Cozaar is a prescription pill that contains the active ingredient losartan. Losartan belongs to the heart- and blood-pressure therapeutic class known as angiotensin II receptor blockers (ARBs). In Hong Kong, Cozaar is approved by the Department of Health and is marketed by Merck Sharp & Dohme (MSD). It is available in strengths of 25 mg, 50 mg, and 100 mg.
Losartan blocks the angiotensin II type 1 (AT₁) receptor. Angiotensin II is a hormone that narrows blood vessels and prompts the kidneys to retain sodium and water, raising blood pressure. By preventing angiotensin II from binding to its receptor, losartan:
The onset of blood-pressure reduction typically occurs within a few hours, with the peak effect reached after about 2 hours. The medication’s half-life is roughly 2 hours, but its active metabolite extends blood-pressure control for up to 24 hours, permitting once-daily dosing.
Cozaar is approved in Hong Kong for the following indications:
These uses are based on regulatory evaluation by the Hong Kong Department of Health, which follows international standards such as those of the FDA and EMA.
These effects are usually transient and may improve as the body adjusts to the medication.
When specific interaction data for Cozaar are limited, patients should disclose all medicines, supplements, and herbal products to their healthcare provider.
Standard dosing for hypertension:
Begin with 50 mg once daily.
If blood pressure is not adequately controlled, the dose may be increased to 100 mg once daily.
A 25 mg starting dose is appropriate for patients who are elderly, have renal impairment, or are prone to low blood pressure.
Diabetic nephropathy: The usual dose is 50 mg once daily; some clinicians may titrate to 100 mg based on kidney-function tests.
Heart failure: Initiate at 12.5 mg to 25 mg once daily, then increase cautiously to the target dose (up to 50 mg) as tolerated.
Administration: Swallow the pill whole with a glass of water. It may be taken with or without food.
Missed dose: If a dose is missed, take it as soon as remembered unless it is close to the next scheduled dose; do not double the dose.
Overdose: Symptoms may include severe hypotension, dizziness, or rapid heartbeat. Seek immediate medical attention; supportive care and monitoring are the primary treatments.
Discontinuation: Do not stop Cozaar abruptly without medical advice, especially in heart-failure patients, as sudden withdrawal can raise blood pressure and worsen heart function.
This article provides educational information about Cozaar and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.
Cozaar contains losartan, an ARB that blocks the AT₁ receptor, whereas many other blood-pressure medicines such as ACE inhibitors block the enzyme that produces angiotensin II. This distinct mechanism can make losartan a suitable alternative for patients who develop cough with ACE inhibitors.
Yes. A low-sodium diet complements the blood-pressure-lowering effect of losartan and is often recommended to help achieve optimal control.
Blood-pressure reduction can be observed within a few hours after the first dose, with the full effect generally reached after 2 weeks of consistent therapy.
Because losartan can raise potassium levels, adding a potassium supplement may increase the risk of hyperkalemia. Discuss any supplements with your healthcare provider before use.
Rise slowly from sitting or lying positions, stay hydrated, and avoid driving or operating machinery until the dizziness resolves. If the symptom persists, contact your healthcare professional.
Most OTC cold remedies do not interact directly with losartan, but NSAID-containing products (e.g., ibuprofen) can affect kidney function and reduce blood-pressure control. Check product labels and consult a pharmacist.
Losartan is metabolized in the liver, so mild hepatic impairment generally does not require dose adjustment. However, severe liver disease may necessitate a lower starting dose and closer monitoring.
Keep the tablets in their original container, protected from heat and moisture. If you travel by air, place them in your carry-on luggage to avoid temperature extremes in checked baggage.
Generic losartan contains the same active ingredient, dosage form, and strength as Cozaar and must meet the same regulatory standards for safety and efficacy.
