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Malegra Fxt Information
Introduction
Malegra Fxt is a fixed‑dose combination medication that contains the phosphodiesterase‑5 (PDE5) inhibitor sildenafil and the selective serotonin reuptake inhibitor (SSRI) fluoxetine. The product is positioned within the Erectile Disability and Men’s Health therapeutic groups. In Hong Kong, erectile dysfunction (ED) affects an estimated 20 % of adult men, while depressive symptoms and premature ejaculation are also prevalent. Malegra Fxt targets the vascular mechanisms of ED through sildenafil and the central serotonergic pathways that influence sexual arousal and premature ejaculation via fluoxetine, providing a dual‑action approach for men who experience both concerns.
What is Malegra Fxt?
Malegra Fxt is a pharmaceutical preparation that combines two well‑characterised active ingredients:
- Sildenafil – a PDE5 inhibitor that enhances nitric‑oxide‑mediated penile blood flow, leading to an erection sufficient for sexual activity.
- Fluoxetine – an SSRI that modulates central serotonin levels, a mechanism that can delay ejaculation and improve mood‑related aspects of sexual performance.
The formulation is manufactured by a licensed supplier that complies with Good Manufacturing Practices (GMP) and is distributed to Hong Kong through our pharmacy‑broker network. Malegra Fxt is intended for adult male patients who require pharmacological support for erectile dysfunction and, where appropriate, co‑existing premature ejaculation or depressive symptoms that affect sexual health.
How Malegra Fxt Works
Sildenafil component
Sildenafil competitively inhibits the PDE5 enzyme in the corpus cavernosum. By blocking PDE5, cyclic guanosine monophosphate (cGMP) degradation is reduced, allowing nitric oxide–stimulated smooth‑muscle relaxation and increased arterial inflow. The result is an erection that develops within 30–60 minutes after oral intake, lasting up to 4–6 hours depending on dose and individual metabolism.
Fluoxetine component
Fluoxetine increases synaptic serotonin by blocking its reuptake into presynaptic neurons. Elevated central serotonin can prolong the ejaculation latency time and improve mood, thereby enhancing overall sexual satisfaction. Therapeutic steady‑state concentrations are typically reached after 1–2 weeks of daily dosing.
When combined, the two agents act on distinct pathways: sildenafil provides the immediate hemodynamic response necessary for erection, while fluoxetine offers a longer‑term modulatory effect on ejaculation control and psychological factors influencing sexual performance.
Conditions Treated with Malegra Fxt
| Indication | Clinical relevance in Hong Kong | Rationale for using Malegra Fxt |
|---|---|---|
| Erectile Dysfunction (ED) | Prevalence ~20 % among men aged 40‑70; often under‑treated due to stigma or cost. | Sildenafil restores penile blood flow, a first‑line therapy for vascular ED. |
| Premature Ejaculation (PE) with co‑existing ED | Surveys indicate 30 % of men with ED also report PE; combined therapy can address both. | Fluoxetine’s serotonergic effect delays ejaculation; the combination targets both problems simultaneously. |
| Depressive symptoms affecting sexual function | Depression prevalence ~5 % in Hong Kong; SSRIs improve mood but may worsen sexual side effects. | Fluoxetine treats underlying mood disorder while sildenafil mitigates erectile side effects of depression. |
Malegra Fxt is not approved for other indications such as pulmonary hypertension or anxiety disorders. Use outside these approved indications should only occur under specialist supervision.
Suitable Candidates for Malegra Fxt Treatment
- Adult males (≥ 18 years) with a confirmed diagnosis of erectile dysfunction.
- Patients who experience premature ejaculation in conjunction with ED, or who have depressive symptoms that impair sexual performance.
- Individuals who have not responded adequately to monotherapy with either sildenafil or fluoxetine alone.
- Men with stable cardiovascular status (e.g., controlled hypertension, no recent myocardial infarction) who can safely use PDE5 inhibitors.
Contraindications / situations where Malegra Fxt may not be appropriate
- Concomitant use of nitrates (e.g., nitroglycerin) or nitric‑oxide donors, as the combination can cause severe hypotension.
- Severe hepatic impairment (Child‑Pugh class C) due to altered fluoxetine metabolism.
