Buy Lithobid
Lithobid

0.6
A long-established medicine used to prevent and treat episodes of mania and depression in bipolar disorder.


Availability
In Stock
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Alternative/Local Brand
Priadel
Active Ingredient(s)
Lithium Carbonate
Primary Category
Mood Stabiliser
Therapeutic Class
Antimanic Agents
Pharmacological Class
Alkali Metal Ion
Indications
Bipolar disorder, Mania, Recurrent depression
Contraindications
Severe kidney disease, Severe heart disease, Dehydration, Untreated hypothyroidism
Minor Side Effects
Thirst, Fine hand tremor, Increased urination
Moderate Side Effects
Weight gain, Nausea, Metallic taste
Serious Side Effects
Lithium toxicity, Confusion, Blurred vision, Seizures, Thyroid problems
Dosage Forms
Tablet, Prolonged-release tablet, Liquid
Administration Route
Oral
Mechanism of Action
Lithium acts on the central nervous system to stabilise moods. It is thought to change the way sodium and neurotransmitters work in nerve and muscle cells, helping to prevent mania and depression.
Prescription Status
Rx
Manufacturer
Essential Pharma
Patient Summary
A long-established medicine used to prevent and treat episodes of mania and depression in bipolar disorder.
Onset Time
1-3 weeks
Duration
Variable (requires regular blood tests)
Storage Instructions
Store at room temperature.
Drug Interactions
NSAIDs (like Ibuprofen), Diuretics, ACE inhibitors, SSRIs
Age Restrictions
Consult specialist for children
Pregnancy Use
Avoid if possible; risk of heart defects.
Alternative Drugs
Quetiapine, Valproate, Olanzapine

What is Lithobid?

Lithobid is a prescription medication that contains lithium carbonate as its active ingredient. It is administered in the form of a 300 mg pill and belongs to the mental health therapeutic class. In Hong Kong, Lithobid is regulated by the Pharmacy and Poisons Ordinance and is available only with a doctor's prescription.

How Does Lithobid Work in the Body?

Lithium carbonate stabilises mood by influencing several neurobiological pathways:

  • Neurotransmitter modulation: Lithium reduces excessive dopamine activity and enhances serotonergic transmission, helping to balance mood swings.
  • Second-messenger systems: It interferes with the phosphoinositide cascade and inhibits glycogen synthase kinase-3 (GSK-3), processes implicated in neuronal signalling and plasticity.
  • Cellular protection: Lithium promotes neuroprotective factors and may improve mitochondrial function, contributing to long-term mood stability.

These actions collectively help control manic episodes and prevent depressive relapses in bipolar disorder.

Conditions Treated by Lithobid

Lithobid is approved by the Hong Kong Department of Health for the following indications:

  • Acute mania associated with bipolar disorder
  • Maintenance therapy to prevent recurrence of manic or depressive episodes in bipolar disorder
  • Long-term prophylaxis of mood instability in patients with bipolar I disorder

Lithium carbonate is considered a first-line option for these conditions because of its proven efficacy in reducing the frequency and severity of mood episodes.

Off-Label and Investigational Applications

Evidence from peer-reviewed studies supports occasional off-label use of lithium carbonate for:

  • Augmentation in treatment-resistant major depressive disorder - modest benefit reported in controlled trials, but not approved by regulatory agencies.
  • Prevention of suicide - observational data suggest lithium may lower suicide risk in mood-disordered patients, though formal guidelines recommend careful clinical judgement.

Off-label use requires medical supervision and individualized risk assessment.

Who Should Use Lithobid? Contraindications

Absolute Contraindications

  • Known hypersensitivity to lithium carbonate or any tablet excipients
  • Severe renal impairment (creatinine clearance < 30 mL/min)
  • Significant cardiovascular disease (e.g., recent myocardial infarction, unstable angina)
  • Pregnancy during the first trimester (risk of congenital heart defects)

Relative Contraindications

  • Moderate renal dysfunction (creatinine clearance 30-60 mL/min) - dose adjustment needed
  • Thyroid disease - monitor thyroid function regularly
  • Elderly patients - increased sensitivity; start at lower dose
  • Use of diuretics, ACE inhibitors, or NSAIDs - may raise lithium levels

Special Populations

  • Pregnancy: Lithium is classified as a Category D medication; discuss risks and benefits with a healthcare provider.
  • Breastfeeding: Lithium passes into breast milk; caution advised.
  • Geriatric patients: Start with a reduced dose and monitor renal function closely.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Tremor (often mild and transient)
  • Increased thirst and frequent urination (polyuria)
  • Mild gastrointestinal upset (nausea, diarrhea)
  • Weight gain
  • Cognitive slowing (“brain fog”)

Serious Adverse Events

  • Lithium toxicity: Symptoms include severe tremor, confusion, seizures, and cardiac arrhythmias. Prompt medical attention is required.
  • Nephrotoxicity: Long-term use may reduce renal function; regular kidney monitoring is essential.
  • Hypothyroidism: Lithium can impair thyroid hormone production; periodic thyroid testing is recommended.

