Buy Generic Dydrogesterone Online

Generic Dydrogesterone Information

Introduction

Dydrogesterone is a synthetic progestogen used primarily to treat hormonal disorders related to the female reproductive system. In Hong Kong it is prescribed for luteal‑phase support, infertility associated with progesterone deficiency, and secondary amenorrhoea, among other indications. The active compound, dydrogesterone, belongs to the Women’s Health and Hormones medication groups. It is available as a generic product and is recognized worldwide under brand names such as Duphaston.

What is Dydrogesterone?

Dydrogesterone is the generic version of the original brand Duphaston, containing the same active compound, dydrogesterone. It is a orally active, biologically selective progestogen that mimics the activity of natural progesterone without the androgenic or glucocorticoid side‑effects seen with some other synthetic steroids. The molecule was first synthesized in the 195s by Schering AG (now part of Bayer). Several reputable manufacturers produce the generic form, and our online pharmacy supplies it as a cost‑effective alternative that meets international quality standards.

How Dydrogesterone Works

Dydrogesterone binds to progesterone receptors in the endometrium, cervix, and myometrium. By activating these receptors it induces the secretory transformation of the uterine lining, creating a receptive environment for embryo implantation and maintaining early pregnancy. The drug also suppresses the release of gonadotropin‑releasing hormone (GnRH), reducing luteinising hormone (LH) surges that could disrupt the hormonal cycle. Pharmacokinetic data show rapid absorption after oral administration, with peak plasma concentrations reached within 2 hours. The elimination half‑life is approximately 12–15 hours, allowing once‑ or twice‑daily dosing depending on the clinical indication.

Conditions Treated with Dydrogesterone

• Luteal‑phase support in assisted reproductive technology (ART) – Enhances endometrial receptivity after in‑vitro fertilisation (IVF) or intra‑uterine insemination (IUI).
• Infertility caused by luteal‑phase defect – Corrects progesterone insufficiency that impairs implantation.
• Secondary amenorrhoea and irregular menstrual cycles – Restores regular shedding of the endometrium by providing cyclical progestogenic stimulus.
• Threatened or recurrent miscarriage – Provides hormonal support to sustain early pregnancy when progesterone levels are low.
• Endometriosis‑associated dysmenorrhoea – Reduces ectopic endometrial proliferation and associated pain.

In Hong Kong, infertility affects roughly 1–2 % of women of reproductive age, and ART cycles have increased steadily over the past decade. Dydrogesterone’s proven efficacy and oral route make it a convenient option within local reproductive‑medicine protocols.

Patient Groups Most Likely to Benefit

• Women undergoing IVF, ICSI, or IUI who require luteal‑phase supplementation.
• Patients with documented luteal‑phase insufficiency (e.g., low serum progesterone in the luteal window).
• Women with irregular or absent menstrual periods secondary to hormonal imbalance, provided thyroid and ovarian function have been otherwise evaluated.
• Patients with a history of early pregnancy loss where progesterone deficiency is implicated.
• Women with endometriosis experiencing painful menstrual cycles, when combined with other hormonal therapies.

Contra‑indications include known hypersensitivity to dydrogesterone, active thrombo‑embolic disease, severe liver impairment, and hormone‑dependent malignancies (e.g., breast or endometrial cancer). Use during pregnancy is permitted only when prescribed for luteal support; inadvertent exposure in the first trimester for other indications should be assessed by a specialist.

Risks, Side Effects, and Interactions

Common

• Nausea or mild gastrointestinal discomfort
• Headache or transient dizziness
• Breast tenderness or mild enlargement
• Fluid retention (mild peripheral edema)

Rare

• Mood alterations (e.g., depressive symptoms)
• Skin reactions such as rash or pruritus
• Elevated liver enzymes (monitoring recommended in patients with pre‑existing hepatic disease)

Serious

• Venous thrombo‑embolism (VTE) – rare but documented, especially in patients with additional risk factors (immobility, inherited clotting disorders).
• Severe allergic reaction (anaphylaxis) – signs include airway swelling, hypotension, and urticaria; requires immediate emergency care.
• Hepatic failure – extremely uncommon; manifests as jaundice, dark urine, or markedly raised transaminases.

Drug–drug interactions

• Anticoagulants (e.g., warfarin, direct oral anticoagulants) – progestogens may enhance anticoagulant effect; INR monitoring recommended.
• CYP3A4 inducers (e.g., rifampicin, carbamazepine, St John’s wort) – may reduce dydrogesterone plasma concentrations, potentially diminishing efficacy.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, grapefruit juice) – may increase exposure, raising the risk of side‑effects.
• Anticonvulsants – some may alter hormone levels; careful endocrine monitoring is advised.

Patients should disclose all concomitant medications, herbal supplements, and over‑the‑counter products to their prescriber.

Practical Use: Dosing, Missed Dose, Overdose

• Luteal‑phase support (ART): 10 mg orally twice daily, commencing after oocyte retrieval and continuing until a viable pregnancy is confirmed (typically 10–12 weeks gestation).
• Secondary amenorrhoea: 10 mg once daily for 10‑14 days each cycle, timed to the luteal phase; may be adjusted based on serum progesterone levels.
• Threatened miscarriage: 10 mg twice daily until the end of the first trimester, under specialist supervision.

