Buy Zydena
Zydena

10.02
Zydena is a medication containing Udenafil, used for the treatment of erectile dysfunction. It helps improve erectile response to allow for satisfactory sexual performance during stimulation.


Ingredient
Availability
In Stock
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Udenafil
Original Manufacturer
Dong-A ST
Product Form
Tablet
Regulatory Classification
Rx
Primary Category
Erectile Dysfunction
Product Category
Phosphodiesterase-5 Inhibitor
Pharmacological Class
PDE5 Inhibitor
Clinical Indications
Erectile dysfunction
Manufacturer Description
Zydena is a medication containing Udenafil, used for the treatment of erectile dysfunction. It helps improve erectile response to allow for satisfactory sexual performance during stimulation.
Mechanism of Action
Relaxes smooth muscles in penile tissues by inhibiting PDE5 to facilitate increased blood flow during arousal.
Route of Administration
Oral
Onset Time
30–60 minutes
Duration
12–24 hours
Contraindications
Nitrate medication
Severe Adverse Events
Vision loss, Priapism
Common Side Effects
Headache, Facial flushing
Uncommon Side Effects
Dyspepsia
Drug Interactions
Nitrates
Pregnancy Safety Warnings
Not applicable.
Age Restrictions
Adult males only.
Storage Guidelines
Store at room temperature.
Related Products
Sildenafil, Tadalafil

Zydena FAQ

Can Zydena be taken with alcohol?

Moderate alcohol intake does not usually interfere with Zydena’s efficacy, but excessive drinking can enhance the drug’s blood-pressure-lowering effects and may reduce erection quality. It is safest to limit alcohol consumption on nights when the medication is used.

How long before sexual activity should I take Zydena?

The recommended timing is 30 - 60 minutes prior to anticipated sexual activity. Taking it earlier may delay onset, while taking it later could reduce its effectiveness.

Is Zydena safe for men with hypertension?

Zydena can be used by men with well-controlled hypertension, but it should be avoided in those taking nitrate medications or who have uncontrolled blood pressure. Regular monitoring by a healthcare professional is advised.

What should I do if I experience a painful erection lasting more than four hours?

A prolonged erection (priapism) is a medical emergency. Seek immediate medical attention to prevent permanent damage to penile tissue.

Does food affect the absorption of Zydena?

Udenafil’s absorption is less affected by food compared with some other PDE5 inhibitors, but a high-fat meal may slightly delay the onset of action. Taking the pill with a light meal or on an empty stomach is acceptable.

Can Zydena be used by men who are taking antidepressants?

Most antidepressants do not have a direct interaction with Udenafil. However, selective serotonin reuptake inhibitors (SSRIs) can sometimes cause sexual dysfunction, which may influence the overall effectiveness of ED treatment. Discuss all medications with a healthcare provider.

Is there a risk of vision loss with Zydena?

Rare cases of non-arteritic anterior ischemic optic neuropathy (NAION) have been reported with PDE5 inhibitors. If you notice sudden vision changes or loss of sight, seek urgent medical care.

What are the tablet’s appearance and imprint?

Zydena tablets are typically round, white, and bear the imprint “100 U-Z.” Appearance may vary by manufacturer, so verify the imprint on the packaging before use.

Can Zydena be taken daily for continuous coverage?

Zydena is intended for on-demand use and should not be taken more than once per day. For men desiring daily therapy, other PDE5 inhibitors with longer half-lives may be considered under medical supervision.

Is a prescription required for Zydena in Hong Kong?

Yes. Zydena is classified as a prescription-only medication in Hong Kong, and it must be dispensed by a licensed pharmacist following a qualified doctor’s order.

What is Zydena?

Zydena is a prescription medication marketed for the treatment of erectile dysfunction (ED). Its active ingredient is Udenafil, a phosphodiesterase-type 5 (PDE5) inhibitor that helps men achieve and maintain an erection sufficient for sexual activity. Zydena is supplied as an oral pill in a 100 mg strength. In Hong Kong, it is classified as a prescription-only drug and must be dispensed by a licensed pharmacist under a physician’s order.

How Zydena Works in the Body

Udenafil belongs to the PDE5 inhibitor class, which includes sildenafil, tadalafil and vardenafil. The drug’s primary action is to block the enzyme phosphodiesterase-type 5 in the smooth-muscle cells of the penile vasculature. By inhibiting PDE5, Udenafil prevents the breakdown of cyclic guanosine monophosphate (cGMP), a messenger that promotes relaxation of penile smooth muscle and dilation of blood vessels. Increased cGMP levels improve blood flow into the corpus cavernosum, facilitating erection when sexual stimulation releases nitric oxide.

  • Onset of action: typically 30 - 60 minutes after oral intake.
  • Peak effect: around 1 - 2 hours.
  • Duration: therapeutic effects may last up to 12 hours, providing a flexible window for sexual activity.

Conditions Treated by Zydena

Zydena is approved for the oral treatment of erectile dysfunction in adult men. Erectile dysfunction is defined as the consistent inability to attain or maintain an erection sufficient for satisfactory sexual performance. The medication is intended for use on an as-needed basis and is not designed for continuous daily dosing.

Regulatory authorities in Hong Kong have recognized Udenafil-containing products as therapeutic options for ED, following assessments that demonstrate efficacy comparable to other PDE5 inhibitors.

