Buy Generic Xylocaine Online

Generic Xylocaine Information

Introduction

Xylocaine (lidocaine) is a widely used local anesthetic and anti‑arrhythmic agent belonging to the amide‑type pain‑relief group. In Hong Kong it is prescribed for a variety of procedures that require temporary loss of sensation, as well as for the treatment of certain cardiac rhythm disorders. The active compound, lidocaine, acts by stabilising neuronal membranes and reducing the ability of nerves to transmit pain signals. Apart from its primary role in local anaesthesia, Xylocaine is also employed in topical formulations for minor skin irritations and in intravenous preparations for acute ventricular arrhythmias.

What is Xylocaine?

Xylocaine is the trade name for the drug lidocaine, an amide‑type local anesthetic first synthesised in the 194s and later commercialised by Astra Zeneca. The medication is available in several pharmaceutical forms, including injectable solutions (.5 %–2 % w/v), topical gels, creams, sprays and transdermal patches. While the original brand name Xylocaine remains well recognised, lidocaine is also marketed under other brand names such as Lignocaine, Numb‑Ex and Anestesin. In Hong Kong both the branded and generic versions are approved by the Department of Health and listed in the Hong Kong Hospital Formulary.

How Xylocaine Works

Lidocaine exerts its effect by blocking voltage‑gated sodium channels on the neuronal cell membrane. When these channels are inhibited, the rapid influx of sodium ions that initiates an action potential is prevented, thereby halting the propagation of nerve impulses. The onset of anaesthesia is typically rapid—within 1–5 minutes for infiltration injections and 2–10 minutes for topical preparations. The duration of effect depends on concentration, the type of formulation, and tissue perfusion; for most injectable solutions the sensory block lasts 30 minutes to 2 hours, while transdermal patches may provide analgesia for up to 12 hours. Lidocaine is metabolised primarily in the liver by CYP3A4 and CYP1A2 to mono‑ethylglycinexylidide (MEGX) and subsequently to glycinexylidide (GX), both of which possess lower pharmacologic activity. The metabolites are eliminated renally, giving a plasma half‑life of approximately 90–120 minutes in healthy adults.

Conditions Treated with Xylocaine

• Local anaesthesia for minor surgical or dental procedures – infiltration, nerve block, and field block techniques allow painless incision, extraction, or suturing.
• Topical analgesia for superficial skin conditions – lidocaine 2 %–5 % gels or creams relieve pain from burns, insect bites, hemorrhoids, and post‑herpetic neuralgia.
• Management of ventricular arrhythmias – intravenous lidocaine (1–1.5 mg/kg bolus followed by infusion) is indicated for acute ventricular ectopy or ventricular tachycardia, especially when amiodarone is contraindicated.
• Diagnostic procedures – lidocaine is used during endoscopy, bronchoscopy, and catheterisation to minimise discomfort.

In Hong Kong, the high prevalence of dental disease and the bustling outpatient surgical landscape create steady demand for safe, rapid‑acting local anaesthetics. Additionally, the aging population exhibits a higher incidence of cardiac arrhythmias, for which lidocaine remains a useful emergency option.

Who is Xylocaine For?

• Adults undergoing minor surgical or dental interventions – patients who need short‑term numbness without systemic sedation.
• Individuals with acute skin pain – those suffering from minor burns, abrasions, or hemorrhoidal discomfort can benefit from topical lidocaine.
• Patients with life‑threatening ventricular arrhythmias – emergency physicians may select intravenous lidocaine when rapid rhythm control is required.
• Patients who are allergic to ester‑type local anaesthetics – lidocaine, an amide, is generally well tolerated in those with ester‑type hypersensitivity.

Contra‑indications

• Known hypersensitivity to lidocaine or other amide local anaesthetics.
• Severe hepatic impairment (reduced metabolism may increase toxicity).
• Certain cardiac conduction disorders (e.g., second‑ or third‑degree AV block without pacemaker) for systemic use.

Risks, Side Effects, and Interactions

Common

• Tingling, numbness, or mild burning at the application/injection site.
• Transient dizziness or light‑headedness, especially with higher topical concentrations.
• Mild gastrointestinal upset (nausea, abdominal discomfort) after systemic administration.

Rare

• Allergic skin reactions, including erythema, pruritus, or urticaria.
• Central nervous system manifestations such as tremor, visual disturbances, or a metallic taste.

Serious

• Systemic toxicity – seizures, profound CNS depression, respiratory arrest, or cardiac arrest due to high plasma concentrations.
• Severe arrhythmias – bradycardia, heart block, or ventricular fibrillation when administered intravenously in excess.
• Methemoglobinemia – a rare oxidising effect leading to cyanosis and reduced oxygen delivery.

Drug–Drug Interactions

• Class Ia anti‑arrhythmics (e.g., quinidine, procainamide) – additive cardiac conduction slowing.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) – may increase plasma lidocaine levels, raising toxicity risk.
• CYP1A2 inducers (e.g., rifampicin, smoking) – may reduce efficacy by accelerating metabolism.
• Other local anaesthetics – concurrent use can raise total amide load and precipitate systemic effects.

Patients should disclose all concomitant medications, especially anti‑arrhythmics, anti‑seizure drugs, and strong enzyme modulators, to the prescribing clinician.

