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Generic P Force Information
Introduction
P Force is a oral medication whose therapeutic purpose is the treatment of erectile dysfunction (ED) in adult men. The product contains the active pharmaceutical ingredient sildenafil, a phosphodiesterase‑type 5 (PDE5) inhibitor that belongs to the men’s‑health drug group. In Hong Kong, sildenafil‑containing medicines are prescribed for men who have difficulty achieving or maintaining a penile erection sufficient for satisfactory sexual activity. P Force is marketed by a licensed pharmaceutical company that conforms to the regulatory standards set by the Hong Kong Department of Health and the Pharmaceutical Validation Board.
What is P Force?
P Force is a generic formulation of sildenafil, the same active compound that underlies well‑known brand‑name products such as Viagra®, Revatio® and Revif‑C®. The tablets are developed to contain a precisely measured amount of sildenafil citrate and are produced under Good Manufacturing Practice (GMP) conditions. Our online pharmacy supplies this generic alternative as a cost‑effective treatment option for men who meet the clinical criteria for ED therapy.
How P Force Works
Sildenafil exerts its effect by reversibly inhibiting the enzyme PDE5, which is responsible for the breakdown of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. During sexual stimulation, nitric oxide (NO) is released from endothelial cells and activates guanylate cyclase, increasing cGMP levels. Elevated cGMP causes smooth‑muscle relaxation, augmented inflow of arterial blood into the penile shafts and an erection. By blocking PDE5, sildenafil prolongs the cG‑MP‑mediated vasodilation, thereby facilitating the erection process. The drug does not trigger an erection in the absence of sexual arousal.
Pharmacokinetic features relevant for clinical use include:
- Onset of action: 30–60 minutes after oral intake.
- Peak plasma concentration: 1 hour (tablet taken with a light meal) to 2 hours (taken with a heavy‑fatty meal).
- Terminal half‑life: Approximately 4 hours, allowing a therapeutic window that typically covers night‑time sexual activity.
- Metabolism: Primarily hepatic via cytochrome P450 3A4 (CYP3A4); renal excretion of inactive metabolites.
Conditions Treated with P Force
| Approved indication | Clinical relevance in Hong Kong |
|---|---|
| Erectile dysfunction (ED) | Population‑based surveys estimate a prevalence of 8–12 % among Hong Kong men aged 40 years and older. Vascular, neurogenic, psychogenic and drug‑induced forms of ED are all responsive to PDE5 inhibition when appropriately evaluated. |
| Pulmonary arterial hypertension (PAH) (off‑label) | Although sildenafil is licensed for PAH under the brand name Revatio®, the indication remains off‑label for the P Force formulation in Hong Kong. Use is restricted to specialist‑prescribed settings. |
ED is the principal therapeutic target; the medication improves endothelial function, penile blood flow and the psycho‑sexual experience, thereby enhancing quality of life and relational satisfaction.
Suitable Candidates for P Force Treatment
P Force is appropriate for adult men who:
- Have a confirmed diagnosis of erectile dysfunction after clinical assessment and, where necessary, objective testing (e.g., nocturnal penile tumescence).
- Possess stable cardiovascular status: no recent (< 3 months) myocardial infarction, unstable angina, severe aortic stenosis, or uncontrolled arrhythmia.
- Are not taking contraindicated concomitant drugs such as nitrates, alpha‑blockers (in high doses), or potent CYP3A4 inhibitors (e.g., ritonavir, clarithromycin) without specialist advice.
- Can adhere to the dosing schedule (typically 25 – 100 mg per dose, not exceeding one dose per 24 hours).
- Have no known hypersensitivity to sildenafil or any tablet excipients.
Patients in whom P Force is not appropriate include:
- Men with severe renal or hepatic impairment where dose reduction is not feasible.
- Individuals with a history of non‑arteritic anterior ischemic optic neuropathy (NAION) or severe visual impairment.
- Those with significant hypotension (systolic < 90 mm Hg) or uncontrolled hypertension (> 180/110 mm Hg).
- Patients on recreational “popping” of nitrates (e.g., nitroglycerin for angina) or requiring immediate vasodilator therapy.
