Valsartan Medications

Valsartan Info

What Is Valsartan?

Valsartan belongs to a class of medicines called angiotensin II receptor blockers (ARBs). It works by relaxing blood vessels so that the heart does not have to pump against high pressure. In Hong Kong, valsartan is available as the single ingredient and as part of the combination product Entresto, which also contains sacubitril.

Medications That Contain Valsartan

The most well-known product that includes valsartan in Hong Kong is Entlo - the brand name for the sacubitril/valsartan combination. Entlo is supplied in tablet form, usually in strengths of 24 mg/26 mg, 49 mg/51 mg, and 97 mg/101 mg of sacubitril/valsartan respectively. While Entlo is the primary branded option, pharmacists also dispense generic valsartan tablets under the name “Valsartan” for patients who need the ARB alone. Both branded and generic forms are approved by the Hong Kong Department of Health and listed on the Pharmacy and Poisons Board register.

Conditions Valsartan Helps Treat

• High blood pressure (hypertension). By widening the arteries, valsartan reduces the force needed for the heart to circulate blood, helping to keep blood pressure within a healthier range.
• Heart failure. In the Entlo combination, valsartan works together with sacubitril to improve the heart’s ability to pump blood and to lessen fatigue and swelling.
• Kidney disease linked to diabetes. Lowering the pressure in the blood vessels can protect the small filters in the kidneys, slowing the progression of diabetic kidney damage.
• After a heart attack. Some patients may be prescribed valsartan to support heart function and reduce the risk of further complications.

These uses align with the approvals granted by the Hong Kong regulatory authorities.

How Valsartan Works

Valsartan blocks the action of a hormone called angiotensin II, which normally narrows blood vessels. By preventing this narrowing, the medicine lets blood flow more freely. The result is a lower pressure in the circulatory system, which eases the workload on the heart and helps improve symptoms of the conditions listed above. Effects on blood pressure can be noticed within a few days of starting treatment, although the full benefit may take a few weeks.

Safety Information

Common Side Effects

• Mild headache
• Dizziness, especially when standing up quickly
• A sensation of tiredness or fatigue
• Slight nausea or stomach discomfort

These reactions are usually temporary and often improve without any special action.

Serious Reactions

• Swelling of the face, lips, tongue, or throat that makes breathing difficult - seek urgent help if this occurs.
• Rapid or irregular heartbeat.
• Persistent low blood pressure causing faintness or confusion.

If any of these signs appear, immediate medical attention is required.

Who Should Be Cautious

• People with known allergy to valsartan or any component of Entlo.
• Individuals with severe kidney impairment or advanced liver disease should discuss use with a health professional.
• Pregnant or breastfeeding women are generally advised to avoid ARBs unless a specialist specifically recommends them.

Interaction Awareness

Valsartan may interact with several other medication groups, such as:

• Other blood pressure medicines that also lower blood pressure, which could cause an excess drop.
• Potassium-rich supplements or potassium-sparing diuretics, raising potassium levels in the blood.
• Non-steroidal anti-inflammatory drugs (NSAIDs) that can affect kidney function when taken together.

Alcohol can also lower blood pressure, so moderate consumption is advisable. For a full interaction list, refer to the specific product information for Entlo or generic valsartan tablets.

What to Know Before Using

Store tablets at room temperature, away from moisture and direct sunlight. Keep them out of reach of children. The length of treatment varies: some people use valsartan for a few weeks to manage a sudden rise in blood pressure, while others may continue long-term for chronic heart conditions. Always follow the instructions that come with your particular medicine, as strengths and dosing regimes differ between products.

Key Terms

Angiotensin II receptor blocker (ARB): A type of drug that relaxes blood vessels by preventing the hormone angiotensin II from tightening them.

Sacubitril: The partner drug in Entlo that helps the heart release substances that widen vessels and reduce fluid buildup.

Information Disclaimer

This article offers general educational information about valsartan as an active substance used in various medicines. Its purpose is to help patients better understand the ingredient and the conditions it is used to treat. It is not a substitute for professional medical advice or for the specific instructions provided with individual products. Medicines containing valsartan may differ in formulation, strength, and directions for use. Always consult the labeling of your particular medication and follow your healthcare provider’s guidance for complete information on proper use, dosage, and safety.