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Vastarel

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Vastarel is a heart medication used alongside other treatments to prevent symptoms of stable angina, such as chest pain and shortness of breath.


Ingredient
Availability
In Stock
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Trimetazidine
Primary Category
Heart Health, Angina Prevention
Therapeutic Class
Cardiovascular System, Anti-anginal drugs
Pharmacological Class
Piperazine derivatives
Indications
Stable angina pectoris, Chest pain prevention
Contraindications
Parkinson's disease, Tremors, Severe kidney impairment
Minor Side Effects
Digestive upset, Dizziness, Headache
Moderate Side Effects
Vomiting, Weakness, Skin rash
Serious Side Effects
Movement disorders, Rigidity, Muscle stiffness, Low platelet count
Dosage Forms
Modified-release tablet
Administration Route
Oral
Mechanism of Action
This drug improves the energy metabolism of heart cells during periods of low oxygen by shifting metabolism from fatty acids to glucose, protecting the heart from ischemic stress.
Prescription Status
Rx
Manufacturer
Servier
Patient Summary
Vastarel is a heart medication used alongside other treatments to prevent symptoms of stable angina, such as chest pain and shortness of breath.
Onset Time
Several days of treatment
Duration
12 hours (modified release versions)
Storage Instructions
Keep out of reach of children. Store below 30°C.
Drug Interactions
No major clinically significant drug interactions documented
Age Restrictions
Adults over 18 only.
Pregnancy Use
Not recommended during pregnancy.
Alternative Drugs
Ranolazine, Nicorandil, Amlodipine

Vastarel: Trimetazidine 20 mg Cap - Heart & Blood Pressure Overview

Vastarel contains the active ingredient trimetazidine, a metabolic agent used to improve cardiac efficiency. It is available in a 20 mg capsule formulation and is classified as a prescription medication for heart-related conditions. In Hong Kong, the product is regulated by the Department of Health and must be prescribed by a qualified healthcare professional.

How Trimetazidine Works in the Body

Trimetazidine acts at the cellular level by shifting heart muscle energy production from fatty-acid oxidation toward glucose oxidation. This metabolic shift requires less oxygen, helping the heart maintain function during periods of reduced blood flow (ischemia).

  • Target pathway: Inhibits mitochondrial long-chain 3-ketoacyl-CoA thiolase, a key enzyme in fatty-acid β-oxidation.
  • Effect on oxygen use: Improves efficiency of oxygen utilization, which can lessen chest pain episodes.
  • Onset and duration: Clinical effects usually appear within a few days of regular dosing and persist as long as the medication is taken.

Conditions Treated with Vastarel

Approved Medical Uses

  • Stable angina pectoris - to reduce the frequency of angina attacks in patients with chronic coronary artery disease.
  • Ischemic heart disease - as an adjunct to standard anti-anginal therapy, helping to improve exercise tolerance.

These indications are recognized by regulatory authorities in Hong Kong and align with the product’s labeling in other jurisdictions.

Off-Label and Investigational Applications

Current peer-reviewed literature does not provide strong evidence for routine off-label use of trimetazidine. Emerging research has explored its potential benefit in heart failure with preserved ejection fraction, but such use remains investigational and should only be considered under specialist supervision.

Disclaimer: Off-label use requires medical supervision and individualized risk assessment.

Who Should Use Vastarel?

Contraindications

  • Known hypersensitivity to trimetazidine or any capsule excipients.
  • Parkinson’s disease, movement disorders, or uncontrolled seizures - trimetazidine may exacerbate these conditions.

Precautions (Relative Contraindications)

  • Severe renal impairment (creatinine clearance < 30 mL/min) - dose adjustment may be needed.
  • Hepatic dysfunction - monitor for accumulation.
  • Pregnancy (especially first trimester) and breastfeeding - limited safety data; avoid unless clearly indicated.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Mild dizziness or headache (often transient).
  • Nausea or gastrointestinal discomfort.
  • Taste disturbances (dysgeusia).

Serious Adverse Events

  • New or worsening movement disorders (e.g., Parkinsonian symptoms).
  • Severe allergic reactions such as skin rash or angioedema.

If any of these occur, seek medical attention promptly.

