Buy Celebrex
Celebrex

0.57
Celebrex is used for inflammation management. As a COX-2 inhibitor, it provides pain relief for conditions like osteoarthritis and rheumatoid arthritis.


Ingredient
Availability
In Stock
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Celecoxib
Reference Brand
Celecoxib
Original Manufacturer
Pfizer
Product Form
Capsule
Regulatory Classification
Rx
Primary Category
Pain Management
Product Category
COX-2 inhibitor
Pharmacological Class
NSAID
Clinical Indications
Arthritis, Acute pain, Dysmenorrhea
Manufacturer Description
Celebrex is used for inflammation management. As a COX-2 inhibitor, it provides pain relief for conditions like osteoarthritis and rheumatoid arthritis.
Mechanism of Action
Celebrex selectively inhibits the COX-2 enzyme, which is responsible for pain and inflammation, while minimizing the effects on gastric protection often seen with conventional NSAIDs.
Route of Administration
Oral
Onset Time
1 hour
Duration
12 hours
Contraindications
Allergy to sulfonamides or aspirin
Severe Adverse Events
Heart attack, stroke, gastrointestinal bleeding, hypertension
Common Side Effects
Headache, Indigestion, Dizziness
Uncommon Side Effects
Stomach discomfort, Diarrhea
Drug Interactions
Warfarin, Fluconazole
Pregnancy Safety Warnings
Avoid during third trimester.
Age Restrictions
Use with caution in elderly.
Storage Guidelines
Store at room temperature.
Related Products
Etoricoxib

Celebrex FAQ

Can I travel internationally with Celebrex tablets?

Yes, Celebrex can be carried in your personal medication bag, but you should keep the original prescription label and pack the medication in its original container. For longer trips, bring a copy of the prescribing doctor’s note in case customs authorities request proof of medical necessity.

Will Celebrex show up on a drug test for work or sports?

Celecoxib is not a controlled substance and is not screened for in standard workplace or athletic drug tests. However, some sports anti-doping agencies maintain a list of prohibited substances; Celebrex is generally permitted but athletes should verify the latest regulations.

How does Celebrex differ from traditional NSAIDs like ibuprofen?

Celebrex selectively inhibits COX-2, whereas ibuprofen blocks both COX-1 and COX-2. This selectivity reduces the risk of stomach ulcers and bleeding but may increase cardiovascular risk relative to non-selective NSAIDs at high doses.

What does the imprint on a Celebrex tablet look like?

In Hong Kong, the 100 mg tablet is typically imprinted with “C 100” and the 200 mg tablet with “C 200”. Imprint details can vary by manufacturer, so verify the markings against the pharmacy label.

Is a generic version of celecoxib available in Hong Kong?

Yes, generic celecoxib tablets that contain the same active ingredient are approved and marketed in Hong Kong. They are bioequivalent to Celebrex and offer a cost-effective alternative.

Can I take Celebrex with alcohol?

Occasional moderate alcohol intake is not contraindicated, but alcohol can irritate the stomach lining and may increase the risk of gastrointestinal bleeding when combined with any NSAID, including Celebrex. Limit alcohol consumption and discuss any concerns with your clinician.

What should I do if I miss a dose while on a twice-daily schedule?

Take the missed dose as soon as you remember, unless it is close to the time of your next scheduled dose. In that case, skip the missed dose and resume your regular dosing interval-do not double the dose.

Does Celebrex affect blood pressure?

Celecoxib can cause fluid retention and may raise blood pressure in some patients, particularly those with pre-existing hypertension. Regular blood pressure monitoring is recommended for individuals on long-term therapy.

Are there any special disposal instructions for expired Celebrex tablets?

Do not flush medications down the toilet. Return unused or expired tablets to a pharmacy take-back program or follow local hazardous-waste disposal guidelines to protect the environment.

How long can I safely store Celebrex before it expires?

When kept at room temperature in its original packaging, Celebrex retains its potency until the expiry date printed on the label, typically 2-3 years from the date of manufacture. Do not use tablets past this date.

What is Celebrex?

Celebrex is a prescription pain-relief medication whose active ingredient is celecoxib. It belongs to the class of selective cyclo-oxygenase-2 (COX-2) non-steroidal anti-inflammatory drugs (NSAIDs). Celebrex is marketed in Hong Kong as a pill available in strengths of 100 mg and 200 mg. The product is regulated under the Pharmacy and Poisons Ordinance and requires a prescription from a qualified healthcare professional.

How Celebrex Works in the Body

Celecoxib selectively inhibits the COX-2 enzyme, which is primarily responsible for producing prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin synthesis, Celebrex diminishes the inflammatory response without substantially affecting COX-1, the enzyme that protects the stomach lining and supports platelet function.

  • Onset of action: Pain relief may begin within 1-2 hours after the first dose.
  • Peak effect: Typically reached 2-3 hours post-dose.
  • Duration: The therapeutic effect lasts about 12 hours, allowing once- or twice-daily dosing depending on the condition.

Conditions Treated by Celebrex

Celebrex is approved in Hong Kong for several musculoskeletal and pain-related indications:

  • Osteoarthritis - alleviates joint pain and improves function.
  • Rheumatoid arthritis - reduces joint inflammation and pain.
  • Ankylosing spondylitis - eases spinal stiffness and discomfort.
  • Acute pain - such as postoperative pain, dental pain, or musculoskeletal injuries.
  • Primary dysmenorrhea - relieves menstrual-related cramping.

These uses are based on clinical trials that demonstrated statistically significant pain reduction compared with placebo and, in many cases, comparable efficacy to traditional non-selective NSAIDs with a more favorable gastrointestinal safety profile.