- Known hypersensitivity to either sildenafil or fluoxetine.
- Uncontrolled hypertension (> 170/100 mmHg) or recent cerebrovascular events.
Clinical assessment should confirm that the patient’s benefit–risk profile aligns with the dual‑action therapy.
Risks, Side Effects, and Interactions
Common
- Headache – vasodilatory effect of sildenafil.
- Flushing – mild erythema, typically transient.
- Indigestion or dyspepsia – related to both agents.
- Nasal congestion – due to PDE5 inhibition.
Rare
- Visual disturbances – bluish tint or altered colour perception; usually resolves without intervention.
- Mood changes – anxiety or agitation associated with fluoxetine initiation.
- Priapism – prolonged erection lasting > 4 hours; requires urgent medical attention.
Serious
- Hypotensive episodes – risk amplified when combined with nitrates or potent antihypertensives.
- Serotonin syndrome – rare but possible when fluoxetine is taken with other serotonergic agents (e.g., tramadol, linezolid).
- Cardiac arrhythmia – especially in patients with underlying QT prolongation.
Drug–Drug Interactions
- Nitrates (e.g., isosorbide dinitrate) – absolute contraindication; can cause life‑ threatening hypotension.
- Alpha‑blockers (e.g., tamsulosin) – may potentiate blood pressure lowering; dose titration recommended.
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) – increase sildenafil plasma levels, raise risk of side effects.
- CYP2C19 inhibitors (e.g., fluvoxamine) – raise fluoxetine concentrations, augment serotonin‑related adverse events.
Patients should disclose all current medications, including over‑the‑counter supplements, to their healthcare provider before initiating Malegra Fxt.
Practical Use: Dosing, Missed Dose, Overdose
- Standard dose (typical formulation): each tablet contains 50 mg sildenafil and 20 mg fluoxetine.
- Administration: take one tablet 30–60 minutes before sexual activity. Do not exceed one tablet per 24 hours. For the fluoxetine component, daily dosing may be continued even on days without sexual activity, as clinically indicated.
- Food: a high‑fat meal can delay sildenafil absorption; a light meal is preferred for predictable onset.
- Missed dose: if a dose is forgotten and sexual activity is not planned within the next 12 hours, skip the tablet. Do not double the dose.
- Overdose: symptoms may include severe hypotension, dizziness, prolonged erection, or serotonin‑related effects (agitation, tremor). Seek immediate medical attention; supportive care includes intravenous fluids, blood pressure monitoring, and, if needed, administration of a phosphodiesterase‑5 antagonist antidote (e.g., intravenous fluids only, as no specific antidote exists).
Patients with renal or hepatic impairment should consult a physician for possible dose adjustment.
Buying Malegra Fxt from Our Online Pharmacy
Malegra Fxt can be purchased directly from our online pharmacy in Hong Kong. Our service offers several advantages for patients seeking a reliable and discreet source of this dual‑action medication:
- Affordable pricing – we source the product near manufacturer cost, passing savings to the consumer without compromising quality.
- Verified quality – all batches are supplied by GMP‑certified overseas manufacturers and undergo independent quality testing before dispatch.
- Guaranteed delivery – options include 7‑day express shipping for urgent needs or approximately 3‑week regular airmail for standard orders. Packages are sealed in neutral‑label envelopes to protect privacy.
- Online‑only access – our pharmacy broker model collaborates with licensed overseas pharmacies, enabling patients to obtain international medications that may not be stocked locally.
Our discreet, pharmacy‑broker service respects patient confidentiality while ensuring that Men’s Health treatments are accessible, especially for those with limited options through traditional pharmacies or insurance schemes.
FAQ
-
Is Malegra Fxt available in both brand‑name and generic forms in Hong Kong?
Yes. The original brand formulations of sildenafil (e.g., Viagra) and fluoxetine (e.g., Prozac) are marketed worldwide. Malegra Fxt is offered as a generic combination that contains the same active ingredients at comparable strength, providing a cost‑effective alternative. -
What is the recommended storage condition for Malegra Fxt?