Drug Interactions

  • Diuretics (thiazides, loop diuretics): Decrease sodium reabsorption, raising lithium concentrations.
  • NSAIDs (ibuprofen, naproxen): Reduce renal clearance of lithium, potentially leading to toxicity.
  • ACE inhibitors and ARBs: May increase lithium levels; monitor serum lithium closely.
  • Selective serotonin reuptake inhibitors (SSRIs): Combined use can heighten risk of serotonin syndrome; clinical oversight needed.

Food and Lifestyle Interactions

  • Sodium intake: Low-salt diets can increase lithium reabsorption, elevating blood levels. Maintain consistent dietary sodium.
  • Alcohol: Moderation advised; excessive intake can worsen tremor and dehydration.
  • Driving and machinery: Lithium may cause mild sedation; evaluate personal response before operating vehicles.

Patients should inform their healthcare provider of all medications, supplements, and herbs before starting Lithobid.

Dosing and Administration Guidelines

  • Standard initial dose: One 300 mg tablet taken twice to three times daily (total 600-900 mg per day).
  • Titration: Dosage is adjusted based on clinical response and serum lithium levels, usually in increments of 300 mg.
  • Maximum dose: Generally not to exceed 1800 mg per day, but individual limits depend on renal function and tolerability.
  • Administration: Swallow the pill whole with a full glass of water. It may be taken with or without food; consistent timing each day helps maintain stable blood levels.
  • Missed dose: Take the missed tablet as soon as remembered unless it is near the time of the next scheduled dose; do not double up.
  • Overdose: Symptoms include severe tremor, vomiting, confusion, and cardiac arrhythmias. Seek emergency medical care; treatment may involve gastric lavage and intravenous fluids.
  • Discontinuation: Do not stop abruptly. Tapering under medical guidance reduces the risk of rebound mood destabilisation.

Exact dosing must be individualized by a qualified healthcare provider.

Monitoring and Follow-Up

  • Serum lithium level: Measured 5-7 days after dose changes; target therapeutic range 0.6-1.2 mmol/L for maintenance.
  • Renal function: Serum creatinine and estimated glomerular filtration rate (eGFR) every 3-6 months.
  • Thyroid function: TSH and free T4 at baseline and semi-annually.
  • Electrocardiogram (ECG): Considered for patients with known cardiac disease or on concurrent QT-prolonging agents.
  • Clinical assessment: Regular evaluation of mood symptoms, side-effects, and adherence.

Storage and Handling

  • Store Lithobid tablets at room temperature (15-30 °C), protected from moisture and direct sunlight.
  • Keep the container tightly closed and out of reach of children.
  • Dispose of unused tablets according to local pharmacy guidelines or Hong Kong’s hazardous waste program.

Medication-Specific Glossary

Therapeutic Window
The serum concentration range (0.6-1.2 mmol/L for lithium) where the drug is effective without causing unacceptable toxicity.
Nephrotoxicity
Damage to the kidneys that can occur with prolonged lithium exposure, potentially leading to reduced renal clearance.
Serum Lithium Level
The concentration of lithium measured in the blood, used to guide dosing and ensure safety.

Medical Disclaimer

This article provides educational information about Lithobid and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Lithobid FAQ

Can I travel with Lithobid and go through airport security?

Lithobid tablets are permitted in both carry-on and checked luggage. Keep them in their original labeled container and carry a copy of the prescription or a doctor's note to avoid delays at security checkpoints.

Does lithium affect my ability to take a driving test?

Lithium may cause mild tremor or drowsiness in some individuals. If you notice any impairment in coordination or alertness, refrain from driving until the effect subsides and discuss the issue with your prescriber.

What do Lithobid tablets look like, and are there imprint codes?

Lithobid 300 mg tablets are typically round, white to off-white, and bear the imprint “LITHOBID 300”. Appearance can vary slightly by manufacturer, so verify the imprint and packaging against the pharmacy label.

Is Lithobid covered by Hong Kong’s public health insurance scheme?

Lithobid is listed on the Hospital Authority’s formulary and may be subsidised for eligible patients. Eligibility depends on clinical indication and prescribing physician’s assessment.

How does Lithobid compare with other mood stabilisers like valproate?

Both lithium and valproate are effective for bipolar disorder, but lithium has the most robust evidence for reducing suicide risk. Valproate may be preferred in patients with renal impairment, while lithium requires regular monitoring of kidney and thyroid function.

Can I take Lithobid with over-the-counter antihistamines for allergies?

Most antihistamines do not interact with lithium, but always inform your healthcare provider of any new OTC medication to confirm safety.

What should I do if I miss a dose while on a weekend?

Take the missed tablet as soon as you remember, unless it is already close to the time of your next scheduled dose. Do not double the dose; maintaining a regular schedule is more important than compensating for a single missed tablet.

Are there any known brand-name alternatives to Lithobid in Hong Kong?

Lithobid is a brand name for lithium carbonate. Generic lithium carbonate tablets of the same strength (300 mg) are also available and are therapeutically equivalent.

How long does a lithium tablet remain stable after opening the bottle?

Lithobid tablets retain potency for at least 24 months when stored in their original container, kept at room temperature, and protected from moisture. Check the expiration date on the packaging.

What are the typical costs for Lithobid compared to generic lithium carbonate?

Brand-name Lithobid may be priced higher than generic lithium carbonate due to branding and distribution factors. Exact prices vary across pharmacies and are subject to government subsidies for eligible patients.

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