limited.

The drug’s oral route offers convenience for patients who prefer tablets over inhalers, especially during travel or when inhaler technique is suboptimal.

Who is Uniphyl Cr For?

• Adults with persistent asthma who remain symptomatic despite optimal inhaled therapy.
• Patients with stable COPD who need additional bronchodilation or have frequent exacerbations despite inhaled long‑acting agents.
• Individuals who cannot tolerate high‑dose inhaled corticosteroids because of local side effects (e.g., oral thrush) and require a systemic bronchodilator with modest anti‑inflammatory properties.
• Elderly patients who have difficulty coordinating inhaler use, provided renal and hepatic function are adequate for safe theophylline metabolism.

Uniphyl Cr is not appropriate for:

• Patients with uncontrolled cardiac arrhythmias, severe hypertension, or recent myocardial infarction, because theophylline can increase heart rate and contractility.
• Individuals with a known hypersensitivity to theophylline, methylxanthines, or any tablet excipients.
• Pregnant or breastfeeding women unless the benefit clearly outweighs potential fetal risk; theophylline crosses the placenta and appears in breast milk.
• Patients with active seizure disorders, as theophylline lowers the seizure threshold at high concentrations.

Risks, Side Effects, and Interactions

Common

• Nausea, vomiting, or abdominal discomfort
• Headache
• Insomnia or nervousness
• Palpitations or mild tachycardia

Rare

• Tremor or muscle weakness
• Hypotension or hypertension (dose‑dependent)
• Rash or mild urticaria

Serious

• Cardiac arrhythmias (e.g., atrial fibrillation, ventricular ectopy)
• Seizures, especially at plasma concentrations >30 µg/mL
• Severe hepatotoxicity (rare, reported with prolonged high‑dose use)
• Life‑threatening anaphylaxis (extremely rare)

Drug‑Drug Interactions

• CYP1A2 inhibitors (e.g., fluoroquinolones, ciprofloxacin; macrolide antibiotics, erythromycin) can raise theophylline levels and increase toxicity risk.
• CYP1A2 inducers (e.g., smoking, carbamazepine, rifampin) may lower plasma concentrations, reducing efficacy.
• Cardiovascular agents (e.g., β‑blockers, digoxin) may have additive effects on heart rate and contractility.
• CNS stimulants (e.g., caffeine, theobromine) can potentiate central nervous system stimulation and insomnia.

Patients should provide a complete medication list to their prescriber and avoid self‑adjusting doses based on perceived symptom changes.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing for adults typically starts at 200 mg once daily, with adjustments made to achieve target serum concentrations (10–20 µg/mL). Some clinicians split the total daily dose into twice‑daily administrations (e.g., 150 mg every 12 hours) to smooth plasma peaks and troughs.
• Missed dose – If a dose is forgotten and it has been less than 6 hours since the scheduled time, take the tablet immediately. If more than 6 hours have passed, skip the missed dose and resume the regular schedule. Do not double‑dose.
• Overdose – Symptoms may include severe vomiting, seizures, and cardiac arrhythmias. Seek emergency medical care promptly. Management includes activated charcoal if presentation is within 1 hour, intravenous benzodiazepines for seizures, and cardiac monitoring.

Practical precautions

• Take Uniphyl Cr with a full glass of water; food does not markedly affect absorption but a consistent routine helps maintain stable blood levels.
• Avoid excessive caffeine while on therapy, as it can exacerbate insomnia and increase theophylline serum concentrations.
• Alcohol may enhance CNS side effects; limit intake.
• Renal or hepatic impairment requires dose reduction and closer serum level monitoring.
• Smoking induces hepatic metabolism, often necessitating a higher maintenance dose to maintain therapeutic levels.

Buying Uniphyl Cr from Our Online Pharmacy

Uniphyl Cr can be obtained safely through our online pharmacy in Hong Kong. Our service offers several advantages for patients seeking reliable access to this essential bronchodilator:

• Affordable pricing – We negotiate directly with overseas licensed manufacturers, allowing us to provide the medication at a price close to the production cost.
• Verified quality – Every batch is sourced from GMP‑certified facilities and undergoes independent quality testing before shipment.
• Guaranteed delivery – Discreet packaging is dispatched via express courier (typically 7 days) or regular airmail (approximately 3 weeks), with tracking available for each order.
• Online‑only access – Our pharmacy broker model connects Hong Kong patients with reputable international suppliers, expanding the range of medicines that may not be stocked locally.
• Privacy‑focused service – We respect patient confidentiality; all orders are processed without revealing personal health information beyond what is required for lawful import.

