Buy Glycomet
Glycomet

0.31
The first-line medication for the treatment of type 2 diabetes, helping to control blood sugar levels.


Ingredient
Availability
In Stock
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Alternative/Local Brand
Glucophage
Active Ingredient(s)
Metformin
Primary Category
Diabetes
Therapeutic Class
Antidiabetic Agents, Biguanides
Pharmacological Class
Biguanides
Indications
Type 2 diabetes mellitus, Polycystic ovary syndrome (off-label)
Contraindications
Severe kidney impairment, Metabolic acidosis, Acute heart failure
Minor Side Effects
Metallic taste, Abdominal pain, Flatulence
Moderate Side Effects
Diarrhoea, Nausea, Loss of appetite
Serious Side Effects
Lactic acidosis, Vitamin B12 deficiency, Liver dysfunction
Dosage Forms
Tablet, Sustained-release tablet, Oral solution
Administration Route
Oral
Mechanism of Action
It reduces the amount of sugar produced by the liver and improves the body's response to insulin, the hormone that controls blood sugar levels. It also reduces the amount of glucose absorbed from food.
Prescription Status
Rx
Manufacturer
USV Private Limited
Patient Summary
The first-line medication for the treatment of type 2 diabetes, helping to control blood sugar levels.
Onset Time
Several days to see significant blood sugar reduction
Duration
8-12 hours
Storage Instructions
Store at room temperature away from moisture.
Drug Interactions
Contrast media (iodine), Cimetidine, Alcohol, Diuretics
Age Restrictions
Suitable for adults and children aged 10 and over.
Pregnancy Use
Considered safe when prescribed by a doctor during pregnancy.
Alternative Drugs
Gliclazide, Sitagliptin, Pioglitazone

What is Glycomet?

Glycomet is a brand-name medication that contains metformin as its sole active ingredient. Metformin belongs to the biguanide class of oral antidiabetic agents and is used worldwide for the management of type 2 diabetes mellitus. In Hong Kong, Glycomet is available only by prescription and is supplied as a 500 mg oral pill. The product is regulated by the Hong Kong Department of Health under the Pharmacy and Poisons Ordinance. While the specific manufacturer of Glycomet is not disclosed here, the formulation follows the same quality standards required for all prescription medicines marketed in Hong Kong.

How Glycomet Works in the Body

Metformin improves blood-glucose control through several complementary actions:

  • Reduction of hepatic glucose production - it inhibits the liver’s ability to generate glucose from non-carbohydrate sources, a process known as gluconeogenesis.
  • Increase of peripheral insulin sensitivity - muscle and fat cells take up glucose more efficiently, lowering circulating blood-sugar levels.
  • Modest effect on intestinal glucose absorption - a small portion of the drug acts locally in the gut to reduce the amount of glucose entering the bloodstream after a meal.

These mechanisms together lower fasting plasma glucose and improve overall glycaemic control without stimulating the pancreas to release more insulin. Metformin’s effect becomes apparent within a few days, reaches a steady state after about two weeks, and its glucose-lowering action persists for the duration of therapy.

Conditions Treated by Glycomet

In Hong Kong, Glycomet is approved for the treatment of type 2 diabetes mellitus in adult patients. It may be used as monotherapy or in combination with other glucose-lowering agents such as sulfonylureas, DPP-4 inhibitors, or insulin when additional control is required. The medication is intended for patients whose diabetes is not adequately managed by diet and exercise alone.

Evidence-Based Off-Label Uses

Metformin is sometimes prescribed for conditions that are not covered by the official label.

  • Polycystic ovary syndrome (PCOS) - Clinical guidelines acknowledge metformin’s benefit in improving ovulatory function and insulin resistance in women with PCOS, although it is not formally approved for this indication in Hong Kong.
  • Prediabetes - Some studies suggest that metformin can delay progression to overt diabetes in high-risk individuals, but use for this purpose remains off-label.

