Buy Bisoprolol
Bisoprolol

0.41
A common beta-blocker used to manage high blood pressure and heart-related conditions by helping the heart beat more steadily.


Availability
In Stock
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Alternative/Local Brand
Cardicor
Active Ingredient(s)
Bisoprolol Fumarate
Primary Category
Blood Pressure, Heart Health
Therapeutic Class
Beta-blockers
Pharmacological Class
Selective beta-1 adrenoceptor antagonists
Indications
High blood pressure (Hypertension), Angina, Heart failure
Contraindications
Severe asthma, Slow heart rate (Bradycardia), Low blood pressure, Severe blood circulation problems
Minor Side Effects
Cold hands and feet, Fatigue, Nausea
Moderate Side Effects
Dizziness, Shortness of breath, Sleep disturbances, Diarrhoea
Serious Side Effects
Worsening heart failure, Fainting, Irregular heartbeat, Allergic reactions
Dosage Forms
Tablet
Administration Route
Oral
Mechanism of Action
Bisoprolol slows down the heart rate and makes the heart more efficient at pumping blood around the body. It blocks the action of adrenaline on the heart, which lowers blood pressure and reduces the heart's workload.
Prescription Status
Rx
Patient Summary
A common beta-blocker used to manage high blood pressure and heart-related conditions by helping the heart beat more steadily.
Onset Time
1-2 hours
Duration
24 hours
Storage Instructions
Store at room temperature.
Drug Interactions
Calcium channel blockers (e.g., Verapamil), Digoxin, Insulin, NSAIDs
Age Restrictions
Safety in children not established.
Pregnancy Use
Not recommended unless essential; may affect foetal growth.
Alternative Drugs
Atenolol, Metoprolol, Propranolol

What Is Bisoprolol?

Bisoprolol, containing the active ingredient bisoprolol fumarate, belongs to the heart and blood-pressure therapeutic class. It is available as an oral pill in strengths of 5 mg and 10 mg. In Hong Kong, bisoprolol is a prescription-only medication (Class B) regulated by the Department of Health. It is commonly prescribed to manage high blood pressure and chronic heart failure.

How Bisoprolol Works in the Body

Bisoprolol is a selective β₁-adrenergic receptor blocker. By binding primarily to β₁ receptors in the heart, it reduces the effects of adrenaline and noradrenaline, leading to:

  • Decreased heart rate - the heart beats more slowly, lowering the workload.
  • Reduced contractility - the force of each heartbeat is modestly diminished.
  • Lowered cardiac output - overall blood flow demand decreases, helping to control blood pressure.

These actions together help to lower arterial pressure and improve symptoms in patients with heart failure. The drug reaches peak plasma concentrations within 2-4 hours after oral ingestion, with an elimination half-life of about 10-12 hours, allowing once-daily dosing.

Conditions Treated by Bisoprolol

  • Essential hypertension - used when blood-pressure goals are not achieved with lifestyle measures alone.
  • Chronic heart failure (NYHA class II-III) - improves survival and reduces hospitalization risk when added to standard heart-failure therapy.

Both indications are approved by the Hong Kong Department of Health, aligned with international regulatory guidance.

Patient Suitability and Contraindications

Who Should Use Bisoprolol?

  • Adults with documented hypertension or stable chronic heart failure.
  • Patients who can tolerate a β-blocker and have no absolute contraindications.

Absolute Contraindications

  • Known hypersensitivity to bisoprolol or any component of the tablet.
  • Severe sinus bradycardia (heart rate < 45 bpm) or second-/third-degree atrioventricular block without a pacemaker.
  • Cardiogenic shock or decompensated heart failure.
  • Untreated pheochromocytoma.

Relative Contraindications

  • Asthma or chronic obstructive pulmonary disease (COPD) with significant bronchospasm.
  • Diabetes mellitus requiring careful glycemic monitoring (β-blockers may mask hypoglycemia symptoms).
  • Severe hepatic impairment (dose adjustment may be needed).
  • Pregnancy (category C) and lactation - only if the potential benefit outweighs risk.

Special Populations

  • Elderly: Start at the lower dose (5 mg) and titrate slowly.
  • Renal impairment: No dosage adjustment is required for mild to moderate dysfunction, but caution is advised in severe renal failure.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Fatigue or tiredness
  • Dizziness, especially on standing (orthostatic hypotension)
  • Cold extremities (hands/feet)
  • Mild headache

These effects are often transient and may lessen as the body adjusts.

Serious Adverse Events

  • Symptomatic bradycardia (heart rate < 45 bpm)
  • Severe hypotension (systolic < 90 mm Hg)
  • Exacerbation of heart failure symptoms (significant shortness of breath, swelling)
  • Acute bronchospasm in susceptible patients

If any of these occur, seek immediate medical attention.

