Buy Generic Cardizem Online

Generic Cardizem Information

Introduction

Cardizem is a calcium‑channel blocker whose active ingredient is diltiazem. It belongs to the blood‑pressure and cardiovascular medication groups and is commonly prescribed in Hong Kong for the management of hypertension, angina pectoris, and certain cardiac rhythm disorders. The drug reduces the workload on the heart and lowers arterial pressure by inhibiting the influx of calcium ions into vascular smooth‑muscle and cardiac myocytes. In the local market, Cardizem is available as immediate‑release tablets, extended‑release capsules, and injectable formulations, providing clinicians with flexibility for acute and chronic therapy.

What is Cardizem?

Cardizem is a pharmaceutical product containing the calcium‑channel blocking agent diltiazem. It was originally developed by a multinational pharmaceutical company that retains worldwide marketing rights; the exact manufacturer of the brand‑name product varies across regions. In Hong Kong, Cardizem is distributed by licensed local wholesalers under the supervision of the Department of Health.

Cardizem is the generic version of the original brand name Cardizem®, containing the same active compound diltiazem. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

How Cardizem Works

Diltiazem binds to L‑type calcium channels located on the cell membranes of vascular smooth muscle and the myocardium. By reducing calcium influx, the drug produces two principal effects:

1. Vasodilation – Relaxation of peripheral arteries decreases systemic vascular resistance, leading to lower blood pressure.
2. Negative chronotropic and inotropic actions – Slower heart‑rate conduction through the atrioventricular node and reduced contractility lessen myocardial oxygen demand, which is beneficial in angina.

The onset of action for immediate‑release tablets is typically 30–60 minutes, with a half‑life of 3–5 hours in healthy adults. Extended‑release formulations maintain therapeutic plasma concentrations for 12–24 hours, allowing once‑daily dosing in many patients. Diltiazem is metabolised primarily by hepatic CYP3A4 enzymes and excreted via bile; renal clearance is minor, which influences dosing in hepatic impairment.

Conditions Treated with Cardizem

• Essential Hypertension – High prevalence in Hong Kong (≈30 % of adults) makes blood‑pressure control a public‑health priority. Diltiazem’s vasodilatory effect lowers systolic and diastolic pressures, often in combination with diuretics or ACE inhibitors.
• Chronic Stable Angina – Reduces myocardial oxygen consumption and relieves chest pain during exertion. Clinical trials have demonstrated a 20–30 % reduction in weekly angina episodes compared with placebo.
• Atrial Fibrillation (Rate Control) – Slows ventricular response by acting on the AV node. Diltiazem is recommended by the Hong Kong Society of Cardiology for acute and chronic rate control when beta‑blockers are contraindicated.
• Post‑Myocardial‑Infarction Management – Early initiation of calcium‑channel blockers can improve left‑ventricular remodeling and reduce recurrent ischemic events.

These indications are approved by the Hong Kong Department of Health and listed in the product’s Summary of Product Characteristics (SPC).

Patient Groups Most Likely to Benefit

• Adults with isolated systolic hypertension – Particularly older patients whose arterial stiffness responds well to vasodilators.
• Patients with effort‑induced angina who cannot tolerate high‑dose nitrates – Diltiazem offers a complementary mechanism of action.
• Individuals with atrial fibrillation who have asthma or chronic obstructive pulmonary disease – Calcium‑channel blockers avoid bronchospasm risk associated with non‑selective beta‑blockers.
• Patients requiring combination therapy – Diltiazem can be paired with diuretics, ACE inhibitors, or statins without major pharmacodynamic conflict.

Contra‑indications include severe heart‑failure with reduced ejection fraction, second‑ or third‑degree AV block without a pacemaker, and uncontrolled hepatic disease. Caution is advised in patients on strong CYP3A4 inhibitors (e.g., clarithromycin) due to increased plasma levels.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing or warmth sensation
• Peripheral edema (especially in lower limbs)
• Dizziness, particularly after the first dose (orthostatic hypotension)

Rare

• Gastrointestinal upset (nausea, abdominal pain)
• Skin rash or pruritus
• Hepatic enzyme elevation (ALT, AST)

Serious

• Severe hypotension leading to syncope
• Bradycardia (heart rate < 50 bpm) or AV‑block progression
• Congestive heart‑failure exacerbation (pulmonary edema)
• Life‑threatening allergic reactions (anaphylaxis)

Clinically Relevant Drug–Drug Interactions

• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, grapefruit juice) – Increase diltiazem plasma concentration; may require dose reduction.
• CYP3A4 inducers (e.g., rifampin, carbamazepine) – Decrease plasma levels; may reduce efficacy.
• Beta‑blockers – Additive negative chronotropic effect; monitor heart‑rate and blood pressure.
• Digoxin – Diltiazem can raise digoxin levels by reducing renal clearance; watch for digoxin toxicity.
• Anticoagulants (warfarin) – Potential modest increase in INR; more frequent coagulation monitoring is advisable.

Patients should disclose all concurrent medications, including herbal supplements, to their prescriber.

