Buy Generic Duphaston Online

Generic Duphaston Information

Introduction

Duphaston is a synthetic progestogen that contains the active compound dydrogesterone. It is classified within the Women’s Health and Birth Control therapeutic groups. In Hong Kong, Duphaston is prescribed for a range of luteal‑phase deficiencies, menstrual disturbances, and for hormone‑replacement therapy (HRT) in post‑menopausal women. Its clinical relevance stems from the need for a progesterone‑only agent that mimics natural progesterone activity without the androgenic side effects associated with some other progestins.

What is Duphaston?

Duphaston is a tablet formulation of dydrogesterone, a micronized, orally active derivative of natural progesterone. The product was originally developed by the pharmaceutical company Abbott (now part of AbbVie) and is marketed in many countries under the brand name Duphaston. Other well‑known brand names that contain the same active ingredient include DuoDren and Dydrogesterone (as a standalone brand). The medication is manufactured according to Good Manufacturing Practice (GMP) standards and is authorized for use in the Hong Kong Special Administrative Region under the Pharmacy and Poisons Ordinance.

How Duphaston Works

Dydrogesterone binds selectively to progesterone receptors in target tissues such as the endometrium, breast, and central nervous system. By activating these receptors, Duphaston reproduces the luteal‑phase actions of endogenous progesterone:

• Endometrial Stabilisation – The drug promotes secretory transformation of the endometrium, creating a receptive environment for embryo implantation and preventing uncontrolled proliferation.
• Inhibition of Gonadotropin Surge – Progesterone feedback reduces the frequency of luteinising hormone (LH) spikes, thereby suppressing premature ovulation in certain therapeutic protocols.
• Anti‑estrogenic Effects – In the breast and uterus, dydrogesterone counteracts estrogen‑driven cell proliferation, which is a key mechanism in HRT and in the management of endometriosis‑related pain.

Pharmacokinetically, oral dydrogesterone is rapidly absorbed, reaching peak plasma concentrations within 1–2 hours. It undergoes extensive hepatic metabolism to inactive metabolites, with an elimination half‑life of approximately 5–7 hours. Steady‑state concentrations are achieved after 2–3 days of consistent dosing.

Conditions Treated with Duphaston

• Luteal‑Phase Deficiency (LPD) – Inadequate endogenous progesterone leads to failed implantation or early miscarriage. Duphaston restores the secretory phase of the menstrual cycle.
• Secondary Amenorrhea & Irregular Menses – Women with absent or irregular periods due to hormonal imbalance benefit from cyclic Duphaston therapy.
• Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD) – Progesterone stabilisation can alleviate mood swings, breast tenderness, and bloating.
• Endometriosis‑Related Pain – By suppressing ectopic endometrial growth, Duphaston reduces pelvic pain and dysmenorrhoea.
• Hormone Replacement Therapy (HRT) – Combined with estrogen, dydrogesterone protects the endometrium in post‑menopausal women, lowering the risk of hyperplasia.
• Assisted Reproductive Technology (ART) – Duphaston is used in controlled ovarian stimulation protocols to support the luteal phase after embryo transfer.

In Hong Kong, prevalence data indicate that menstrual irregularities affect up to 25 % of women of reproductive age, while endometriosis is diagnosed in approximately 1–2 % of the female population. These figures underline the clinical demand for reliable progestogenic agents such as Duphaston.

Patient Groups Most Likely to Benefit

• Women with Confirmed Luteal‑Phase Deficiency – Diagnosed through mid‑luteal progesterone measurement (<10 ng/mL) or recurrent early pregnancy loss.
• Patients Seeking Non‑Androgenic Progesterone – Dydrogesterone exhibits minimal affinity for androgen receptors, making it suitable for women sensitive to androgenic side effects (e.g., acne, hirsutism).
• Post‑menopausal Women Requiring Endometrial Protection – Particularly when combined with oral estradiol for HRT.
• Women undergoing In‑Vitro Fertilisation (IVF) – As part of luteal support after embryo transfer.

Contra‑indications include active thromboembolic disease, known hypersensitivity to dydrogesterone, uncontrolled hypertension, and hormone‑dependent malignancies (e.g., breast cancer). Caution is advised in patients with severe liver disease or a history of cholestasis.

Risks, Side Effects, and Interactions

Common

• Nausea or mild gastrointestinal upset
• Headache or dizziness
• Breast tenderness or swelling
• Fluid retention leading to mild oedema

Rare

• Mood changes (e.g., depression, irritability)
• Skin reactions such as rash or pruritus
• Elevated liver enzymes (transient)

Serious

• Venous thrombo‑embolism (VTE) – rare but reported, especially when combined with estrogen therapy.
• Severe allergic reactions (anaphylaxis) – extremely uncommon.
• Hepatic dysfunction – rare cases of cholestatic hepatitis have been described.

Drug–Drug Interactions

• Anticoagulants (warfarin, DOACs) – Progestogens may enhance the anticoagulant effect; monitor INR or relevant coagulation parameters.
• CYP3A4 Inducers (e.g., rifampicin, carbamazepine) – May reduce plasma concentrations of dydrogesterone, potentially diminishing therapeutic effect.
• Antihistamines and Sedatives – May potentiate dizziness or somnolence.

Patients should inform their physician of all concomitant medications, including over‑the‑counter herbal products such as St. John’s wort, which is a known CYP3A4 inducer.

