Clomipramine is a tricyclic antidepressant used to manage obsessive-compulsive disorder and other anxiety-related conditions.
Clomipramine belongs to the tricyclic antidepressant (TCA) class of medicines. It is primarily used to influence mood and anxiety by affecting certain brain chemicals. In Hong Kong, clomipramine is marketed under the brand name Anafranil as well as in generic tablet form simply called clomipramine.
The two main products that contain clomipramine in Hong Kong are:
Both versions are oral tablets taken with water. The tablets may be scored for splitting, allowing flexible dosing as directed by a prescriber. Availability may differ between public hospitals, private clinics and community pharmacies, but the active ingredient remains the same.
Clomipramine is approved for several mental-health conditions:
These conditions are generally managed in adults and adolescents, depending on clinical judgement. The drug’s impact on brain chemistry makes it useful for both mood-related and anxiety-related problems.
Clomipramine works by increasing the amount of serotonin and norepinephrine - two chemicals that help regulate mood and anxiety - available in the brain. By keeping more of these chemicals active, the medication can stabilize emotional responses and reduce obsessive thoughts. Effects are usually felt after a few weeks of regular use, rather than immediately.
People taking clomipramine often report mild, temporary effects such as:
These symptoms typically lessen as the body adapts to the medication.
Although rare, certain reactions require urgent medical attention:
If any of these occur, seek help at an accident-and-emergency department immediately.
Clomipramine may not be suitable for everyone. Individuals with a history of heart problems, severe liver disease, or untreated narrow-angle glaucoma should discuss alternatives with their prescriber. Pregnant or breastfeeding persons should also speak with a healthcare professional, as the medication passes into breast milk. Those known to be allergic to clomipramine or any of its tablet ingredients should avoid it.
Clomipramine can interact with several other drug groups:
For a full list of possible interactions, refer to the information page for each specific product.
Store tablets in a dry place at room temperature, away from direct sunlight and moisture. Most clomipramine regimens are intended for short-term to medium-term use, though some patients may continue under regular review. Always follow the instructions printed on the medication label and any guidance provided by your pharmacy or clinician. Remember that each product - Anafranil or generic clomipramine - may have slightly different packaging or dosing recommendations; check the specific leaflet for details.
Tricyclic antidepressant (TCA): A group of medicines that influence brain chemicals to improve mood and anxiety.
Serotonin: A brain chemical that helps regulate mood, sleep and appetite.
Norepinephrine: A chemical that contributes to alertness and the body’s response to stress.
Obsessive-Compulsive Disorder (OCD): A mental-health condition marked by unwanted, recurring thoughts and repetitive actions.
Serotonin syndrome: A rare but serious condition caused by too much serotonin activity, leading to rapid heart rate, high temperature and confusion.
This article offers general educational information about clomipramine as an active substance used in various medicines. Its purpose is to help patients better understand the ingredient and the conditions it is used to treat. It is not a substitute for professional medical advice or for the specific instructions provided with individual products. Medicines containing clomipramine may differ in formulation, strength, and directions for use. Always consult the labeling of your particular medication and follow your healthcare provider’s guidance for complete information on proper use, dosage, and safety.
