Buy Generic Periactin Online

Generic Periactin Information

Introduction

Periactin is a prescription‑only medication whose active ingredient is cyproheptadine, an antihistamine classified within the first‑generation H1‑receptor antagonists. In Hong Kong the drug is listed under the “Allergy” therapeutic group and is commonly used to relieve symptoms of allergic rhinitis, urticaria, and other histamine‑mediated conditions. Cyproheptadine also possesses antiserotonergic activity, which extends its clinical utility to appetite stimulation and the management of certain serotonin‑related disorders. The medication is marketed by several multinational manufacturers; in many regions the brand name Periactin is recognized alongside other trade names such as Cyproheptadin and Serevent‑C.

What is Periactin?

Periactin is a tablet formulation that contains cyproheptadine hydrochloride as its sole active pharmaceutical ingredient. It belongs to the first‑generation antihistamine class, a group developed in the 195s to block H1 histamine receptors in peripheral tissues. The drug is produced by several licensed pharmaceutical firms; the most widely distributed brand in the United States and Europe is marketed by Schering‑Plough (now part of Merck & Co.). In Hong Kong the same formulation is imported under the Periactin label and is listed in the Department of Health’s Medicines Register.

Cyproheptadine’s pharmacological profile includes:

• Strong antagonism of H1‑histamine receptors, reducing vascular permeability and itch.
• Antagonism of peripheral serotonin (5‑HT2) receptors, accounting for its appetite‑stimulating effects.
• Mild anticholinergic activity, which may produce sedation in some patients.

How Periactin Works

Cyproheptadine competitively binds to the H1 histamine receptor on mast cells, basophils, and vascular endothelial cells. By preventing histamine from activating these receptors, the drug limits the cascade that leads to vasodilation, edema, and pruritus. The antiserotonergic effect is mediated through blockade of the 5‑HT2 receptor subtype, decreasing serotonergic stimulation of the hypothalamic appetite centre and mitigating serotonin‑induced gastrointestinal hypermotility.

On oral administration, cyproheptadine is absorbed rapidly from the gastrointestinal tract. Peak plasma concentrations are typically reached within 1–2 hours, and the drug’s elimination half‑life ranges from 8 to 12 hours in healthy adults. This pharmacokinetic profile supports once‑ or twice‑daily dosing, depending on the indication and patient tolerance. The drug is extensively metabolized by hepatic cytochrome P450 enzymes (primarily CYP2D6) and excreted mainly in the urine as inactive metabolites.

Conditions Treated with Periactin

• Allergic Rhinitis – Seasonal or perennial nasal congestion, sneezing, and watery discharge are attenuated by H1 blockade.
• Urticaria (Hives) – Red, raised wheals and itching respond to cyproheptadine’s antihistaminic action.
• Dermatologic Pruritus – Chronic itch of unknown origin often improves with first‑generation antihistamines.
• Appetite Stimulation – In patients with weight loss due to chronic illness (e.g., cancer, cystic fibrosis), the antiserotonergic effect promotes increased caloric intake.
• Serotonin Syndrome Adjunct – Although not a first‑line therapy, cyproheptadine may be used off‑label to counteract excess serotonergic activity in severe cases.

In Hong Kong, allergic rhinitis prevalence approaches 20 % of the adult population, driven by high pollen counts and indoor allergens. Urticaria accounts for a significant proportion of dermatology visits, making cyproheptadine a valuable therapeutic option for primary‑care physicians and allergists.

Who is Periactin For?

• Adults with moderate to severe allergic rhinitis unresponsive to intranasal corticosteroids or saline irrigation.
• Patients experiencing persistent urticaria despite avoidance of known triggers.
• Individuals with clinically documented appetite loss where nutritional support alone has been insufficient.
• Adults requiring an antiserotonergic adjunct in controlled settings (e.g., confirmed serotonin syndrome).

Contraindications include known hypersensitivity to cyproheptadine or any excipients, severe hepatic impairment, and concurrent use of monoamine‑oxidase inhibitors (MAOIs). Caution is advised in the elderly, patients with narrow-angle glaucoma, and those with a history of cardiac arrhythmia.

Risks, Side Effects, and Interactions

Common

• Drowsiness or sedation
• Dry mouth, throat, or nasal passages
• Dizziness or light‑headedness, especially when standing quickly
• Increased appetite and mild weight gain

Rare

• Visual disturbances (blurred vision, photophobia)
• Urinary retention, particularly in men with prostatic hypertrophy
• Exacerbation of asthma symptoms due to anticholinergic effects

Serious

• Severe allergic reaction (anaphylaxis) – rare but possible
• Cardiac arrhythmias (QT prolongation) in patients with pre‑existing conduction disorders
• Hepatotoxicity – isolated case reports of elevated liver enzymes

Drug‑Drug Interactions

• MAO inhibitors (e.g., phenelzine, selegiline): potentiation of serotonergic effects may precipitate serotonin syndrome.
• CNS depressants (benzodiazepines, opioids, alcohol): additive sedation and impaired psychomotor performance.
• CYP2D6 inhibitors (e.g., fluoxetine, quinidine): may increase cyproheptadine plasma concentrations, heightening adverse‑event risk.
• Anticholinergic agents (e.g., diphenhydramine, atropine): combined anticholinergic load can exacerbate dry mouth, constipation, and urinary retention.

