Buy Acular
Acular

12.5
NSAID eye drops used to treat pain and inflammation after cataract surgery.


Availability
In Stock
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Alternative/Local Brand
Acular
Active Ingredient(s)
Ketorolac Trometamol
Primary Category
Eye Care, Pain Relief
Therapeutic Class
Ophthalmologicals, Anti-inflammatory agents, non-steroids
Pharmacological Class
Non-Steroidal Anti-Inflammatory Drug (NSAID)
Indications
Eye inflammation after surgery, Allergic conjunctivitis itchiness
Contraindications
Late pregnancy, NSAID-induced asthma, Hypersensitivity
Minor Side Effects
Temporary stinging, Irritation, Blurred vision
Moderate Side Effects
Eye pain, Allergic reactions, Dry eye
Serious Side Effects
Corneal thinning, Corneal perforation, Severe inflammation
Dosage Forms
Eye drops
Administration Route
Ophthalmic
Mechanism of Action
Ketorolac blocks the production of prostaglandins, which are chemicals that cause pain and inflammation in the eye. This reduces swelling and discomfort after eye procedures.
Prescription Status
Rx
Manufacturer
AbbVie (Allergan)
Patient Summary
NSAID eye drops used to treat pain and inflammation after cataract surgery.
Onset Time
30-60 minutes
Duration
6-8 hours
Storage Instructions
Store below 25°C. Discard 28 days after opening.
Drug Interactions
Topical steroids, Blood thinners
Age Restrictions
Consult doctor for paediatric use
Pregnancy Use
Avoid in the third trimester specifically.
Alternative Drugs
Diclofenac eye drops, Nevanac

What is Acular?

Acular is an ophthalmic solution that contains the active ingredient ketorolac trometamol. It belongs to the eye-care therapeutic class and is formulated as a clear, sterile 0.4 % solution packaged in a single-use bottle. In Hong Kong, Acular is available by prescription and is marketed for the temporary relief of ocular itching associated with seasonal allergic conjunctivitis, as well as for the control of inflammation and pain following certain eye surgeries. The same active ingredient is also supplied as a generic ketorolac ophthalmic solution.

How Acular Works in the Body

Ketorolac trometamol is a non-steroidal anti-inflammatory drug (NSAID). When administered as eye drops, it:

  • Inhibits cyclo-oxygenase (COX-1 and COX-2) enzymes in ocular tissues.
  • This inhibition blocks the conversion of arachidonic acid to prostaglandins, which are mediators of inflammation, pain, and itching.
  • By reducing prostaglandin levels, ketorolac diminishes the vascular dilation, edema, and sensory nerve activation that cause ocular discomfort.

The drug’s local action provides rapid symptom relief while minimizing systemic exposure. Effects typically begin within minutes, peak within an hour, and can last several hours after each dose.

Conditions Treated by Acular

  • Seasonal allergic conjunctivitis - temporary relief of eye itching, redness, and tearing.
  • Post-operative inflammation and pain - used after uncomplicated cataract surgery, refractive surgery, or other minor ocular procedures to control postoperative discomfort and swelling.

These indications are approved by Hong Kong’s Department of Health and are supported by clinical studies that demonstrate the efficacy of topical ketorolac in reducing ocular inflammation and pruritus.

Patient Suitability and Contraindications

Who Should Use Acular?

  • Adults and adolescents who experience seasonal allergic eye itching.
  • Patients who have undergone ocular surgery and require short-term anti-inflammatory therapy, as directed by their ophthalmologist.

Absolute Contraindications

  • Known hypersensitivity to ketorolac, other NSAIDs, or any component of the eye-drop formulation.
  • Active ocular infection (bacterial, viral, or fungal) in the eye to be treated.
  • Perforated globe or severe ocular trauma.

Relative Contraindications

  • History of recurrent corneal ulceration or severe dry eye disease.
  • Use of other topical NSAIDs or corticosteroids in the same eye without professional guidance.
  • Pregnancy (first trimester) and lactation - safety has not been established; a healthcare professional should weigh risks and benefits.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Transient stinging or burning sensation upon instillation.
  • Temporary blurred vision that clears within a few minutes.
  • Mild ocular discomfort or foreign-body sensation.

These effects are usually brief and resolve without intervention.

Serious Adverse Events

  • Corneal ulceration or keratitis - rare but may require immediate medical attention.
  • Severe allergic reactions (e.g., swelling of the eyelid, rash, conjunctival hyperemia).
  • Persistent eye pain, redness, or visual changes beyond the expected treatment period.

If any serious symptom occurs, discontinue the drops and seek ophthalmic care promptly.

Drug Interactions

  • Topical NSAIDs: Using another ophthalmic NSAID concurrently can increase the risk of corneal complications.
  • Systemic NSAIDs: No significant pharmacokinetic interaction is expected, but clinicians may consider cumulative prostaglandin inhibition in patients with extensive systemic NSAID use.
  • Anticoagulants: Systemic bleeding risk is not increased by topical ketorolac, yet caution is advised for patients on high-dose anticoagulants undergoing eye surgery.

