Buy Dulera
Dulera

62
An inhaler used twice daily to help prevent asthma symptoms and control long-term breathing difficulties.


Availability
In Stock
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Mometasone Furoate, Formoterol Fumarate
Primary Category
Asthma Treatment
Therapeutic Class
Respiratory System, Antiasthmatics, Adrenergics in combination with corticosteroids
Pharmacological Class
Corticosteroid, Long-acting Beta-agonist (LABA)
Indications
Asthma prevention, Wheezing, Shortness of breath
Contraindications
Acute asthma attack, Severe milk protein allergy, Hypersensitivity to ingredients
Minor Side Effects
Dry mouth, Hoarseness, Sore throat
Moderate Side Effects
Headache, Sinusitis, Upper respiratory tract infection
Serious Side Effects
Pneumonia, Fungal infection in the mouth (thrush), Rapid heartbeat, Tremor, Vision changes
Dosage Forms
Inhalation Aerosol
Administration Route
Inhalation
Mechanism of Action
Dulera contains two medicines: a steroid to reduce inflammation and swelling in the airways, and a long-acting bronchodilator to help keep the airways open, making it easier to breathe over time.
Prescription Status
Rx
Manufacturer
Organon
Patient Summary
An inhaler used twice daily to help prevent asthma symptoms and control long-term breathing difficulties.
Onset Time
15 to 30 minutes
Duration
12 hours
Storage Instructions
Store at room temperature with the mouthpiece down.
Drug Interactions
Ketoconazole, Beta-blockers, MAO inhibitors, Diuretics
Age Restrictions
Not recommended for children under 12
Pregnancy Use
Consult a doctor; use only if the benefit outweighs the risk.
Alternative Drugs
Symbicort, Advair, Fostair

What is Dulera?

Dulera is a prescription inhaler that contains two active ingredients: mometasone furoate, a corticosteroid, and formoterol fumarate, a long-acting β2-adrenergic agonist (LABA). It belongs to the asthma and breathing therapeutic class and is available in a fixed-dose combination of 6 µg mometasone furoate / 200 µg formoterol fumarate per inhalation. In Hong Kong, Dulera is regulated by the Department of Health and is only supplied with a professional prescription.

How Dulera Works in the Body

  • Mometasone furoate reduces airway inflammation by binding to glucocorticoid receptors, which suppresses the release of inflammatory mediators such as cytokines and prostaglandins. This leads to decreased swelling and mucus production in the bronchial walls.
  • Formoterol fumarate stimulates β2-adrenergic receptors on airway smooth muscle, causing rapid relaxation (bronchodilation). Formoterol has a fast onset (within minutes) and a prolonged effect lasting up to 12 hours, helping to keep the airways open between doses.

Together, the anti-inflammatory action of mometasone and the bronchodilatory effect of formoterol provide both maintenance control of asthma symptoms and relief of occasional breathlessness.

Conditions Treated by Dulula

Dulera is approved for the long-term, maintenance treatment of asthma in adults and adolescents (12 years and older) when a combination of an inhaled corticosteroid (ICS) and a LABA is indicated. It is not intended for acute asthma attacks; a short-acting bronchodilator (e.g., salbutamol) should be used for sudden symptoms.

Off-Label and Investigational Applications

No high-quality evidence currently supports off-label uses of Dulera. Any consideration of non-approved indications must be discussed with a qualified healthcare professional and undertaken only under close supervision.

Who Should Not Use Dulera?

Absolute contraindications

  • Known hypersensitivity to mometasone furoate, formoterol fumarate, or any component of the inhaler.
  • History of severe allergic reactions (e.g., anaphylaxis) to other inhaled corticosteroids or LABAs.

Relative contraindications / cautions

  • Pregnancy & breastfeeding - Animal studies show no direct harm, but human data are limited. Use only if the potential benefit justifies the potential risk.
  • Cardiac conditions - Patients with uncontrolled arrhythmias, coronary artery disease, or severe hypertension should be evaluated carefully because β2-agonists can increase heart rate and cause palpitations.
  • Thyroid disease - Hyperthyroidism may amplify the cardiovascular effects of formoterol.
  • Severe liver impairment - May affect metabolism of mometasone; dose adjustment may be needed.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Oral thrush (candidiasis) - Often occurs when the inhaler is not rinsed after use.
  • Hoarseness or voice changes - Linked to local steroid exposure.
  • Headache - Reported in a small proportion of users.
  • Muscle cramps - May be related to β2-agonist activity.

Serious Adverse Events

  • Paradoxical bronchospasm - Sudden worsening of breathing; seek immediate medical help.
  • Throat swelling or severe allergic reaction - Signs include difficulty swallowing, swelling of the face or lips, and hives.
  • Cardiovascular symptoms - Rapid heartbeat, chest pain, or high blood pressure should be reported promptly.

Drug Interactions

  • Other β2-agonists or LABAs - Concomitant use can increase the risk of tachycardia and tremor.
  • Beta-blockers (e.g., propranolol) - May reduce the bronchodilator effect of formoterol and potentially trigger bronchospasm.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) - Can raise systemic levels of mometasone, increasing the risk of steroid-related side effects.
  • Diuretics and sympathomimetic agents - May potentiate cardiovascular effects.

Patients should always inform their healthcare provider of all prescription medicines, over-the-counter products, herbal supplements, and vitamins they are taking.