Patients should disclose all over‑the‑counter products, herbal supplements, and prescription medicines to their healthcare provider before initiating Periactin.

Practical Use: Dosing, Missed Dose, Overdose

• Standard adult dose for allergic rhinitis or urticaria: 4 mg (one tablet) taken once daily at bedtime; some clinicians increase to 4 mg twice daily if symptoms persist.
• Appetite stimulation dose: 4 mg taken in the morning, often combined with a second 4 mg dose at night, not to exceed 12 mg per day.

Missed dose: If a dose is forgotten within 12 hours, it may be taken as soon as remembered. If the scheduled time for the next dose is near, skip the missed tablet to avoid double dosing.

Overdose: Acute ingestion of more than 30 mg may cause marked sedation, hypotension, and anticholinergic toxicity. Immediate medical attention is required; supportive care includes airway protection, monitoring of vital signs, and activated charcoal if presentation is early.

Precautions:

• Take with food or a full glass of water to minimize gastrointestinal irritation.
• Avoid alcohol and other sedating substances while on therapy.
• Patients with hepatic or renal impairment should start at the lower end of the dosing range and be monitored closely.

Buying Periactin from Our Online Pharmacy

Periactin can be obtained safely from our online pharmacy in Hong Kong. We source the medication from licensed overseas manufacturers who comply with Good Manufacturing Practice (GMP) standards, ensuring that each tablet meets the same quality specifications as those sold in regulated markets.

Key advantages of purchasing through our platform include:

• Affordability – Prices are set close to the manufacturer’s cost, offering a substantial saving compared with local retail outlets.
• Verified Quality – Every batch undergoes third‑party laboratory testing for potency, purity, and contaminants before dispatch.
• Reliable Delivery – Discreet packaging is shipped via express courier (typically 5–7 business days) or regular airmail (approximately 3 weeks), with tracking available for all orders.
• Online‑Only Access – Our pharmacy broker service collaborates with overseas licensed pharmacies, enabling patients who face limited local supply or insurance restrictions to obtain the medication without compromising privacy.

We adhere to Hong Kong’s import regulations for personal use, providing clear guidance on permissible quantities and customs documentation.

FAQ

• Is Periactin available in both brand‑name and generic forms in Hong Kong?
  Yes. The original brand name is Periactin, but generic cyproheptadine tablets are also approved and marketed. Generic versions contain the identical active ingredient and are typically less expensive.

• Does Periactin require refrigeration or special temperature control?
  No. Periactin tablets should be stored at room temperature (15 °C to 30 °C), protected from excessive heat, moisture, and direct sunlight.

• What does the packaging of Periactin look like when ordered online?
  Tablets are supplied in a blister pack inside a sealed cardboard box. Each blister contains 10 mg tablets, and the outer box displays the product name, batch number, expiry date, and a tamper‑evident seal.

• Can Periactin be imported for personal use without a prescription in Hong Kong?
  Personal import of prescription medicines requires a valid prescription from a licensed practitioner. Import without documentation may be seized by customs.

• Are there specific warnings for Asian populations taking cyproheptadine?
  Studies indicate a slightly higher prevalence of CYP2D6 poor metabolizer phenotypes in some Asian groups, which can lead to increased plasma levels and a greater risk of sedation. Dose adjustment may be considered under medical supervision.

• How does cyproheptadine differ from newer second‑generation antihistamines?
  Unlike second‑generation agents (e.g., cetirizine, loratadine), cyproheptadine crosses the blood‑brain barrier more readily, producing sedation and anticholinergic effects. However, its additional serotonin antagonism makes it useful for appetite stimulation and serotonin syndrome adjunct therapy.

• Is it safe to travel internationally with Periactin?
  Yes, provided the medication is kept in its original labeled container, accompanied by a copy of the prescription, and declared if required by the destination country’s customs regulations.

• What are the inactive ingredients in Periactin tablets?
  Common excipients include lactose monohydrate, microcrystalline cellulose, magnesium stearate, and talc. Patients with severe lactose intolerance should verify the formulation with the supplier.

• Does cyproheptadine affect drug testing for employment or sports?
  Cyproheptadine is not listed as a prohibited substance by major anti‑doping agencies, but its sedative properties may be noted in clinical toxicology screens.

• Can Periactin be taken with herbal supplements such as St. John’s wort?
  St. John’s wort induces CYP3A4 and may reduce cyproheptadine plasma concentrations, potentially diminishing therapeutic effect. Patients should discuss any herbal product use with their healthcare provider.

• What is the shelf life of Periactin tablets after they are received?
  The manufacturer assigns a 24‑month expiry date from the date of production. Patients should avoid using tablets past this date, even if stored correctly.

Glossary

First‑Generation Antihistamine

A class of H1‑receptor blockers that can cross the blood‑brain barrier, often causing sedation and anticholinergic side effects.

Antiserotonergic Activity

The ability of a drug to block serotonin receptors (particularly 5‑HT2), which can influence appetite, mood, and vascular tone.

Cytochrome P450 (CYP) Enzyme

A family of liver enzymes responsible for metabolizing many drugs; variations can affect drug concentrations and adverse‑event risk.

Half‑Life

The time required for the plasma concentration of a drug to decrease by 50 %; influences dosing frequency.

⚠️ Disclaimer

The information provided about Periactin is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Periactin for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.