Buy Temovate
Temovate

7.79
A very strong steroid treatment used on the skin to reduce inflammation and irritation in severe skin conditions.


Category
Availability
In Stock
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Alternative/Local Brand
Dermovate
Active Ingredient(s)
Clobetasol Propionate
Primary Category
Skin Care, Anti-inflammatory
Therapeutic Class
Corticosteroids, potent (group IV)
Pharmacological Class
Corticosteroids
Indications
Psoriasis, Recalcitrant eczemas, Lichen planus, Discoid lupus erythematosus
Contraindications
Untreated skin infections, Rosacea, Acne vulgaris, Perioral dermatitis, Itching without inflammation
Minor Side Effects
Burning sensation, Stinging, Skin redness
Moderate Side Effects
Thinning of the skin, Stretch marks, Changes in skin colour, Increased hair growth
Serious Side Effects
Blurry vision, Weight gain in the face, Adrenal suppression, Severe allergic reaction
Dosage Forms
Cream, Ointment, Scalp Application
Administration Route
Topical
Mechanism of Action
It is a highly potent steroid that reduces the swelling, itching, and redness associated with various skin conditions by inhibiting the release of inflammatory substances in the skin cells.
Prescription Status
Rx
Manufacturer
GlaxoSmithKline
Patient Summary
A very strong steroid treatment used on the skin to reduce inflammation and irritation in severe skin conditions.
Onset Time
Within a few days
Duration
Variable based on skin absorption
Storage Instructions
Store below 30°C. Keep the cap tightly closed.
Drug Interactions
Ritonavir, Itraconazole
Age Restrictions
Not recommended for children under 1 year of age.
Pregnancy Use
Use with caution; should only be used if the potential benefit justifies the risk.
Alternative Drugs
Betamethasone, Hydrocortisone, Eumovate

What is Temovate?

Temovate is a prescription-only skin-care product that contains the active ingredient clobetasol propionate, a high-potency topical corticosteroid. It is supplied in a tube containing 15 g or 30 g of cream. In Hong Kong, Temovate is regulated by the Department of Health and is classified as a prescription-only medicine (POM).

The medication works by reducing inflammation, itching, and redness on the skin. It is commonly prescribed for a range of inflammatory dermatoses where strong anti-inflammatory action is required.

How Temovate Works in the Body

Clobetasol propionate belongs to the class of synthetic glucocorticoids. When applied to the skin, it:

  • Binds to intracellular glucocorticoid receptors, altering gene transcription.
  • Decreases the production of inflammatory mediators such as prostaglandins and cytokines.
  • Reduces the migration of immune cells to the site of inflammation.
  • Suppresses the activity of fibroblasts, limiting excess tissue growth.

These actions lead to rapid relief of erythema, edema, and pruritus. Because the drug is applied topically, systemic absorption is minimal when used as directed, limiting whole-body side effects.

Conditions Treated by Temovate

Temovate is FDA/EMA-approved for the same indications recognized in Hong Kong for high-potency topical corticosteroids. Commonly approved uses include:

  • Plaque psoriasis
  • Eczema (atopic dermatitis) that is resistant to lower-potency steroids
  • Lichen planus
  • Discrete inflammatory dermatoses (e.g., seborrheic dermatitis, contact dermatitis) where strong anti-inflammatory control is needed

The medication is intended for adults and children over 12 years when the benefit outweighs potential risks.

Patient Suitability and Contraindications

Who Should Use Temovate?

  • Individuals with confirmed inflammatory skin conditions listed above.
  • Patients who have not responded adequately to lower-potency corticosteroids.

Absolute Contraindications

  • Known hypersensitivity to clobetasol propionate or any cream excipients.
  • Untreated skin infections (bacterial, fungal, viral) in the area of application.
  • Areas of thin skin such as the face, axillae, groin, or intertriginous zones (unless specifically instructed by a clinician).

Relative Contraindications

  • Pregnant or breastfeeding women - use only if clearly justified.
  • Patients with systemic diseases that may be worsened by corticosteroids (e.g., uncontrolled diabetes, hypertension).
  • Children under 12 years of age.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Mild burning, stinging, or itching at the application site
  • Dryness or peeling of the skin
  • Temporary discoloration (hypopigmentation) of the treated area

These reactions are usually transient and resolve with continued use or after stopping the medication.

Serious Adverse Events

  • Skin atrophy (thinning) with prolonged use, especially on thin-skinned areas
  • Telangiectasia (visible small blood vessels) or striae (stretch marks)
  • Systemic corticosteroid effects (e.g., adrenal suppression) - rare, usually linked to extensive use over large body surface areas

If any of these occur, patients should discontinue the product and seek medical evaluation promptly.

Drug Interactions

Topical clobetasol generally has limited systemic interaction potential. However, caution is advised when used concurrently with:

  • Systemic corticosteroids - may increase risk of systemic glucocorticoid effects.
  • Antibiotics or antifungals applied to the same area - may alter absorption.

