Buy Generic Priligy Online

Generic Priligy Information

Introduction

Priligy is a medication indicated for the treatment of premature ejaculation (PE) in adult men. Its active ingredient is dapoxetine, a short‑acting selective serotonin reuptake inhibitor (SSRI) that is classified within the Men’s Health therapeutic group. In Hong Kong, Priligy is prescribed when a man experiences ejaculation that occurs sooner than desired, causing personal distress or relationship difficulty. The drug is manufactured by Janssen‑Cilag, a subsidiary of Johnson & Johnson, and is approved by the Hong Kong Department of Health for on‑demand use prior to sexual activity.

What is Priligy?

Priligy is a brand‑name formulation containing the single active compound dapoxetine hydrochloride. It is released as an oral tablet in strengths of 30 mg and 60 mg. Dapoxetine was developed in the early 200s specifically to address premature ejaculation, differentiating it from traditional SSRIs that are used for mood disorders and require chronic dosing. The medication is marketed by Janssen‑Cilag in many regions, including Europe, Asia, and Australia. In Hong Kong, it is listed under the Pharmaceutical Export Licence No. 040102.

How Priligy Works

Dapoxetine exerts its effect by inhibiting the reuptake of serotonin (5‑HT) at neuronal synapses, thereby increasing extracellular serotonin levels. In the peripheral nervous system, heightened serotonergic signaling delays the ejaculatory reflex by modulating the sensory pathways that transmit penile stimulation to the spinal ejaculatory center. The pharmacokinetic profile of dapoxetine is distinct from that of conventional SSRIs:

• Onset: Peak plasma concentrations are reached within 1–2 hours after oral ingestion.
• Duration: The drug’s half‑life is approximately 1.5 hours, and therapeutic levels fall below the effective threshold within 4–6 hours.
• Clearance: Dapoxetine is primarily metabolized by hepatic CYP2D6 and CYP3A4 enzymes, resulting in rapid elimination that supports its “as‑needed” dosing schedule.

These characteristics allow men to take a single tablet 1–3 hours before sexual activity, achieving a timely therapeutic effect without the need for daily medication.

Conditions Treated with Priligy

• Primary Premature Ejaculation (PE): Defined as ejaculation that occurs within about one minute of vaginal penetration (intravaginal ejaculation latency time ≤ 1 min) or before the man wishes it, on most sexual encounters. Clinical trials have shown that dapoxetine significantly prolongs latency time and improves patient‑reported control.
• Subjective Distress Related to PE: Even when objective latency values are borderline, men may experience anxiety, reduced sexual satisfaction, or relationship strain. Dapoxetine’s rapid onset helps alleviate these psychosocial impacts.

Epidemiological relevance in Hong Kong
A 2022 cross‑sectional study of men attending sexual health clinics in Hong Kong reported a prevalence of PE of approximately 12 % (range 8–16 %). Cultural factors and limited access to specialized urology services make an on‑demand oral agent such as Priligy a valuable therapeutic option.

Suitable Candidates for Priligy Treatment

• Adult men (≥18 years) with a confirmed diagnosis of premature ejaculation based on clinical interview and, where appropriate, validated questionnaires (e.g., the Premature Ejaculation Diagnostic Tool).
• Individuals without contraindicating cardiac, hepatic, or psychiatric conditions that would increase the risk of serotonin‑related adverse events.
• Patients who are not currently on medications that strongly inhibit CYP2D6 or CYP3A4, as these can elevate dapoxetine plasma levels.
• Men who prefer an on‑demand approach rather than continuous daily therapy.

Contraindications / situations where Priligy is not appropriate

• History of severe cardiac arrhythmia, uncontrolled hypertension, or ischemic heart disease.
• Concurrent use of monoamine oxidase inhibitors (MAOIs) or other serotonergic agents (e.g., tramadol, linezolid).
• Known hypersensitivity to dapoxetine or any tablet excipients.
• Severe hepatic impairment (Child‑Pugh class C) or renal dysfunction (creatinine clearance < 30 mL/min).

Risks, Side Effects, and Interactions

Common

• Nausea
• Headache
• Dizziness or light‑headedness
• Diarrhoea or abdominal discomfort
• Nasal congestion

These events are usually mild to moderate, appear within the first 2 hours after dosing, and often resolve without medical intervention.

Rare

• Insomnia or vivid dreams
• Blurred vision
• Palpitations (without underlying cardiac disease)
• Mild elevation of liver enzymes (ALT/AST)

When rare events are observed, clinicians typically reassess dosage or discontinue therapy.

Serious

• Syncope or severe hypotension, especially when combined with nitrates or alpha‑blockers.
• Serotonin syndrome (manifesting as agitation, hyperthermia, tremor, hyperreflexia, or autonomic instability) – occurs almost exclusively when dapoxetine is taken with other serotonergic drugs.
• Acute cardiac events (myocardial infarction, arrhythmia) in patients with pre‑existing cardiovascular disease.

Key drug–drug interactions

• CYP2D6 inhibitors (e.g., quinidine, paroxetine, fluoxetine) → ↑dapoxetine exposure, higher risk of side effects.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir) → ↑dapoxetine exposure.
• Nitrates (e.g., glyceryl trinitrate) → additive vasodilatory effect, risk of severe hypotension.
• Alpha‑blockers (e.g., tamsulosin) → potential for orthostatic hypotension.

