Buy Generic Revatio Online

Generic Revatio Information

Introduction

Revatio is a prescription medication that contains the phosphodiesterase‑5 (PDE‑5) inhibitor sildenafil. Although best known for erectile‑dysfunction treatment under other brand names, Revatio is approved for the management of pulmonary arterial hypertension (PAH) and, in some jurisdictions, for certain forms of heart failure. In Hong Kong, the drug is listed on the Hospital Authority formulary for PAH and can be obtained through licensed pharmacies. The active compound, sildenafil, belongs to the broader Erectile Dysfunction and Men’s Health medication group.

What is Revatio?

Revatio is a tablet formulation that delivers a fixed dose of sildenafil citrate. It was originally developed by Pfizer and received regulatory approval for pulmonary arterial hypertension in the early 200s. The product is marketed under the Revatio brand name worldwide, while the same active ingredient is sold as Viagra, Revatio, or generic sildenafil in other markets.

Revatio is the generic version of the original brand‑name medication that contains the same active compound sildenafil. Our online pharmacy provides this generic alternative as a cost‑effective treatment option.

How Revatio Works

Sildenafil selectively inhibits the enzyme phosphodiesterase‑5 (PDE‑5). In the pulmonary vasculature, PDE‑5 breaks down cyclic guanosine monophosphate (cGMP), a messenger that relaxes smooth muscle. By blocking PDE‑5, Revatio increases cGMP levels, leading to:

1. Vasodilation of pulmonary arteries – reduces pulmonary vascular resistance and lowers mean pulmonary artery pressure.
2. Improved right‑ventricular output – the heart pumps more efficiently against a lower afterload.

The onset of clinical effect typically occurs within 30–60 minutes after oral administration, with a duration of action of up to 4 hours. Sildenafil is primarily metabolised by hepatic CYP3A4 and CYP2C9 enzymes; the terminal half‑life averages 3–5 hours, allowing once‑ or twice‑daily dosing depending on the indication.

Conditions Treated with Revatio

• Pulmonary Arterial Hypertension (PAH) – a progressive condition characterised by elevated pulmonary arterial pressure, leading to right‑heart failure. In Hong Kong, the prevalence of PAH is estimated at 15–25 cases per million, with a higher incidence among women aged 30–60. Sildenafil improves exercise capacity (6‑minute walk distance) and delays disease progression.

• Pulmonary Hypertension associated with Left‑Heart Disease – selective use of sildenafil may benefit patients with combined pre‑ and post‑capillary PH when conventional therapy is insufficient.

• Off‑label use in certain types of heart failure – recent guideline updates suggest PDE‑5 inhibition can enhance cardiac output and reduce hospitalisation in selected systolic heart‑failure patients, though this remains investigational in Hong Kong.

Revatio is not approved for erectile dysfunction in Hong Kong under the Revatio label; that indication is covered by other sildenafil brand names (e.g., Viagra).

Suitable Candidates for Revatio Treatment

• Confirmed diagnosis of PAH (World Health Organization Group 1) by right‑heart catheterisation.
• Adults (≥18 years) with functional class II–III symptoms (e.g., dyspnoea on exertion) who are not adequately controlled with endothelin‑receptor antagonists or prostacyclin analogues.
• Patients with PAH secondary to connective‑tissue disease (systemic sclerosis, lupus) who require oral therapy.

Contra‑indications / situations where Revatio is not appropriate

• Concomitant use of nitrates or nitric‑oxide donors (risk of severe hypotension).
• Severe hepatic impairment (Child‑Pugh C) or end‑stage renal disease not on dialysis.
• Known hypersensitivity to sildenafil or any tablet excipient.
• Uncontrolled systemic hypertension (>180/110 mmHg).

Clinicians should perform baseline evaluation (echocardiogram, six‑minute walk test, laboratory panel) before initiating therapy and monitor for hemodynamic response and adverse events.

Risks, Side Effects, and Interactions

Common

• Headache
• Flushing
• Dyspepsia (indigestion)
• Nasal congestion
• Visual disturbances (blue‑tinted vision)

These events usually appear within the first few doses and resolve without intervention.

Rare

• Priapism (prolonged erection) – requires urgent medical attention.
• Myalgia or back pain – related to smooth‑muscle relaxation in other vascular beds.
• Hearing loss – sudden sensorineural hearing loss has been reported infrequently.

Serious

• Severe hypotension, especially when combined with nitrates or alpha‑blockers.
• Cardiovascular events (myocardial infarction, stroke) in patients with pre‑existing coronary artery disease.
• Pulmonary edema in patients with left‑sided heart failure not previously identified.

Drug–Drug Interactions

• Nitrates (e.g., nitroglycerin, isosorbide dinitrate) – contraindicated; additive vasodilation may cause life‑threatening hypotension.
• Alpha‑blockers (e.g., doxazosin, prazosin) – use with caution; may intensify blood‑pressure lowering effect.
• CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) – increase sildenafil plasma concentrations; dose reduction of Revatio is recommended.
• CYP3A4 inducers (e.g., carbamazepine, rifampicin) – reduce efficacy; consider alternative therapy.

Patients should disclose all prescription, over‑the‑counter, and herbal products before starting Revatio.