Missed dose: If a dose is forgotten and the scheduled time is less than 12 hours away, take the missed tablet as soon as remembered; otherwise skip it and resume the regular schedule. Do not double‑dose.

Overdose: Acute overdose is unlikely to be fatal. Symptoms may include severe nausea, vomiting, or dizziness. Seek medical attention promptly; supportive care (e.g., activated charcoal) may be administered in a clinical setting.

Precautions: Take the tablet with water; food does not markedly affect absorption but a light meal may reduce gastrointestinal upset. Avoid alcohol excess, as it can potentiate hepatic strain. Patients with a history of depression, liver disease, or clotting disorders should be evaluated before initiation.

Buying Dydrogesterone from Our Online Pharmacy

Patients residing in Hong Kong can purchase dydrogesterone safely from our online pharmacy. We offer:

• Affordable pricing – generic cost is close to the manufacturer’s supply price, delivering significant savings compared with brand‑name equivalents.
• Verified quality – all batches are sourced from licensed overseas manufacturers that comply with GMP (Good Manufacturing Practice) standards and are inspected by independent third‑party laboratories.
• Guaranteed delivery – discreet packaging, express shipping within 7 days for most orders, and a regular airmail option (~3 weeks) for larger quantities.
• Online‑only access – we specialize in providing international medications that may not be stocked in local community pharmacies, ensuring continuity of care for patients following specialist‑prescribed regimens.

Our service operates as a pharmacy broker, partnering with accredited foreign pharmacies and suppliers. This model enables us to uphold privacy, maintain regulatory compliance, and deliver medicines directly to the patient’s doorstep without the need for an in‑person pharmacy visit.

FAQ

• Can I obtain dydrogesterone without a Hong Kong‑issued prescription?
  Dydrogesterone is a prescription‑only medication in Hong Kong. Our online pharmacy requires a valid prescription from a licensed practitioner before processing the order, in accordance with local regulations.

• Is the generic dydrogesterone chemically identical to the brand‑name Duphaston?
  Yes. The generic version contains the same active molecule, dosage strength, and pharmaceutical grade as Duphaston, ensuring equivalent therapeutic efficacy.

• How should I store dydrogesterone tablets purchased online?
  Store at controlled room temperature (15‑30 °C), away from direct sunlight, moisture, and heat sources. Do not refrigerate unless instructed by the supplier.

• What packaging does the medication arrive in?
  Each order is sealed in tamper‑evident blister packs or bottles, labeled with the product name, strength, batch number, and expiry date. The outer envelope is discreet and unmarked.

• Are there any special considerations for Asian patients taking dydrogesterone?
  Current clinical data do not indicate ethnicity‑specific dosing adjustments. However, clinicians may monitor liver function more closely in populations with a higher prevalence of hepatitis B or C.

• Can I use dydrogesterone as part of a telemedicine treatment plan?
  Yes. Many telehealth providers in Hong Kong prescribe dydrogesterone after a virtual assessment, provided that appropriate investigations (e.g., serum progesterone, ultrasound) have been performed.

• Is there a risk of the medication interacting with traditional Chinese herbal remedies?
  Certain herbs, such as St John’s wort (hypericum) and ginseng, can affect CYP3A4 metabolism and may alter dydrogesterone levels. Patients should disclose all herbal use to their physician.

• What is the typical cost difference between generic dydrogesterone and the brand version in Hong Kong?
  Generic pricing is usually 30‑50 % lower than the branded product, depending on dosage and quantity. Exact figures are displayed on our website during checkout.

• How long does shipping take for international orders to Hong Kong?
  Express delivery generally arrives within 5‑7 business days; standard airmail takes 2‑3 weeks. Tracking information is provided for all shipments.

• Can I return unused tablets if I experience side effects?
  Unopened, undamaged medication may be returned in accordance with our return policy, provided it is within the stipulated period and accompanied by the original receipt.

• Is dydrogesterone safe for use during breastfeeding?
  Limited data suggest minimal transfer into breast milk, but clinicians often weigh the benefit‑risk ratio individually. Women should discuss continuation with their obstetrician or lactation consultant.

• Does dydrogesterone require regular blood monitoring?
  Serum progesterone levels are typically checked at the start of therapy to confirm deficiency; subsequent monitoring is based on clinical response rather than routine laboratory testing.

Glossary

Progestogen

A class of hormones that mimic the activity of natural progesterone, influencing the menstrual cycle, pregnancy, and uterine lining.

Luteal‑phase defect

A condition where the post‑ovulatory phase produces insufficient progesterone, leading to poor endometrial development and potential infertility.

GMP (Good Manufacturing Practice)

International quality standards that ensure pharmaceutical products are consistently produced and controlled according to established guidelines.

⚠️ Disclaimer

The information provided about Dydrogesterone is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Dydrogesterone for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.