Practical Use: Dosing, Missed Dose, Overdose

• Immediate‑release tablets: 30 mg to 120 mg taken 2–3 times daily, with each dose spaced at least 6 hours apart.
• Extended‑release capsules: 120 mg to 360 mg once daily, usually taken in the morning with food to minimise gastrointestinal irritation.
• Injectable form: .25 mg/kg administered intravenously over 2 minutes for acute rate control; may be repeated after 15 minutes if required.

Missed dose – If a dose is forgotten, take it as soon as remembered unless it is almost time for the next scheduled dose. Do not double‑dose.

Overdose – Symptoms may include severe hypotension, bradycardia, and cardiac conduction abnormalities. Immediate medical attention is essential. Management includes supportive measures, intravenous fluids, and, if needed, administration of atropine for bradycardia or vasopressors for hypotension.

Precautions – Avoid excessive alcohol which can potentiate hypotensive effects. Food does not markedly affect absorption of the extended‑release formulation but may reduce gastrointestinal discomfort. Patients with hepatic impairment should start at the lower end of the dosing range and be monitored closely.

Buying Cardizem from Our Online Pharmacy

Cardizem can be purchased from our online pharmacy in Hong Kong. Our service offers several advantages for patients seeking reliable access to this medication:

• Affordable pricing – Prices are set close to manufacturer cost, providing significant savings compared with retail pharmacy rates.
• Verified quality – We source products only from reputable overseas licensed pharmacies that comply with Good Manufacturing Practice (GMP) standards.
• Guaranteed delivery – Discreet packaging is shipped via express courier (typically 7 days) or regular airmail (approximately 3 weeks). Tracking information is provided for every order.
• Online‑only convenience – Patients who lack regular pharmacy access, have limited insurance coverage, or prefer privacy can obtain Cardizem without leaving home.

Our platform operates as a pharmacy‑broker service. We partner with internationally licensed suppliers, allowing us to import generic diltiazem under strict regulatory oversight. Every order undergoes a mandatory professional evaluation by an independent, licensed healthcare professional to ensure safety and appropriateness. This model respects patient confidentiality while maintaining high clinical standards.

FAQ

• Is Cardizem covered by the Hong Kong Hospital Authority’s drug formulary?
  The Hospital Authority includes diltiazem in its essential medicines list, but coverage depends on the specific hospital’s procurement policies and the patient’s eligibility for public healthcare subsidies.

• Can Cardizem be used during pregnancy or lactation?
  Diltiazem is classified as pregnancy category C. Limited data suggest it may be used when the therapeutic benefit outweighs potential fetal risk. Breast‑feeding mothers should consult a physician because diltiazem passes into breast milk in small amounts.

• What is the shelf‑life of Cardizem tablets once received?
  Unopened tablets retain full potency for up to 36 months from the date of manufacture, as indicated on the packaging. After opening, store them in a dry, room‑temperature environment and discard after six months.

• Does Cardizem require special storage conditions, such as refrigeration?
  No. Cardizem should be stored at controlled room temperature (15 °C–30 °C), protected from moisture and direct sunlight. Refrigeration is unnecessary and may cause condensation on tablets.

• How does the extended‑release formulation differ from the immediate‑release version?
  Extended‑release capsules release diltiazem gradually over 12–24 hours, allowing once‑daily dosing and smoother plasma concentration curves. Immediate‑release tablets provide rapid absorption, suitable for dose titration or acute symptom control.

• Can Cardizem be imported for personal use without a Hong Kong prescription?
  Importation of prescription‑only medicines for personal use requires a valid local prescription. Our online pharmacy assists by facilitating the professional evaluation step, ensuring compliance with local regulations while providing a streamlined ordering process.

• Are there known differences in diltiazem formulation between the US, EU, and Asian markets?
  The active ingredient and basic pharmacokinetic profile are consistent worldwide. However, excipient composition (binders, fillers) may vary, potentially influencing tolerability in sensitive individuals. Our suppliers use formulations that meet the International Council for Harmonisation (ICH) standards.

• What packaging does Cardizem arrive in when ordered online?
  Cardizem is shipped in tamper‑evident, resealable blister packs or sealed bottles, each labeled with batch number, expiry date, and regulatory compliance statements. The outer packaging is discreet, bearing only the order reference and delivery address.

• Is Cardizem compatible with telemedicine‑based treatment plans?
  Yes. Many telehealth providers in Hong Kong prescribe diltiazem after remote clinical assessment. Our online pharmacy supports this model by delivering the medication promptly after the required professional evaluation.

Glossary

Calcium‑Channel Blocker

A class of drugs that inhibit the influx of calcium ions through L‑type calcium channels, leading to vasodilation and reduced cardiac contractility.

Extended‑Release (XR)

A formulation designed to release the active ingredient slowly over an extended period, allowing less frequent dosing and steadier plasma concentrations.

CYP3A4

An enzyme of the cytochrome P450 family responsible for metabolising many drugs, including diltiazem; inhibitors or inducers of this enzyme can alter drug levels.

AV Node

The atrioventricular node is a cardiac conduction pathway that regulates the timing of electrical signals from the atria to the ventricles; slowing its conduction reduces heart‑rate.

⚠️ Disclaimer

The information provided about Cardizem is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Cardizem for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.