Who Should Not Use Zydena?

Absolute Contraindications

  • Known hypersensitivity to Udenafil or any excipients in the pill.
  • Concurrent use of nitrates (e.g., nitroglycerin, isosorbide dinitrate) in any form, due to risk of severe hypotension.
  • Unstable cardiovascular disease, including recent (within 6 weeks) myocardial infarction, unstable angina, or uncontrolled arrhythmias.
  • History of non-arteritic anterior ischemic optic neuropathy (NAION) or other retinal vascular disorders.

Relative Contraindications

  • Severe hepatic impairment (Child-Pugh Class C).
  • Moderate to severe renal impairment (creatinine clearance < 30 mL/min).
  • Use of alpha-blockers (e.g., tamsulosin) - dose titration and blood pressure monitoring are advised.
  • Recent (within 3 months) stroke or major cardiovascular event.

Special Populations

  • Pregnant or lactating women: not applicable, as the drug is indicated for men only.
  • Pediatric patients: safety and efficacy have not been established; use is prohibited.
  • Older adults: initiate at the recommended dose (100 mg) but monitor for hypotension and visual disturbances, especially in those with comorbidities.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Headache - usually mild and transient.
  • Facial flushing - a warm sensation lasting minutes to an hour.
  • Nasal congestion - occasional stuffiness or runny nose.
  • Dyspepsia - mild indigestion or stomach discomfort.

Serious Adverse Events

  • Sudden loss of vision (e.g., NAION) - requires immediate medical evaluation.
  • Sudden hearing loss - rare but urgent.
  • Priapism (erection lasting > 4 hours) - seek emergency care to prevent permanent damage.
  • Severe hypotension - especially when combined with nitrates or potent vasodilators.

Drug Interactions

  • Nitrates - additive vasodilatory effect can cause life-threatening low blood pressure.
  • Alpha-blockers - may amplify blood-pressure-lowering actions; adjust dose cautiously.
  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) - can increase Udenafil plasma levels, heightening side-effect risk.
  • CYP3A4 inducers (e.g., rifampin, carbamazepine) - may reduce therapeutic efficacy.

Food and Lifestyle Interactions

  • High-fat meals may delay onset slightly; however, Udenafil’s absorption is less food-dependent than some other PDE5 inhibitors.
  • Alcohol in excess can exacerbate hypotension and diminish erection quality; moderate consumption is advisable.
  • Grapefruit can inhibit CYP3A4 and modestly raise drug concentrations; avoid large quantities.
  • Operating machinery - most men tolerate normal activities, but dizziness or hypotension warrants caution.

Patients should disclose all medications, supplements, and herbal products to their healthcare provider before starting Zydena.

How to Take Zydena

  • Standard dosing: One 100 mg pill taken orally with water, approximately 30-60 minutes before anticipated sexual activity.
  • Frequency: Do not exceed one tablet per day.
  • Food: Can be taken with or without food; a high-fat meal may modestly delay onset.
  • Special populations: Elderly or men with mild hepatic/renal impairment may continue the same dose but should be monitored closely; dose reduction is not routinely required unless adverse effects emerge.

Missed Dose

If an erection does not occur, do not take an additional tablet. Wait for the next planned sexual activity and take a single 100 mg dose as directed.

Overdose

Symptoms may include profound hypotension, prolonged erection, dizziness, or syncope. Seek emergency medical attention promptly. There is no specific antidote; treatment is supportive, focusing on blood-pressure stabilization and symptom management.

Discontinuation

Zydena does not require tapering. If therapy is stopped, the drug is cleared from the body within 24 hours. Should side effects become problematic, consult a healthcare professional for alternative management.

Monitoring and Follow-Up

Before initiating therapy, clinicians typically assess cardiovascular status, including blood pressure and any history of heart disease. After starting Zydena, patients should:

  • Report any episodes of chest pain, severe dizziness, or visual changes immediately.
  • Return for follow-up if they experience recurrent side effects or if they have started new medications that may interact.

Routine laboratory monitoring is not required for most patients, but periodic evaluation of liver and kidney function may be advisable in those with known impairment.

Storage and Handling

  • Store the tablets at room temperature (20 - 25 °C), away from excess moisture and direct sunlight.
  • Keep the container tightly closed and out of reach of children.
  • Do not use the medication after the expiration date printed on the package.
  • Dispose of unused tablets according to local pharmacy-take-back programs or the instructions on the medication label.

Medication-Specific Glossary

Phosphodiesterase-type 5 (PDE5) inhibitor
A class of drugs that block the PDE5 enzyme, preventing the breakdown of cGMP and thereby enhancing penile blood flow during sexual stimulation.
cGMP (Cyclic Guanosine Monophosphate)
A second messenger molecule that relaxes smooth muscle in the penis, facilitating increased blood flow and erection.
Nitrovasodilator
Medications (e.g., nitrates) that release nitric oxide to widen blood vessels; their simultaneous use with PDE5 inhibitors can cause dangerous drops in blood pressure.
Priapism
A prolonged, often painful erection lasting more than four hours; it is a medical emergency that can lead to permanent tissue damage if not treated promptly.

Medical Disclaimer

This article provides educational information about Zydena and is not a substitute for professional medical advice. Treatment decisions, including the use of unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

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