Evidence-Based Off-Label Uses

Celecoxib has been studied in other clinical contexts, most notably for familial adenomatous polyposis (FAP), a hereditary condition that predisposes to colon cancer. While celecoxib is approved for FAP in some jurisdictions, it remains an off-label indication in Hong Kong.

  • Off-label use: Treatment of FAP.
  • Evidence strength: Multiple randomized controlled trials have shown a modest reduction in polyp burden.
  • Regulatory status: Not approved for FAP by the Hong Kong Department of Health.
  • Disclaimer: Off-label use requires close supervision by a specialist and individualized risk assessment.

Who Should Not Use Celebrex?

Absolute Contraindications

  • Known hypersensitivity to celecoxib or any other COX-2 inhibitor.
  • History of asthma, urticaria, or anaphylaxis triggered by aspirin or other NSAIDs.
  • Severe uncontrolled heart failure, recent myocardial infarction, or stroke.
  • Active gastrointestinal ulceration or bleeding.

Relative Contraindications

  • Moderate renal impairment (creatinine clearance < 30 mL/min).
  • Moderate hepatic disease (Child-Pugh B or C).
  • Pregnancy (especially third trimester) and lactation - celecoxib is not recommended.
  • Use in patients on anticoagulants or antiplatelet therapy requires careful risk-benefit evaluation.

Patients with any of the above conditions should discuss alternatives with their healthcare provider.

Safety Profile and Interactions

Common Side Effects

  • Stomach upset, dyspepsia, or mild abdominal pain.
  • Headache or dizziness.
  • Diarrhoea or constipation.

These effects are usually transient and may be mitigated by taking the pill with food.

Serious Adverse Events

  • Cardiovascular events: Increased risk of thrombotic episodes such as heart attack and stroke, particularly at higher doses or in patients with existing cardiovascular disease.
  • Severe gastrointestinal bleeding: Though less common than with non-selective NSAIDs, serious bleeding can still occur.
  • Skin reactions: Rare cases of Stevens-Johnson syndrome or toxic epidermal necrolysis have been reported.
  • Renal toxicity: Acute kidney injury may develop, especially in dehydrated patients or those with pre-existing kidney disease.

Any sudden chest pain, shortness of breath, severe abdominal pain, or unexplained bruising warrants immediate medical attention.

Drug Interactions

  • Major: Concomitant use with anticoagulants (warfarin, direct oral anticoagulants) can amplify bleeding risk.
  • Moderate: ACE inhibitors or ARBs may reduce renal function when combined with celecoxib; monitoring of renal function is advised.
  • CYP2C9 inhibitors (e.g., fluconazole, amiodarone) can increase celecoxib plasma levels, potentially heightening adverse effects.
  • Other NSAIDs - concurrent therapy can increase gastrointestinal and cardiovascular toxicity; avoid unless specifically directed.

Patients should disclose all prescription medicines, over-the-counter drugs, herbal products, and supplements before starting Celebrex.

Food and Lifestyle Interactions

  • Alcohol: May increase the risk of gastrointestinal bleeding; limit intake.
  • Driving: Celebrex does not impair cognition, but dizziness can occur; use caution if affected.
  • Sun exposure: No specific photosensitivity has been identified, but standard sun protection is advisable for all medications.

How to Take Celebrex

  • Osteoarthritis: 100 mg twice daily, or 200 mg once daily.
  • Rheumatoid arthritis: 200 mg twice daily.
  • Acute pain: A single 200 mg dose, followed by 100 mg twice daily if needed for up to 6 days.
  • Dysmenorrhea: 200 mg once daily for up to 3 days.

The tablet should be swallowed whole with water; it may be taken with or without food, although taking it with a meal can reduce stomach irritation.

Special Populations

  • Elderly: Start with the lowest effective dose; monitor renal function.
  • Renal impairment: Dose reduction is recommended; avoid if creatinine clearance < 30 mL/min.
  • Hepatic impairment: Use the lowest dose; avoid in severe liver disease.

Missed Dose

If a dose is missed, take it as soon as remembered unless it is almost time for the next scheduled dose. Do not double the dose.

Overdose

Symptoms may include severe stomach pain, nausea, vomiting, and dizziness. Seek emergency medical care; treatment is supportive, and activated charcoal may be considered if presentation is early.

Discontinuation

Celebrex does not generally require tapering, but abrupt cessation after long-term high-dose therapy should be discussed with a physician to monitor for rebound pain or inflammation.

Monitoring and Follow-Up

  • Baseline labs: Kidney (serum creatinine, eGFR) and liver function tests.
  • Periodic labs: Repeat renal and hepatic panels every 3-6 months for chronic users.
  • Cardiovascular assessment: Blood pressure and lipid profile monitoring for patients with cardiovascular risk factors.
  • Clinical review: Evaluate pain control, joint function, and any emerging side effects at each follow-up visit.

Storage and Handling

  • Store the pills at 20 °C to 25 °C (room temperature), away from excess heat, moisture, and direct sunlight.
  • Keep the container tightly closed and out of reach of children.
  • Do not use tablets that are discoloured, chipped, or past the expiry date indicated on the packaging.

Medication-Specific Glossary

COX-2 (Cyclo-oxygenase-2)
An enzyme that produces prostaglandins involved in inflammation and pain; selective inhibition reduces inflammation while sparing gastric protection.
Prostaglandin
Lipid compounds that mediate inflammation, pain, fever, and protect the stomach lining; reduced synthesis leads to analgesic and anti-inflammatory effects.
Thrombotic Risk
The potential for blood clot formation, which may increase the chance of heart attack or stroke, especially at higher NSAID doses.

Medical Disclaimer

This article provides educational information about Celebrex and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

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