Disclaimer: Off-label use requires medical supervision and an individualized risk assessment. These applications have not received formal regulatory approval in Hong Kong.

Who Should (Not) Use Glycomet?

Ideal Patient Profile

  • Adults with a confirmed diagnosis of type 2 diabetes mellitus.
  • Individuals with measurable insulin resistance who can tolerate oral medication.

Absolute Contraindications

  • Known hypersensitivity to metformin or any of the tablet’s inactive ingredients.
  • Severe renal impairment (eGFR < 30 mL/min/1.73 m²).
  • Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
  • Current treatment with radiographic contrast agents for intravascular use (unless renal function can be restored after the procedure).

Relative Contraindications & Special Populations

  • Moderate renal impairment (eGFR 30-45 mL/min/1.73 m²): dose reduction and close monitoring are advised.
  • Pregnancy - Metformin crosses the placenta; it is classified as category B in many jurisdictions, but its safety profile in pregnancy is still evaluated case by case.
  • Lactation - Small amounts are excreted in breast milk; benefits and risks should be weighed.
  • Elderly patients - Age-related decline in renal function may necessitate lower starting doses.

If any of these conditions apply, a healthcare professional should assess suitability before initiating therapy.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Gastro-intestinal upset (nausea, abdominal discomfort, diarrhoea) - often transient and can be reduced by taking the tablet with food.
  • Metallic taste - typically mild and short-lasting.
  • Loss of appetite - may accompany the gastrointestinal symptoms.

Serious Adverse Events

  • Lactic acidosis - a rare but life-threatening condition characterized by rapid breathing, muscle pain, and abdominal discomfort. Immediate medical attention is required if symptoms arise.
  • Vitamin B12 deficiency - prolonged use can lower B12 levels, leading to neuropathy or anemia; periodic monitoring is recommended.

Drug Interactions

  • Contrast media (iodinated) - can precipitate acute kidney injury; metformin should be held before and after the procedure according to renal function.
  • Cimetidine - may increase metformin plasma concentrations; dose adjustment may be needed.
  • Alcohol - excessive intake raises the risk of lactic acidosis; moderate consumption is advised.
  • Other antidiabetic agents - concurrent use may increase the risk of hypoglycaemia, especially with insulin or sulfonylureas; dose titration of the additional agent is often required.

Food and Lifestyle Interactions

  • Take with meals - helps minimise gastrointestinal irritation.
  • Alcohol moderation - limit intake to reduce acidosis risk.
  • Driving or operating machinery - metformin does not impair cognition, but severe hypoglycaemia (rare when used alone) could affect performance; patients should be aware of symptoms.

Patients should disclose all prescription medicines, over-the-counter drugs, herbal supplements, and dietary habits to their prescriber before starting Glycomet.

How to Take Glycomet

  • Standard starting dose: one 500 mg tablet taken orally with the first main meal of the day.
  • Titration: the dose may be increased by one additional 500 mg tablet once daily (maximum 2 tablets = 1000 mg per day) after at least one week, based on tolerability and glycaemic response. Further increments can be made to a maximum of 2000 mg per day (four 500 mg tablets) as needed. All increments use the same 500 mg tablet strength, so no new dosage forms are introduced.
  • Renal-adjusted dosing: for patients with eGFR 30-45 mL/min/1.73 m², the maximum daily dose should not exceed 1000 mg, in divided doses.
  • Administration advice: swallow the tablet whole; do not crush or chew. The pill can be taken with water and should be accompanied by food to reduce stomach upset.
  • Missed dose: if a dose is forgotten, take it with the next main meal. Do not double the dose to “catch up.”
  • Overdose: symptoms may include severe diarrhoea, nausea, abdominal pain, and rapid breathing. Seek emergency medical care; supportive measures and monitoring of lactate levels are standard.
  • Discontinuation: abrupt cessation is generally safe because metformin does not cause withdrawal. However, patients should discuss alternative glucose-lowering strategies with their provider before stopping.