Practical Use: Dosing, Missed Dose, Overdose

• Injectable lidocaine (.5 %–2 % solution) – for infiltration anesthesia, a typical dose is 1–4 mg/kg not exceeding 300 mg per procedure. For ventricular arrhythmia, an initial bolus of 1–1.5 mg/kg (up to 100 mg) may be followed by an infusion of 1–4 mg/min, titrated to effect.
• Topical lidocaine 2 %–5 % gel/cream – apply a thin layer to the affected area, no more than 4 g per 24 hours. For hemorrhoidal ointment, the dose is usually 4 g at bedtime.
• Transdermal lidocaine patch (5 %/7 mg cm⁻²) – one patch (10 cm²) applied once daily for up to 12 hours, then removed for at least 12 hours.

Missed Dose
Topical preparations are generally scheduled as needed; if a dose is omitted, apply the next dose at the regular interval. Do not double the dose to compensate.

Overdose Management
Signs of systemic toxicity require immediate medical attention. Initial measures include securing the airway, providing oxygen, and controlling seizures with benzodiazepines. In severe cases, intravenous lipid emulsion therapy is recommended per the 2022 European Resuscitation Council guidelines.

Precautions

• Avoid administration in sites with poor vascularity (e.g., distal extremities) unless a vasoconstrictor is added.
• Do not combine with other local anaesthetics without specialist guidance.
• Limit alcohol consumption for several hours before and after systemic use, as ethanol can potentiate CNS depression.
• In patients with hepatic disease, reduce total dose by 25–50 % and monitor plasma levels if possible.

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FAQ

• Is Xylocaine available in both brand‑name and generic forms in Hong Kong?
  Yes. The original brand Xylocaine is marketed by Astra Zeneca, while numerous generic lidocaine products are approved by the Hong Kong Department of Health. Generic versions contain the same active ingredient and meet identical quality standards.

• How should Xylocaine be stored to maintain potency?
  Store tablets, gels and injectable vials at room temperature (15 °C–30 °C), protected from direct sunlight, heat and moisture. Avoid refrigeration unless the product label explicitly requires it.

• Can I travel internationally with Xylocaine, and are there any customs restrictions?
  Personal quantities for self‑use (typically up to a 30‑day supply) are permitted for import into Hong Kong under the “personal medication” exemption, provided the product is in its original packaging and accompanied by a copy of the prescription or medical certificate.

• What are the differences between lidocaine creams and patches?
  Creams or gels are applied directly to the skin and are absorbed rapidly, offering short‑term relief (2–6 hours). Patches contain a controlled-release matrix that delivers a steady dose over 12 hours, suitable for chronic localized pain such as post‑herpetic neuralgia.

• Does lidocaine interact with over‑the‑counter antihistamines?
  Second‑generation antihistamines (e.g., cetirizine) have minimal interaction risk. First‑generation agents (e.g., diphenhydramine) may increase CNS depression when combined with systemic lidocaine, especially in higher doses.

• Is there a risk of developing tolerance to topical lidocaine?
  Tolerance is uncommon with intermittent use. Continuous application beyond 12 hours per day may reduce efficacy and increase the chance of systemic absorption, so adherence to recommended dosing intervals is important.

• Can Xylocaine be used for chronic lower‑back pain?
  While lidocaine injections can be part of a multimodal pain‑management plan for radicular back pain, oral or topical lidocaine is not indicated for chronic deep‑tissue musculoskeletal pain. Consultation with a pain specialist is required for such interventions.

• Are there any special considerations for Asian patients regarding lidocaine dosing?
  Pharmacokinetic studies in Asian populations show similar metabolism to other ethnic groups, but some patients with lower body weight may require dose adjustments to avoid systemic toxicity, particularly for intravenous use.

• What inactive ingredients are commonly found in lidocaine injectable solutions?
  Most injectable formulations contain sodium chloride (as an isotonic agent), hydrochloric acid or sodium hydroxide for pH adjustment, and water for injection. Preservative‑free versions are also available for patients with sensitivity.

• How does the onset time of lidocaine compare with other local anaesthetics like bupivacaine?
  Lidocaine has a faster onset (1–5 minutes) but a shorter duration (30 minutes–2 hours) than bupivacaine, which typically begins acting within 5–10 minutes and may provide anaesthesia for up to 6 hours. Choice depends on the required length of surgical or diagnostic procedure.

Glossary

Amide‑type local anaesthetic

A class of local anaesthetics, including lidocaine, that contain an amide bond in their chemical structure, generally offering longer stability and lower allergic potential than ester‑type agents.

Voltage‑gated sodium channel

Protein channels on nerve cell membranes that open in response to changes in electrical voltage, allowing sodium ions to enter and initiate an action potential. Lidocaine blocks these channels to prevent nerve signaling.

Systemic toxicity

Adverse effects that occur when a drug enters the bloodstream in high concentrations, affecting organs such as the central nervous system and heart, potentially leading to seizures or cardiac arrest.

Transdermal patch

A medicated adhesive bandage delivering a drug through the skin into the systemic circulation at a controlled rate over an extended period.

⚠️ Disclaimer

The information provided about Xylocaine is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Xylocaine for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.