Buy Generic Zestoretic Online

Generic Zestoretic Information

Introduction

Zestoretic is a fixed‑dose combination tablet of lisinopril and hydrochlorothiazide indicated for the treatment of hypertension. In Hong Kong, uncontrolled high blood pressure remains a major risk factor for stroke, myocardial infarction and renal disease, making effective pharmacotherapy essential. Zestoretic belongs to the blood‑pressure medication group and is marketed worldwide by AstraZeneca. The combination targets two complementary pathways: an angiotensin‑converting‑enzyme (ACE) inhibitor (lisinopril) and a thiazide diuretic (hydrochlorothiazide), providing additive blood‑pressure reduction with a single daily pill.

What is Zestoretic?

Zestoretic is a prescription‑only oral tablet that contains two active ingredients:

• Lisinopril 20 mg (or 10 mg depending on strength) – an ACE inhibitor that blocks the conversion of angiotensin I to angiotensin II.
• Hydrochlorothiazide 12.5 mg (or 25 mg) – a thiazide‑type diuretic that promotes sodium and water excretion.

The product is manufactured by AstraZeneca and distributed in many regions under the brand name Zestoretic. It is formulated as a film‑coated tablet for oral use, supplied in blister packs of 30 tablets. The medication is classified as a combination antihypertensive therapy and is approved for adult patients with essential hypertension, particularly when monotherapy does not achieve target blood‑pressure goals.

How Zestoretic Works

Lisinopril inhibits the angiotensin‑converting enzyme, preventing formation of angiotensin II, a potent vasoconstrictor. Reduced angiotensin II levels lead to vasodilation, decreased aldosterone secretion, and lower systemic vascular resistance.

Hydrochlorothiazide acts on the distal convoluted tubule of the kidney, blocking Na⁺/Cl⁻ reabsorption. The resulting natriuresis reduces plasma volume, decreasing cardiac output. The diuretic also promotes vasodilation through a direct effect on arteriolar smooth muscle.

When combined, the two agents provide complementary mechanisms: rapid volume reduction from the diuretic and sustained vasodilatory control from the ACE inhibitor. Clinical onset of antihypertensive effect occurs within 2 hours for lisinopril and 1–2 hours for hydrochlorothiazide; steady‑state blood‑pressure control is typically achieved after 2‑3 weeks of consistent dosing. Both drugs are eliminated primarily by renal excretion, with lisinopril having a half‑life of ~12 hours and hydrochlorothiazide ~6‑15 hours.

Conditions Treated with Zestoretic

• Essential (primary) hypertension – the primary indication. In Hong Kong, prevalence of hypertension among adults exceeds 25 %, and combination therapy improves the proportion of patients reaching <130/80 mm Hg.
• Hypertension with fluid overload – such as in mild chronic kidney disease (CKD) stages 1‑3, where diuretic action assists in volume management while ACE inhibition protects renal function.
• Resistant hypertension – defined as uncontrolled blood pressure despite treatment with two antihypertensives of different classes; adding a fixed‑dose ACE‑inhibitor/thiazide combination is a guideline‑supported strategy (e.g., Hong Kong Cardiology Society, 2022).

Suitable Candidates for Zestoretic Treatment

• Adults (≥18 years) diagnosed with stage 1 or stage 2 essential hypertension whose blood‑pressure targets are not met with monotherapy.
• Patients already tolerant of both lisinopril and thiazide diuretics individually, as the fixed‑dose format improves adherence.
• Individuals without a history of angio‑edema, severe renal impairment (eGFR < 30 mL/min/1.73 m²), or hyperkalemia, because the ACE‑inhibitor component can exacerbate these conditions.
• Patients who can maintain adequate dietary potassium intake and who are monitored for electrolyte disturbances, especially serum potassium and sodium.

Contra‑indications include known hypersensitivity to lisinopril, hydrochlorothiazide, or any component of the tablet; pregnancy (ACE inhibitors are teratogenic); and concomitant use of aliskiren in patients with diabetes.

Risks, Side Effects, and Interactions

Common

• Dry cough (ACE‑inhibitor related)
• Light‑headedness or dizziness, especially after the first dose (postural hypotension)
• Increased urination or mild electrolyte imbalance (thiazide effect)
• Headache

Rare

• Taste disturbances (dysgeusia)
• Elevated serum creatinine or reduced eGFR (ACE‑inhibitor effect on renal haemodynamics)
• Skin rash or pruritus

Serious

• Angio‑edema involving face, lips, tongue or airway – a medical emergency.
• Severe hypotension leading to syncope or organ hypoperfusion.
• Hyperkalemia (>5.5 mmol/L) or serious hyponatremia, which may cause cardiac arrhythmias or neurological symptoms.
• Acute interstitial nephritis or sudden worsening of renal function.

Drug–drug interactions

• Potassium‑sparing diuretics (e.g., spironolactone) or potassium supplements – increase risk of hyperkalaemia.
• Non‑steroidal anti‑inflammatory drugs (NSAIDs) – may blunt antihypertensive effect and impair renal clearance.
• Lithium – ACE inhibition can raise lithium levels, risking toxicity.
• Other antihypertensives (beta‑blockers, calcium‑channel blockers) – additive blood‑pressure lowering; dose adjustments may be necessary.
• Ciclosporin or tacrolimus – heightened risk of nephrotoxicity.

