Buy Luvox
Luvox

1.11
An SSRI antidepressant primarily used for the treatment of OCD and clinical depression.


Ingredient
Availability
In Stock
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Alternative/Local Brand
Fa發verin
Active Ingredient(s)
Fluvoxamine
Primary Category
Mental Health
Therapeutic Class
Antidepressants, Selective Serotonin Reuptake Inhibitors (SSRIs)
Pharmacological Class
SSRIs
Indications
Obsessive-compulsive disorder (OCD), Major depressive disorder
Contraindications
Concurrent use with Tizanidine, Use of MAOIs, Hypersensitivity
Minor Side Effects
Nausea, Dry mouth, Sleepiness
Moderate Side Effects
Sweating, Tremor, Anxiety, Change in taste
Serious Side Effects
Serotonin syndrome, Abnormal bleeding, Suicidal thoughts in young adults, Hyponatraemia
Dosage Forms
Tablet
Administration Route
Oral
Mechanism of Action
It works by increasing the levels of serotonin, a chemical messenger in the brain that helps maintain mental balance. By blocking its reuptake, it helps reduce obsessive thoughts and compulsive behaviours.
Prescription Status
Rx
Manufacturer
Abbott
Patient Summary
An SSRI antidepressant primarily used for the treatment of OCD and clinical depression.
Onset Time
2-4 weeks
Duration
15-20 hours
Storage Instructions
Store at room temperature.
Drug Interactions
Theophylline, Clozapine, Warfarin, NSAIDs
Age Restrictions
Approved for OCD in children from age 8.
Pregnancy Use
Not typically recommended unless benefit outweighs risk.
Alternative Drugs
Fluoxetine, Sertraline, Paroxetine

What is Luvox?

Luvox is a brand-name medication that contains the active ingredient fluvoxamine, an antidepressant classified as a selective serotonin reuptake inhibitor (SSRI). It is supplied in pill form and is available in 50 mg and 100 mg strengths. In Hong Kong, Luvox is a prescription-only product and is regulated by the Hong Kong Department of Health. The medication is primarily indicated for certain anxiety-related disorders and works by modestly increasing serotonin levels in the brain.

How Luvox Works in the Body

Fluvoxamine belongs to the SSRI class. It blocks the serotonin transporter protein on presynaptic neurons, which reduces the re-absorption (reuptake) of serotonin back into the nerve cell. This results in higher concentrations of serotonin remaining in the synapse, enhancing serotonergic neurotransmission. The increased serotonin activity helps to normalize mood and anxiety pathways, which underlies its therapeutic effect in obsessive-compulsive and anxiety disorders. Onset of clinical benefit typically occurs within 2-4 weeks, with peak effects observed after several weeks of consistent dosing.

Conditions Treated by Luvox

Luvox is approved in many regulatory regions, including Hong Kong, for the following indications:

  • Obsessive-Compulsive Disorder (OCD) - reduction of obsessions and compulsions in adults.
  • Social Anxiety Disorder (SAD) - alleviation of anxiety symptoms in social situations.

These uses are supported by clinical trial data reviewed by health authorities such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), and the approvals have been adopted by Hong Kong’s regulatory framework.

Off-Label Uses

Evidence from peer-reviewed studies suggests that fluvoxamine may be beneficial for other conditions, although these uses are not formally approved:

  • Major Depressive Disorder (MDD) - some trials show improvement in depressive symptoms, but regulatory approval is limited to OCD and SAD.
  • Panic Disorder - case series have reported symptom reduction when fluvoxamine is used off-label.

Disclaimer: Off-label use requires medical supervision and an individualized risk assessment. Patients should discuss potential benefits and risks with a qualified healthcare professional.

Who Should Not Use Luvox?

Absolute Contraindications

  • Known hypersensitivity to fluvoxamine or any excipients in the pill.
  • Concurrent use of monoamine oxidase inhibitors (MAOIs), or use of an MAOI within 14 days of stopping Luvox.
  • Severe hepatic impairment (Child-Pugh class C) where fluvoxamine metabolism is significantly reduced.

Relative Contraindications

  • Pregnancy and lactation - fluvoxamine crosses the placenta and is excreted in breast milk; risk-benefit assessment is necessary.
  • Renal impairment - dosage adjustment may be required if creatinine clearance is markedly reduced.
  • Bipolar disorder - SSRIs can precipitate manic episodes; mood stabilizers should be in place if indicated.
  • History of seizures - fluvoxamine may lower seizure threshold in susceptible individuals.

Special Populations

  • Elderly patients - may be more sensitive to side effects such as dizziness or hyponatremia; start at the lower dose and titrate slowly.
  • Patients with hepatic disease - consider lower initial dosing and monitor liver function tests.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Nausea, headache, insomnia, and dry mouth are frequently reported.
  • Mild dizziness or light-headedness, especially during the first weeks of therapy.
  • Transient gastrointestinal upset that often improves with continued use.

Serious Adverse Events

  • Serotonin syndrome - a potentially life-threatening condition characterized by agitation, hyperthermia, tremor, and autonomic instability. Immediate medical attention is required.
  • Suicidal thoughts - increased risk in young adults and adolescents during early treatment; close monitoring is essential.
  • Hyponatremia - particularly in elderly patients or those taking diuretics; watch for confusion, seizures, or severe fatigue.