Monitoring and Follow-Up

  • Glycated haemoglobin (HbA1c): measured every 3 months after therapy initiation or dose adjustment, then at least twice yearly once stable.
  • Renal function: serum creatinine and eGFR should be checked before starting Glycomet and periodically (at least annually, more often if risk factors exist).
  • Vitamin B12 levels: consider testing annually for patients on long-term metformin therapy.
  • Clinical assessment: patients should be instructed to report persistent gastrointestinal symptoms, signs of hypoglycaemia, or any unexplained fatigue.

Regular follow-up enables timely dose optimisation and early detection of adverse effects.

Storage and Handling

  • Store Glycomet tablets at room temperature (15-30 °C), away from direct sunlight, moisture, and heat sources.
  • Keep the container tightly closed and out of reach of children.
  • Do not use the medication past the expiry date printed on the packaging.
  • Unused tablets should be disposed of according to local pharmaceutical waste guidelines or returned to a pharmacy for safe disposal.

Medication-Specific Glossary

Lactic Acidosis
A metabolic complication characterised by an accumulation of lactate in the blood, leading to low pH. It is a rare but serious risk of metformin, especially in patients with impaired kidney function.
HbA1c
A laboratory measure of average blood glucose over the previous 2-3 months, expressed as a percentage. It guides long-term diabetes management.
eGFR (estimated Glomerular Filtration Rate)
A calculation that estimates kidney filtration capacity, used to adjust dosing of renally excreted drugs such as metformin.
Biguanide
The chemical class to which metformin belongs; biguanides lower blood glucose primarily by reducing hepatic glucose output.

Medical Disclaimer

This article provides educational information about Glycomet and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Glycomet FAQ

Can I take Glycomet if I have a history of heart disease?

Metformin is generally safe for patients with stable cardiovascular disease and may even provide modest cardioprotective benefits. However, clinicians will review individual cardiac status and concomitant medicines before prescribing.

Will Glycomet affect my cholesterol levels?

Some studies have shown modest reductions in LDL cholesterol and triglycerides with metformin therapy, but it is not a primary lipid-lowering agent. Patients requiring cholesterol control should continue appropriate lipid-lowering medications.

Is it necessary to monitor blood pressure while on Glycomet?

Metformin does not directly influence blood pressure. Routine monitoring remains important for overall diabetes management, especially because hypertension often co-exists with type 2 diabetes.

Can I travel internationally with Glycomet tablets?

Yes, but keep the medication in its original labelled container, carry a copy of the prescription, and be prepared to present it at customs if requested. Avoid storing the pills in extreme heat or humidity during travel.

Do different countries use different inactive ingredients in Glycomet?

Formulations can vary by market, which may affect tablet colour, size, or excipients such as lactose or microcrystalline cellulose. Patients with specific allergies should review the local product leaflet.

How long does a Glycomet tablet stay effective after the expiry date?

Stability beyond the printed expiry date is not guaranteed. Using expired medication may result in reduced efficacy or unknown safety, so it should be discarded.

Is metformin safe for people with mild liver disease?

Metformin is primarily eliminated unchanged by the kidneys, not the liver. Mild hepatic impairment does not usually contraindicate its use, but clinicians will assess overall liver function and potential for lactic acidosis.

Can Glycomet be taken with a high-protein diet?

A high-protein diet does not interfere with metformin’s absorption or action. Patients should maintain consistent meal patterns to help minimise gastrointestinal side effects.

What should I do if I experience persistent diarrhoea on Glycomet?

Persistent diarrhoea may indicate intolerance. Patients should contact their healthcare provider, who may recommend dose reduction, gradual titration, or switching to an extended-release formulation if available.

Are there any special considerations for athletes using Glycomet?

Athletes should monitor blood glucose closely, especially during intense training or competition, as exercise can enhance metformin’s glucose-lowering effect. Hydration and carbohydrate intake should be planned to avoid hypoglycaemia.

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