Drug Interactions

  • Major: Concomitant use with other anti-anginal agents (e.g., nitrates, beta-blockers) may increase the risk of hypotension; monitor blood pressure.
  • Moderate: Drugs that affect renal clearance (e.g., certain diuretics) may require dose adjustment.
  • CYP enzymes: Trimetazidine is not a significant substrate or inhibitor of common CYP pathways, but clinicians should still review all concurrent medications.

Food and Lifestyle Interactions

  • Take capsules with or without food; consistency aids absorption.
  • No known interaction with alcohol, but excessive intake can worsen cardiovascular risk.
  • No evidence that trimetazidine impairs driving or operating machinery.

How to Take Vastarel

  • Standard adult dosing: 20 mg capsule taken three times daily with meals.
  • Renal adjustment: For moderate renal impairment, a healthcare provider may reduce the frequency to twice daily.
  • Administration: Swallow the capsule whole; do not crush or chew.
  • Missed dose: Take the missed dose as soon as remembered unless it is near the time of the next scheduled dose. Do not double the dose.
  • Overdose: Symptoms may include severe nausea, vomiting, and dizziness. Seek emergency medical care; supportive treatment is the mainstay.
  • Discontinuation: Abrupt stopping is generally safe, but patients should discuss any changes with their prescriber to assess the need for a taper.

Monitoring and Follow-Up

  • Blood pressure and heart rate should be measured regularly to assess therapeutic response.
  • Electrocardiogram (ECG) may be performed at baseline and during follow-up in patients with known cardiac disease.
  • Renal function tests are advisable before initiating therapy and periodically thereafter in at-risk individuals.

Storage and Handling

  • Store capsules at room temperature (15-30 °C), protected from light and moisture.
  • Keep out of reach of children and pets.
  • Do not use past the expiration date printed on the label.

Medication-Specific Glossary

Ischemia
A condition where blood flow (and thus oxygen) is insufficient to meet tissue demands, often affecting the heart muscle.
Angina pectoris
Chest discomfort caused by reduced blood flow to the heart, typically triggered by physical exertion or stress.
Metabolic modulation
The process of altering cellular energy pathways to improve efficiency, as achieved by trimetazidine’s shift from fatty-acid to glucose oxidation.

Medical Disclaimer

This article provides educational information about Vastarel and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Vastarel FAQ

What is the difference between Vastarel and generic trimetazidine?

Vastarel is a branded formulation of trimetazidine that contains 20 mg of the active ingredient per capsule. Generic versions contain the same amount of trimetazidine but may differ in inactive ingredients, appearance, or packaging.

Can I take Vastarel if I have a history of migraine?

Trimetazidine is not known to trigger migraines, but individual responses vary. Discuss your migraine history with a healthcare professional before starting the medication.

How quickly can I expect relief from angina after beginning Vastarel?

Clinical improvement often becomes noticeable within a few days of regular dosing, but full therapeutic benefit may take several weeks as the heart adapts to the metabolic changes.

Are there any dietary restrictions while taking Vastarel?

There are no specific food restrictions, but maintaining a balanced diet low in saturated fats supports overall heart health and complements the medication’s effects.

Will Vastarel appear on a standard drug test for employment or sports?

Trimetazidine is not part of routine occupational drug screens, but it is listed on the World Anti-Doping Agency (WADA) prohibited list. Athletes should verify sport-specific regulations before use.

Can I travel with Vastarel tablets in my hand luggage?

Yes, you may carry your prescribed capsules in hand luggage, provided they are in their original packaging with a clear prescription label. Keep them easily accessible for security inspection.

What should I do if I accidentally swallow two capsules at once?

Do not induce vomiting. Seek immediate medical attention or contact a poison control center for guidance, as the dosage may exceed the recommended amount.

Is Vastarel safe for people with mild liver disease?

Mild hepatic impairment generally does not require dose modification, but liver function should be evaluated periodically, and any concerns discussed with a prescriber.

How does Vastarel compare to other anti-anginal drugs like beta-blockers?

Beta-blockers reduce heart rate and contractility, while Vastarel improves the heart’s metabolic efficiency without affecting heart rate. They can be used together, but a clinician should tailor therapy to each patient’s needs.

What is the typical cost difference between Vastarel and generic trimetazidine in Hong Kong?

Brand-name products often carry a higher price due to branding and distribution costs. Generic equivalents usually offer a lower-cost option, though exact pricing varies among pharmacies and insurance coverage.

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