Practical Use: Dosing, Missed Dose, Overdose

• Standard Regimens –

  • Luteal‑Phase Support / HRT: 10 mg orally once daily, usually taken in the evening.
  • Amenorrhea or PMS: 10 mg daily for 10–14 days per cycle, starting on day 21 of the menstrual cycle or as prescribed.
  • IVF Luteal Support: 10 mg twice daily from the day of embryo transfer for 14 days, then tapered as advised.

• Missed Dose – Take the missed tablet as soon as remembered within 12 hours. If it is close to the time of the next scheduled dose, skip the missed tablet and continue the regular schedule. Do not double‑dose.

• Overdose – Acute overdose of dydrogesterone is unlikely to be life‑threatening. Symptoms may include nausea, vomiting, or severe dizziness. Seek medical attention promptly; supportive care is the mainstay of treatment.

• Precautions –

  • Food does not significantly affect absorption; tablets may be taken with or without meals.
  • Alcohol intake does not alter efficacy but may exacerbate dizziness.
  • Patients with uncontrolled diabetes should monitor glycaemic control, as progesterone can affect insulin sensitivity.

Buying Duphaston from Our Online Pharmacy

Duphaston can be purchased safely from our online pharmacy in Hong Kong. Our service combines several advantages for patients seeking reliable hormone therapy:

• Affordable Pricing – We source Duphaston directly from licensed overseas manufacturers, allowing us to offer prices that approach the manufacturer’s cost.
• Verified Quality – Every batch is inspected by certified pharmacists and comes with a full chain‑of‑custody record, ensuring that the product meets international quality standards.
• Guaranteed Delivery – Discreet, reliable shipping options include express delivery within 7 days for metropolitan Hong Kong addresses, and standard airmail (approximately 3 weeks) for remote locations.
• Online‑Only Access – Our pharmacy broker service collaborates with overseas licensed pharmacies, enabling access to medications that may be unavailable or expensive in local retail outlets.
• Privacy‑Focused – Packaging is unbranded and sent in tamper‑evident envelopes, respecting patient confidentiality throughout the transaction.

Our platform is designed for adults who have a prescription from a qualified Hong Kong clinician but require a more convenient or cost‑effective way to obtain Duphaston. All orders are processed by licensed pharmacists who verify prescription authenticity before dispatch.

FAQ

• Can Duphaston be taken together with oral contraceptive pills?
  Duphaston is a progestogen and is not intended to be combined with combined oral contraceptives. Doing so may increase the risk of hormonal excess and adverse effects. If contraception is required while using Duphaston, a non‑hormonal method or a progestin‑only pill prescribed separately should be considered.

• Is a prescription required to order Duphaston online in Hong Kong?
  Yes. Hong Kong law mandates a valid prescription from a licensed practitioner for any progesterone product, including Duphaston. Our online pharmacy verifies the prescription before processing the order.

• What is the difference between Duphaston and other progesterone brands like Provera?
  Duphaston contains dydrogesterone, a structurally selective progesterone analogue with minimal androgenic activity. Provera (medroxyprogesterone acetate) is a different synthetic progestin that can exhibit more androgenic side effects. The choice depends on the therapeutic goal and patient tolerance.

• Will Duphaston affect my cholesterol levels?
  Short‑term use of dydrogesterone has not been shown to produce clinically significant changes in lipid profiles. Long‑term HRT regimens should be monitored periodically for cholesterol and cardiovascular risk factors.

• Can Duphaston be used during breastfeeding?
  Dydrogesterone passes into breast milk in very low concentrations. While many clinicians consider it compatible with lactation for short periods, the decision should be individualized and discussed with a healthcare professional.

• Are there any dietary restrictions while taking Duphaston?
  No specific foods are known to interfere with the absorption or metabolism of dydrogesterone. Patients should maintain a balanced diet and avoid excessive alcohol, which can exacerbate dizziness.

• What should I do if I experience severe headache while on Duphaston?
  Severe or persistent headache may be a warning sign of vascular complications. Seek immediate medical evaluation, especially if accompanied by visual changes, nausea, or focal neurological symptoms.

• How long can I stay on Duphaston for HRT?
  Duphaston may be used for several years as part of a combined HRT regimen, provided that regular follow‑up assesses cardiovascular, bone, and cancer risk. The duration is individualized based on patient health status.

• Is it safe to travel internationally with Duphaston medication?
  Yes, provided that you carry a copy of the prescription and keep the medication in its original packaging. Some countries may require a doctor’s note; check local regulations before travel.

• Can Duphaston be divided into half‑tablets for dose adjustments?
  The tablets are scored and can be split accurately. However, any dose modification should be directed by a prescriber to ensure therapeutic effectiveness.

• Does Duphaston have any interaction with herbal supplements like black cohosh?
  Black cohosh may have estrogen‑like activity. When combined with Duphaston, it could alter the hormonal balance, potentially diminishing the intended progestogenic effect. Discuss any supplement use with your physician.

Glossary

Progesterone Receptor

A protein inside target cells that binds progesterone or its analogues, triggering cellular responses such as endometrial maturation.

Luteal‑Phase Deficiency

A condition where the corpus luteum fails to produce sufficient progesterone after ovulation, leading to an inadequate secretory endometrium.

Endometrium

The inner lining of the uterus that thickens under estrogen influence and becomes receptive to implantation under progesterone action.

Pharmacokinetics

The study of how a drug is absorbed, distributed, metabolized, and eliminated by the body.

⚠️ Disclaimer

The information provided about Duphaston is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Duphaston for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.