By choosing our platform, patients benefit from a cost‑effective, reliable, and private avenue to obtain Uniphyl Cr when local pharmacies have limited stock or when insurance coverage does not include this specific formulation.

FAQ

• Can Uniphyl Cr be taken with other asthma inhalers?
  Yes, Uniphyl Cr is commonly used as an add‑on to inhaled corticosteroids and long‑acting β2‑agonists. The combination can improve overall control, but the prescribing physician should review the full medication regimen to avoid overlapping side effects.

• What should I do if I travel abroad with Uniphyl Cr?
  Keep the medication in its original packaging, carry a copy of the prescription (or a physician’s letter if required), and store the tablets at room temperature away from humidity. Check the destination country's import regulations for personal medication before departure.

• Does the tablet have a specific shape or color that helps identify it?
  Uniphyl Cr tablets are typically round, bicolored (white core with a blue coating), and embossed with the imprint “U‑200”. The appearance may vary slightly between manufacturers but the imprint remains consistent for identification.

• Are there any differences between the formulation sold in Hong Kong and that exported from Europe?
  The core active ingredient—Theophylline—remains the same. In some regions, filler excipients such as lactose may be substituted with alternative binders to meet local pharmacopeial standards. These variations do not affect the therapeutic dose but may be relevant for patients with specific excipient allergies.

• Is it safe for patients with mild liver dysfunction to use Uniphyl Cr?
  Mild hepatic impairment generally does not require dose adjustment, but clinicians often monitor serum theophylline levels more closely because reduced metabolism can increase drug exposure. Severe liver disease warrants a reduced starting dose and frequent monitoring.

• How does smoking affect the effectiveness of Uniphyl Cr?
  Cigarette smoke induces the enzyme CYP1A2, accelerating theophylline clearance. Smokers may need a higher maintenance dose to achieve therapeutic plasma concentrations, and they should be counseled on smoking cessation to stabilize drug levels.

• Can theophylline cause drug‑testing false positives?
  Theophylline does not typically interfere with standard occupational or sports drug‑testing panels. However, its structural similarity to caffeine may be noted in specialized metabolic screens, though it is not a prohibited substance.

• What storage conditions are recommended for Hong Kong’s humid climate?
  Store Uniphyl Cr in a tightly sealed container at a temperature between 15 °C and 30 °C, away from direct sunlight and moisture. A desiccant packet placed inside the container can help maintain dryness, especially during the humid summer months.

• Is there a pediatric formulation of Uniphyl Cr?
  Currently, Uniphyl Cr is marketed for adult use only. Pediatric dosing requires weight‑based calculations and is generally managed with liquid theophylline preparations under strict medical supervision.

• How long does it take to notice an improvement after starting Uniphyl Cr?
  Clinical benefits may become apparent within 2–3 days as plasma concentrations reach steady state, but full therapeutic effect is often realized after 1 week of consistent dosing. Patients should continue regular inhaled therapy during this period.

• Does theophylline have any impact on blood glucose levels?
  At therapeutic doses, theophylline has minimal effect on glucose metabolism. However, high plasma concentrations can stimulate catecholamine release, potentially causing transient hyperglycemia in susceptible individuals.

• What are the environmental considerations for disposing of unused tablets?
  Unused or expired Uniphyl Cr should be returned to a pharmacy waste‑collection point or disposed of according to Hong Kong’s hazardous pharmaceutical waste guidelines. Do not flush tablets down the toilet, as they can contaminate water supplies.

Glossary

Methylxanthine

A class of compounds, including theophylline and caffeine, that stimulate the central nervous system and relax smooth muscle by inhibiting phosphodiesterase enzymes.

Therapeutic window

The plasma concentration range in which a drug provides optimal efficacy with acceptable safety. For theophylline, this is typically 10–20 µg/mL.

Cytochrome P450 (CYP) enzymes

A family of liver enzymes responsible for metabolizing many medications. Theophylline is mainly processed by CYP1A2, CYP2E1, and CYP3A4.

Bronchodilator

A medication that widens the airways by relaxing bronchial smooth muscle, improving airflow and reducing respiratory resistance.

⚠️ Disclaimer

The information provided about Uniphyl Cr is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Uniphyl Cr for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.