Practical Use: Dosing, Missed Dose, Overdose

• Standard dosing for PAH: 20 mg three times daily (approximately 8 hours apart) after a titration period that may start at 10 mg. Some clinicians adjust to 40 mg three times daily based on response and tolerability.
• Administration: Swallow whole tablet with water; may be taken with or without food. High‑fat meals can delay peak plasma concentrations but do not affect overall exposure.
• Missed dose: If a dose is missed and the next scheduled dose is >4 hours away, take the missed tablet as soon as remembered. Skip the dose if the next administration is imminent to avoid double‑dosing.
• Overdose: Symptoms may include profound hypotension, syncope, and priapism. Seek emergency medical care immediately. Supportive measures (fluid resuscitation, vasopressors) are the mainstay of treatment; no specific antidote exists.
• Renal or hepatic impairment: In moderate hepatic impairment, reduce the dose to 20 mg twice daily. In severe renal impairment (eGFR < 30 mL/min), use with caution and consider specialist supervision.

Patients should store Revatio at controlled room temperature (15‑30 °C) in a dry place, away from direct sunlight and moisture.

Buying Revatio from Our Online Pharmacy

Our online pharmacy in Hong Kong offers Revatio as a reliable, cost‑effective option for patients who encounter limited stock or high prices in conventional outlets. Key advantages include:

• Affordable pricing – we source the medication near the original manufacturer cost, passing savings directly to the consumer.
• Verified quality – all batches are supplied by licensed overseas pharmacies that meet international Good Manufacturing Practice (GMP) standards.
• Guaranteed delivery – discreet packaging with express shipping (typically 7 days) or regular airmail (~3 weeks) for bulk orders.
• Online‑only access – a convenient portal that respects privacy; our service operates as a pharmacy broker, collaborating with overseas licensed suppliers to bring international medications to Hong Kong residents.

Patients seeking an alternative to local pharmacy prices or who require a steady supply for chronic PAH management can safely obtain Revatio through our platform.

FAQ

• Is Revatio available in both brand‑name and generic forms in Hong Kong?
  Yes. Revatio is marketed under its original brand name, while generic sildenafil tablets—identical in dosage and composition—are also approved and widely dispensed in Hong Kong pharmacies.

• What storage conditions are recommended for Revatio tablets?
  Store at room temperature between 15 °C and 30 °C, protected from moisture, light, and excessive heat. Do not refrigerate or freeze the tablets.

• Can Revatio be shipped to Hong Kong without a local prescription?
  Importation for personal use requires a valid prescription from a licensed Hong Kong practitioner. Our online pharmacy facilitates the ordering process but does not replace the legal requirement for a prescription.

• Does the formulation of Revatio differ between regions such as the US, EU, and Asia?
  The active ingredient, sildenafil citrate, is identical worldwide. Inactive excipients (e.g., lactose, magnesium stearate) may vary slightly to meet local regulatory specifications, but therapeutic equivalence is maintained.

• How does food intake affect the absorption of Revatio?
  A high‑fat meal can delay the time to reach maximum plasma concentration by up to 1 hour, though overall exposure remains unchanged. Taking the tablet with a light meal or on an empty stomach is therefore optional and based on patient preference.

• What are the considerations for travel with Revatio?
  Keep tablets in their original labeled containers, carry a copy of the prescription, and ensure they remain within the allowable quantity for personal import (usually up to a 30‑day supply). Hand‑luggage is preferred to avoid temperature extremes in cargo holds.

• Are there any known differences in efficacy of sildenafil among Asian populations?
  Pharmacokinetic studies indicate comparable exposure in Asian and non‑Asian groups when standard doses are used. However, some clinicians observe a slightly higher incidence of facial flushing, likely related to genetic variations in drug metabolism.

• What clinical trials established Revatio’s role in pulmonary arterial hypertension?
  The pivotal phase III trial (START‑PAH, 2005) demonstrated a significant improvement in 6‑minute walk distance and hemodynamic parameters compared with placebo. Subsequent long‑term extension studies confirmed durability of benefit and an acceptable safety profile.

• Can Revatio be used together with other PAH‑specific therapies?
  Yes. Sildenafil is frequently combined with endothelin‑receptor antagonists (e.g., bosentan) or prostacyclin analogues (e.g., iloprost) to achieve additive hemodynamic effects. Combination therapy should be prescribed and monitored by a specialist.

• What should a patient do if they experience a sudden loss of vision while taking Revatio?
  Immediate medical evaluation is required. Sudden visual loss may indicate non‑arteritic anterior ischemic optic neuropathy, a rare but serious adverse event linked to PDE‑5 inhibitors. Discontinuation of the medication is typically advised pending specialist assessment.

Glossary

Phosphodiesterase‑5 (PDE‑5) inhibitor

A class of drugs that block the enzyme PDE‑5, leading to increased levels of cyclic guanosine monophosphate (cGMP) and resulting in vascular smooth‑muscle relaxation.

Pulmonary arterial hypertension (PAH)

A chronic disease defined by a mean pulmonary artery pressure ≥25 mmHg at rest, measured by right‑heart catheterisation, which can cause right‑ventricular failure.

Right‑heart catheterisation

An invasive diagnostic procedure that measures pressures in the right atrium, right ventricle, and pulmonary artery, providing definitive confirmation of PAH.

Cytochrome P450 (CYP) enzymes

Liver enzymes responsible for metabolising many medications; CYP3A4 and CYP2C9 are the primary isoforms that process sildenafil.

⚠️ Disclaimer

The information provided about Revatio is for general knowledge only. It does not replace professional medical consultation. All treatment decisions should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Revatio for individuals who may have limited availability through traditional pharmacies, prescription‑based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.