Buy Generic Exelon Online

Generic Exelon Information

Introduction

Exelon (Rivastigmine Tartrate) is a cholinesterase inhibitor approved for the treatment of mild to moderate Alzheimer’s disease and Parkinson’s disease dementia. The medication is marketed in Hong Kong for its ability to improve cognition and functional abilities in affected adults. Exelon belongs to the therapeutic groups of general health and Alzheimer’s disease management. It is supplied by several manufacturers, most notably Novartis, and is available in oral capsules and transdermal patches. In Hong Kong, Exelon is prescribed when disease‑modifying therapies are needed to maintain daily living skills and delay functional decline.

What is Exelon?

Exelon is a prescription medication containing the active compound Rivastigmine Tartrate. It is classified as a reversible acetylcholinesterase inhibitor and a pseudo‑irreversible butyrylcholinesterase inhibitor. The drug was developed by Novartis and is marketed worldwide under the brand name Exelon. In addition to the oral capsule formulation (1.5 mg, 3 mg, 4.5 mg, 6 mg), a once‑daily transdermal patch (4.6 mg/24 h, 9.5 mg/24 h) is available for patients who have difficulty swallowing or experience gastrointestinal side effects from the oral route.

Exelon is the generic version of the original brand Rivastigmine‑based products, containing the same active compound Rivastigmine Tartrate. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

How Exelon Works

Rivastigmine Tartrate blocks the activity of acetylcholinesterase and butyrylcholinesterase, enzymes that degrade the neurotransmitter acetylcholine in the central nervous system. By inhibiting these enzymes, Exelon increases the concentration of acetylcholine at synaptic clefts, enhancing cholinergic neurotransmission. Improved cholinergic signaling correlates with better memory, attention, and executive function in patients with Alzheimer’s disease or Parkinson’s disease dementia.

Pharmacokinetic highlights:

• Onset of action: Clinical effects may become apparent within 2–4 weeks of consistent dosing.
• Duration: The drug’s half‑life is approximately 3 hours for oral capsules; the transdermal patch provides a steadier serum level over 24 hours, reducing peak‑trough fluctuations.
• Clearance: Rivastigmine is metabolised primarily by hepatic esterases and eliminated via renal excretion of inactive metabolites. Dose adjustments are required in severe hepatic impairment.

Conditions Treated with Exelon

• Alzheimer’s disease (mild to moderate): Clinical trials have demonstrated that Exelon improves scores on the Alzheimer’s Disease Assessment Scale‑Cognitive (ADAS‑Cog) and global function scales. In Hong Kong, the prevalence of Alzheimer’s disease is rising with an ageing population, creating a clear need for disease‑modifying agents.
• Parkinson’s disease dementia: Rivastigmine is the only cholinesterase inhibitor approved for this indication in many jurisdictions, including Hong Kong. It addresses cognitive deficits that are not adequately managed by dopaminergic therapy alone.
• Off‑label cognitive impairment: Some physicians prescribe Exelon for mixed dementia or severe cognitive decline when standard treatments are insufficient, although such use requires careful monitoring.

Who is Exelon For?

• Adults diagnosed with mild to moderate Alzheimer’s disease: Patients who exhibit measurable decline in memory and daily functioning, confirmed by neuropsychological testing.
• Patients with Parkinson’s disease dementia: Individuals whose cognitive symptoms interfere with motor management or quality of life.
• Patients unable to tolerate oral cholinesterase inhibitors: The transdermal patch offers a convenient alternative for those with severe gastrointestinal upset or dysphagia.
• Contraindications: Exelon should not be used in patients with known hypersensitivity to rivastigmine, severe hepatic impairment (Child‑Pugh class C), or active peptic ulcer disease. Caution is advised in patients with cardiac arrhythmias, as increased vagal tone may precipitate bradycardia.

Risks, Side Effects, and Interactions

Common

• Nausea, vomiting, and loss of appetite
• Diarrhoea or loose stools
• Weight loss (particularly with oral capsules)
• Headache and dizziness

Rare

• Abdominal cramps or gastrointestinal ulceration
• Elevated liver enzymes (transient)
• Cutaneous reactions at the patch site (e.g., erythema, pruritus)

Serious

• Severe bradycardia or heart block, especially in patients on β‑blockers or with pre‑existing conduction disorders
• Syncope or falls related to orthostatic hypotension
• Acute cholinergic crisis (excessive salivation, muscle fasciculations, respiratory distress) – usually due to overdose

Drug–drug interactions

• Anticholinergic agents (e.g., atropine, scopolamine) may blunt the therapeutic effect of Exelon.
• β‑blockers, digoxin, or other agents that lower heart rate can potentiate bradycardia; regular ECG monitoring is recommended.
• Non‑steroidal anti‑inflammatory drugs (NSAIDs) increase the risk of gastrointestinal bleeding when combined with Exelon’s gastrointestinal side effects.
• Acetylcholinesterase inhibitors (e.g., donepezil, galantamine) should not be combined due to additive cholinergic toxicity.