Patients should inform their pharmacist of all concomitant medicines, including over‑the‑counter products and herbal supplements.

Practical Use: Dosing, Missed Dose, Overdose

• Starting dose: For most adults, Zestoretic 10 mg lisinopril/12.5 mg hydrochlorothiazide once daily. Dose may be titrated to 20 mg/25 mg once daily based on blood‑pressure response and tolerability.
• Administration: Take the tablet in the morning with or without food. Consistency in timing helps maintain stable plasma concentrations.
• Missed dose: If a dose is forgotten within 12 hours, take it as soon as remembered. Skip the dose if it is near the time of the next scheduled dose; do not double‑dose.
• Overdose: Symptoms may include profound hypotension, dizziness, fainting, or electrolyte abnormalities. Seek emergency medical care immediately. Treatment is supportive; activated charcoal is ineffective for these agents.

Precautions

• Avoid excessive alcohol, which can enhance hypotensive effects.
• Monitor serum electrolytes (sodium, potassium) and renal function periodically, especially in patients with CKD or diabetes.
• Pregnant women must not use Zestoretic; ACE inhibitors are contraindicated in all trimesters.

Buying Zestoretic from Our Online Pharmacy

Patients in Hong Kong who encounter limited stock or high out‑of‑pocket costs can obtain Zestoretic through our online pharmacy in Hong Kong. Our service offers:

• Affordable pricing – sourced near manufacturer cost, providing a cost‑effective alternative to local retail pharmacies.
• Verified quality – all tablets are supplied by licensed overseas pharmacies that adhere to Good Manufacturing Practice (GMP) standards.
• Guaranteed delivery – discreet packaging with express shipping (7 days) or regular airmail (~3 weeks) to any Hong Kong address.
• Privacy‑first approach – as a pharmacy broker service, we coordinate with overseas licensed suppliers while maintaining strict confidentiality of patient information.

Our online platform enables convenient, reliable access to Zestoretic for individuals who may have restricted insurance coverage or who prefer a direct‑to‑consumer model.

FAQ

• Is Zestoretic available in both brand‑name and generic forms in Hong Kong?
  Yes. The original brand‑name product is marketed as Zestoretic by AstraZeneca, while generic versions containing the same active ingredients—lisinopril and hydrochlorothiazide—are also approved and distributed by other manufacturers.

• What should I do if I travel outside Hong Kong with Zestoretic?
  Carry the medication in its original container with a pharmacist‑approved label. Keep it in a temperature‑controlled environment (15‑30 °C) and avoid exposure to high humidity or direct sunlight.

• Does Zestoretic require refrigeration?
  No. Zestoretic tablets are stable at room temperature; they should be stored in a cool, dry place away from moisture and heat sources.

• What are the inactive ingredients in Zestoretic tablets?
  In addition to the active compounds, Zestoretic contains lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, and a film‑coating polymer. Patients with severe lactose intolerance should discuss alternatives with their clinician.

• Can Zestoretic be imported for personal use into Hong Kong?
  Personal import of prescription medicines is permitted under Hong Kong customs regulations when the quantity does not exceed a 3‑month supply and a valid prescription is provided. Our online pharmacy assists with customs documentation to ensure compliance.

• Are there specific warnings for Asian populations using Zestoretic?
  Clinical data indicate that Asian patients may have a higher propensity for angio‑edema with ACE inhibitors. Physicians often start with a lower dose and monitor closely for signs of swelling or respiratory compromise.

• How does Zestoretic compare with lisinopril monotherapy?
  Adding hydrochlorothiazide to lisinopril typically yields an additional 5‑10 mm Hg reduction in systolic blood pressure, improving the likelihood of reaching guideline‑recommended targets. The combination also simplifies dosing, enhancing adherence.

• What clinical trials support the use of Zestoretic?
  Large-scale randomized studies, such as the ASCOT‑LLA trial and the HOPE‑III trial, demonstrated superior blood‑pressure control and reduced cardiovascular events when ACE inhibitors were combined with thiazide diuretics compared with monotherapy.

• Is there a risk of drug testing interference with Zestoretic?
  Neither lisinopril nor hydrochlorothiazide is typically screened for in occupational drug tests. However, certain sports anti‑doping agencies may flag ACE inhibitors as prohibited substances in specific contexts; athletes should verify applicable regulations.

• Do tablet strengths differ between regions?
  Yes. In the United States, the common strengths are 10 mg/12.5 mg and 20 mg/25 mg. In the European Union and Asia, a 5 mg/12.5 mg formulation is also available for patients requiring lower ACE‑inhibitor doses.

Glossary

ACE inhibitor

A class of medication that blocks the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced blood pressure.

Thiazide diuretic

A type of diuretic that promotes sodium and water excretion by inhibiting Na⁺/Cl⁻ reabsorption in the distal tubule, thereby lowering plasma volume and blood pressure.

Angio‑edema

Rapid swelling of the deeper layers of skin and mucosa, often involving the lips, tongue, or airway; a serious adverse reaction associated with ACE inhibitors.

eGFR (estimated Glomerular Filtration Rate)

A calculated measure of kidney function based on serum creatinine, age, sex, and body size; used to assess renal clearance of medications.

⚠️ Disclaimer

The information provided about Zestoretic is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Zestoretic for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.