Food and Lifestyle Interactions

  • Food - No specific dietary restrictions; the inhaler can be used with or without meals.
  • Alcohol - Moderate consumption is generally safe, but excessive alcohol may worsen asthma control.
  • Driving - Formoterol’s bronchodilator effect does not impair driving, but any dizziness or severe side effects should be reported before operating machinery.

How to Take Dulera

  • Standard dosing - One inhalation (containing 6 µg mometasone furoate + 200 µg formoterol fumarate) twice a day, preferably every 12 hours.
  • Administration technique -
  • Shake the inhaler gently before use.
  • Exhale fully, place the mouthpiece between the lips, and press down firmly while inhaling slowly and deeply.
  • Hold the breath for about 10 seconds, then exhale slowly.
  • Rinse the mouth with water and spit it out after each dose to reduce the risk of oral thrush.
  • Missed dose - If a dose is missed, take it as soon as remembered unless it is near the time of the next scheduled dose; do not double up.
  • Overdose - Symptoms may include severe throat irritation, wheezing, rapid heart rate, or tremor. Seek emergency medical attention; treatment is supportive and may involve bronchodilators and corticosteroid therapy.
  • Discontinuation - Do not stop abruptly. If therapy needs to be stopped, the prescriber will usually taper the corticosteroid component to avoid rebound airway inflammation.

Dosing must be individualized by a healthcare provider. The above regimen reflects the labeled strength (6/200 µg) and typical twice-daily schedule.

Monitoring and Follow-Up

  • Lung function tests (spirometry) should be performed before initiating therapy and periodically thereafter to assess control.
  • Inhaler technique review at each clinic visit helps ensure optimal drug delivery.
  • Oral health - Regular dental check-ups are recommended because inhaled steroids can increase the risk of oral infections.
  • Cardiovascular monitoring - Patients with known heart disease should have blood pressure and heart rate checked regularly.

Storage and Handling

  • Store the inhaler at room temperature (15-30 °C), away from direct heat and moisture.
  • Keep the device in its original packaging until use to protect the mouthpiece from contamination.
  • Do not freeze the inhaler.
  • Replace the inhaler after 12 weeks of regular use or when the dose counter indicates the device is empty, even if the medication appears to remain.
  • For disposal, follow local pharmaceutical waste guidelines or return the empty inhaler to a pharmacy that offers a take-back program.

Medication-Specific Glossary

Formoterol
A long-acting β2-adrenergic agonist that relaxes airway smooth muscle, providing bronchodilation for up to 12 hours.
Mometasone furoate
A potent inhaled corticosteroid that reduces airway inflammation by inhibiting multiple inflammatory pathways.
Bronchodilator
A medication that widens the air passages in the lungs, improving airflow and reducing shortness of breath.
Inhaler dose counter
An integrated mechanism that displays the number of remaining actuations, helping patients know when to replace the device.

Medical Disclaimer

This article provides educational information about Dulera and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Dulera FAQ

Can Dulera be used as a rescue inhaler for sudden asthma attacks?

No. Dulera is designed for maintenance therapy and does not act quickly enough for acute symptom relief. Patients should keep a short-acting bronchodilator, such as salbutamol, for rescue use.

What should I do if I develop a hoarse voice while using Dulera?

A hoarse voice is a common local effect of inhaled corticosteroids. Rinse your mouth with water after each inhalation and consider using a spacer device to reduce throat exposure. If the symptom persists, discuss it with your prescriber.

Is it safe to use Dulera during marathon training?

Dulera does not impair exercise capacity and may improve airway stability during endurance activities. However, athletes should monitor for any unusual breathlessness or heart palpitations and report them promptly.

Does travel across Hong Kong borders require any special paperwork for Dulera?

Prescription inhalers are allowed for personal use when accompanied by a valid prescription or a doctor's letter. Carry the medication in its original packaging and keep the prescription handy for customs inspection.

How can I tell if my inhaler still contains medication?

The inhaler’s dose counter shows the number of actuations remaining. When the counter reaches “0” or the inhaler feels loose after pressing, the medication is depleted and the device should be replaced.

Are there any differences between Dulera and other combination inhalers like Advair?

Both contain an inhaled corticosteroid and a LABA, but they differ in the specific steroid (mometasone vs. fluticasone) and LABA (formoterol vs. salmeterol) as well as the fixed dose strengths. Choice of inhaler is guided by individual response, side-effect profile, and prescriber preference.

Can I use a spacer with the Dulera inhaler?

Yes. A spacer can improve drug deposition in the lungs and reduce oropharyngeal side effects, especially for patients who have difficulty coordinating inhalation.

What is the expiry date policy for Dulera in Hong Kong?

The expiration date is printed on the inhaler canister. Do not use the medication past this date, as potency may decline and the device’s performance can be compromised.

Will Dulera affect my eligibility for routine drug testing at work?

Dulera contains mometasone (a corticosteroid) and formoterol (a LABA). These substances are not typically screened for in standard workplace drug panels, but athletes subject to anti-doping testing should verify compliance with relevant regulations.

How do I dispose of an empty Dulera inhaler responsibly?

Return the empty canister to a pharmacy that participates in medication take-back programs, or follow the Hong Kong Environmental Protection Department’s guidelines for safe disposal of pharmaceutical waste.

Categories