Buy Generic Motilium Online

Generic Motilium Information

Introduction

Motilium (domperidone) belongs to the Gastro Health group of medicines and is commonly used in Hong Kong to alleviate symptoms of gastrointestinal motility disturbance. The active compound, domperidone, is a dopamine‑D₂ receptor antagonist that enhances gastric emptying and reduces nausea. In addition to its primary indication for functional dyspepsia, Motilium is prescribed for reflux‑related discomfort, chemotherapy‑induced nausea, and as an adjunct in treating certain motility disorders. The drug is marketed by Janssen‑Cilag (a Johnson & Johnson subsidiary) and is listed on the Hong Kong Pharmacy and Poisons Board (PPB) register.

What is Motilium?

Motilium is a tablet formulation that contains 10 mg of domperidone per tablet. It is classified as a peripheral dopamine‑D₂ receptor antagonist used to improve upper gastrointestinal motility. Domperidone was first synthesized in the 197s by Janssen Pharmaceutica and subsequently approved in many jurisdictions for nausea, vomiting, and gastroparesis. In Hong Kong, Motilium is registered as a prescription‑only medication, reflecting the need for professional oversight due to potential cardiac safety concerns.

How Motilium Works

Domperidone blocks dopamine receptors located on the chemoreceptor trigger zone (CTZ) of the medulla and, importantly, on the smooth muscle cells of the gastrointestinal tract. By antagonising D₂ receptors peripherally, the drug:

• Increases the amplitude of gastric contractile waves, accelerating gastric emptying.
• Reduces the sensation of nausea by preventing dopamine‑mediated activation of the CTZ without crossing the blood‑brain barrier in appreciable amounts.

The onset of anti‑nausea effect typically occurs within 30–60 minutes after oral administration, with peak plasma concentrations reached in about 1–2 hours. Domperidone has a half‑life of 7–9 hours and is primarily cleared via hepatic metabolism (CYP3A4). Because it does not significantly affect central dopamine pathways, it carries a lower risk of extrapyramidal side effects than other anti‑emetics such as metoclopramide.

Conditions Treated with Motilium

• Functional dyspepsia – characterized by early satiety, bloating, and upper abdominal discomfort. Improved gastric emptying relieves these symptoms in up to 70 % of patients in randomized trials.
• Gastro‑oesophageal reflux disease (GERD) – domperidone reduces transient lower oesophageal sphincter relaxations, decreasing reflux episodes.
• Gastroparesis – delayed gastric emptying, often secondary to diabetes or postoperative states, responds to domperidone’s pro‑kinetic action.
• Chemotherapy‑induced nausea and vomiting (CINV) – used as an adjunct to 5‑HT₃ antagonists for delayed CINV when dopamine‑mediated pathways predominate.
• Post‑operative nausea – single‑dose administration before anaesthesia emergence can lower incidence of nausea.

In Hong Kong, the prevalence of functional dyspepsia is estimated at 15–20 % of adults, making Motilium a frequently prescribed option in gastroenterology clinics.

Who is Motilium For?

Motilium is appropriate for adult patients who experience:

• Persistent upper‑GI symptoms (e.g., nausea, bloating, early satiety) that are not explained by structural disease.
• Documented delayed gastric emptying on scintigraphic or breath‑test assessment.
• CINV that persists beyond the acute phase despite standard anti‑emetic regimens.

Contra‑indications – Motilium should be avoided in individuals with known prolonged QT interval, severe hepatic impairment, or concurrent use of potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin). Caution is advised in patients over 65 years of age because age‑related cardiac risk may be heightened.

Risks, Side Effects, and Interactions

Common

• Dry mouth – due to decreased salivary secretion.
• Headache – mild, transient, usually resolves without intervention.
• Abdominal cramps – related to increased motility.

Rare

• Elevated prolactin levels – may cause galactorrhoea or menstrual irregularities in women.
• Extrapyramidal symptoms – extremely uncommon because domperidone does not cross the blood‑brain barrier appreciably.

Serious

• Cardiac arrhythmias – QT‑interval prolongation leading to torsades de pointes, especially when combined with other QT‑prolonging agents or in patients with electrolyte disturbances.
• Severe hepatic injury – rare cases of hepatitis reported; monitor liver function in long‑term therapy.

Clinically Relevant Interactions

• CYP3A4 inhibitors (ketoconazole, clarithromycin, itraconazole) – increase domperidone plasma concentrations, raising cardiac risk.
• CYP3A4 inducers (rifampicin, carbamazepine) – may reduce efficacy.
• Anticholinergics – may counteract pro‑kinetic effect.
• Other QT‑prolonging drugs (macrolide antibiotics, fluoroquinolones, anti‑arrhythmics) – additive risk of arrhythmia.