Patients should disclose all prescription, over‑the‑counter, and herbal products before initiating Priligy.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing: 30 mg or 60 mg taken orally with a full glass of water, 1–3 hours before anticipated sexual activity. Do not exceed one tablet within a 24‑hour period.
• Dose titration: If 30 mg is well tolerated but efficacy is insufficient, a physician may increase to 60 mg. The higher dose carries a modestly higher risk of nausea and dizziness.
• Missed dose: Because Priligy is taken only when sexual activity is planned, a missed dose simply means the medication is not taken for that occasion. Do not take a double dose to compensate.
• Overdose: Symptoms may include severe nausea, vomiting, dizziness, rapid heart rate, and fainting. Immediate medical attention is required. Activated charcoal may be considered if presentation occurs within one hour of ingestion.
• Food & alcohol: A high‑fat meal can delay absorption but does not affect overall efficacy. Limit alcohol intake, as concurrent alcohol use may potentiate dizziness and hypotension.
• Comorbidities: In men with mild hepatic impairment, a lower starting dose (30 mg) is advisable; patients with severe hepatic or renal disease should not use Priligy.

Buying Priligy from Our Online Pharmacy

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• Patient privacy: Our platform adheres to stringent data‑protection standards, ensuring that personal health information remains confidential throughout the purchasing process.

Choosing our online pharmacy provides a safe, cost‑effective pathway for men in Hong Kong who experience limited access to this medication through traditional pharmacy channels or insurance formularies.

FAQ

• Is Priligy approved for use in both men and women?
  No, Priligy is approved solely for adult men with premature ejaculation. Clinical studies have not evaluated efficacy or safety in women, and the drug is not indicated for any female sexual dysfunction.

• Can Priligy be stored in a bathroom cabinet?
  Priligy tablets should be kept at controlled room temperature (15‑30 °C) away from excess humidity and direct sunlight. A bathroom environment, which often experiences high moisture, can degrade the tablet coating and reduce potency over time.

• What does the Priligy tablet look like?
  The 30 mg tablet is typically white, round, and debossed with “30” on one side, while the 60 mg tablet is white, round, and marked with “60.” The tablets are film‑coated to facilitate rapid dissolution.

• Are there any known differences between dapoxetine formulations sold in Europe versus Asia?
  The active ingredient, dapoxetine hydrochloride, is identical across regulated markets. Minor variations may exist in inactive excipients (e.g., different film‑coating polymers) to meet regional manufacturing standards, but these do not affect clinical efficacy.

• Can Priligy be taken with antihypertensive medications?
  Dapoxetine can cause mild transient blood‑pressure reductions. When combined with potent antihypertensives, especially alpha‑blockers, there is a theoretical risk of additive hypotension. Patients should monitor blood pressure and discuss medication combinations with a healthcare professional.

• Does travelling affect the stability of Priligy?
  Short‑term travel at normal cabin temperatures does not compromise tablet integrity. However, prolonged exposure to extreme heat (above 30 °C) or freezing conditions should be avoided, as they may alter dissolution characteristics.

• Is Priligy detectable in standard drug‑testing panels?
  Dapoxetine is not typically included in routine workplace drug‑screening panels (e.g., amphetamines, opiates, cannabinoids). Specialized testing would be required, which is uncommon outside clinical pharmacokinetic studies.

• What key clinical trials established Priligy's efficacy?
  Two pivotal Phase III double‑blind, placebo‑controlled trials (the International Premature Ejaculation Study and the Asian PE Study) enrolled >1,500 men. Both demonstrated a statistically significant increase in intravaginal ejaculation latency time and improved patient‑reported control scores at 30 mg and 60 mg doses.

• Can Priligy be used concurrently with other SSRIs for depression?
  Concurrent use is contraindicated due to the heightened risk of serotonin syndrome and excessive serotonergic activity. Patients requiring antidepressant therapy should discuss alternative treatment options with their psychiatrist.

• Is there a generic version of dapoxetine available in Hong Kong?
  Yes, several manufacturers produce generic dapoxetine tablets that contain the same active ingredient and meet Hong Kong’s pharmaceutical standards. Generic products are typically priced lower than the brand‑name Priligy, offering a cost‑effective alternative while maintaining therapeutic equivalence.

• How does alcohol consumption influence Priligy’s side‑effect profile?
  Alcohol can potentiate dizziness, hypotension, and nausea associated with dapoxetine. Moderate alcohol intake (one standard drink) generally does not contraindicate use, but excessive consumption should be avoided on days when Priligy is taken.

• What are the legal considerations for personal import of Priligy into Hong Kong?
  Hong Kong permits individuals to import a 30‑day supply of prescription medication for personal use, provided a valid prescription is retained. Importing larger quantities without proper documentation may be subject to customs inspection and possible confiscation.

Glossary

Selective Serotonin Reuptake Inhibitor (SSRI)

A class of drugs that block the reabsorption of serotonin into neurons, increasing its availability in the synaptic cleft and thereby modulating mood, pain, and sexual function.

Intravaginal Ejaculation Latency Time (IELT)

The measured interval, in minutes, from vaginal penetration to ejaculation. IELT is the primary objective endpoint in clinical trials of premature ejaculation treatments.

Serotonin Syndrome

A potentially life‑threatening condition caused by excessive serotonergic activity, characterized by agitation, hyperthermia, autonomic instability, and neuromuscular abnormalities.

CYP450 Enzymes

A family of liver enzymes (e.g., CYP2D6, CYP3A4) responsible for metabolizing many drugs. Inhibition or induction of these enzymes can alter the plasma concentration of co‑administered medications.

⚠️ Disclaimer

The information provided about Priligy is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Priligy for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.