Drug Interactions

  • Major interactions - co-administration with MAOIs, other SSRIs, or serotonin-enhancing agents (e.g., triptans) can precipitate serotonin syndrome.
  • Moderate interactions - fluvoxamine is a strong inhibitor of the CYP1A2 enzyme; concomitant use of drugs metabolised by CYP1A2 (e.g., theophylline, clozapine) may increase their plasma concentrations.
  • Common interacting agents - warfarin, antiplatelet drugs, and certain antipsychotics may require dose adjustments or enhanced monitoring.

Food and Lifestyle Interactions

  • Luvox can be taken with or without food; however, a consistent routine (e.g., with breakfast) may improve tolerability.
  • Caffeine metabolism may be slowed due to CYP1A2 inhibition; patients sensitive to caffeine should monitor intake.
  • No specific restrictions on alcohol, but excessive consumption can exacerbate sedation or dizziness.

How to Take Luvox

  • Standard dosing - most adults start with 50 mg once daily. If tolerated, the dose may be increased to 100 mg once daily after 1 week. The maximum recommended daily dose is 300 mg, but the available strengths are 50 mg and 100 mg tablets.
  • Administration - swallow the pill whole with a glass of water. Do not crush or chew unless specifically instructed.
  • Dose adjustments - for patients with moderate hepatic impairment, a lower starting dose (e.g., 25 mg) may be considered. Renal impairment does not usually require dose change, but clinical judgment is advised.
  • Missed dose - take the missed tablet as soon as remembered unless it is near the time of the next scheduled dose. Do not double up.
  • Overdose - symptoms may include severe nausea, vomiting, dizziness, or seizures. Seek emergency medical care immediately; supportive care is the mainstay of treatment.
  • Discontinuation - abrupt stopping can lead to discontinuation syndrome (e.g., flu-like symptoms, insomnia). A gradual taper, typically decreasing the dose by 25-50 mg per week, is recommended under medical supervision.

Monitoring and Follow-Up

  • Baseline assessment - evaluate psychiatric history, liver function, and renal function before initiating therapy.
  • Follow-up visits - usually scheduled after 2-4 weeks to assess efficacy, tolerability, and any emerging side effects.
  • Laboratory monitoring - liver enzymes may be checked periodically in patients with pre-existing hepatic disease. Serum sodium should be monitored in older adults on diuretics.
  • Suicidality screening - crucial during the first few months of treatment, especially in patients under 25 years of age.

Storage and Handling

  • Keep tablets at room temperature (≤ 30 °C), away from excess moisture and direct sunlight.
  • Store the medication in its original container, tightly closed, and out of reach of children.
  • Do not use the product after the expiration date printed on the package.

Medication-Specific Glossary

Selective Serotonin Reuptake Inhibitor (SSRI)
A class of antidepressants that block the reuptake of serotonin, increasing its availability in the brain.
Serotonin Reuptake Inhibition
The process by which an SSRI reduces the reabsorption of serotonin into the presynaptic neuron, enhancing neurotransmission.
Serotonin Syndrome
A potentially life-threatening reaction caused by excess serotonergic activity, characterized by mental status changes, autonomic instability, and neuromuscular abnormalities.
CYP1A2 Inhibition
The blocking of the cytochrome P450 1A2 enzyme, which can raise plasma levels of drugs metabolised by this pathway.

Medical Disclaimer

This article provides educational information about Luvox and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Luvox FAQ

Can Luvox be taken in the evening?

Luvox may be taken at any time of day, but many patients prefer morning dosing to reduce the likelihood of insomnia. If night-time dosing is chosen, monitor for sleep disturbances and discuss any concerns with a pharmacist or physician.

What should I do if I miss a dose on the weekend?

If the missed dose is within a few hours, take it as soon as you remember. If it is close to the next scheduled dose, skip the missed tablet and continue with the regular dosing schedule. Doubling the dose is not recommended.

Does Luvox interact with over-the-counter antihistamines?

First-generation antihistamines (e.g., diphenhydramine) can increase drowsiness when combined with Luvox. Second-generation antihistamines (e.g., cetirizine) generally have a lower risk of interaction, but patients should still monitor for excessive sedation.

Is Luvox safe for use during pregnancy?

Fluvoxamine crosses the placenta and its safety in pregnancy has not been definitively established. It should only be used when the potential benefits outweigh the risks, and this decision must be made in consultation with an obstetrician.

Can I travel with Luvox on an international flight?

Yes, but keep the medication in its original labelled container, carry a copy of the prescription, and store it in your hand luggage to avoid temperature extremes. Some countries may require a medical certificate for controlled medications.

What are the visual differences between 50 mg and 100 mg Luvox tablets?

In most markets, the 50 mg tablet is smaller and may be scored for splitting, while the 100 mg tablet is larger and typically unscored. The exact appearance can vary by manufacturer, so verify the imprint code on the packaging.

Does Luvox affect drug testing for employment?

Luvox is not a prohibited substance in standard workplace drug screens. However, occupational health programs may request a medication list, and patients should disclose their use of Luvox when asked.

How long does it take for Luvox to reach steady-state levels in the body?

Steady-state concentrations are usually achieved after about 5 days of consistent dosing, reflecting its half-life of approximately 15-20 hours.

Is there a risk of weight gain with Luvox?

Weight changes are not a prominent side effect of fluvoxamine. Some patients may experience slight weight loss due to reduced appetite, while others report stable weight. Regular monitoring is advised if weight changes become a concern.

Can Luvox be switched to another SSRI without a washout period?

Direct switching between SSRIs can increase the risk of serotonin syndrome. A short washout period (typically 2-5 days) or a cross-taper strategy is often recommended, but the exact approach should be individualized by a prescriber.

Categories