Patients should disclose all concurrent medications, including over‑the‑counter products and herbal supplements such as St John’s wort.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dose – 10 mg taken 30 minutes before meals, up to three times daily (maximum 30 mg per day). For CINV, a single 10 mg dose may be administered every 8 hours.
• Renal or hepatic impairment – dose reduction to 5 mg two to three times daily is recommended.
• Missed dose – take the forgotten dose as soon as remembered unless the next scheduled dose is within 4 hours; in that case, skip the missed dose and resume the regular schedule. Do not double‑dose.
• Overdose – symptoms may include severe nausea, vomiting, dizziness, or cardiac arrhythmia. Immediate medical attention is essential; supportive care and cardiac monitoring are the mainstays of treatment.

Precautions – avoid alcohol, as it can exacerbate gastric irritation. Take domperidone with a full glass of water; food does not markedly affect absorption, but taking it before meals maximises pro‑kinetic benefit.

Buying Motilium from Our Online Pharmacy

Motilium can be obtained safely from our online pharmacy in Hong Kong. We source the medication from licensed international wholesalers who meet Good Manufacturing Practice (GMP) standards, ensuring product authenticity and potency.

• Affordable pricing – our cost structure mirrors manufacturer pricing, providing a lower out‑of‑pocket expense compared with many brick‑and‑mortar pharmacies.
• Verified quality – each batch undergoes third‑party testing for active ingredient content, dissolution, and impurity profile.
• Guaranteed delivery – discreet packaging with express shipping (typically 7 days) or regular airmail (~3 weeks) to any Hong Kong address.
• Pharmacy‑broker model – we act as a broker between overseas licensed pharmacies and Hong Kong customers, preserving privacy and facilitating access to medications that may have limited local availability.

Our platform is designed for patients who need a reliable, confidential, and cost‑effective way to obtain Motilium without compromising safety.

FAQ

• Is Motilium available in both tablet and liquid formulations?
  Motilium is marketed primarily as 10 mg tablets. A liquid suspension is not commercially available in Hong Kong, although some overseas suppliers may offer compounded preparations for patients who have difficulty swallowing tablets.

• Can Motilium be stored in a refrigerator?
  The medication should be kept at room temperature (20 °C–25 °C). Refrigeration is unnecessary and may cause condensation that could affect tablet integrity.

• What does the imprint on a Motilium tablet look like?
  Standard 10 mg domperidone tablets carry the imprint “10 DOM” on one side and are white, round, film‑coated tablets. Appearance may vary slightly between manufacturers.

• Does Motilium cross the blood‑brain barrier?
  Domperidone has limited ability to cross the blood‑brain barrier, which is why it produces fewer central nervous system side effects compared with other dopamine antagonists.

• Are there special import restrictions for Motilium in Hong Kong?
  Personal import of prescription medicines in quantities not exceeding a 30‑day supply requires a valid prescription and declaration to customs. Importing larger amounts without proper authorization may be prohibited.

• How does domperidone differ from metoclopramide?
  Both are pro‑kinetic agents, but domperidone acts peripherally with minimal central activity, whereas metoclopramide penetrates the CNS and carries a higher risk of extrapyramidal effects.

• What is the earliest age for using Motilium?
  The drug is approved for adult use only; pediatric dosing has not been established, and safety in children remains uncertain.

• Can taking domperidone affect hormone tests?
  Domperidone can raise prolactin levels modestly, which may influence laboratory assessments of pituitary function or cause mild galactorrhoea.

• Is there a known interaction between Motilium and grapefruit juice?
  Grapefruit juice inhibits CYP3A4, potentially increasing domperidone concentrations and the risk of QT prolongation. Patients should avoid large amounts of grapefruit while on the medication.

• What are the most common reasons for discontinuing Motilium?
  Patients often stop therapy due to side effects such as dry mouth, headache, or concerns about cardiac safety after receiving appropriate counseling.

Glossary

Dopamine‑D₂ receptor antagonist

A drug that blocks dopamine binding at D₂ receptors, reducing dopamine‑mediated effects such as nausea and slowing of gastrointestinal motility.

QT interval

A measurement on an electrocardiogram that reflects the time for ventricular depolarisation andolarisation; prolongation can predispose to dangerous heart rhythms.

CYP3A4

An enzyme in the liver responsible for metabolising many drugs; inhibitors raise the level of drugs processed by this pathway, while inducers lower it.

Prokinetic

An agent that enhances gastrointestinal motility, facilitating the movement of food through the stomach and intestines.

⚠️ Disclaimer

The information provided about Motilium is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Motilium for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.