Store the tablets at room temperature (15 °C–30 °C), away from direct sunlight, excess heat, and moisture. Do not keep the product in bathrooms or near kitchen sinks where humidity is high. -
Can I travel with Malegra Fxt on an international flight?
Yes, provided the medication is in its original packaging or a clearly labelled container. Carry a copy of the prescription or a doctor’s note, as some jurisdictions may request documentation for SSRIs and PDE5 inhibitors. -
Does the tablet appearance differ between regions?
Malegra Fxt tablets are typically blue‑capped, round, and imprinted with “50/20” to denote the sildenafil (50 mg) and fluoxetine (20 mg) content. Formulation appearance may vary slightly depending on the overseas supplier, but the active ingredient ratios remain consistent. -
Are there any specific warnings for Asian populations?
Some studies indicate that Asian males may experience enhanced sensitivity to PDE5 inhibitors, potentially leading to a higher incidence of mild hypotension. Starting with a lower dose (e.g., 25 mg sildenafil) is advisable, and dose titration should be guided by a physician. -
Will taking Malegra Fxt affect standard drug testing (e.g., workplace tests)?
Sildenafil is not a prohibited substance in most occupational drug‑testing panels. Fluoxetine, as an SSRI, may be detected in specialized toxicology screens but is generally not flagged in routine workplace tests. -
Can I take Malegra Fxt with alcohol?
Moderate alcohol consumption (≤ 2 standard drinks) typically does not interfere with the efficacy of sildenafil. However, excessive alcohol can impair erection capacity and increase the risk of side effects such as dizziness. Patients are advised to limit intake. -
Is there any difference between the formulation used in the United States versus Europe?
The active ingredient strengths (50 mg sildenafil, 20 mg fluoxetine) are standardized across regions. Minor variations may exist in inactive excipients (e.g., filler agents) to meet local regulatory requirements, but therapeutic performance remains equivalent. -
How long does Malegra Fxt remain stable after the expiry date?
Manufacturers guarantee potency up to the printed expiry date under proper storage conditions. Using the product beyond this date may reduce efficacy and increase the risk of degradation products; therefore, it should be discarded and replaced. -
What are the environmental considerations for disposing of unused tablets?
Unused Malegra Fxt should be disposed of through a pharmacy take‑back program or as directed by local waste‑management authorities. Flushing tablets down the toilet is discouraged due to potential water‑source contamination.
Glossary
- Phosphodiesterase‑5 (PDE5) inhibitor
- A class of drugs that block the enzyme PDE5, preventing the breakdown of cGMP and thereby facilitating penile erection.
- Selective serotonin reuptake inhibitor (SSRI)
- An antidepressant that increases serotonin levels by inhibiting its reabsorption into presynaptic neurons, influencing mood and, in some contexts, ejaculation latency.
- Serotonin syndrome
- A potentially life‑threatening condition caused by excessive serotonergic activity, characterized by agitation, hyperthermia, autonomic instability, and neuromuscular abnormalities.
- Hypotension
- A clinically significant drop in blood pressure, which can cause dizziness, fainting, or shock, especially when vasodilatory agents like sildenafil are combined with other blood‑pressure‑lowering medications.
⚠️ Disclaimer
The information provided about Malegra Fxt is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Malegra Fxt for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
Information about ordering Malegra Fxt in online pharmacy asia
One can buy Malegra Fxt online by accepting the following conditions:- Buyer is above or equal 18 years old;
- Buyer does't have any contraindications to sildenafil, fluoxetine and fully familiar with medication Malegra Fxt;
- No paper instructions about side effect warnings or usage directions are sent with Malegra Fxt medication. They are available online on our website for information purposes only;
- Ordered medication will be shipped in anonymous discreet package without disclosing its content;
Please note we may not guarantee worry free delivery to some countries where strict customs rules may apply. If you have questions please call us or use Live chat. After you place your order we may call you back for verification purposes. We may also call you back if we suspect that there may be a problems with delivery to your country. Please also refer to our FAQ page for more details. Below is a sample list of safe counties in Asia where delivery is usually worry free: Australia, New Zealand, Malaysia, Singapore, Philippines, Indonesia, Thailand, Japan, South Korea, China, Hong Kong, Pacific islands and many others outside of asia.