Drug Interactions

  • Major: Concomitant use with other β-blockers, calcium-channel blockers (e.g., verapamil, diltiazem) may cause excessive bradycardia or hypotension.
  • Moderate: Antihypertensives (ACE inhibitors, ARBs, diuretics) may enhance blood-pressure-lowering effects; dose titration may be required.
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) can increase bisoprolol plasma levels, necessitating careful monitoring.

Food and Lifestyle Interactions

  • No specific food restrictions, but taking the pill with a light snack can reduce gastrointestinal upset.
  • Alcohol can potentiate hypotensive effects; limit intake.
  • Driving or operating machinery should be approached cautiously until the individual knows how bisoprolol affects them.

How to Take Bisoprolol

  • Standard dosing: Start with 5 mg once daily. If blood-pressure control is inadequate and the drug is well tolerated, the dose may be increased to 10 mg once daily.
  • Administration: Swallow the tablet whole with a glass of water. It can be taken with or without food.
  • Missed dose: Take the missed dose as soon as remembered on the same day; do not double the next dose.
  • Overdose: Symptoms may include profound bradycardia, severe hypotension, and respiratory distress. Seek emergency care; treatment is mainly supportive with possible use of atropine or glucagon under medical supervision.
  • Discontinuation: Do not stop abruptly, especially in heart-failure patients. The dose should be tapered gradually under physician guidance to avoid rebound tachycardia or hypertension.

Monitoring and Follow-Up

  • Blood pressure: Check weekly until target is reached, then at least every 3-6 months.
  • Heart rate: Monitor resting heart rate; aim for 60-80 bpm unless otherwise directed.
  • Renal and hepatic function: Baseline labs and periodic review in patients with known organ impairment.
  • Heart-failure status: Assess for changes in symptoms such as dyspnea, edema, or fatigue; adjust therapy as needed.

Storage and Handling

  • Store tablets at room temperature (15-30 °C), away from excess moisture and direct sunlight.
  • Keep the container tightly closed and out of reach of children.
  • Do not use tablets beyond the printed expiration date; discard safely according to local pharmacy guidelines.

Medication-Specific Glossary

β₁-adrenergic receptor
A protein on heart cells that responds to adrenaline, increasing heart rate and contractility; selective blockade reduces these effects.
NYHA class
New York Heart Association functional classification describing the severity of heart-failure symptoms (I = no limitation, IV = symptoms at rest).
Bradycardia
A slower than normal heart rate, usually defined as < 60 beats per minute in adults.

Medical Disclaimer

This article provides educational information about bisoprolol and is not a substitute for professional medical advice. Treatment decisions, including the use of bisoprolol for any indication, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Bisoprolol FAQ

Can bisoprolol be taken with other blood-pressure medicines?

Yes, bisoprolol is often combined with other antihypertensives such as ACE inhibitors or thiazide diuretics. The combination can improve blood-pressure control, but the prescribing physician should monitor for additive effects on heart rate and blood pressure.

What should I do if I feel dizzy after the first dose?

Dizziness is a common initial side effect as the body adjusts. Sit or lie down until the feeling passes, and rise slowly from sitting or lying positions to minimize orthostatic symptoms. Report persistent dizziness to your healthcare provider.

Are there any differences between bisoprolol tablets made in different countries?

Tablets approved in Hong Kong meet the same pharmacopeial standards as those produced elsewhere. Inactive ingredients (excipients) may vary slightly, which can affect tolerability for patients with specific allergies; check the product label if you have known sensitivities.

Is bisoprolol safe for people with mild asthma?

Bisoprolol is selective for β₁ receptors, which reduces the risk of bronchospasm compared with non-selective β-blockers. However, caution is still advised, and a physician may prefer an alternative if asthma is moderate to severe.

Can I travel internationally with bisoprolol tablets?

Yes, but keep the medication in its original packaging with a copy of the prescription. Some countries require a doctor's note for chronic medications; check the destination country's regulations before travel.

Will bisoprolol affect my cholesterol test results?

Bisoprolol does not directly influence lipid metabolism, so cholesterol levels are unaffected. However, improved blood-pressure control may indirectly support overall cardiovascular health.

How long does it take for bisoprolol to lower blood pressure?

Blood-pressure reduction can be observed within a few days, but the full effect may take 2-4 weeks as the dose is titrated and the body adjusts.

Is it necessary to have a specific diet while on bisoprolol?

No strict diet is required. Maintaining a balanced, low-salt diet helps overall blood-pressure management and complements the medication’s effect.

Can bisoprolol be crushed or split?

The tablets are designed for whole-tablet ingestion. Crushing or splitting may alter the release profile and reduce efficacy. If dose adjustment is needed, ask a pharmacist for a suitable formulation.

What is the cost comparison between bisoprolol and other β-blockers in Hong Kong?

Generic bisoprolol is generally less expensive than brand-name β-blockers, reflecting its widespread use and availability. Exact pricing varies by pharmacy and insurance coverage; consult local dispensaries for up-to-date information.

Categories