Food and Lifestyle Interactions

  • No known food interactions; the drops are applied directly to the eye.
  • Alcohol consumption does not affect the efficacy or safety of Acular.
  • Patients should avoid swimming or submerging the eyes for at least 15 minutes after instillation to allow the medication to absorb.

How to Take Acular

  • Standard dosing: Instill one drop into the affected eye(s) twice daily (morning and evening) or as directed by the prescribing ophthalmologist.
  • Administration tips:
  • Wash hands thoroughly before use.
  • Tilt the head back, pull down the lower eyelid to create a small pocket, and place a single drop without touching the bottle tip to the eye or surrounding tissues.
  • Close the eye gently for a few seconds and press the inner corner (nasal canthus) to reduce systemic absorption.
  • Missed dose: If a dose is forgotten, apply it as soon as remembered unless it is within 2 hours of the next scheduled dose; in that case, skip the missed dose and resume the regular schedule.
  • Overdose: Accidental administration of more than the prescribed number of drops may cause marked ocular irritation, redness, and tearing. Rinse the eye with sterile saline and seek ophthalmic evaluation if discomfort persists.
  • Discontinuation: The medication can be stopped once itching or postoperative inflammation has resolved, typically after 5-7 days. No tapering is required, but abrupt cessation should be discussed with the eye-care provider if the patient has ongoing ocular inflammation.

Monitoring and Follow-Up

  • Post-operative patients should have a follow-up visit within 1 week to assess inflammation control and wound healing.
  • If allergic conjunctivitis symptoms persist beyond 7 days despite regular use, the patient should return for re-evaluation.
  • Any unexpected visual changes, persistent pain, or signs of infection warrant immediate ophthalmic review.

Storage and Handling

  • Keep the bottle at room temperature (15-30 °C), protected from direct sunlight and moisture.
  • Store in its original container with the cap tightly closed.
  • Do not freeze.
  • Once opened, use the product within 30 days (or as indicated on the label) to maintain sterility.
  • Keep out of reach of children and pets.
  • Dispose of empty bottles according to local pharmaceutical waste guidelines.

Medication-Specific Glossary

COX Inhibition
The process by which ketorolac blocks cyclo-oxygenase enzymes, preventing prostaglandin synthesis and thereby reducing inflammation and pain.
Prostaglandin
Lipid compounds that act locally to promote inflammation, vasodilation, and pain signaling in ocular tissues.
Post-operative Inflammation
The normal inflammatory response that occurs after eye surgery, characterized by redness, swelling, and discomfort; controlled with anti-inflammatory agents like ketorolac.
Topical NSAID
A non-steroidal anti-inflammatory drug formulated for application directly onto the eye surface, delivering local therapeutic effects with minimal systemic absorption.

Medical Disclaimer

This article provides educational information about Acular and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Acular FAQ

Can Acular be used for non-allergic eye irritation?

Acular is formulated specifically for allergic conjunctivitis and postoperative inflammation. Using it for other types of eye irritation is considered off-label and should only be done after an eye-care professional evaluates the underlying cause.

How long does a single bottle of Acular last?

A standard 5 mL bottle containing a 0.4 % solution provides approximately 100 drops. At the recommended dose of one drop twice daily, one bottle can last about 50 days, assuming proper storage and no waste.

Is there a risk of systemic side effects from Acular?

Because the medication is applied topically to the eye, systemic absorption is minimal. Systemic side effects commonly associated with oral NSAIDs are therefore unlikely, though rare systemic reactions can occur in highly sensitive individuals.

Can Acular be used while wearing contact lenses?

It is advisable to remove contact lenses before instilling the drops and wait at least 15 minutes before reinserting them. This helps avoid dilution of the medication and reduces the chance of lens contamination.

What should I do if I experience prolonged burning after instillation?

Mild burning usually resolves within a few minutes. If the sensation lasts longer than 10 minutes, becomes severe, or is accompanied by redness or visual changes, rinse the eye with sterile saline and seek ophthalmic evaluation promptly.

Is Acular safe for use in children?

Acular is generally approved for patients aged 12 years and older. Use in younger children should only occur under the direct supervision and prescription of a pediatric ophthalmologist.

Can I travel internationally with Acular?

Yes, but keep the bottle in its original packaging, include a copy of the prescription, and declare it at customs if required. Ensure the medication remains within the recommended temperature range during travel.

Does Acular interact with over-the-counter eye drops like artificial tears?

Artificial tears can be used alongside Acular, but it is best to administer them at least 5 minutes apart to avoid dilution of either product. Consult an eye-care professional for a personalized schedule.

Why does Acular come in a bottle rather than a single-use vial?

The bottle design protects the solution from light and contamination while allowing patients to dispense exact drops. Once opened, the bottle maintains sterility for a limited period (usually 30 days).

Will Acular affect my ability to drive or operate machinery?

Transient blurred vision may occur briefly after instillation. Patients should avoid driving or operating heavy machinery until vision clears, typically within a few minutes.

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