Practical Use: Dosing, Missed Dose, Overdose

• Initial oral dose: 1.5 mg twice daily with food. Dose may be increased every 2–4 weeks to a maximum of 6 mg twice daily, based on tolerability.
• Transdermal patch: Start with a 4.6 mg/24 h patch applied to a clean, hair‑free area of the upper back, chest, or upper arm. After 4 weeks, the dose may be increased to 9.5 mg/24 h if needed. Rotate application sites to avoid skin irritation.
• Missed dose: If a dose is missed for more than 12 hours, skip the missed dose and resume the regular schedule. Do not double‑dose. For the patch, apply a new patch as soon as possible; if more than 12 hours have elapsed, remove the old patch and start a new one.
• Overdose: Symptoms include severe nausea, vomiting, excessive salivation, muscle weakness, and bradycardia. Seek emergency medical care immediately. Gastrointestinal decontamination (activated charcoal) may be considered if presentation is within one hour of ingestion.
• Precautions: Take oral capsules with meals to minimise gastrointestinal upset. Avoid alcohol, which can exacerbate nausea. Patients with renal impairment should be monitored for accumulation of inactive metabolites, though dose adjustment is rarely required.

Buying Exelon from Our Online Pharmacy

Exelon can be purchased directly from our online pharmacy in Hong Kong. Our service offers:

• Affordable pricing: We source generic Rivastigmine Tartrate at near‑manufacturer cost, passing savings to patients.
• Verified quality: All products are obtained from licensed overseas suppliers that meet stringent GMP standards.
• Guaranteed delivery: Discreet packaging with express shipping (≈ 7 days) or regular airmail (≈ 3 weeks). Tracking is provided for every order.
• Online‑only access: Patients who face limited local pharmacy stock or restrictive insurance formularies can obtain Exelon without leaving home.

Our pharmacy operates as a broker service, partnering with internationally accredited pharmacies to ensure a reliable, confidential supply chain. Privacy is protected through encrypted transactions and discreet packaging, respecting the sensitive nature of dementia medication.

FAQ

• Is Exelon available in both capsule and patch formulations?
  Yes, Exelon is marketed as oral capsules (1.5 mg–6 mg per dose) and as a transdermal patch (4.6 mg/24 h or 9.5 mg/24 h). The patch is often preferred for patients with swallowing difficulties or severe gastrointestinal side effects.

• Can the Exelon patch be applied while showering?
  The patch should be applied to clean, dry skin and allowed to adhere for at least 30 minutes before exposure to water. After the initial adhesion period, brief contact with water (e.g., a quick shower) is generally acceptable, but prolonged immersion may reduce patch efficacy.

• What should be done if the Exelon patch falls off prematurely?
  If the patch detaches before the scheduled 24‑hour change, remove any remaining adhesive residue, apply a new patch to a different skin site, and continue the normal dosing schedule. Do not re‑attach the partially detached patch.

• Does Exelon require special storage conditions?
  Both capsules and patches should be stored at room temperature (15 °C–30 °C) away from direct sunlight, moisture, and heat. Do not refrigerate or freeze the medication, as this may affect potency.

• Are there any known differences in formulation between regions?
  The active ingredient, Rivastigmine Tartrate, is identical worldwide. However, excipients such as filler and adhesive polymers may vary between EU, US, and Asian formulations. These differences rarely impact clinical efficacy but may affect tolerability in sensitive individuals.

• Can Exelon be imported for personal use in Hong Kong?
  Personal import of prescription medicines is allowed under Hong Kong customs regulations when the product is for personal use, accompanied by a valid prescription, and the quantity does not exceed a three‑month supply. Our online pharmacy assists with documentation to facilitate lawful import.

• Is there a risk of a positive drug test while taking Exelon?
  Rivastigmine is not screened for in standard occupational drug testing panels. Patients should not experience false‑positive results attributable to Exelon.

• How does age affect Exelon dosing?
  Elderly patients often experience increased sensitivity to cholinergic side effects. Starting doses are typically lower (e.g., 1.5 mg twice daily) with slower titration. Renal and hepatic function should be assessed periodically.

• What is the historical significance of Rivastigmine development?
  Rivastigmine was first synthesized in the 197s by Japanese researchers and later patented by Novartis. It received FDA approval in 200 for Alzheimer’s disease, marking the introduction of a dual cholinesterase inhibitor that offered an alternative to earlier agents such as donepezil.

• How does Exelon compare to other cholinesterase inhibitors in terms of side‑effect profile?
  Compared with donepezil or galantamine, Exelon (particularly the patch) has a lower incidence of gastrointestinal upset but a higher risk of skin irritation at the patch site. The dual inhibition of both acetylcholinesterase and butyrylcholinesterase may provide modestly greater cognitive benefit in some patients, though head‑to‑head trials show comparable efficacy.

Glossary

Acetylcholinesterase Inhibitor

A drug class that blocks the enzyme responsible for breaking down acetylcholine, thereby enhancing cholinergic neurotransmission in the brain.

Butyrylcholinesterase

An enzyme similar to acetylcholinesterase, found in plasma and the central nervous system; inhibition contributes to the overall increase in acetylcholine levels.

Transdermal Patch

A medicated adhesive strip applied to the skin that delivers a controlled dose of drug through the dermal layers into systemic circulation.

Cholinergic Crisis

A potentially life‑threatening condition resulting from excessive acetylcholine activity, characterized by muscarinic (salivation, bronchorrhea) and nicotinic (muscle weakness) symptoms.

⚠️ Disclaimer

The information provided about Exelon is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Exelon for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.