Patients should inform their healthcare provider of all topical and oral medications, including over-the-counter products and herbal supplements.

Food and Lifestyle Interactions

  • No known food interactions.
  • Alcohol consumption does not affect topical absorption, but excessive use can exacerbate skin irritation.
  • Sun exposure may increase the risk of skin thinning; sunscreen or protective clothing is recommended for treated areas.

How to Take Temovate

  • Standard dosing: Apply a thin layer to the affected skin once daily, preferably in the evening. The amount varies with the size of the area (often expressed as “finger-tip units” - one fingertip unit covers approximately 2 cm²).
  • Maximum duration: Generally limited to 2-4 weeks of continuous use. Longer treatment should be under specialist supervision.
  • Special populations:
  • Elderly: Use the lowest effective amount; monitor for skin thinning.
  • Renal/hepatic impairment: No dose adjustment needed for topical use, but systemic monitoring is advised if large surface areas are treated.
  • Application instructions:
  • Wash hands before and after application.
  • Do not cover the treated area with occlusive dressings unless directed by a clinician.
  • Missed dose: Apply as soon as remembered; if it is near the time of the next scheduled dose, skip the missed one-do not double the dose.
  • Overdose: In case of accidental ingestion or extensive skin application, seek emergency care. Signs may include severe nausea, vomiting, headache, or signs of systemic corticosteroid excess.
  • Discontinuation: Sudden cessation after prolonged use may precipitate rebound inflammation; tapering the potency or frequency is recommended under medical guidance.

Monitoring and Follow-Up

  • Skin assessment: Review the treated area every 1-2 weeks for signs of atrophy or worsening condition.
  • Laboratory tests: Not routinely required for short-term topical therapy; consider adrenal function tests if therapy exceeds 4 weeks on large body areas.
  • When to seek care: New infection signs (pus, increased redness), severe skin thinning, or systemic symptoms such as unexplained weight gain, hypertension, or hyperglycemia.

Storage and Handling

  • Store the tube at room temperature, protected from excess heat and direct sunlight.
  • Keep the container tightly closed when not in use.
  • Do not freeze.
  • Keep out of reach of children and pets.
  • Dispose of unused medication according to local pharmacy take-back programs or the instructions on the label.

Medication-Specific Glossary

Glucocorticoid receptor
A protein within cells that binds corticosteroids, initiating anti-inflammatory gene expression.
Skin atrophy
Thinning of the epidermis and dermis, often presenting as fragility or visible veins.
Finger-tip unit (FTU)
A practical measure for topical applications; one FTU of cream approximates the amount needed to cover a 2 cm² area.

Medical Disclaimer

This article provides educational information about Temovate and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Temovate FAQ

Can I use Temovate on my face?

Temovate is a very potent corticosteroid; routine use on the face is discouraged because the facial skin is thin and prone to atrophy. If a clinician determines facial treatment is necessary, they will prescribe the lowest effective amount and monitor closely.

How long does a 15 g tube last?

The duration depends on the size of the treated area. For moderate psoriasis covering about 10 % of body surface area, a 15 g tube may last roughly 2-3 weeks when applied once daily.

Is Temovate safe during pregnancy?

Use only if the potential benefit justifies the potential risk to the fetus. Topical corticosteroids can be absorbed systemically, so a healthcare provider should evaluate alternatives first.

What should I do if the cream becomes discolored?

Do not use the product if there are noticeable changes in color, texture, or smell, as this may indicate degradation. Contact your pharmacy for a replacement.

Can I apply Temovate over a bandage?

Generally, occlusive dressings increase drug absorption and should be avoided unless specifically instructed by a clinician.

Will Temovate interact with my oral antihistamines?

Topical clobetasol has minimal systemic interaction, so routine antihistamines (e.g., cetirizine) are not expected to cause problems. Always list all medications for your prescriber.

How does Temovate differ from over-the-counter hydrocortisone creams?

Temovate is a Class I (super-potent) corticosteroid, whereas most OTC hydrocortisone products are Class VII (mild). Temovate provides stronger and faster anti-inflammatory effects but carries higher risk of side effects.

Is a prescription required to obtain Temovate in Hong Kong?

Yes, Temovate is classified as a prescription-only medicine in Hong Kong and must be dispensed by a licensed pharmacist upon presentation of a valid prescription.

Can I travel with Temovate in my hand luggage?

Yes, provided the tube complies with airline liquid restrictions (generally ≤100 ml per container) and is clearly labeled. Keep it in its original packaging to avoid confusion at security.

What happens if I stop using Temovate abruptly after several weeks?

Sudden cessation after prolonged use may cause rebound inflammation or a flare-up of the underlying skin condition. A gradual taper-reducing frequency or potency-is recommended under medical supervision.

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