Risks, Side Effects, and Interactions
Common adverse events
- Flushing – warmth and redness of the face or upper chest, usually transient.
- Headache – mild to moderate, often responds to simple analgesics.
- Indigestion (dyspepsia) – may be alleviated by taking the tablet with food.
- Nasal congestion – reversible after discontinuation.
Rare adverse events
- Myalgia – muscle pain, occasionally associated with back pain; resolves with dose adjustment.
- Visual disturbances – blurred vision or altered colour perception (rare, usually reversible).
- Priapism – prolonged erection lasting > 4 hours; requires emergency medical attention.
Serious adverse events
- Hypotension – clinically significant fall in blood pressure when combined with nitrates or high‑dose alpha‑blockers; may lead to syncope or shock.
- Cardiovascular events – myocardial infarction, stroke or sudden cardiac death in patients with high baseline risk; causality is often multifactorial.
- Severe allergic reactions – angioedema, anaphylaxis; immediate discontinuation and medical treatment are mandatory.
Clinically relevant drug–drug interactions
- Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Concomitant use can cause profound vasodilation and hypotension; contraindicated.
- Alpha‑blockers (e.g., doxazosin, tamsulosin): Combined use may precipitate symptomatic hypotension; if co‑administration is medically necessary, dosing must be staggered and blood pressure closely monitored.
- CYP3A4 inhibitors (e.g., ketoconazole, macrolide antibiotics, certain antiretrovirals): Elevate sildenafil plasma levels, increasing the risk of toxicity; dose reduction or avoidance is advised.
- CYP3A4 inducers (e.g., rifampin, carbamazepine, St. John’s wort): May lower sildenafil exposure, potentially reducing efficacy.
Practical Use: Dosing, Missed Dose, Overdose
- Typical starting dose: 25 mg taken orally about one hour before anticipated sexual activity. Dose titration to 50 mg or 100 mg is based on efficacy and tolerability; the maximum recommended dose is 100 mg per 24‑hour period.
- Administration with food: Sildenafil absorption is decreased by a high‑fat meal; for maximal effect, tablets may be taken with a light meal or on an empty stomach.
- Missed dose: If the effect is absent after a dose, a second dose within the same 24‑hour period must not be taken. Instead, wait for the next scheduled dose.
- Overdose management: Acute overdose can lead to marked hypotension, severe headache, vision changes, or prolonged erection. If overdose is suspected, seek immediate medical assistance; symptomatic treatment with intravenous fluids and vasopressors may be required under clinical supervision.
- Alcohol and tobacco: Moderate alcohol consumption does not significantly affect efficacy, but excessive intake can potentiate vasodilatory effects. Smoking may impair endothelial function and reduce overall response to PDE5 inhibition.
Buying P Force from Our Online Pharmacy
P Force can be purchased from our online pharmacy in Hong Kong. The service offers:
- Affordable pricing – Generics are sourced at near‑manufacturer cost, providing a lower purchase price than branded alternatives.
- Verified quality – All products are obtained from certified overseas suppliers that meet international pharmacopeial standards.
- Guaranteed delivery – Discreet, reliable shipping is provided; express parcels arrive within 7 days, while standard airmail may take up to 3 weeks.
- Pharmacy‑broker model – We collaborate with licensed overseas pharmacies and suppliers, enabling a discreet service that respects patient privacy while complying with Hong Kong import regulations.
Patients who face limited access to regular pharmacies or whose insurance schemes restrict brand‑name coverage may find the generic option a practical solution.
FAQ
-
Is P Force available in both brand‑name and generic forms in Hong Kong?
Yes. The active ingredient, sildenafil, is marketed under brand names such as Viagra® and Revatio®, while generic formulations like P Force contain the same molecule at comparable strength, typically at a lower price point. -
What is the recommended storage condition for P Force tablets?
Store at room temperature (15 °C – 30 °C), away from moisture, heat, and direct sunlight. Do not keep the medication in a bathroom or near a kitchen sink to avoid humidity‑related degradation. -
Does P Force require cold‑chain transportation when imported?
No. Sildenafil tablets are stable at ambient temperatures and do not need refrigerated shipping. Our online pharmacy uses standard packaging that protects the tablets from excess heat and moisture. -
How many tablets are provided per package when ordered through our online pharmacy?
Packages are dispatched in blister packs containing 30 individual tablets, each bearing the dose strength indicated on the label (e.g., 25 mg, 50 mg or 100 mg). -
Can P Force be safely imported for personal use under Hong Kong regulations?
Personal import of a single‑supply of sildenafil‑containing medicines for personal use is allowed, provided the product is declared and the recipient holds a valid prescription from a Hong Kong‑registered clinician. Our pharmacy ensures that all shipments comply with relevant customs requirements. -
Are there specific warnings for Asian patients taking sildenafil?
Pharmacokinetic studies show that Asian populations may have slightly higher plasma concentrations at equivalent doses. Clinicians often start with 25 mg and titrate carefully, monitoring for hypotension or visual changes. -
Does the formulation of P Force differ between regions such as the EU, US, and Asia?
The active ingredient (sildenafil citrate) is identical worldwide, but excipients like fillers, binders, or lubricants may vary according to local regulatory specifications. However, bioequivalence is confirmed through standardized testing. -
What is the half‑life of sildenafil and its relevance to dosing intervals?
The average terminal half‑life is about 4 hours. Because efficacy persists for up to 4–5 hours after ingestion, dosing more than once per 24 hours is unnecessary and may increase the risk of adverse events. -
How does sildenafil interact with common recreational drugs?
Combining sildenafil with nitrates (e.g., “popping” nitroglycerin for chest pain) can cause dangerous hypotension. Caution is also advised with illicit use of certain SSRIs or recreational stimulants that may affect cardiovascular dynamics. -
Is there any difference in onset time when sildenafil is taken with a high‑fat meal?
A high‑fat meal can delay absorption, extending the onset from 30 minutes to up to 90 minutes. For the most reliable effect, patients are advised to take the tablet with a light meal or on an empty stomach. -
What clinical trials established the efficacy of sildenafil for erectile dysfunction?
Pivotal phase III studies conducted in the late‑199s, involving > 3,000 men with various etiologies of ED, demonstrated statistically significant improvement in the International Index of Erectile Function (IIEF) scores compared with placebo. These data supported the regulatory approval of sildenafil for ED worldwide.
Glossary
- Phosphodiesterase‑type 5 (PDE5) inhibitor
- A class of drugs that block the PDE5 enzyme, preventing the breakdown of cGMP and thereby promoting smooth‑muscle relaxation in the penis.
- cGMP (Cyclic guanosine monophosphate)
- A secondary messenger that mediates vasodilation in response to nitric oxide, essential for the erection process.
- Bioequivalence
- A designation indicating that two drug products release the same amount of active ingredient into the bloodstream at comparable rates and extents.
- Hypotension
- An abnormally low blood‑pressure reading (generally systolic < 90 mm Hg) that can lead to dizziness, fainting, or shock.
Disclaimer
The information provided about P Force is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to P Force for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
Information about ordering Generic P Force in online pharmacy asia
Please note that this medicine is a generic version of P Force.One can buy Generic P Force online by accepting the following conditions:
- Buyer is above or equal 18 years old;
- Buyer does't have any contraindications to sildenafil and fully familiar with medication P Force;
- No paper instructions about side effect warnings or usage directions are sent with Generic P Force medication. They are available online on our website for information purposes only;
- Ordered medication will be shipped in anonymous discreet package without disclosing its content;
Please note we may not guarantee worry free delivery to some countries where strict customs rules may apply. If you have questions please call us or use Live chat. After you place your order we may call you back for verification purposes. We may also call you back if we suspect that there may be a problems with delivery to your country. Please also refer to our FAQ page for more details. Below is a sample list of safe counties in Asia where delivery is usually worry free: Australia, New Zealand, Malaysia, Singapore, Philippines, Indonesia, Thailand, Japan, South Korea, China, Hong Kong, Pacific islands and many others outside of asia.